Cited by 424Food Chemistry and Fat AnalysisPhytochemicals and Antioxidant ActivitiesNitric Oxide and Endothelin Effects

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Cocoa and Cardiovascular Health

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Corti, Roberto, Flammer, Andreas J., Hollenberg, Norman K., Lüscher, Thomas F.·2009·Circulation

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Abstract

Epidemiological data demonstrate that regular dietary intake of plant-derived foods and beverages reduces the risk of coronary heart disease and stroke. Among many ingredients, cocoa might be an important mediator. Indeed, recent research demonstrates a beneficial effect of cocoa on blood pressure, insulin resistance, and vascular and platelet function. Although still debated, a range of potential mechanisms through which cocoa might exert its benefits on cardiovascular health have been proposed, including activation of nitric oxide and antioxidant and antiinflammatory effects. This review summarizes the available data on the cardiovascular effects of cocoa, outlines potential mechanisms involved in the response to cocoa, and highlights the potential clinical implications associated with its consumption.

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See all 424

Authors: Corti, R., Flammer, A. J., Hollenberg, N. K., & Lüscher, T. F.
Affiliations: Brigham and Women's Hospital (US)
From the Cardiovascular Center, Cardiology University Hospital, Zurich, Switzerland (R.C., A.J.F., T.F.L.), and Department of Medicine and Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass (N.K.H.).
ORCID: Corti, Roberto
Flammer, Andreas J.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-03-17
Volume: 119
Issue: 10
Pages: 1433-1441
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.108.827022
OpenAlex: W2105296434
Cited by: 424
References: 105
Citations by year: 2026: 6 · 2025: 9 · 2024: 14 · 2023: 12 · 2022: 23 · 2021: 17 · 2020: 15 · 2019: 19 · 2018: 35 · 2017: 29 · 2016: 30 · 2015: 27 · 2014: 31 · 2013: 38 · 2012: 46
FWCI: 5.34
Type: journal article
Language: en
Open access: green
www.zora.uzh.ch
Licence: other-oa
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Food Chemistry and Fat Analysis
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: Theobroma cacao, cardiovascular health, coronary artery disease, stroke, blood pressure, insulin resistance, vascular function, platelet function, nitric oxide, antioxidant activity, anti-inflammatory activity, plant-based foods
MeSH terms: Adult, Aged, Antioxidants, Beverages, Cacao, Catechin, Endothelium, Vascular, Female, Flavonoids, Food Handling, Heart Diseases, Humans, Hyperlipidemias, Hypertension, Indians, Central American, Insulin Resistance, Iowa, Male, Phytotherapy, Medicine, Traditional, Middle Aged, Nitric Oxide, Platelet Aggregation, Switzerland, Overweight

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