Obesity and suppressed B-type natriuretic peptide levels in heart failure
Open accessAbstract
Objectives This investigation evaluated the relationship between obesity and B-type natriuretic peptide (BNP) in heart failure.Background Obesity is a major risk factor for the development of heart failure, but the precise mechanisms remain uncertain. Physiologically, natriuretic peptides and lipolysis are closely linked.Methods A total of 318 patients with heart failure were evaluated between June 2001 and June 2002. Levels of BNP were compared in obese (body mass index [BMI] > or =30 kg/m(2)) and nonobese (BMI <30 kg/m(2)) patients with respect to New York Heart Association functional class and lean body weight-adjusted peak aerobic oxygen consumption. In a subset of 36 patients, plasma levels of tumor necrosis factor-alpha, interleukin-6, and soluble intercellular adhesion molecule-1 were measured.Results The population's BMI was 29.4 +/- 6.6 kg/m(2); 24% were lean (BMI <25 kg/m(2)), 31% overweight (BMI > or =25 to 29.9 kg/m(2)), and 45% obese (BMI > or =30 kg/m(2)). Obese patients were younger, more often African American, and more likely to have a history of antecedent hypertension, but less likely to have coronary artery disease and with only a trend toward diabetes mellitus. Levels of BNP were significantly lower in obese than in nonobese subjects (205 +/- 22 and 335 +/- 39 pg/ml, respectively; p = 0.0007), despite a similar severity of heart failure and cytokine levels. Multivariate regression analysis identified BMI as an independent negative correlate of BNP level. There were no differences in emergency department visits, heart failure hospitalization, or death between the obese and nonobese patients at 12-month follow-up.Conclusions Our investigation indicates that a state of reduced natriuretic peptide level exists in the obese individual with heart failure.
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Obese subjects have lower levels of serum BNP than normal-weight controls with similar pulmonary capillary wedge pressure.
“Interestingly, obese subjects have lower levels of serum BNP than normal-weight controls with similar pulmonary capillary wedge pressure (232).”
From Cardiac remodeling in obesity (2008) · cites this paper as [232]
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Cites
Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241 · see citing works
Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure
Maisel, A. S., Krishnaswamy, P., Nowak, R. M., McCord, J., Hollander, J. E., Duc, P., Omland, T., Storrow, A. B., Abraham, W. T., Wu, A. H. B., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020233 · Cited by 3,346 · see citing works
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093 · see citing works
Wasting as independent risk factor for mortality in chronic heart failure
Anker, S. D., Ponikowski, P. P., Varney, S. J., Chua, T. P., Clark, A. L., Webb-Peploe, K., Harrington, D., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07015-8 · Cited by 1,399 · see citing works
Lipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265 · see citing works
Plasma brain natriuretic peptide concentration: impact of age and gender
Redfield, M. M., Rodeheffer, R. J., Jacobsen, S. J., Mahoney, D. W., Bailey, K. R., & Burnett, J. C. J. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02059-4 · Cited by 1,140 · see citing works
Overweight, Obesity, and Health Risk
National Task Force on the Prevention and Treatment of Obesity (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.7.898 · Cited by 963 · see citing works
The relationship between obesity and mortality in patients with heart failure
Horwich, T. B., Fonarow, G. C., Hamilton, M. A., MacLellan, W. R., Woo, M. A., & Tillisch, J. H. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01448-6 · Cited by 867 · see citing works
Natriuretic peptides: a new lipolytic pathway in human adipocytes
Sengenès, C., Berlan, M., de Glisezinski, I., Lafontan, M., & Galitzky, J. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.10.1345 · Cited by 531 · see citing works
McCullough, P. A., Duc, P., Omland, T., McCord, J., Nowak, R. M., Hollander, J. E., Herrmann, H. C., Steg, P. G., Westheim, A. S., Knudsen, C. W., et al. (2003) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50118 · Cited by 524 · see citing works
