Association of Maternal Diabetes Mellitus in Pregnancy With Offspring Adiposity Into Early Adulthood: Sibling Study in a Prospective Cohort of 280 866 Men From 248 293 Families
Open accessAbstract
Background—: Maternal diabetes mellitus in pregnancy results in greater offspring adiposity at birth. It is unclear whether it is associated with greater adiposity into adulthood, and if so, whether this is via intrauterine mechanisms or shared familial characteristics. Methods and Results—: A record-linkage prospective cohort study of 280 866 singleton-born Swedish men from 248 293 families was used to explore the intrauterine effect of maternal diabetes mellitus on offspring body mass index (BMI) in early adulthood. Maternal diabetes mellitus during pregnancy was associated with greater mean BMI at age 18 in their sons. The difference in BMI was similar within brothers and between nonsiblings. BMI of men whose mothers had diabetes mellitus during their pregnancy was on average 0.94 kg/m 2 greater (95% confidence interval [CI], 0.35 to 1.52) than in their brothers born before their mother was diagnosed with diabetes, after adjustment for birth year, maternal age, parity and education, birth weight, gestational age, and age at assessment of BMI. Early-pregnancy BMI was positively associated with son's BMI between nonsiblings, but there was no association within brothers. Adjustment of the maternal diabetes–offspring BMI association for maternal BMI did not alter the association either within brothers or between nonsiblings. Results were also robust to sensitivity analyses restricting the within-sibling analyses to siblings born within 3 years of each other. Conclusion—: Maternal diabetes mellitus has long-term consequences for greater BMI in offspring; this association is likely to be via intrauterine mechanisms, and is independent of maternal BMI in early pregnancy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Maternal diabetes mellitus, regardless of type, has long-term effects on the risk of diabetes mellitus and obesity in offspring.
“Maternal diabetes mellitus, regardless of the type (that is, pre-existing type 1 diabetes mellitus or T2DM, or GDM), has long-term effects on the risk of diabetes mellitus and obesity in offspring172,210–216.”
From A global view of hypertensive disorders and diabetes mellitus during pregnancy (2022) · cites this paper as [213]
The Introduction and Discussion report an association between maternal diabetes during pregnancy and greater offspring BMI or obesity later in life, and the study measured BMI in sons at age 18. The Discussion says the study could not distinguish gestational diabetes from pre-existing type 1 or type 2 diabetes, so it cannot establish an effect for each type. It also did not assess offspring diabetes risk. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe finding of increased obesity among younger siblings born after maternal diabetes was duplicated in a study of Swedish male siblings.
“This finding of increased obesity rates among the younger siblings born after the maternal development of diabetes was duplicated in a study of Swedish male siblings.43”
From Gestational Diabetes Mellitus (2019) · cites this paper as [43]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hyperglycemia and adverse pregnancy outcomes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707943 · Cited by 5,563 · see citing works
Childhood obesity: public-health crisis, common sense cure
Ebbeling, C. B., Pawlak, D. B., & Ludwig, D. S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09678-2 · Cited by 2,980 · see citing works
Banting lecture 1980: of pregnancy and progeny.
Freinkel, N. (1980) · Diabetes · doi:10.2337/diab.29.12.1023 · Cited by 1,366 · see citing works
Dabelea, D., Hanson, R. L., Lindsay, R. S., Pettitt, D. J., Imperatore, G., Gabir, M. M., Roumain, J., Bennett, P. H., & Knowler, W. C. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2208 · Cited by 1,277 · see citing works
A quality study of a medical birth registry
Cnattingius, S., Ericson, A., Gunnarskog, J., & Källén, B. (1990) · Scandinavian Journal of Social Medicine · doi:10.1177/140349489001800209 · Cited by 972 · see citing works
