Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca 2+ /Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839 · see citing works

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

Bae, Y. S., Kang, S. W., Seo, M. S., Baines, I., Tekle, E., Chock, P. B., & Rhee, S. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.217 · Cited by 1,208 · see citing works

Neuronal Ca2+/calmodulin-dependent protein kinases.

Hanson, P., & Schulman, H. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.003015 · Cited by 628 · see citing works

Activation of protein kinase C by tyrosine phosphorylation in response to H 2 O 2

Konishi, H., Tanaka, M., Takemura, Y., Matsuzaki, H., Ono, Y., Kikkawa, U., & Nishizuka, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11233 · Cited by 604 · see citing works

Activation of the JAK-STAT pathway by reactive oxygen species

Simon, A. R., Rai, U., Fanburg, B. L., & Cochran, B. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.6.c1640 · Cited by 600 · see citing works

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

Ushio‐Fukai, M., Alexander, R. W., Akers, M., Yin, Q., Fujio, Y., Walsh, K., & Griendling, K. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22699 · Cited by 558 · see citing works

CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

Passier, R., Zeng, H., Frey, N., Naya, F. J., Nicol, R. L., McKinsey, T. A., Overbeek, P. A., Richardson, J. A., Grant, S. R., & Olson, E. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8551 · Cited by 521 · see citing works

Phosphorylation of Endothelial Nitric Oxide Synthase in Response to Fluid Shear Stress

Corson, M. A., James, N. L., Latta, S. E., Nerem, R. M., Berk, B. C., & Harrison, D. G. (1996) · Circulation Research · doi:10.1161/01.res.79.5.984 · Cited by 511 · see citing works

Interactions of oxidants with vascular signaling systems

Wolin, M. S. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.6.1430 · Cited by 463 · see citing works

Transcriptional and Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Hydrogen Peroxide

Drummond, G. R., Cai, H., Davis, M. E., Ramasamy, S., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.86.3.347 · Cited by 430 · see citing works

c-Src Is Required for Oxidative Stress-mediated Activation of Big Mitogen-activated Protein Kinase 1 (BMK1)

Abe, J., Takahashi, M., Ishida, M., Lee, J.-D., & Berk, B. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20389 · Cited by 272 · see citing works

Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes

Carballo, M., Conde, M., El Bekay, R., Martı́n-Nieto, J., Camacho, M. J., Monteseirı́n, J., Conde, J., Bedoya, F. J., & Sobrino, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17580 · Cited by 266 · see citing works

Src and Cas Mediate JNK Activation but Not ERK1/2 and p38 Kinases by Reactive Oxygen Species

Yoshizumi, M., Abe, J., Haendeler, J., Huang, Q., & Berk, B. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11706 · Cited by 263 · see citing works

Signal transduction by reactive oxygen species in non-phagocytic cells

Finkel, T. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.3.337 · Cited by 256 · see citing works

Fyn and JAK2 Mediate Ras Activation by Reactive Oxygen Species

Abe, J., & Berk, B. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21003 · Cited by 210 · see citing works

Ca2+/Calmodulin-dependent Kinase II and Calcineurin Play Critical Roles in Endothelin-1-induced Cardiomyocyte Hypertrophy

Zhu, W., Zou, Y., Shiojima, I., Kudoh, S., Aikawa, R., Hayashi, D., Mizukami, M., Toko, H., Shibasaki, F., Yazaki, Y., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15239 · Cited by 179 · see citing works

Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells

Vepa, S., Scribner, W. M., Parinandi, N. L., English, D. K., Garcia, J. G. N., & Natarajan, V. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.1.l150 · Cited by 139 · see citing works

CaM kinase II: a protein kinase with extraordinary talents germane to insulin exocytosis.

