Cited by 418Lipoproteins and Cardiovascular HealthLipid metabolism and disordersCholesterol and Lipid Metabolism

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Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents: A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, With the Council on Cardiovascular Nursing

McCrindle, Brian W., Urbina, Elaine M., Dennison, Barbara A., Jacobson, Marc S., Steinberger, Julia, Rocchini, Albert P., Hayman, Laura L., Daniels, Stephen R.·2007·Circulation

DOI 10.1161/circulationaha.107.181946

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Abstract

Despite compliance with lifestyle recommendations, some children and adolescents with high-risk hyperlipidemia will require lipid-lowering drug therapy, particularly those with familial hypercholesterolemia. The purpose of this statement is to examine new evidence on the association of lipid abnormalities with early atherosclerosis, discuss challenges with previous guidelines, and highlight results of clinical trials with statin therapy in children and adolescents with familial hypercholesterolemia or severe hypercholesterolemia. Recommendations are provided to guide decision-making with regard to patient selection, initiation, monitoring, and maintenance of drug therapy.

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Authors: McCrindle, B. W., Urbina, E. M., Dennison, B. A., Jacobson, M. S., Steinberger, J., Rocchini, A. P., Hayman, L. L., & Daniels, S. R.
Affiliations: Hospital for Sick Children (CA)
ORCID: McCrindle, Brian W.
Urbina, Elaine M.
Dennison, Barbara A.
Steinberger, Julia
Hayman, Laura L.
Daniels, Stephen R.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-04-10
Volume: 115
Issue: 14
Pages: 1948-1967
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.107.181946
OpenAlex: W2070344375
Cited by: 418
References: 153
Citations by year: 2026: 5 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 19 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 18 · 2015: 23 · 2014: 26 · 2013: 32 · 2012: 36
FWCI: 53.43
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: familial hypercholesterolemia, severe hypercholesterolemia, lipid-lowering therapy, statins, early atherosclerosis, children and adolescents, patient selection, treatment monitoring
MeSH terms: Contraindications, Adolescent, Adult, Age Factors, Anticholesteremic Agents, Hypolipidemic Agents, Arteriosclerosis, Child, Child, Preschool, Cholesterol, Dietary, Clinical Trials as Topic, Combined Modality Therapy, Dietary Fats, Exercise Therapy, Female, Humans, Hyperlipoproteinemia Type II, Hyperlipoproteinemias, Infant, Cholesterol, LDL, Male, Phytotherapy, Middle Aged, Obesity, Risk Factors, Ultrasonography, HIV Infections, HIV Protease Inhibitors, Age of Onset, Disease Progression, Diet, Fat-Restricted, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Metabolic Syndrome, Diabetes Complications, Dyslipidemias

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Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents: A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, With the Council on Cardiovascular Nursing

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