Predicting Preschooler Obesity at Birth: The Role of Maternal Obesity in Early Pregnancy
Whitaker, R. C. (2004) · PEDIATRICS · doi:10.1542/peds.114.1.e29 · Cited by 817 · see citing works
Clausen, T. D., Mathiesen, E. R., Hansen, T., Pedersen, O., Jensen, D. M., Lauenborg, J., & Damm, P. (2008) · Diabetes Care · doi:10.2337/dc07-1596 · Cited by 724 · see citing works
Maternal Gestational Diabetes, Birth Weight, and Adolescent Obesity
Gillman, M. W., Rifas‐Shiman, S. L., Berkey, C. S., Field, A. E., & Colditz, G. A. (2003) · PEDIATRICS · doi:10.1542/peds.111.3.e221 · Cited by 709 · see citing works
(1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-3-461 · Cited by 663 · see citing works
Excessive Obesity in Offspring of Pima Indian Women with Diabetes during Pregnancy
Pettitt, D. J., Baird, H. R., Aleck, K. A., Bennett, P. H., & Knowler, W. C. (1983) · New England Journal of Medicine · doi:10.1056/nejm198302033080502 · Cited by 530 · see citing works
Increased fetal adiposity: a very sensitive marker of abnormal in utero development
Catalano, P. M., Thomas, A., Huston-Presley, L., & Amini, S. B. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(03)00828-7 · Cited by 519 · see citing works
WEIGHT AND LENGTH AT BIRTH OF INFANTS OF DIABETIC MOTHERS
Pedersen, J. (1954) · European Journal of Endocrinology · doi:10.1530/acta.0.0160330 · Cited by 495 · see citing works
Developmental programming of obesity in mammals
Taylor, P. D., & Poston, L. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2005.032854 · Cited by 473 · see citing works
(1998) · PubMed · Cited by 404 · see citing works
Jovanovic, L. (2001) · JAMA · doi:10.1001/jama.286.20.2516 · Cited by 399 · see citing works
The Swedish Medical Birth Register - a summary of content and quality
Källén, B. A. J., & Källén, K. (2003) · Lund University Publications (Lund University) · Cited by 398 · see citing works
Proceeding From Observed Correlation to Causal Inference: The Use of Natural Experiments
Rutter, M. L. (2007) · Perspectives on Psychological Science · doi:10.1111/j.1745-6916.2007.00050.x · Cited by 397 · see citing works
The predisposition to obesity and diabetes in offspring of diabetic mothers
Dabelea, D. (2007) · Diabetes Care · doi:10.2337/dc07-s211 · Cited by 384 · see citing works
Kral, J. G., Biron, S., Simard, S., Hould, F., Lebel, S., Marceau, S., & Marceau, P. (2006) · PEDIATRICS · doi:10.1542/peds.2006-1379 · Cited by 378 · see citing works
Heslehurst, N., Ells, L. J., Simpson, H., Batterham, A. M., Wilkinson, J. R., & Summerbell, C. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01180.x · Cited by 349 · see citing works
Lawlor, D., Benfield, L., Logue, J., Tilling, K., Howe, L., Fraser, A., Cherry, L., Watt, P., Ness, A., Smith, G. D., et al. (2010) · British medical journal · doi:10.1136/bmj.c6224 · Cited by 315 · see citing works
Self-citationDiabetes and Obesity in the Offspring of Pima Indian Women With Diabetes During Pregnancy
Pettitt, D. J., Nelson, R. G., Saad, M. F., Bennett, P. H., & Knowler, W. C. (1993) · Diabetes Care · doi:10.2337/diacare.16.1.310 · Cited by 295 · see citing works
The known and unknown of leptin in pregnancy
Mouzon, S. H., Lepercq, J. A., & Catalano, P. M. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.06.064 · Cited by 293 · see citing works
Effect of a diabetic environment in utero on predisposition to type 2 diabetes
Sobngwi, E., Boudou, P., Mauvais‐Jarvis, F., Leblanc, H., Velho, G., Vexiau, P., Porcher, R., Hadjadj, S., Pratley, R. E., Tataranni, P. A., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13505-2 · Cited by 285 · see citing works
Lawlor, D., Smith, G., O'callaghan, M., Alati, R., Mamun, A. A., Williams, G., & Najman, J. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwk030 · Cited by 280 · see citing works
Self-citationA. Lawlor, D., Fraser, A., Lindsay, R. S., Ness, A., Dabelea, D., Catalano, P., Davey Smith, G., Sattar, N., & Nelson, S. M. (2010) · Diabetologia · doi:10.1007/s00125-009-1560-z · Cited by 238 · see citing works
Self-citationPerinatal Nutrition and Hormone-Dependent Programming of Food Intake
Plagemann, A. (2006) · Hormone Research in Paediatrics · doi:10.1159/000091511 · Cited by 194 · see citing works
