The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis
Abstract
Abstract—Nitric oxide (NO) was originally discovered as a vasodilator product of the endothelium. Over the last 15 years, this vascular mediator has been shown to have important antiplatelet actions as well. By activating guanylyl cyclase, inhibiting phosphoinositide 3-kinase, impairing capacitative calcium influx, and inhibiting cyclooxygenase-1, endothelial NO limits platelet activation, adhesion, and aggregation. Platelets are also an important source of NO, and this platelet-derived NO pool limits recruitment of platelets to the platelet-rich thrombus. A deficiency of bioactive NO is associated with arterial thrombosis in animal models, individuals with endothelial dysfunction, and patients with a deficiency of the extracellular antioxidant enzyme glutathione peroxidase-3. This enzyme catalyzes the reduction of hydrogen and lipid peroxides, which limits the availability of these reactive oxygen species to react with and inactivate NO. The complex biochemical reactions that underlie the function and inactivation of NO in the vasculature represent an important set of targets for therapeutic intervention for the prevention and treatment of arterial thrombotic disorders.
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In the citing paper
“NO has a vasodilating effect and inhibits platelet aggregation [63].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [63]
In the citing paper
“NO has a vasodilating effect and inhibits platelet aggregation [63].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [63]
In the citing paper
“The activation of platelets is mediated by NO through the soluble guanylate cyclase (sGC) pathway.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [121]
In the citing paper
“The NO produced by eNOS contributes to the thromboresistant properties of the endothelial lining of blood vessels by inhibiting platelet activation.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [121]
In the citing paper
“In addition, the cGMP increases cyclic adenosine monophosphate (cAMP) levels indirectly through phosphodiesterase III, which will also decrease the intracellular calcium concentration.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [121]
In the citing paper
“The NO activated sGC ultimately results in reduced intracellular calcium, inhibition of platelet phosphoinositide 3-kinase (PI3), and reduced affinity as well as number of surface membrane fibrinogen binding sites on platelets (GPIIb/IIIa).117,121–126”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [121]
Citations
Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
Self-citationUpregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors
Laufs, U., Fata, V. L., Plutzky, J., & Liao, J. K. (1998) · Circulation · doi:10.1161/01.cir.97.12.1129 · Cited by 1,837
ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91481-4 · Cited by 1,437
Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7674 · Cited by 1,238
Self-citationIgnarro, L. J., Byrns, R. E., Buga, G. M., & Wood, K. S. (1987) · Circulation Research · doi:10.1161/01.res.61.6.866 · Cited by 1,164
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11310.x · Cited by 811
Katsuki, S., Arnold, W. P., Mittal, C. K., & Murad, F. (1977) · PubMed · Cited by 700
Nitric oxide metabolism and breakdown
Kelm, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00020-1 · Cited by 673
Chambers, I., Frampton, J., Goldfarb, P. S., Affara, N. A., McBain, W., & Harrison, P. R. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04350.x · Cited by 667
Mellion, B. T., Ignarro, L. J., Ohlstein, E. H., Pontecorvo, E., Hyman, A. L., & Kadowitz, P. (1981) · Blood · doi:10.1182/blood.v57.5.946.946 · Cited by 639
Endothelium‐dependent inhibition of platelet aggregation
Azuma, H., Ishikawa, M., & Sekizaki, S. (1986) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1986.tb10218.x · Cited by 532
Laufs, U., Gertz, K. R., Huang, P. L., Nickenig, G., Böhm, M., Dirnagl, U., & Endres, M. (2000) · Stroke · doi:10.1161/01.str.31.10.2442 · Cited by 389
Nitric oxide released from activated platelets inhibits platelet recruitment.
