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Atrial Arrhythmias in Adults With Congenital Heart Disease
Abstract
Background Atrial arrhythmias increase disease burden in the general adult population. Adults with congenital heart lesions constitute a rapidly growing group of patients with cardiovascular disease. We hypothesized that atrial arrhythmias increase with age and impair health outcomes in this population. Methods and results We conducted a population-based analysis of prevalence, lifetime risk, mortality, and morbidity associated with atrial arrhythmias in adults with congenital heart disease from l983 to 2005. In 38 428 adults with congenital heart disease in 2005, 5812 had atrial arrhythmias. Overall, the 20-year risk of developing atrial arrhythmia was 7% in a 20-year-old subject and 38% in a 50-year-old subject. More than 50% of patients with severe congenital heart disease reaching age 18 years developed atrial arrhythmias by age 65 years. In patients with congenital heart disease, the hazard ratio of any adverse event in those with atrial arrhythmias compared with those without was 2.50 (95% confidence interval, 2.38 to 2.62; P Conclusions Atrial arrhythmias occurred in 15% of adults with congenital heart disease. The lifetime incidence increased steadily with age and was associated with a doubling of the risk of adverse events. An increase in resource allocation should be anticipated to deal with this increasing burden.
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“By age 50 years, approximately 38% of patients with ACHD will develop an atrial arrhythmia, and by age 65 years, >50% of patients with severe CHD will develop atrial arrhythmias (660).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [660]
In the citing paper
“By age 50 years, approximately 38% of patients with ACHD will develop an atrial arrhythmia, and by age 65 years, >50% of patients with severe CHD will develop atrial arrhythmias (660).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [660]
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Supraventricular Tachycardia in Special Population
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Cohen, S., & Bajolle, F. (2017) · EMC - Cardiologie · doi:10.1016/s1166-4568(16)66580-4
Bouchardy, J., Rutz, T., Bernardo, S. D., Prša, M., Monney, P., & Pruvot, E. (2015) · HeartRhythm Case Reports · doi:10.1016/j.hrcr.2015.12.008
“Atrial arrhythmias are a common complication in the long-term follow-up of CHD patients, with a negative impact on morbidity and mortality.(1,2) Dextro-transposition of the great arteries (d-TGA) is one of the most lifethreatening types of CHD, accounting for approximately 2 cases per 10,000 live births and 3% of all…”
Self-citationArrhythmias in Adult Congenital Heart Disease
Triedman, J. K., & Walsh, E. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6929-1.00017-4 · Cited by 2
Peruzzi, M., Biondi-Zoccai, G., Marullo, A., & Frati, G. (2015) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2014.12.022
Focal Atrial Tachycardia in a Patient With Surgically Corrected Tetralogy of Fallot
Gonzalez, M. (2014) · Cardiology Research · doi:10.14740/cr316w
“In a retrospective study, the incidence of atrial arrhythmias was linked to a two- to threefold increase risk of developing congestive heart failure [8].”
BackgroundHayes, D., Wang, P. J., Asirvatham, S., & Friedman, P. (2012) · doi:10.1002/9781118483923.ch7
Late Arrhythmias: Current Approaches
Foresti, S., Tavera, M. C., Lupo, P., & Cappato, R. (2012) · Springer eBooks · doi:10.1007/978-88-470-2358-1_14
“In various single and multicenter studies, late morbidity and mortality after repair of ToF have been reported to be caused by cardiac ventricular arrhythmias [4–6].”
BackgroundShould complex ACHD patients have periodic Holter monitoring
Moodie, D., & Broberg, C. (2012) · Progress in Pediatric Cardiology · doi:10.1016/j.ppedcard.2012.05.010
“In a population based analysis of ACHD by Bouchardy, the 20-year risk of developing atrial arrhythmia was 7% in a 20 year-old subject and 38% in a 50 year-old subject [8].”