Smith, G. D., Steer, C. D., Leary, S. D., & Ness, A. (2007) · Archives of Disease in Childhood · doi:10.1136/adc.2006.104869 · Cited by 189 · see citing works
Obesity in offspring of diabetic Pima Indian women despite normal birth weight
Pettitt, D. J., Knowler, W. C., Bennett, P. H., Aleck, K. A., & Baird, H. R. (1987) · Diabetes Care · doi:10.2337/diacare.10.1.76 · Cited by 183 · see citing works
Lawlor, D. A., Timpson, N. J., Harbord, R. M., Leary, S. D., Ness, A., McCarthy, M. I., Frayling, T. M., Hattersley, A. T., & Smith, G. D. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050033 · Cited by 180 · see citing works
Self-citationWeiss, P., Scholz, H.-P., Haas, J., Tamussino, K. F., Seißler, J., & Borkenstein, M. H. (2000) · Diabetes Care · doi:10.2337/diacare.23.7.905 · Cited by 163 · see citing works
Stettler, N., Tershakovec, A. M., Zemel, B. S., Leonard, M. B., Boston, R. C., Katz, S. H., & Stallings, V. A. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.378 · Cited by 155 · see citing works
Cardiovascular and metabolic abnormalities in the offspring of diabetic pregnancy
Manderson, J. G., Mullan, B. A., Patterson, C., Hadden, D. R., Traub, A. I., & McCance, D. R. (2002) · Diabetologia · doi:10.1007/s00125-002-0865-y · Cited by 153 · see citing works
Additive Interactions of Maternal Prepregnancy BMI and Breast‐feeding on Childhood Overweight
Li, C., Kaur, H., Choi, W. S., Huang, T. T. ‐., Lee, R. E., & Ahluwalia, J. S. (2005) · Obesity Research · doi:10.1038/oby.2005.48 · Cited by 142 · see citing works
Gestational Diabetes and the Risk of Offspring Obesity
Whitaker, R. C., PEPE, M. S., Seidel, K. D., Wright, J. A., & Knopp, R. H. (1998) · PEDIATRICS · doi:10.1542/peds.101.2.e9 · Cited by 136 · see citing works
D'Onofrio, B. M., Singh, A. L., Iliadou, A. N., Lambe, M. P., Hultman, C. M., Grann, M., Neiderhiser, J. M., & Lichtenstein, P. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.33 · Cited by 103 · see citing works
Self-citationProgramming of Adiposity in Offspring of Mothers With Type 1 Diabetes at Age 7 Years
Lindsay, R. S., Nelson, S. M., Walker, J. D., Greene, S. A., Milne, G., Sattar, N. A., & Pearson, D. W. M. (2010) · Diabetes Care · doi:10.2337/dc09-1766 · Cited by 74 · see citing works
Lawlor, D. A., Clark, H. R., Smith, G. D., & Leon, D. A. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2412 · Cited by 64 · see citing works
Self-citationLawlor, D. A., Hübinette, A., Tynelius, P., Leon, D. A., Smith, G. D., & Rasmussen, F. E. (2007) · Circulation · doi:10.1161/circulationaha.106.646661 · Cited by 63 · see citing works
Self-citationIliadou, A. N., Koupil, I., Villamor, E., Altman, D., Hultman, C. M., Långström, N., & Cnattingius, S. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq064 · Cited by 49 · see citing works
Self-citationMann, V., Stavola, B. L. D., & Leon, D. A. (2004) · Statistics in Medicine · doi:10.1002/sim.1853 · Cited by 31 · see citing works
Kral, J. G., Biron, S., Simard, S., Hould, F., Lebel, S., Marceau, S., & Marceau, P. (2007) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000259147.93208.9f · Cited by 28 · see citing works
Calcium and Vitamin D Metabolism in Hypocalcemic Vitamin D-Resistant Rickets Carriers
Nicolaidou, P., Papadopoulou, A., Georgouli, H., Matsinos, Y. G., Tsapra, H., Fretzayas, A., Giannoulia‐Karantana, A., Kitsiou, S., Douros, K., Papassotiriou, I., et al. (2006) · Hormone Research in Paediatrics · doi:10.1159/000091043 · Cited by 12 · see citing works
Lawlor, D. A., Timpson, N. J., Harbord, R. M., Leary, S. D., Ness, A., McCarthy, M. I., Fraying, T. M., Hattersley, A. T., & Smith, G. D. (2007) · Early Human Development · doi:10.1016/s0378-3782(07)70058-0 · Cited by 12 · see citing works
Self-citationCommentary: Smoking during pregnancy--genes and environment weigh in
Knopik, V. S. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq125 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hampl, S. E., Hassink, S. G., Skinner, A. C., Armstrong, S. C., Barlow, S. E., Bolling, C. F., Avila Edwards, K. C., Eneli, I., Hamre, R., Joseph, M. M., et al. (2023) · Pediatrics · doi:10.1542/peds.2022-060640 · Cited by 1,389 · see citing works
Association of Maternal Diabetes With Autism in Offspring
