Circadian Clocks and Metabolism

Coordination of circadian timing in mammals

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

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Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice

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Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index

Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477 · see citing works

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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Adverse metabolic and cardiovascular consequences of circadian misalignment

Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351 · see citing works

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329 · see citing works

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198 · see citing works

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works

Mammalian Sirtuins: Biological Insights and Disease Relevance

Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

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Circadian integration of metabolism and energetics

Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910 · see citing works

Resetting central and peripheral circadian oscillators in transgenic rats

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Resetting of circadian time in peripheral tissues by glucocorticoid signaling

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Transplanted Suprachiasmatic Nucleus Determines Circadian Period

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Entrainment of the circadian clock in the liver by feeding

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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

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Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

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Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight

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Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight

Kalra, S. P. (1999) · Endocrine Reviews · doi:10.1210/er.20.1.68 · Cited by 1,554 · see citing works

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528 · see citing works

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works

Extensive and divergent circadian gene expression in liver and heart

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The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

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Social jetlag and obesity

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SIRT1 regulates circadian clock gene expression through PER2 deacetylation

Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376 · see citing works

Circadian Control of the NAD ⁺ Salvage Pathway by CLOCK-SIRT1

Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198 · see citing works

SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.057 · Cited by 1,162 · see citing works

Posttranslational Mechanisms Regulate the Mammalian Circadian Clock

Lee, C., Etchegaray, J., Cagampang, F. R. A., Loudon, A. S. I., & Reppert, S. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00610-9 · Cited by 1,158 · see citing works

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

Someya, S., Yu, W., Hallows, W. C., Xu, J., Vann, J. M., Leeuwenburgh, C., Tanokura, M., Denu, J. M., & Prolla, T. A. (2010) · Cell · doi:10.1016/j.cell.2010.10.002 · Cited by 1,150 · see citing works

Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo

Matsuo, T., Yamaguchi, S., Mitsui, S., Emi, A., Shimoda, F., & Okamura, H. (2003) · Science · doi:10.1126/science.1086271 · Cited by 1,132 · see citing works

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD ⁺ Biosynthesis

Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., et al. (2009) · Science · doi:10.1126/science.1171641 · Cited by 1,126 · see citing works

A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock

Sato, T. K., Panda, S., Miraglia, L. J., Reyes, T. M., Rudic, R. D., McNamara, P., Naik, K. A., FitzGerald, G. A., Kay, S. A., & Hogenesch, J. B. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.018 · Cited by 1,115 · see citing works

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α

Fu, J., Gaetani, S., Oveisi, F., Verme, J., Serrano, A., de Fonseca, F. D., Rosengarth, A., Luecke, H., Giacomo, B. D., Tarzia, G., et al. (2003) · Nature · doi:10.1038/nature01921 · Cited by 1,113 · see citing works

BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works

Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059 · see citing works

Physiological significance of a peripheral tissue circadian clock

Lamia, K. A., Storch, K.-F., & Weitz, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806717105 · Cited by 1,048 · see citing works

Circadian rhythms from flies to human

Panda, S., Hogenesch, J. B., & Kay, S. A. (2002) · Nature · doi:10.1038/417329a · Cited by 1,044 · see citing works

AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

Lamia, K. A., Sachdeva, U. M., DiTacchio, L., Williams, E. C., Alvarez, J. G., Egan, D. F., Vasquez, D. S., Juguilon, H., Panda, S., Shaw, R. J., et al. (2009) · Science · doi:10.1126/science.1172156 · Cited by 958 · see citing works

Circadian timing of food intake contributes to weight gain

Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W. (2009) · Obesity · doi:10.1038/oby.2009.264 · Cited by 953 · see citing works

Nuclear Receptor Expression Links the Circadian Clock to Metabolism

Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 934 · see citing works

Association of sleep time with diabetes mellitus and impaired glucose tolerance

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Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27 485 people

Karlsson, B., Knutsson, A., & Lindahl, B. (2001) · Occupational and Environmental Medicine · doi:10.1136/oem.58.11.747 · Cited by 924 · see citing works

Peroxiredoxins are conserved markers of circadian rhythms

Edgar, R. S., Green, E. W., Zhao, Y., Gerben Van Ooijen, A., Olmedo, M., Qin, X., Xu, Y. Q., Pan, M., Valekunja, U. K., Feeney, K. A., et al. (2012) · Nature · doi:10.1038/nature11088 · Cited by 915 · see citing works

Effects of poor and short sleep on glucose metabolism and obesity risk

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Circadian clocks in human red blood cells

O'Neill, J. S., & Reddy, A. B. (2011) · Nature · doi:10.1038/nature09702 · Cited by 830 · see citing works

<i>Associations between Sleep Loss and Increased Risk of Obesity and Diabetes</i>

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Light at night increases body mass by shifting the time of food intake

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A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms

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Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

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Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

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Circadian rhythms, sleep, and metabolism

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Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus

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Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways

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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

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An anorexic lipid mediator regulated by feeding

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Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism

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System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock

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Leptin Regulation of the Mesoaccumbens Dopamine Pathway

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Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism

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Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.

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Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation

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Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation

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Crosstalk between components of circadian and metabolic cycles in mammals

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Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

Ripperger, J. A., & Schibler, U. (2006) · Nature Genetics · doi:10.1038/ng1738 · Cited by 593 · see citing works

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590 · see citing works

Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms

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Sirtuins: critical regulators at the crossroads between cancer and aging

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Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

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Circadian orchestration of the hepatic proteome

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Effects of exogenous melatonin on sleep: a meta-analysis

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Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling

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Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis

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The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock

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The hypothalamic integrator for circadian rhythms

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Circadian rhythms persist without transcription in a eukaryote

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Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation

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Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation

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Characterization of Peripheral Circadian Clocks in Adipose Tissues

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The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1

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SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

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Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver

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Glucocorticoid hormones inhibit food‐induced phase‐shifting of peripheral circadian oscillators

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