The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Increased Inducible Nitric Oxide Synthase Expression Contributes to Myocardial Dysfunction and Higher Mortality After Myocardial Infarction in Mice
Open accessAbstract
Background — Inducible nitric oxide synthase (iNOS) is expressed in the myocardium after myocardial infarction (MI) and in heart failure. Its pathophysiological role in these conditions, however, is not clear. We hypothesized that increased NO production from iNOS expression causes myocardial dysfunction and results in higher mortality after MI. Methods and Results — MI was induced by left coronary artery ligation in iNOS −/− mutant and wild-type mice. Mortality was followed up for 30 days. MI resulted in a significant increase in mortality in both iNOS −/− and wild-type mice compared with sham operation ( P <0.01). Mortality was significantly decreased and LV myocardial contractility was increased, however, in iNOS −/− mice compared with the wild-type mice ( P <0.05). Five days after MI, myocardial iNOS mRNA expression, plasma nitrate and nitrite concentrations, and myocardial and plasma nitrotyrosine levels were significantly increased in wild-type compared with iNOS −/− mutant mice ( P <0.05). Both basal LV +dP/dt and its response to dobutamine were significantly increased in iNOS −/− compared with the wild-type mice ( P <0.05). Conclusions — Increased NO production from iNOS expression contributes to myocardial dysfunction and mortality after MI in mice.
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Cited by
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Nitric oxide signalling in cardiovascular health and disease
Farah, C., Michel, L. Y. M., & Balligand, J.-L. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.224 · Cited by 779
Reactive oxygen species in cardiovascular disease
Sugamura, K., & Keaney (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.004 · Cited by 769
Weirather, J., Hofmann, U. D. W., Beyersdorf, N., Ramos, G. C., Vogel, B., Frey, A., Ertl, G., Kerkau, T., & Frantz, S. (2014) · Circulation Research · doi:10.1161/circresaha.115.303895 · Cited by 699
Cardiogenic Shock Complicating Acute Myocardial Infarction: Expanding the Paradigm
Hochman, J. S. (2003) · Circulation · doi:10.1161/01.cir.0000075927.67673.f2 · Cited by 641
Metadata
- Authors
- Feng, Q., Lu, X., Jones, D. L., Shen, J., & Arnold, J. M. O.
- Venue
- Circulation
- Published
- 2001-08-07
- Volume
- 104
- Issue
- 6
- Pages
- 700-704
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2159938243
- Cited by
- 293
- References
- 32
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Feng, Q., Lu, X., Jones, D. L., Shen, J., & Arnold, J. M. O. (2001). Increased Inducible Nitric Oxide Synthase Expression Contributes to Myocardial Dysfunction and Higher Mortality After Myocardial Infarction in Mice. Circulation. https://doi.org/10.1161/hc3201.092284
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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