Freedman, J. E., Loscalzo, J., Barnard, M. R., Alpert, C. S., Keaney, J. F., & Michelson, A. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119540 · Cited by 387
Self-citationα-Tocopherol Inhibits Aggregation of Human Platelets by a Protein Kinase C–Dependent Mechanism
Freedman, J. E., Farhat, J. H., Loscalzo, J., & Keaney, J. F. (1996) · Circulation · doi:10.1161/01.cir.94.10.2434 · Cited by 309
Self-citationScharfstein, J., Keaney, J. F., Slivka, A., Welch, G. N., Vita, J. A., Stamler, J. S., & Loscalzo, J. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117480 · Cited by 288
Self-citationKurosu, H., Maehama, T., Okada, T., Yamamoto, T., Hoshino, S.-I., Fukui, Y., Ui, M., Hazeki, O., & Katada, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24252 · Cited by 260
Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol
Cooke, J. P., Stamler, J. S., Andon, N., Davies, P. F., McKinley, G., & Loscalzo, J. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.3.h804 · Cited by 257
Self-citationSULFHYDRYL REQUIREMENT FOR RELAXATION OF VASCULAR SMOOTH MUSCLE
Needleman, P., Jakschik, B. A., & Johnson, E. M. (1973) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29678-1 · Cited by 250
N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.
Stamler, J. S., Mendelsohn, M. E., Amarante, P., Smick, D., Andon, N., Davies, P. F., Cooke, J. P., & Loscalzo, J. (1989) · Circulation Research · doi:10.1161/01.res.65.3.789 · Cited by 243
Self-citationZai, A., Rudd, M. A., Scribner, A. W., & Loscalzo, J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4890 · Cited by 234
Self-citationMaddipati, K. R., & Marnett, L. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45392-6 · Cited by 233
Marks, D. S., Vita, J. A., Folts, J. D., Keaney, J. F., Welch, G. N., & Loscalzo, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118328 · Cited by 230
Self-citationDeficient Platelet-Derived Nitric Oxide and Enhanced Hemostasis in Mice Lacking the NOSIII Gene
Freedman, J. E., Sauter, R., Battinelli, E. M., Ault, K. A., Knowles, C., Huang, P. L., & Loscalzo, J. (1999) · Circulation Research · doi:10.1161/01.res.84.12.1416 · Cited by 219
Self-citationInhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty
Ej, L., Brown, A. S., Belder, A. D., Smith, R. E. A., Martin, J., Wainwright, R. J., Thomas, M. R., Radomski, M. W., & Moncada, S. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90287-9 · Cited by 202
Kucera, G. L., & Rittenhouse, S. E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39361-5 · Cited by 201
Expression of constitutive endothelial nitric oxide synthase in human blood platelets
Sase, K., & Michel, T. M. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02191-k · Cited by 193
Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine.
Mendelsohn, M. E., O'Neill, S., George, D., & Loscalzo, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30619-1 · Cited by 191
Self-citationN-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin.
Loscalzo, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112024 · Cited by 189
Self-citationPtasznik, A., Traynor‐Kaplan, A., & Bokoch, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19969 · Cited by 176
An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombosis.
Folts, J. D. (1991) · PubMed · Cited by 175
Impaired Platelet Production of Nitric Oxide Predicts Presence of Acute Coronary Syndromes
Freedman, J. E., Ting, B., Hankin, B., Loscalzo, J., Keaney, J. F., & Vita, J. A. (1998) · Circulation · doi:10.1161/01.cir.98.15.1481 · Cited by 172
Self-citationDecreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis.
Freedman, J. E., Loscalzo, J., Benoit, S. E., Valeri, C. R., Barnard, M. R., & Michelson, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118522 · Cited by 171
Self-citationGlutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols.
