Cited by 107Lipoproteins and Cardiovascular HealthLipid metabolism and disordersCholesterol and Lipid Metabolism

Remnant lipoproteins as therapeutic targets

Havel, Richard J.·2000·Current Opinion in Lipidology

Abstract

Increasing evidence suggests that subsets of triglyceride-rich lipoproteins are particularly atherogenic. These include particles with some, but not necessarily all the properties classically attributed to remnants. Cholesteryl ester-enrichment seems to be a common feature of these particles, some of which can be taken up by macrophages by a novel receptor that recognizes species of apolipoprotein B but not apolipoprotein E. These characteristics seem to be common to postprandial and hypertriglyceridemic very low density lipoproteins as well as chylomicron remnants. Remnant-like triglyceride-rich lipoproteins that exhibit several potentially atherogenic properties can be quantified by a simple test that shows promise for identifying individuals at high risk for lesion formation and clinical events. Available hygienic and pharmaceutical measures that effectively lower the concentration of atherogenic triglyceride-rich lipoproteins deserve wider use.

Integrity signals

Registry

Crossref · 10.1097/00041433-200012000-00008

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The increase in the postprandial levels of remnant lipoprotein after meals can cause atherosclerosis.

    “Zilversmit et al. proposed that the increase in the postprandial levels of remnant lipoprotein after meals can cause atherosclerosis. Considerable evidence has been accumulated thereafter, and this hypothesis has therefore been established as the disease concept238, 243–245).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Havel, R. J.
Affiliations
University of California, San Francisco (US)
Corresponding author
Havel, Richard J.
Venue
Current Opinion in Lipidology
Published
2000-12
Volume
11
Issue
6
Pages
615-620
ISSN
0957-9672 (ISSN-L)
OpenAlex
W2084853272
Cited by
107
References
59
Citations by year
2026: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 3
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Lipidology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
remnant lipoproteins, triglyceride-rich lipoproteins, atherogenic lipoproteins, macrophage uptake, chylomicron remnants, VLDL, postprandial lipemia, hypertriglyceridemia, atherosclerosis risk assessment, therapeutic target, lipid-lowering therapy
MeSH terms
Animals, Apolipoproteins B, Apolipoproteins E, Arteriosclerosis, Cholesterol Esters, Chylomicrons, Humans, Lipoproteins, Lipoproteins, HDL, Lipoproteins, VLDL, Macrophages, Triglycerides, Hypertriglyceridemia, Chylomicron Remnants

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review