Easom, R. A. (1999) · Diabetes · doi:10.2337/diabetes.48.4.675 · Cited by 128 · see citing works

Hydrogen Peroxide Induces Intracellular Calcium Oscillations in Human Aortic Endothelial Cells

Hu, Q., Corda, S., Zweier, J. L., Capogrossi, M. C., & Ziegelstein, R. C. (1998) · Circulation · doi:10.1161/01.cir.97.3.268 · Cited by 127 · see citing works

Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cells

Sullivan, S. G., Chiu, D. T.-Y., Errasfa, M., Wang, J. M., Qi, J.-S., & Stern, A. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90042-6 · Cited by 122 · see citing works

A working model of CaM kinase II activity in hippocampal long-term potentiation and memory

Fukunaga, K., & Miyamoto, E. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(00)00139-5 · Cited by 120 · see citing works

Hydrogen peroxide activation of cytosolic phospholipase A2 in vascular smooth muscle cells

Rao, G. N., Runge, M. S., & Alexander, R. W. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(95)91997-z · Cited by 106 · see citing works

Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid

Ramasamy, S., Parthasarathy, S., & Harrison, D. G. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33888-8 · Cited by 92 · see citing works

Differential Roles of Ca2+/Calmodulin-Dependent Protein Kinase II and Mitogen-Activated Protein Kinase Activation in Hippocampal Long-Term Potentiation

Liu, J., Fukunaga, K., Yamamoto, H., Nishi, K., & Miyamoto, E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08292.1999 · Cited by 87 · see citing works

Hydrogen peroxide-induced DNA damage is independent of nuclear calcium but dependent on redox-active ions

Jornot, L., Petersen, H., & Junod, A. F. (1998) · Biochemical Journal · doi:10.1042/bj3350085 · Cited by 77 · see citing works

Up-regulation of Endothelial Nitric-oxide Synthase Promoter by the Phosphatidylinositol 3-Kinase γ/Janus Kinase 2/MEK-1-dependent Pathway

Cieslik, K. A., Abrams, C. S., & Wu, K. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005305200 · Cited by 65 · see citing works

Herbimycin A suppresses NF‐κB activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells

Nishiya, T., Uehara, T., & Nomura, Y. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00933-z · Cited by 63 · see citing works

Hydrogen peroxide elicits activation of bovine pulmonary arterial soluble guanylate cyclase by a mechanism associated with its metabolism by catalase

Wolin, M. S., & Burke, T. M. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90623-1 · Cited by 63 · see citing works

Phospholipase C, Protein Kinase C, Ca2+/Calmodulin‐Dependent Protein Kinase II, and Tyrosine Phosphorylation Are Involved in Carbachol‐Induced Phospholipase D Activation in Chinese Hamster Ovary Cells Expressing Muscarinic Acetylcholine Receptor of Caenorhabditis elegans

Min, D. S., Cho, N. J., Yoon, S. H., Lee, Y. H., Hahn, S., Lee, K.-H., Kim, M., & Jo, Y. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750274.x · Cited by 38 · see citing works

Possible involvement of Janus kinase Jak2 in interferon-γ induction of nitric oxide synthase in rat glial cells

Kitamura, Y., Takahashi, H., Nomura, Y., & Taniguchi, T. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00212-9 · Cited by 35 · see citing works

Calcium/Calmodulin‐Stimulated Protein Kinase II Is Present in Primary Cultures of Cerebral Endothelial Cells

Deli, M. A., Joó, F., Krizbai, I. A., Lengyel, I., Nunzi, M. G., & Wolff, J. R. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13429.x · Cited by 35 · see citing works

Evidence suggesting that iron and calcium are interrelated in oxidant-induced DNA damage

Golconda, M. S., Ueda, N., & Shah, S. V. (1993) · Kidney International · doi:10.1038/ki.1993.373 · Cited by 29 · see citing works

Thrombin-Mediated ET-1 Gene Regulation Involves CaM Kinases and Calcineurin in Human Endothelial Cells

Marsen, T. A., Simonson, M. S., & Dunn, M. J. (1995) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199506263-00002 · Cited by 14 · see citing works

In situ hybridization with digoxigenin labeled oligonucleotide probes: detection of CAMK-II gene expression in primary cultures of cerebral endothelial cells.