Freedman, J. E., Frei, B. B., Welch, G. N., & Loscalzo, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118047 · Cited by 153
Self-citationAnnich, G. M., Meinhardt, J. P., Mowery, K. A., Ashton, B. A., Merz, S. I., Hirschl, R. B., Meyerhoff, M. E., & Bartlett, R. H. (2000) · Critical Care Medicine · doi:10.1097/00003246-200004000-00001 · Cited by 152
Folts, J. D., Stamler, J. S., & Loscalzo, J. (1991) · Circulation · doi:10.1161/01.cir.83.6.2122 · Cited by 149
Self-citationTrepakova, E. S., Cohen, R. A., & Bolotina, V. M. (1999) · Circulation Research · doi:10.1161/01.res.84.2.201 · Cited by 135
Liu, Z., Rudd, M. A., Freedman, J. E., & Loscalzo, J. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37255-6 · Cited by 131
Self-citationPhosphoinositide 3-Kinase γ and p85/Phosphoinositide 3-Kinase in Platelets
Zhang, J., Zhang, J. C., Shattil, S. J., Cunningham, M. C., & Rittenhouse-Simmons, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6265 · Cited by 129
Shen, Q., Chu, F., & Newburger, P. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82146-9 · Cited by 123
Vascular oxidant stress: Molecular mechanisms and pathophysiological implications
Zalba, G., Beaumont, J., José, G. S., Fortuño, A., Fortuño, M. A., & Dı́ez, J. (2000) · Journal of Physiology and Biochemistry · doi:10.1007/bf03179777 · Cited by 123
Long-term Smoking Impairs Platelet-Derived Nitric Oxide Release
Ichiki, K., Ikeda, H., Haramaki, N., Ueno, T., & Imaizumi, T. (1996) · Circulation · doi:10.1161/01.cir.94.12.3109 · Cited by 117
Stamler, J. S., & Loscalzo, J. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90686-4 · Cited by 107
Self-citationMinuz, P., Andrioli, G., Degan, M., Gaino, S., Ortolani, R., Tommasoli, R., Zuliani, V., Lechi, A., & Lechi, C. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.8.1248 · Cited by 102
Effects of nitric oxide/EDRF on platelet surface glycoproteins
Michelson, A. D., Benoit, S., Furman, M. I., Breckwoldt, W. L., Rohrer, M. J., Barnard, M. R., & Loscalzo, J. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.5.h1640 · Cited by 101
Self-citationPigazzi, A., Heydrick, S. J., Folli, F. B., Benoit, S., Michelson, A. D., & Loscalzo, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14368 · Cited by 101
Self-citationStamler, J. S., Vaughan, D. E., & Loscalzo, J. (1989) · Circulation Research · doi:10.1161/01.res.65.3.796 · Cited by 92
Self-citationBoulos, C., Jiang, H., & Balazy, M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39223-7 · Cited by 92
Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide
Nappi, A. J., & Vass, E. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(97)00125-6 · Cited by 91
Platelet Behaviour and Drugs Used in Cardiovascular Disease
Hampton, J. R., Harrison, M. J., Honour, A. J., & Mitchell, J. R. A. (1967) · Cardiovascular Research · doi:10.1093/cvr/1.2.101 · Cited by 89
Kenet, G., Freedman, J., Shenkman, B., Regina, E., Brok-Simoni, F., Holzman, F., Vavva, F., Brand, N., Michelson, A., Trolliet, M., et al. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.8.2017 · Cited by 83
Self-citationBiphasic Activation of PKBα/Akt In Platelets
Banfíƈ, H., Downes, C. P., & Rittenhouse, S. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11630 · Cited by 81
Jahn, B., & Hänsch, G. M. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000235282 · Cited by 80
Nitric oxide release from resting human platelets
Zhou, Q., Hellermann, G., & Solomonson, L. P. (1995) · Thrombosis Research · doi:10.1016/0049-3848(95)90868-g · Cited by 80
Majka, M., Ratajczak, J., Kowalska, M. A., & Ratajczak, M. Z. (2000) · European Journal Of Haematology · doi:10.1034/j.1600-0609.2000.90112.x · Cited by 77
Nong, Z., Hoylaerts, M., Pelt, N. V., Collen, D., & Janssens, S. P. (1997) · Circulation Research · doi:10.1161/01.res.81.5.865 · Cited by 74
Tsikas, D., Ikic, M., Tewes, K. S., Raida, M., & Frölich, J. C. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01633-0 · Cited by 73
Characterization of the hydroperoxide-reducing activity of human plasma
Maddipati, K. R., Gasparski, C. M., & Marnett, L. J. (1987) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(87)90075-0 · Cited by 72
