Cited by 476Congenital Heart Disease StudiesCardiovascular and Diving-Related ComplicationsCardiac Arrhythmias and Treatments

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Atrial Arrhythmias in Adults With Congenital Heart Disease

Abstract

Background Atrial arrhythmias increase disease burden in the general adult population. Adults with congenital heart lesions constitute a rapidly growing group of patients with cardiovascular disease. We hypothesized that atrial arrhythmias increase with age and impair health outcomes in this population. Methods and results We conducted a population-based analysis of prevalence, lifetime risk, mortality, and morbidity associated with atrial arrhythmias in adults with congenital heart disease from l983 to 2005. In 38 428 adults with congenital heart disease in 2005, 5812 had atrial arrhythmias. Overall, the 20-year risk of developing atrial arrhythmia was 7% in a 20-year-old subject and 38% in a 50-year-old subject. More than 50% of patients with severe congenital heart disease reaching age 18 years developed atrial arrhythmias by age 65 years. In patients with congenital heart disease, the hazard ratio of any adverse event in those with atrial arrhythmias compared with those without was 2.50 (95% confidence interval, 2.38 to 2.62; P Conclusions Atrial arrhythmias occurred in 15% of adults with congenital heart disease. The lifetime incidence increased steadily with age and was associated with a doubling of the risk of adverse events. An increase in resource allocation should be anticipated to deal with this increasing burden.

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Crossref · 10.1161/circulationaha.109.866319

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Metadata

Authors
Bouchardy, J., Therrien, J., Pilote, L., Ionescu-Ittu, R., Martucci, G., Bottega, N., & Marelli, A. J.
Affiliations
  • McGill University Health Centre (CA)
  • From the McGill Adult Unit for Congenital Heart Disease Excellence, McGill University Health Center and the Jewish General Hospital (J.B., J.T., R.I.-I., G.M., N.B., A.J.M.) and Division of Internal Medicine, McGill University Health Centre Research Institute (L.P., R.I.-I.), Montreal, Quebec, Canada.
Venue
Circulation
Published
2009-10-27
Volume
120
Issue
17
Pages
1679-1686
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2075290555
Cited by
476
References
0
Citations by year
2026: 23 · 2025: 26 · 2024: 33 · 2023: 36 · 2022: 22 · 2021: 30 · 2020: 32 · 2019: 34 · 2018: 44 · 2017: 47 · 2016: 25 · 2015: 34 · 2014: 18 · 2013: 24 · 2012: 20
FWCI
10.52
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords
atrial arrhythmias, adult congenital heart disease, atrial fibrillation, lifetime risk, prevalence, mortality, stroke, heart failure, cardiac interventions, health burden, aging
MeSH terms
Adult, Age Factors, Aged, Atrial Fibrillation, Female, Follow-Up Studies, Heart Defects, Congenital, Humans, Male, Middle Aged, Population Surveillance, Retrospective Studies, Cohort Studies, Young Adult

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