Xiang, A. H., Wang, X., Martinez, M. P., Walthall, J. C., Curry, E. S., Page, K., Buchanan, T. A., Coleman, K. J., & Getahun, D. (2015) · JAMA · doi:10.1001/jama.2015.2707 · Cited by 395 · see citing works
Thompson, D. M., Berger, H. M., Feig, D. S., Gagnon, R. J., Kader, T., Keely, E., Kozak, S. E., Ryan, E. A., Sermer, M., & Vinokuroff, C. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.01.044 · Cited by 381 · see citing works
Szmuilowicz, E. D., Josefson, J. L., & Metzger, B. E. (2019) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2019.05.001 · Cited by 364 · see citing works
Maternal obesity during pregnancy and cardiovascular development and disease in the offspring
Gaillard, R. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-0085-7 · Cited by 322 · see citing works
A global view of hypertensive disorders and diabetes mellitus during pregnancy
Jiang, L., Tang, K., Magee, L. A., von Dadelszen, P., Ekeroma, A., Li, X., Zhang, E., & Bhutta, Z. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00734-y · Cited by 314 · see citing works
Yu, Y., Arah, O. A., Liew, Z., Cnattingius, S., Olsen, J., Sørensen, H. T., Qin, G., & Li, J. (2019) · BMJ · doi:10.1136/bmj.l6398 · Cited by 305 · see citing works
Sharp, G. C., Lawlor, D. A., Richmond, R. C., Fraser, A., Simpkin, A. J., Suderman, M. J., Shihab, H. A., Lyttleton, O., McArdle, W. L., Ring, S. M., et al. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv042 · Cited by 286 · see citing works
Self-citationRuchat, S.-M., Houde, A.-A., Voisin, G., St‐Pierre, J., Perron, P., Baillargeon, J., Gaudet, D., Hivert, M., Brisson, D., & Bouchard, L. (2013) · Epigenetics · doi:10.4161/epi.25578 · Cited by 259 · see citing works
Hyperglycemia During Pregnancy and Long-Term Offspring Outcomes
Bianco, M. E., & Josefson, J. L. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1267-6 · Cited by 253 · see citing works
From conception to infancy — early risk factors for childhood obesity
Larqué, E., Labayen, I., Flodmark, C., Lissau, I., Czernin, S., Moreno, L. A., Pietrobelli, A., & Widhalm, K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0219-1 · Cited by 251 · see citing works
Farahvar, S., Walfisch, A., & Sheiner, E. (2018) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2018.1476135 · Cited by 235 · see citing works
The offspring of the diabetic mother – Short- and long-term implications
Mitanchez, D., Yzydorczyk, C., Siddeek, B., Boubred, F., Benahmed, M., & Siméoni, U. (2014) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2014.08.004 · Cited by 223 · see citing works
Maternal obesity, gestational weight gain and diet as determinants of offspring long term health.
Poston, L. (2012) · Best practice & research. Clinical endocrinology & metabolism · doi:10.1016/j.beem.2012.03.010 · Cited by 218 · see citing works
Agarwal, P., Morriseau, T. S., Kereliuk, S. M., Doucette, C. A., Wicklow, B. A., & Dolinsky, V. W. (2018) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2017.1422109 · Cited by 202 · see citing works
Maternal adiposity—a determinant of perinatal and offspring outcomes?
Lawlor, D. A., Relton, C., Sattar, N., & Nelson, S. M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.176 · Cited by 192 · see citing works
Self-citationNehring, I., Chmitorz, A., Reulen, H.-J., von Kries, R., & Ensenauer, R. E. (2013) · Diabetic Medicine · doi:10.1111/dme.12286 · Cited by 171 · see citing works
Cheong, J. N., Wlodek, M. E., Moritz, K. M., & Cuffe, J. S. M. (2016) · The Journal of Physiology · doi:10.1113/jp271745 · Cited by 147 · see citing works
Patro-Gołąb, B., Santos, S., Voerman, E., Lawlor, D. A., Jaddoe, V. W. V., Gaillard, R., Patro-Gołąb, B., Santos, S., Voerman, E., Barros, H., et al. (2018) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(18)30273-6 · Cited by 147 · see citing works
Self-citationLong-Term Health Outcomes in Offspring Born to Women with Diabetes in Pregnancy
Fraser, A., & Lawlor, D. A. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0489-x · Cited by 143 · see citing works
Self-citationPage, K. A., LUO, S. H., Wang, X., Chow, T., Alves, J. M., Buchanan, T. A., & Xiang, A. H. (2019) · Diabetes Care · doi:10.2337/dc18-2581 · Cited by 142 · see citing works
Lawlor, D. A., Lichtenstein, P., Fraser, A., & Långström, N. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.009324 · Cited by 142 · see citing works