Effect of Nitric Oxide Synthase Inhibition on Bleeding Time in Humans
Simon, D. I., Stamler, J. S., Loh, E., Loscalzo, J., Francis, S. A., & Creager, M. A. (1995) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199508000-00022 · Cited by 68
Self-citationKader, K. N., Akella, R., Ziats, N. P., Lakey, L. A., Harasaki, H., Ranieri, J. P., & Bellamkonda, R. V. (2000) · Tissue Engineering · doi:10.1089/10763270050044425 · Cited by 65
The potent platelet inhibitory effects of S-nitrosated albumin coating of artificial surfaces
Maalej, N. M., Albrecht, R. M., Loscalzo, J., & Folts, J. D. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00687-1 · Cited by 62
Self-citationα‐Tocopherol and protein kinase C inhibition enhance platelet‐derived nitric oxide release
Freedman, J. E., Li, L., Sauter, R., & Keaney, J. F. (2000) · The FASEB Journal · doi:10.1096/fj.00-0360fje · Cited by 62
Platelet-Derived Nitric Oxide and Coronary Risk Factors
Ikeda, H., Takajo, Y., Murohara, T., Ichiki, K., Adachi, H., Haramaki, N., Katoh, A., & Imaizumi, T. (2000) · Hypertension · doi:10.1161/01.hyp.35.4.904 · Cited by 61
Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets
Chen, L., Salafranca, M. N., & Mehta, J. L. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.4.h1854 · Cited by 58
Reduced thiols and the effect of intravenous nitroglycerin on platelet aggregation
Stamler, J. S., Cunningham, M. C., & Loscalzo, J. (1988) · The American Journal of Cardiology · doi:10.1016/0002-9149(88)90962-9 · Cited by 54
Self-citationInhibition of Platelet Adhesion to Collagen by cGMP-Elevating Agents
Wu, C., Ko, F., & Teng, C. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.5998 · Cited by 43
Stagliano, N. E., Zhao, W., Prado, R., Dewanjee, M. K., Ginsberg, M. D., & Dietrich, W. D. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199711000-00007 · Cited by 39
Activation of PI 3-kinase by G protein βγ subunits
Hazeki, O., Okada, T., Kurosu, H., Takasuga, S., Suzuki, T., & Katada, T. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00106-4 · Cited by 38
S-Nitrosothiols Are Stored by Platelets and Released during Platelet–Neutrophil Interactions
Hirayama, A., Noronha-Dutra, A. A., Gordge, M. P., Neild, G. H., & Hothersall, J. S. (1999) · Nitric Oxide · doi:10.1006/niox.1999.0208 · Cited by 36
Megson, I. L., Sogo, N., Mazzei, F. A., Butler, A. R., Walton, J. C., & Webb, D. J. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703731 · Cited by 35
Yanagi, S., Sada, K., Tohyama, Y., Tsubokawa, M., Nagai, K., Yonezawa, K., & Yamamura, H. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.00329.x · Cited by 30
Anfossi, G., Russo, I., Massucco, P., Mattiello, L., Perna, P., Tassone, F., & Trovati, M. (1999) · Thrombosis Research · doi:10.1016/s0049-3848(99)00011-0 · Cited by 26
Fujimoto, Y., Tagano, S., Ogawa, K., Sakuma, S., & Fujita, T. (1998) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(98)90087-4 · Cited by 21
Inbal, A., Gurevitz, O. T., Tamarin, I., Eskaraev, R., Chetrit, A., Novicov, I., Feldman, M., Varon, D., Eldar, M., & Loscalzo, J. (1999) · Blood · doi:10.1182/blood.v94.5.1693 · Cited by 16
Self-citationEffects of sodium selenite on in vitro interactions between platelets and endothelial cells
Ricetti, M. M., Guidi, G. C., Tecchio, C., Bellisola, G., Rigo, A., & Perona, G. (1999) · International Journal of Clinical & Laboratory Research · doi:10.1007/s005990050068 · Cited by 12
Gurevitz, O. T., Eldar, M., Skutelsky, E., Tamarin, I., Shenkman, B., Eskaraev, R., Castel, D., Loscalzo, J., & Inbal, A. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614136 · Cited by 11
Self-citationHorowitz, J. D. (2003) · Humana Press eBooks · doi:10.1385/1-59259-002-0:383 · Cited by 5
Jones, D. N. (1988) · Nature · doi:10.1038/336524a0 · Cited by 1
Flagged first, then by citations
Research works printed but not linked: 18
- Cunningham M, Loscalzo J. Nitroprusside can induce clinically important platelet dysfunction only detectable in vitro by incubation with reduced thiol. Clin Res. 1985;33:337A.