BackgroundAdults with Congenital Heart Disease
Yetman, A., & Webb, G. D. (2012) · doi:10.1002/9781444398786.ch53
Atrial Fibrillation in Children
Martin, T., & Hagenbuch, S. (2012) · InTech eBooks · doi:10.5772/26547
“…transposition of the great arteries, single ventricle, tetralogy of Fallot and Marfan syndrome (Attenhofer Jost et al., 2005; Berger et al., 2005; Bouchardy et al., 2009; Chatzis et al., 2008; Chauvaud et al 2001; Collins, 2009; Hallioglu et al., 2004; Hayashi et al, 2006; Kammeraad et al.,…”
BackgroundEditors, T. (2011) · Circulation · doi:10.1161/circulationaha.111.073965
Arrhythmias in Different Heart Diseases and Situations
de Luna, A. B. (2011) · Wiley eBooks · doi:10.1002/9781444391749.ch11
Critical Care Management of the ACHD Patient with Arrhythmias and Conduction Disorders
Lindsay, I., Moore, J., & Balaji, S. (2019) · Intensive Care of the Adult with Congenital Heart Disease · doi:10.1007/978-3-319-94171-4_16
The Ideal Intensive Care Unit for Adults with Congenital Heart Disease
Briston, D., & Daniels, C. J. (2019) · Intensive Care of the Adult with Congenital Heart Disease · doi:10.1007/978-3-319-94171-4_1
Ablation of Persistent and Long-Standing Persistent Atrial Fibrillation
Montgomery, J. A., & Michaud, G. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-52992-1.00019-3
Lancaster, T. S., Eghtesady, P., & Damiano, R. J. (2018) · Elsevier eBooks · doi:10.1016/b978-1-4557-0760-7.00068-1
Ablation of Postoperative Atrial Tachycardia in Congenital Heart Disease
Triedman, J. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-52992-1.00013-2
131 – Catheter Ablation in Congenital Heart Disease
Walsh, E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-44733-1.00131-0
Definition and Diagnosis of Heart Failure in Adult Congenital Heart Disease
Broberg, C. S. (2018) · Congenital heart disease in adolescents and adults · doi:10.1007/978-3-319-77803-7_3
74 – Atrial Tachycardia in Adults With Congenital Heart Disease
Abrams, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-44733-1.00074-2
Acute Heart Failure in Adult Patients with Congenital Heart Disease
de Bruaene, A. V., & Roche, S. (2018) · Congenital heart disease in adolescents and adults · doi:10.1007/978-3-319-77803-7_9
Berul, C. I., & Webster, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-37804-8.00027-4
Acute Management of Arrhythmias in Patients with Known Congenital Heart Disease
Bianchi, F., & Grossi, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-24328-3_7
“Prevalence of ATs is 3 times higher than what is observed in general population, and it is reported that 20-year-old patients with CHD have an equivalent risk of a 55-year-old women without CHD: patients with CHD are young with aged hearts [ 9 ]; atrial fi brillation (AF) is less common than atrial fl utter accounting…”
BackgroundMoore, J. P., Mandapati, R., Shannon, K., Batra, A. S., & Balaji, S. (2013) · Springer eBooks · doi:10.1007/978-1-4471-4619-3_183
“[5] reported that atrial arrhythmias occurred in 15 % of adults with congenital heart disease.”
BackgroundAssessment of the Adult with Congenital Heart Disease
Lui, G. K. (2013) · Springer eBooks · doi:10.1007/978-1-4471-4619-3_220
Cardiopathies congénitales à l’âge adulte
Iserin, L., & Barré, É. (2014) · Springer eBooks · doi:10.1007/978-2-8178-0257-2_17
Atrial Tachyarrhythmias in Adults With Congenital Heart Disease
Yap, S., Harris, L., & Marelli, A. J. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2856-5.00078-9
Self-citationRitme- en geleidingsstoornissen
Zeppenfeld, K., Roos-Hesselink, J. W., & Bink-Boelkens, M. (2013) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-0307-6_22
Arrhythmias in adult patients after total correction of tetralogy of Fallot (RCD code: V-2B.0)
Żygadło, A., Pająk, L. T., Dłużniewska, N., Olszowska, M., & Podolec, P. S. (2013) · Journal of Rare Cardiovascular Diseases · doi:10.20418/jrcd.vol1no4.64
Niebauer, J. (2011) · Springer eBooks · doi:10.1007/978-1-84882-794-3
Metadata
- Authors
- Bouchardy, J., Therrien, J., Pilote, L., Ionescu-Ittu, R., Martucci, G., Bottega, N., & Marelli, A. J.
- Affiliations
- McGill University Health Centre (CA)
- From the McGill Adult Unit for Congenital Heart Disease Excellence, McGill University Health Center and the Jewish General Hospital (J.B., J.T., R.I.-I., G.M., N.B., A.J.M.) and Division of Internal Medicine, McGill University Health Centre Research Institute (L.P., R.I.-I.), Montreal, Quebec, Canada.
- Venue
- Circulation
- Published
- 2009-10-27
- Volume
- 120
- Issue
- 17
- Pages
- 1679-1686
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2075290555
- Cited by
- 476
- References
- 0
- Citations by year
- 2026: 23 · 2025: 26 · 2024: 33 · 2023: 36 · 2022: 22 · 2021: 30 · 2020: 32 · 2019: 34 · 2018: 44 · 2017: 47 · 2016: 25 · 2015: 34 · 2014: 18 · 2013: 24 · 2012: 20
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- atrial arrhythmias, adult congenital heart disease, atrial fibrillation, lifetime risk, prevalence, mortality, stroke, heart failure, cardiac interventions, health burden, aging
- MeSH terms
- Adult, Age Factors, Aged, Atrial Fibrillation, Female, Follow-Up Studies, Heart Defects, Congenital, Humans, Male, Middle Aged, Population Surveillance, Retrospective Studies, Cohort Studies, Young Adult
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