Fish oil supplements may increase the risk for atrial fibrillation: what does this mean?
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Methodological concerns have been raised regarding prior interventional analyses, including inconsistent reporting of AF outcomes, potential informative censoring due to longer survival in omega-3 treated groups compared to placebo groups, and/or discrepancies in AF case ascertainment.
“methodological concerns have been raised regarding prior interventional analyses including inconsistent reporting of AF outcomes, potential informative censoring due to longer survival in omega-3 treated groups compared to placebo groups5, and/or discrepancies in AF case ascertainment6.”
From Effects of Omega-3 Fatty Acid Treatment on Risk for Atrial Fibrillation: An Updated Meta-Analysis of 35 Trials including 114 592 Individuals (2026) · cites this paper as [5]
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Cites
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Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
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Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus
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n–3 Fatty Acids in Patients with Multiple Cardiovascular Risk Factors
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Effects of n-3 Fatty Acid Supplements in Elderly Patients After Myocardial Infarction
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Pro- and antiarrhythmic properties of a diet rich in fish oil
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Effects of Omega-3 Fatty Acid Supplements on Arrhythmias
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Omega-3 Fatty Acids and Arrhythmias
Marcus, M. D., & Link, M. S. (2024) · Circulation · doi:10.1161/circulationaha.123.065769 · Cited by 24 · see citing works
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect
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Bringing the Potential Benefits of Omega-3 to a Higher Level
Laukkanen, J. A., Bernasconi, A. A., & Lavie, C. J. (2024) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2024.02.015 · Cited by 14 · see citing works
Do omega-3 fatty acids increase risk of atrial fibrillation?
Bork, C. S., Myhre, P. L., & Schmidt, E. B. (2022) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000907 · Cited by 9 · see citing works
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Associations Between Plasma Omega-3, Fish Oil Use and Risk of AF in the UK BiobankPreprint
O’Keefe, E. L., O’Keefe, J. H., Tintle, N., Franco, W. G., Westra, J., & Harris, W. S. (2025) · medRxiv · doi:10.1101/2025.04.04.25325263 · Cited by 2 · see citing works
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Fish oil supplements in patients with chronic kidney disease
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Supplementierung mit Omega-3-Fettsäuren steigert Risiko für Vorhofflimmern
(2022) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-1817-1596
Do Fish Oil Supplements Reduce A-Fib?
Khoukaz, H. B., Vadali, M., & Fay, W. P. (2022) · PubMed Central
Lowance, M., Wang, E., Graybow, M., & Milanaik, R. L. (2025) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000001475
OXIDATIVE STABILITY OF FLAXSEED OIL: EFFECTS OF TOCOPHEROLS, PHYTOSTEROLS AND EXTRACTION CONDITIONSPreprint
Candioti, L. V., Negro, E., Mancini, S., & Bernal, C. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5556936
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Nguyen, M. K. H. M., Carlsen, K. R. R., Andersen, V. H., Schmidt, E. B., Venø, S. K., & Bork, C. (2026) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2026.100653
- Authors
- Samuel, M., & Nattel, S.
- Affiliations
- Montreal Heart Institute (CA)
- Venue
- Circulation
- Published
- 2021-12-21
- Volume
- 144
- Issue
- 25
- Pages
- 1991-1994
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W4200075221
- Cited by
- 16
- References
- 15
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2022: 4
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- fish oil supplements, omega-3 fatty acids, atrial fibrillation, cardiovascular risk
- MeSH terms
- Atrial Fibrillation, Fish Oils, Humans, Dietary Supplements
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