Self-citationRisk Factors for Unhealthy Weight Gain and Obesity among Children with Autism Spectrum Disorder
Dhaliwal, K. K., Orsso, C. E., Richard, C., Haqq, A. M., & Zwaigenbaum, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133285 · Cited by 149 · see citing works
The consequences of obesity and excess weight gain in pregnancy
Norman, J. E., & Reynolds, R. M. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111003077 · Cited by 134 · see citing works
Approaches for drawing causal inferences from epidemiological birth cohorts: A review
Richmond, R. C., Al-Amin, A., Smith, G. D., & Relton, C. L. (2014) · Early Human Development · doi:10.1016/j.earlhumdev.2014.08.023 · Cited by 134 · see citing works
Effect of Maternal Cardiovascular Conditions and Risk Factors on Offspring Cardiovascular Disease
Palinski, W. (2014) · Circulation · doi:10.1161/circulationaha.113.001805 · Cited by 131 · see citing works
Lawlor, D. A., Richmond, R. C., Warrington, N. M., McMahon, G., Smith, G. D., Bowden, J., & Evans, D. M. (2017) · Wellcome Open Research · doi:10.12688/wellcomeopenres.10567.1 · Cited by 129 · see citing works
Self-citationGrunnet, L. G., Hansen, S., Hjort, L., Madsen, C. M., Kampmann, F. B., Thuesen, A. C. B., Granstrømi, C., Strøm, M., Maslova, E., Frikke‐Schmidt, R., et al. (2017) · Diabetes Care · doi:10.2337/dc17-0514 · Cited by 126 · see citing works
Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus
Ruchat, S.-M., Hivert, M., & Bouchard, L. (2013) · Nutrition Reviews · doi:10.1111/nure.12057 · Cited by 128 · see citing works
Sharp, G. C., Lawlor, D. A., & Richardson, S. S. (2018) · Social Science & Medicine · doi:10.1016/j.socscimed.2018.07.035 · Cited by 128 · see citing works
Self-citationDiabetes in pregnancy and infant adiposity: systematic review and meta-analysis
Logan, K., Gale, C., Hyde, M. J., Santhakumaran, S., & Modi, N. (2016) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2015-309750 · Cited by 125 · see citing works
Farrar, D., Simmonds, M. C., Griffin, S. C., Duarte, A., Lawlor, D. A., Sculpher, M., Fairley, L., Golder, S., Tuffnell, D. J., Bland, M., et al. (2016) · Health Technology Assessment · doi:10.3310/hta20860 · Cited by 119 · see citing works
Self-citationLawlor, D. A. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys209 · Cited by 114 · see citing works
Self-citationGestational diabetes and childhood obesity: what is the link?
Kim, S. Y., Sharma, A. J., & Callaghan, W. M. (2012) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e328359f0f4 · Cited by 112 · see citing works
Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus
Hu, H. Z., Ha, S., Henderson, B. H., Warner, T. D., Roth, J., Kan, H., & Xu, X. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408456 · Cited by 113 · see citing works
Fleten, C., Nystad, W., Stigum, H., Skjærven, R., Lawlor, D. A., Smith, G. D., & Næss, Ø. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws134 · Cited by 110 · see citing works
Self-citationMitanchez, D., Burguet, A., & Siméoni, U. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.10.076 · Cited by 105 · see citing works
Early postnatal life as a critical time window for determination of long-term metabolic health
Plagemann, A., Harder, T., Schellong, K., Schulz, S., & Stupin, J. H. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.03.008 · Cited by 104 · see citing works
Maternal Low-Grade Chronic Inflammation and Intrauterine Programming of Health and Disease
Parisi, F., Milazzo, R., Savasi, V. M., & Cetin, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041732 · Cited by 103 · see citing works
Lepercq, J. A., Lin, J., Hall, G. C., Wang, E., Dain, M., Riddle, M. C., & Home, P. (2012) · Obstetrics and Gynecology International · doi:10.1155/2012/649070 · Cited by 94 · see citing works
Fine particular matter and its constituents in air pollution and gestational diabetes mellitus
Yu, G., Ao, J., Cai, J., Luo, Z., Martin, R. V., van Donkelaar, A., Kan, H., & Zhang, J. (2020) · Environment International · doi:10.1016/j.envint.2020.105880 · Cited by 94 · see citing works
Ferreira, D. L. S., Williams, D. M., Kangas, A. J., Soininen, P., Ala‐Korpela, M., Smith, G. D., Järvelin, M., & Lawlor, D. A. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002376 · Cited by 91 · see citing works