Body composition and prognosis in chronic systolic heart failure: the obesity paradox
Lavie, C. J., Osman, A. F., Milani, R. V., & Mehra, M. R. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00031-6 · Cited by 486 · see citing works
Self-citationThe prognosis of heart failure in the general population: the Rotterdam Study
Mosterd, A. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2533 · Cited by 470 · see citing works
Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo
Mohamed‐Ali, V., Goodrick, S., Bulmer, K., Holly, J. M. P., Yudkin, J. S., & Coppack, S. W. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e971 · Cited by 397 · see citing works
Dimorphic Cardiac Adaptation to Obesity and Arterial Hypertension
Messerli, F. H., SUNDGAARD-RIISE, K., REISIN, E. D., DRESLINSKI, G. R., Ventura, H. O., OIGMAN, W., FROHLICH, E. D., & DUNN, F. G. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-99-6-757 · Cited by 336 · see citing works
Self-citationImpaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart
Young, M. E., Guthrie, P. H., Razeghi, P., Leighton, B., Abbasi, S., Patil, S. U., Youker, K. A., & Taegtmeyer, H. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2587 · Cited by 295 · see citing works
Alpert, M. A., Lambert, C. R., Panayiotou, H., Terry, B. E., Cohen, M. V., Massey, C. V., Hashimi, M. W., & Mukerji, V. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80338-5 · Cited by 292 · see citing works
Expression of natriuretic peptide receptors in human adipose and other tissues
Sarzani, P., Dessı̀-Fulgheri, P., Paci, V. M., Espinosa, E., & RAPPELLI, A. (1996) · Journal of Endocrinological Investigation · doi:10.1007/bf03349021 · Cited by 254 · see citing works
Natriuretic peptides: a new lipolytic pathway in human adipocytes
Sengenès, C. (2000) · The FASEB Journal · doi:10.1096/fj.14.10.1345 · Cited by 199 · see citing works
Osman, A. F., Mehra, M. R., Lavie, C. J., Núñez, E., & Milani, R. V. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00985-2 · Cited by 198 · see citing works
Self-citationContrasting clinical properties and exercise responses in obese and lean hypertensive patients
Weber, M. A., Neutel, J. M., & Smith, D. H. G. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01103-7 · Cited by 122 · see citing works
Fasting inhibits natriuretic peptides clearance receptor expression in rat adipose tissue
Sarzani, R., Paci, V. M., Zingaretti, C. M., Pierleoni, C., Cinti, S., Cola, G., RAPPELLI, A., & Dess??-Fulgheri, P. (1995) · Journal of Hypertension · doi:10.1097/00004872-199511000-00004 · Cited by 104 · see citing works
The problem of obesity and hypertension.
Frohlich, E. D., Messerli, F. H., Reisin, E., & Dunn, F. G. (1983) · Hypertension · doi:10.1161/01.hyp.5.5_pt_2.iii71 · Cited by 88 · see citing works
Self-citationThe natriuretic peptide system in obesity-related hypertension: new pathophysiological aspects.
Dessı̀-Fulgheri, P., Sarzani, R., & RAPPELLI, A. (1999) · PubMed · Cited by 77 · see citing works
Obesity and Heart Failure — Risk Factor or Mechanism?
Massie, B. M. (2002) · New England Journal of Medicine · doi:10.1056/nejme020065 · Cited by 62 · see citing works
Regulation of lipolysis: natriuretic peptides and the development of cachexia
Kalra, P. R., & Tigas, S. K. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00241-3 · Cited by 57 · see citing works
Hypertension and obesity after the menopause.
RAPPELLI, A. (2002) · PubMed · Cited by 42 · see citing works
B-Type natriuretic peptide: From bench to bedside
Adams, K. F., Mathur, V. S., & Gheorghiade, M. (2003) · American Heart Journal · doi:10.1067/mhj.2003.152 · Cited by 37 · see citing works
Given Diabetes, Is Fat Better Than Thin?
Ross, C. C., Langer, R. D., & Barrett-Connor, E. L. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.650 · Cited by 30 · see citing works
Platelet aggregation, blood viscosity and serum lipids in hypertensive and obese children
Haszon, I., Papp, F., Kovács, J., Bors, M., Németh, I., Bereczki, C., & Túri, S. (2003) · European Journal of Pediatrics · doi:10.1007/s00431-003-1156-4 · Cited by 23 · see citing works
Recent data on the regulation of lipolysis by catecholamines and natriuretic peptides.