- 10.1161/circ.83.6.1904015 · DOI
- 10.1161/res.61.6.2890446 · DOI
- 10.1161/res.65.3.2548765 · DOI
- 10.1161/res.65.3.2504509 · DOI
- Keaney JF Jr, Stamler JS, Scharftstein J, Folts JD, Loscalzo J. Nitric oxide forms a stable adduct with serum albumin that has potent antiplatelet properties in vivo. Clin Res. 1992;40:194A. Abstract.
- 10.1161/res.81.5.865 · DOI
- Pigazzi A, Fabian A, Johnson J, Upchurch GR, Loscalzo J. Identification of nitric oxide synthases in human megakaryocytes and platelets. Circulation. 1995;92:I-365.
- 10.1161/res.84.12.1416 · DOI
- 10.1161/circ.94.10.2434 · DOI
- 10.1161/str.31.10.2442 · DOI
- 10.1161/circ.97.12.1129 · DOI
- 10.1161/hyp.35.4.904 · DOI
- 10.1161/circ.94.12.3109 · DOI
- 10.1161/circ.98.15.1481 · DOI
- 10.1161/atvb.19.8.2017 · DOI
- Voetsch B, Bierl C, Damasceno BP, Annichino-Bizzacchi JM, Arruda VR, Loscalzo J. A novel promoter polymorphism in the plasma glutathione peroxidase gene associated with arterial ischemic stroke in the young. Circulation. 2000;102:II-704.
- 10.1161/atvb.18.8.1248 · DOI
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Metadata
- Authors
- Loscalzo, J.
- Affiliations
- Boston University (US)
- Corresponding author
- Loscalzo, Joseph
- ORCID
- Loscalzo, Joseph
- Venue
- Circulation Research
- Published
- 2001-04-27
- Volume
- 88
- Issue
- 8
- Pages
- 756-762
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2113684546
- Cited by
- 612
- References
- 80
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 22 · 2023: 21 · 2022: 22 · 2021: 19 · 2020: 25 · 2019: 15 · 2018: 28 · 2017: 25 · 2016: 16 · 2015: 24 · 2014: 27 · 2013: 28 · 2012: 29
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL61795, HL 55993, HL58976, R01HL058976, P50HL055993)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- nitric oxide, platelet activation, arterial thrombosis, endothelial dysfunction, glutathione peroxidase 3, phosphatidylinositol 3-kinase, cyclooxygenase-1, guanylate cyclase, platelet aggregation, thromboprophylaxis
- MeSH terms
- Animals, Arteries, Blood Platelets, Endothelium, Vascular, Glutathione Peroxidase, Humans, Nitric Oxide, Thrombosis, Vasodilator Agents, Platelet Activation, Reactive Oxygen Species, Nitric Oxide Donors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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