Self-citationPrimordial Prevention of High Blood Pressure in Childhood
Falkner, B. E., & Lurbe, E. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14059 · Cited by 89 · see citing works
ISGANAITIS, E. M., Woo, M., Ma, H., Chen, M., Kong, W., Lytras, A., Sales, V., DeCoste-Lopez, J., Lee, K.-J., Leatherwood, C. L., et al. (2013) · Diabetes · doi:10.2337/db13-0558 · Cited by 89 · see citing works
Elliott, H. R., Sharp, G. C., Relton, C. L., & Lawlor, D. A. (2019) · Diabetologia · doi:10.1007/s00125-019-05011-8 · Cited by 87 · see citing works
Self-citationRuchat, S.-M., & Mottola, M. F. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2402 · Cited by 85 · see citing works
Childhood consequences of maternal obesity and excessive weight gain during pregnancy
Gaillard, R., Felix, J. F., Duijts, L., & Jaddoe, V. W. V. (2014) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.12506 · Cited by 85 · see citing works
Patti, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1298-0 · Cited by 84 · see citing works
Chen, Q., Francis, E. C., Hu, G., & Chen, L. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.01.007 · Cited by 82 · see citing works
Richmond, R. C., Timpson, N. J., Felix, J. F., Palmer, T., Gaillard, R., McMahon, G., Smith, G. D., Jaddoe, V. W. V., & Lawlor, D. A. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002221 · Cited by 81 · see citing works
Self-citationBrand, J. S., West, J., Tuffnell, D. J., Bird, P. K., Wright, J., Tilling, K. M., & Lawlor, D. A. (2018) · BMC Medicine · doi:10.1186/s12916-018-1191-7 · Cited by 78 · see citing works
Self-citationGarcia-Vargas, L., Addison, S. S., Nistala, R., Kurukulasuriya, D., & Sowers, J. R. (2012) · Cardiorenal Medicine · doi:10.1159/000337734 · Cited by 78 · see citing works
Patel, S., Fraser, A., Smith, G. D., Lindsay, R. S., Sattar, N. A., Nelson, S. M., & Lawlor, D. A. (2011) · Diabetes Care · doi:10.2337/dc11-1633 · Cited by 72 · see citing works
Self-citationPregnancy Weight Gain and Childhood Body Weight: A Within-Family Comparison
Ludwig, D. S., Rouse, H. L., & Currie, J. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001521 · Cited by 68 · see citing works
MAHUTTE, N. G., Kamga-Ngandé, C., Sharma, A. M., & Sylvestre, C. V. (2018) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2018.04.030 · Cited by 69 · see citing works
Wu, Y., Bible, P. W., Long, S., Ming, W., Ding, W., Long, Y., Wen, X., Li, X., Deng, X., Deng, Y., et al. (2019) · Acta Diabetologica · doi:10.1007/s00592-019-01434-2 · Cited by 66 · see citing works
Pedersen, M., Olsen, S. F., Halldorsson, T. I., Zhang, C., Hjortebjerg, D., Ketzel, M., Grandström, C., Sørensen, M., Damm, P., Langhoff‐Roos, J., et al. (2017) · Environment International · doi:10.1016/j.envint.2017.09.003 · Cited by 65 · see citing works
Li, S., Zhu, Y., Yeung, E. H., Chavarro, J. E., Yuan, C., Field, A. E., Missmer, S. A., Mills, J. L., Hu, F. B., & Zhang, C. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyx151 · Cited by 65 · see citing works
Patel, S., Lawlor, D., Callaway, M., Macdonald-Wallis, C., Sattar, N., & Fraser, A. (2016) · BMC Pediatrics · doi:10.1186/s12887-016-0585-y · Cited by 58 · see citing works
Self-citationChildhood Health Consequences of Maternal Obesity during Pregnancy: A Narrative Review
Gaillard, R., Santos, S., Duijts, L., & Felix, J. F. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000453077 · Cited by 63 · see citing works
Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice
Nicholas, L. M., Nagao, M., Kusinski, L. C., Fernandez‐Twinn, D. S., Eliasson, L., & Ozanne, S. E. (2019) · Diabetologia · doi:10.1007/s00125-019-05037-y · Cited by 65 · see citing works
O’Neill, K. E., Alexander, J., Azuma, R., Xiao, R., Snyder, N. W., Mesaros, C., Blair, I. A., & Pinney, S. E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092696 · Cited by 63 · see citing works
Patel, R., Martin, R. M., Kramer, M. S., Oken, E., Bogdanovich, N., Matush, L., Smith, G. D., & Lawlor, D. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014607 · Cited by 60 · see citing works
