Effects of Omega-3 Fatty Acid Supplements on Arrhythmias
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Methodological concerns have been raised regarding prior interventional analyses, including inconsistent reporting of AF outcomes, potential informative censoring due to longer survival in omega-3 treated groups compared to placebo groups, and/or discrepancies in AF case ascertainment.
“methodological concerns have been raised regarding prior interventional analyses including inconsistent reporting of AF outcomes, potential informative censoring due to longer survival in omega-3 treated groups compared to placebo groups5, and/or discrepancies in AF case ascertainment6.”
From Effects of Omega-3 Fatty Acid Treatment on Risk for Atrial Fibrillation: An Updated Meta-Analysis of 35 Trials including 114 592 Individuals (2026) · cites this paper as [6]
The results section (pp. 331–333; exact page unavailable in our copy) reports fewer cardiac deaths in the omega-3 group than in the placebo group (1.7% versus 2.2%). That supports a mortality difference, but the paper does not establish longer overall survival or raise informative censoring as a concern for AF analyses. (LLM, conf=0.76)
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Cardiovascular health and Omega-3s
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- Authors
- Parish, S., Mafham, M., Offer, A., Barton, J., Wallendszus, K., Stevens, W., Buck, G., Haynes, R., Collins, R., Bowman, L., Armitage, J., & On behalf of the ASCEND Study Collaborative Group
- Affiliations
- University of Oxford (GB)
- ORCID
- Venue
- Circulation
- Published
- 2020-01-28
- Volume
- 141
- Issue
- 4
- Pages
- 331-333
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2994308405
- Cited by
- 26
- References
- 5
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 2
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research UK
- British Heart Foundation (SP/08/010/25939, CH/1996001/9454, SP/14/3/31114, PG/05/013/18296, SP/03/002)
- Medical Research Council (MC_UU_00017/5)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Keywords
- omega-3 fatty acids, dietary supplements, cardiac arrhythmias, antiarrhythmic effect, cardiovascular risk
- MeSH terms
- Arrhythmias, Cardiac, Female, Humans, Male, Fatty Acids, Omega-3, Dietary Supplements
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