Lafontan, M., Berlan, M., Štich, V., Crampes, F., Rivière, D., de Glisezinski, I., Sengenès, C., & Galitzky, J. (2002) · PubMed · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.012 · Cited by 2,862 · see citing works
Obesity and Cardiovascular Disease
Lavie, C. J., Milani, R. V., & Ventura, H. O. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.068 · Cited by 2,326 · see citing works
Self-citationHeidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001063 · Cited by 4,922 · see citing works
WRITING COMMITTEE MEMBERS, Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.167586 · Cited by 2,251 · see citing works
State of the art: using natriuretic peptide levels in clinical practice
Maisel, A., Mueller, C., Adams, K., Anker, S. D., Aspromonte, N., Cleland, J. G. F., Cohen-Solal, A., Dahlstrom, U., DeMaria, A., Di Somma, S., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.07.014 · Cited by 839 · see citing works
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure
Kistorp, C., Faber, J., Galatius, S., Gustafsson, F., Frystyk, J., Flyvbjerg, A., & Hildebrandt, P. (2005) · Circulation · doi:10.1161/circulationaha.104.530972 · Cited by 605 · see citing works
Das, S. R., Drazner, M. H., Dries, D. L., Vega, G. L., Stanek, H. G., Abdullah, S. M., Canham, R. M., Chung, A. K., Leonard, D., Wians, F. H., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.555573 · Cited by 433 · see citing works
Obesity and the Obesity Paradox in Heart Failure
Horwich, T. B., Fonarow, G. C., & Clark, A. L. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.05.005 · Cited by 392 · see citing works
The obesity paradox, weight loss, and coronary disease
Lavie, C. J., Milani, R. V., Artham, S. M., Patel, D. A., & Ventura, H. O. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.06.006 · Cited by 237 · see citing works
Self-citationManagement of cardiovascular diseases in patients with obesity
Lavie, C. J., Arena, R., Alpert, M. A., Milani, R. V., & Ventura, H. O. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.108 · Cited by 218 · see citing works
Self-citationJordan, J., Birkenfeld, A. L., Melander, O., & Moro, C. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11081 · Cited by 68 · see citing works
Savoia, C., Volpe, M., Alonzo, A., Rossi, C., & Rubattu, S. (2010) · Clinical Science · doi:10.1042/cs20090204 · Cited by 35 · see citing works
Bertoni, A. G., Wagenknecht, L. E., Kitzman, D. W., Marcovina, S. M., Rushing, J. T., Espeland, M. A., & ; and Brain Natriuretic Peptide Subgroup of the Look AHEAD Research Group (2012) · Obesity · doi:10.1038/oby.2011.296 · Cited by 34 · see citing works
Gastric Bypass Surgery Elevates NT-ProBNP Levels
Abrahamsson, N., Engström, B. E., Sundbom, M., & Karlsson, F. A. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0889-z · Cited by 33 · see citing works
Cardiac natriuretic peptides in plasma increase after dietary induced weight loss in obesity
Kistorp, C., Bliddal, H., Goetze, J. P., Christensen, R., & Faber, J. (2014) · BMC Obesity · doi:10.1186/s40608-014-0024-2 · Cited by 31 · see citing works
- Authors
- Mehra, M. R., Uber, P. A., Park, M. H., Scott, R. L., Ventura, H. O., Harris, B. C., & Frohlich, E. D.
- Affiliations
- Ochsner Health System (US)
- Ochsner Medical Center (US)
- Corresponding author
- Mehra, Mandeep R
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 43
- Issue
- 9
- Pages
- 1590-1595
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2161106868
- Cited by
- 534
- References
- 30
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 17 · 2023: 22 · 2022: 20 · 2021: 18 · 2020: 14 · 2019: 11 · 2018: 23 · 2017: 23 · 2016: 25 · 2015: 19 · 2014: 21 · 2013: 16 · 2012: 32
- FWCI
- 22.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- obesity, brain natriuretic peptide, heart failure, body mass index, natriuretic peptides, lipolysis, cytokines, TNF-α, interleukin-6, soluble intercellular adhesion molecule-1, lean body weight, heart failure hospitalization, mortality
- MeSH terms
- Adult, Age Factors, Aged, Creatinine, Female, Heart Failure, Humans, Louisiana, Male, Middle Aged, Obesity, Predictive Value of Tests, Sex Factors, Statistics as Topic, Stroke Volume, Biomarkers, Body Mass Index, Multivariate Analysis, Cytokines, Natriuretic Peptide, Brain
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