Self-citationMarco, L. J., McCloskey, K., Vuillermin, P., Burgner, D. P., Said, J. M., & Ponsonby, A. (2012) · Experimental Diabetes Research · doi:10.1155/2012/565160 · Cited by 59 · see citing works
Tanvig, M. H. (2014) · PubMed · Cited by 59 · see citing works
Wang, C., Zhu, W., Wei, Y., Feng, H., Su, R., & Yang, H. (2015) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-015-0682-1 · Cited by 56 · see citing works
Development of Early Adiposity in Infants of Mothers With Gestational Diabetes Mellitus
Logan, K., Emsley, R., Jeffries, S., Andrzejewska, I., Hyde, M. J., Gale, C., Chappell, K. E., Mandalia, S., Santhakumaran, S., Parkinson, J. R. C., et al. (2016) · Diabetes Care · doi:10.2337/dc16-0030 · Cited by 58 · see citing works
Fraser, A., Almqvist, C., Larsson, H., Långström, N., & Lawlor, D. A. (2013) · Diabetologia · doi:10.1007/s00125-013-3065-z · Cited by 55 · see citing works
Self-citationWestvik‐Johari, K., Romundstad, L. B., Lawlor, D. A., Bergh, C., Gissler, M., Henningsen, A.-K. A., Håberg, S. E., Wennerholm, U., Tiitinen, A. E., Pinborg, A. B., et al. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003683 · Cited by 54 · see citing works
Self-citationBlue, E. K., Sheehan, B. M., Nuss, Z. V., Boyle, F. A., Hocutt, C. M., Gohn, C. R., Varberg, K. M., McClintick, J. N., & Haneline, L. S. (2015) · Diabetes · doi:10.2337/db14-1709 · Cited by 53 · see citing works
Atay, Z., & Bereket, A. (2016) · Obesity Medicine · doi:10.1016/j.obmed.2016.05.005 · Cited by 53 · see citing works
Gestational Diabetes Mellitus: Its Epidemiology and Implication beyond Pregnancy
Chen, L., Mayo, R., Chatry, A., & Hu, G. (2016) · Current Epidemiology Reports · doi:10.1007/s40471-016-0063-y · Cited by 52 · see citing works
Long-term cardiovascular risk in relation to birth weight and exposure to maternal diabetes mellitus
Stuart, A., Amer‐Wåhlin, I., Persson, J., & Källén, K. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.03.032 · Cited by 51 · see citing works
Epigenetic control of variation and stochasticity in metabolic disease
Panzeri, I., & Pospisilik, J. A. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.010 · Cited by 50 · see citing works
Santorelli, G., Petherick, E., Wright, J., Wilson, B., Haider, S., Cameron, N., & Johnson, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071183 · Cited by 49 · see citing works
Cardiometabolic health of children conceived by assisted reproductive technologies
Yeung, E. H., & Druschel, C. M. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.12.015 · Cited by 46 · see citing works
Ge, Z., Zhang, C., Schatten, H., & Sun, Q. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.118141 · Cited by 47 · see citing works
Moullec, N. L., Fianu, A., Maillard, O., Chazelle, É., Naty, N., Schneebeli, C., Gérardin, P., Huiart, L., Charles, M.-A. A., & Favier, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195531 · Cited by 47 · see citing works
Developmental Plasticity, Epigenetics and Human Health
Low, F. M., Gluckman, P. D., & Hanson, M. A. (2012) · Evolutionary Biology · doi:10.1007/s11692-011-9157-0 · Cited by 45 · see citing works
Tieu, J., Shepherd, E., Middleton, P., & Crowther, C. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010211.pub3 · Cited by 48 · see citing works
Excess nutrient supply in early life and its later metabolic consequences
Ojha, S., Saroha, V., Symonds, M. E., & Budge, H. (2013) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12061 · Cited by 44 · see citing works
Healthy Lifestyle During Early Pregnancy and Risk of Gestational Diabetes Mellitus
Badon, S. E., Enquobahrie, D. A., Wartko, P. D., Miller, R. S., Qiu, C., Gelaye, B., Sorensen, T. K., & Williams, M. A. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx095 · Cited by 44 · see citing works
Bond, T. A., Richmond, R. C., Karhunen, V., Cuéllar-Partida, G., Borges, M. C., Zuber, V., Alves, A. C., Mason, D., Yang, T., Gunter, M. J., et al. (2022) · BMC Medicine · doi:10.1186/s12916-021-02216-w · Cited by 43 · see citing works
Self-citationEarly life nutrition and the opportunity to influence long-term health: an Australasian perspective
Davies, P. S. W., Funder, J. W., Palmer, D. J., Sinn, J. K. H., Vickers, M. H., Wall, C. R., & Party, A. T. A. A. N. Z. E. L. N. W. (2016) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174415007989 · Cited by 41 · see citing works
