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Shared Risk Factors in Cardiovascular Disease and Cancer
Open accessAbstract
Cardiovascular disease (CVD) and cancer are the 2 leading causes of death worldwide. Although commonly thought of as 2 separate disease entities, CVD and cancer possess various similarities and possible interactions, including a number of similar risk factors (eg, obesity, diabetes mellitus), suggesting a shared biology for which there is emerging evidence. Although chronic inflammation is an indispensable feature of the pathogenesis and progression of both CVD and cancer, additional mechanisms can be found at their intersection. Therapeutic advances, despite improving longevity, have increased the overlap between these diseases, with millions of cancer survivors now at risk of developing CVD. Cardiac risk factors have a major impact on subsequent treatment-related cardiotoxicity. In this review, we explore the risk factors common to both CVD and cancer, highlighting the major epidemiological studies and potential biological mechanisms that account for them.
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Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Renehan, A. G., Tyson, M., Egger, M., Heller, R. F., & Zwahlen, M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60269-x · Cited by 5,219
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
Lloyd-Jones, D. M., Hong, Y., Labarthe, D., Mozaffarian, D., Appel, L. J., Van Horn, L., Greenlund, K., Daniels, S., Nichol, G., Tomaselli, G. F., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192703 · Cited by 4,750
Heidenreich, P. A., Trogdon, J. G., Khavjou, O. A., Butler, J., Dracup, K., Ezekowitz, M. D., Finkelstein, E. A., Hong, Y., Johnston, S. C., Khera, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e31820a55f5 · Cited by 3,208
Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · Diabetes Care · doi:10.2337/dc10-0666 · Cited by 2,366
Body-mass index and mortality among 1.46 million white adults
Berrington de Gonzalez, A., Hartge, P., Cerhan, J. R., Flint, A. J., Hannan, L., MacInnis, R. J., Moore, S. C., Tobias, G. S., Anton-Culver, H., Freeman, L. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000367 · Cited by 2,317
Esposito, K., Nappo, F., Marfella, R., Giugliano, G., Giugliano, F., Ciotola, M., Quagliaro, L., Ceriello, A., & Giugliano, D. (2002) · Circulation · doi:10.1161/01.cir.0000034509.14906.ae · Cited by 1,961
VEGF and the quest for tumour angiogenesis factors
Ferrara, N. (2002) · Nature Reviews Cancer · doi:10.1038/nrc909 · Cited by 1,536
Rothwell, P. M., Wilson, M., Elwin, C.-E., Norrving, B., Algra, A., Warlow, C. P., & Meade, T. W. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61543-7 · Cited by 1,351
Cited by
Nutrition, inflammation and cancer
Zitvogel, L., Pietrocola, F., & Kroemer, G. (2017) · Nature Immunology · doi:10.1038/ni.3754 · Cited by 446
Freisling, H., Viallon, V., Lennon, H., Bagnardi, V., Ricci, C., Butterworth, A. S., Sweeting, M., Muller, D., Romieu, I., Bazelle, P., et al. (2020) · BMC Medicine · doi:10.1186/s12916-019-1474-7 · Cited by 376
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272
“Nonetheless, the frequent clustering of cancer and cardiometabolic diseases within the same individual indicates common etiological pathways, in which IR and inflammation are of paramount importance [160,161].”
BackgroundSun, Y., Liu, B., Rong, S., Du, Y., Xu, G., Snetselaar, L. G., Wallace, R. B., & Bao, W. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.014629 · Cited by 210
Thompson, A. S., Tresserra-Rimbau, A., Karavasiloglou, N., Jennings, A., Cantwell, M., Hill, C., Perez-Cornago, A., Bondonno, N. P., Murphy, N., Rohrmann, S., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.4714 · Cited by 203
Seiler, A., Klaas, V., Tröster, G., & Fagundes, C. P. (2017) · Psycho-Oncology · doi:10.1002/pon.4489 · Cited by 176
“In addition, weight gain, including obesity, is a common complication after cancer treatment and is associated with the increased incidence of chronic conditions like cardiovascular disease, diabetes, and hypertension, as well as secondary cancers and primary cancer recurrence.(23) Up to 71% of cancer survivors are ov…”
BackgroundAvan, A., Tavakoly Sany, S. B., Ghayour‐Mobarhan, M., Rahimi, H. R., Tajfard, M., & Ferns, G. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26791 · Cited by 182
O’Connor, E. A., Evans, C. V., Ivlev, I., Rushkin, M. C., Thomas, R. G., Martin, A., & Lin, J. S. (2022) · JAMA · doi:10.1001/jama.2021.15650 · Cited by 151
Cardiotoxicity of Anticancer Therapeutics
Dong, J., & Chen, H. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00009 · Cited by 95
di Candia, A. M., de Avila, D. X., Moreira, G. R., Villacorta, H., & Maisel, A. S. (2021) · American Heart Journal Plus: Cardiology Research and Practice · doi:10.1016/j.ahjo.2021.100046 · Cited by 79
Antidepressant use and risk of adverse outcomes: population-based cohort study
Bansal, N., Hudda, M., Payne, R. A., Smith, D. J., Kessler, D., & Wiles, N. (2022) · BJPsych Open · doi:10.1192/bjo.2022.563 · Cited by 66
Repurposing drugs targeting metabolic diseases for cancer therapeutics
Pillai U, J., Ray, A., Maan, M., & Dutta, M. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103684 · Cited by 31
Ke, Y., Fan, H., Zhao, Y., Fu, X., Wang, M., Gao, Y., Chen, Y., Huo, W., Zhang, W., Wang, L., et al. (2024) · Food & Function · doi:10.1039/d3fo05246j · Cited by 18
Lee, K. (2021) · European Journal of Cancer Care · doi:10.1111/ecc.13365 · Cited by 8
Tripathi, A., Arsha, S., Thapa, A., Thapa, S., Chand, S., Frishman, W. H., & Aronow, W. S. (2024) · Cardiology in Review · doi:10.1097/crd.0000000000000759 · Cited by 4
Metadata
- Authors
- Koene, R. J., Prizment, A. E., Blaes, A., & Konety, S. H.
- Venue
- Circulation
- Published
- 2016-03-15
- Volume
- 133
- Issue
- 11
- Pages
- 1104-1114
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2298991506
- Cited by
- 1,494
- References
- 16
- FWCI
- 64.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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