The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Cocoa and Cardiovascular Health
Open accessAbstract
Epidemiological data demonstrate that regular dietary intake of plant-derived foods and beverages reduces the risk of coronary heart disease and stroke. Among many ingredients, cocoa might be an important mediator. Indeed, recent research demonstrates a beneficial effect of cocoa on blood pressure, insulin resistance, and vascular and platelet function. Although still debated, a range of potential mechanisms through which cocoa might exert its benefits on cardiovascular health have been proposed, including activation of nitric oxide and antioxidant and antiinflammatory effects. This review summarizes the available data on the cardiovascular effects of cocoa, outlines potential mechanisms involved in the response to cocoa, and highlights the potential clinical implications associated with its consumption.
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In the citing paper
“In laboratory studies and randomized trials, flavonoid-rich cocoa has small but measurable benefits on BP, endothelial function, insulin resistance, and blood lipids.295-297”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [296]
In the citing paper
“A few short-term trials of other dietary sources (e.g., tea, red wine, grapes) or specific flavonoid extracts have not consistently improved BP, lipid levels, or endothelial function.295-297”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [296]
In the citing paper
“In laboratory studies and randomized trials, flavonoid-rich cocoa has small but measurable benefits on BP, endothelial function, insulin resistance, and blood lipids.295-297”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [297]
In the citing paper
“A few short-term trials of other dietary sources (e.g., tea, red wine, grapes) or specific flavonoid extracts have not consistently improved BP, lipid levels, or endothelial function.295-297”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [297]
Citations
Cites
1 retracted
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Vascular endothelial cells synthesize nitric oxide from L-arginine
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Cited by
Sorted by citations
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216
Important Flavonoids and Their Role as a Therapeutic Agent
Ullah, A., Munir, S., Badshah, S. L., Khan, N., Ghani, L., Poulson, B. G., Emwas, A.-H., & Jaremko, M. (2020) · Molecules · doi:10.3390/molecules25225243 · Cited by 1,696
“Isoflavone, anthocyanins [120], and cocoa [121] flavan-3-ols improve vascular health [122].”
BackgroundThe Assessment of Endothelial Function
Flammer, A. J., Anderson, T. J., Celermajer, D. S., Creager, M. A., Deanfield, J. E., Ganz, P., Hamburg, N. M., Lüscher, T. F., Shechter, M., Taddei, S., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.093245 · Cited by 1,157
Self-citationBioavailability of bioactive food compounds: a challenging journey to bioefficacy.
Rein, M. J., Renouf, M., Cruz-Hernandez, C., Actis-Goretta, L., Thakkar, S. K., & Pinto, M. I. D. S. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04425.x · Cited by 763
Basic biochemical mechanisms behind the health benefits of polyphenols
Fraga, C. G., Galleano, M., Verstraeten, S. V., & Oteiza, P. I. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.006 · Cited by 769
Metadata
- Authors
- Corti, R., Flammer, A. J., Hollenberg, N. K., & Lüscher, T. F.
- Affiliations
- Brigham and Women's Hospital (US)
- From the Cardiovascular Center, Cardiology University Hospital, Zurich, Switzerland (R.C., A.J.F., T.F.L.), and Department of Medicine and Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass (N.K.H.).
- Venue
- Circulation
- Published
- 2009-03-17
- Volume
- 119
- Issue
- 10
- Pages
- 1433-1441
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2105296434
- Cited by
- 424
- References
- 105
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 14 · 2023: 12 · 2022: 23 · 2021: 17 · 2020: 15 · 2019: 19 · 2018: 35 · 2017: 29 · 2016: 30 · 2015: 27 · 2014: 31 · 2013: 38 · 2012: 46
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- other-oa
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food Chemistry and Fat Analysis
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- Theobroma cacao, cardiovascular health, coronary artery disease, stroke, blood pressure, insulin resistance, vascular function, platelet function, nitric oxide, antioxidant activity, anti-inflammatory activity, plant-based foods
- MeSH terms
- Adult, Aged, Antioxidants, Beverages, Cacao, Catechin, Endothelium, Vascular, Female, Flavonoids, Food Handling, Heart Diseases, Humans, Hyperlipidemias, Hypertension, Indians, Central American, Insulin Resistance, Iowa, Male, Phytotherapy, Medicine, Traditional, Middle Aged, Nitric Oxide, Platelet Aggregation, Switzerland, Overweight
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