Vik, K. L., Romundstad, P., Carslake, D., Smith, G. D., & Nilsen, T. I. L. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dyt250 · Cited by 42 · see citing works
Blažević, S. A., Horvatiček, M., Kesić, M., Zill, P., Hranilović, D., Ivanišević, M., Desoyé, G., & Štefulj, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179934 · Cited by 40 · see citing works
Xie, X., Gao, H., Zeng, W., Chen, S., Feng, L., Deng, D., Qiao, F., Liao, L., McCormick, K. L., Ning, Q., et al. (2015) · Clinical Science · doi:10.1042/cs20140688 · Cited by 40 · see citing works
Dalrymple, K. V., Tydeman, F. A. S., Taylor, P. D., Flynn, A. C., O'Keeffe, M. M., Briley, A. L., Santosh, P., Hayes, L., Robson, S. C., Nelson, S. M., et al. (2020) · Pediatric Obesity · doi:10.1111/ijpo.12725 · Cited by 40 · see citing works
Self-citationKleinwechter, H. J. (2011) · Der Diabetologe · doi:10.1007/s11428-010-0672-x · Cited by 39 · see citing works
Allehdan, S., Basha, A. S., Asali, F., & Tayyem, R. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.07.040 · Cited by 39 · see citing works
High-fat diet alters the dopamine and opioid systems: effects across development
Reyes, T. M. (2012) · International Journal of Obesity Supplements · doi:10.1038/ijosup.2012.18 · Cited by 36 · see citing works
Rees, S., Chadha, R., Donovan, L., Guitard, A. L. T., Koppula, S., Laupacis, A., Simpson, S., & Johnson, J. A. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.08.219 · Cited by 36 · see citing works
Hockett, C. W., Harrall, K. K., Moore, B. F., Starling, A. P., Bellatorre, A. C., Sauder, K. A., Perng, W., Scherzinger, A. L., Garg, K., Ringham, B. M., et al. (2019) · Diabetologia · doi:10.1007/s00125-019-04981-z · Cited by 37 · see citing works
Ormazábal, V., Nair, S., Carrión, F., McIntyre, D. H., & Salomón, C. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01597-3 · Cited by 35 · see citing works
Charting the Maternal and Infant Microbiome: What Is the Role of Diabetes and Obesity in Pregnancy?
Singh, S., Karagas, M. R., & Mueller, N. T. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0836-9 · Cited by 34 · see citing works
Reducing intergenerational obesity and diabetes risk
Sauder, K. A., & Ritchie, N. D. (2021) · Diabetologia · doi:10.1007/s00125-020-05341-y · Cited by 34 · see citing works
Developmental Origins of Cardiovascular Disease
Yeung, E. H., Robledo, C. A., Boghossian, N. S., Zhang, C., & Mendola, P. (2014) · Current Epidemiology Reports · doi:10.1007/s40471-014-0006-4 · Cited by 34 · see citing works
Nicholas, L. M., & Ozanne, S. E. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0116 · Cited by 35 · see citing works
Hyperglycemia in Pregnancy and Women’s Health in the 21st Century
McIntyre, D. H., Fuglsang, J., Kampmann, U., Knorr, S., & Ovesen, P. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192416827 · Cited by 40 · see citing works
Oral Hypoglycemic Agents in pregnancy: An Update
Nagandla, K., De, S., & Kanagasabai, S. (2013) · The Journal of Obstetrics and Gynecology of India · doi:10.1007/s13224-012-0312-z · Cited by 31 · see citing works
- Authors
- Lawlor, D. A., Lichtenstein, P., & Långström, N.
- Affiliations
- Karolinska Institutet (SE)
- Venue
- Circulation
- Published
- 2011-01-25
- Volume
- 123
- Issue
- 3
- Pages
- 258-265
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC4440894
- OpenAlex
- W2148068387
- Cited by
- 273
- References
- 45
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 14 · 2023: 22 · 2022: 14 · 2021: 11 · 2020: 12 · 2019: 22 · 2018: 18 · 2017: 23 · 2016: 23 · 2015: 20 · 2014: 15 · 2013: 25 · 2012: 24
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- Vetenskapsrådet
- Medical Research Council
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077659)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- maternal diabetes, pregnancy, offspring adiposity, body mass index, early adulthood, intrauterine programming, paternal BMI
- MeSH terms
- Adolescent, Adult, Female, Humans, Male, Mothers, Obesity, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Sweden, Cohort Studies, Body Mass Index, Diabetes, Gestational, Adult Children, Siblings, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review