Krizbai, I. A., Deli, M. A., Lengyel, I., Maderspach, K., Pákáski, M., Joó, F., & Wolff, J. R. (1993) · PubMed · Cited by 2 · see citing works

Role of Oxidative Modifications in Atherosclerosis

Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,611 · see citing works

Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

Fleming, I., & Busse, R. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00323.2002 · Cited by 941 · see citing works

Hydrogen peroxide regulation of endothelial function: Origins, mechanisms, and consequences

Cai, H. “. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.06.021 · Cited by 568 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues

Balligand, J.-L., Feron, O., & Dessy, C. (2009) · Physiological Reviews · doi:10.1152/physrev.00042.2007 · Cited by 477 · see citing works

Nitric Oxide and the Vascular Endothelium

Moncada, S., & Higgs, E. A. (2006) · Springer eBooks · doi:10.1007/3-540-32967-6_7 · Cited by 408 · see citing works

Redox Control of Endothelial Function and Dysfunction: Molecular Mechanisms and Therapeutic Opportunities

Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383 · see citing works

Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy?

Kojda, G., & Hambrecht, R. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.032 · Cited by 370 · see citing works

Endothelial mechanotransduction, nitric oxide and vascular inflammation

Harrison, D. G., WIDDER, J., Grumbach, I. M., Chen, W., Weber, M., & Searles, C. D. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01621.x · Cited by 337 · see citing works

Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling

Förstermann, U., & Li, H. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01196.x · Cited by 299 · see citing works

Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments

Xiang, M., Lu, Y., Xin, L., Gao, J., Shang, C., Jiang, Z., Lin, H., Fang, X., Qu, Y., Wang, Y., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6614009 · Cited by 301 · see citing works

Interplay of calcium and cadmium in mediating cadmium toxicity

Choong, G. M. Y., Liu, Y., & Templeton, D. M. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.01.007 · Cited by 293 · see citing works

NADPH oxidases in cardiovascular disease

Brandes, R. P., Weißmann, N., & Schröder, K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.030 · Cited by 266 · see citing works

NAD(P)H Oxidase–Dependent Self-Propagation of Hydrogen Peroxide and Vascular Disease

Cai, H. “. (2005) · Circulation Research · doi:10.1161/01.res.0000163631.07205.fb · Cited by 241 · see citing works

CaMKII in the Cardiovascular System: Sensing Redox States

Erickson, J. R., He, B. J., Grumbach, I. M., & Anderson, M. E. (2011) · Physiological Reviews · doi:10.1152/physrev.00018.2010 · Cited by 238 · see citing works

Vascular nitric oxide: formation and function

Loscalzo, J., & Jin (2010) · Journal of Blood Medicine · doi:10.2147/jbm.s7000 · Cited by 227 · see citing works

Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights

Mason, S. A., Trewin, A. J., Parker, L., & Wadley, G. D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101471 · Cited by 226 · see citing works

Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression

Searles, C. D. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00457.2005 · Cited by 210 · see citing works

Regulation of endothelial-type NO synthase expression in pathophysiology and in response to drugs

Li, H., Wallerath, T., Münzel, T. F., & Förstermann, U. (2002) · Nitric Oxide · doi:10.1016/s1089-8603(02)00111-8 · Cited by 205 · see citing works

NADPH Oxidases in Heart Failure: Poachers or Gamekeepers?

Zhang, M., Perino, A., Ghigo, A., Hirsch, E., & Shah, A. M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4550 · Cited by 196 · see citing works

Gene Therapy of Endothelial Nitric Oxide Synthase and Manganese Superoxide Dismutase Restores Delayed Wound Healing in Type 1 Diabetic Mice

Luo, J., Wang, Y., Fu, W., Wu, J., & Chen, A. F. (2004) · Circulation · doi:10.1161/01.cir.0000137969.87365.05 · Cited by 187 · see citing works

Oxidative Stress in Hypertension: Role of the Kidney

Araújo, M., & Wilcox, C. S. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5259 · Cited by 187 · see citing works

Akt-Dependent Phosphorylation of Serine 1179 and Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase 1/2 Cooperatively Mediate Activation of the Endothelial Nitric-Oxide Synthase by Hydrogen Peroxide

Cai, H. “., Li, Z., Davis, M. E., Kanner, W. A., Harrison, D. G., & Dudley, S. C. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.325 · Cited by 187 · see citing works

Regulation of Endothelial Barrier Function

Yuan, S. Y., & Rigor, R. R. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00025ed1v01y201101isp013 · Cited by 183 · see citing works

NAD(P)H Oxidase-derived Hydrogen Peroxide Mediates Endothelial Nitric Oxide Production in Response to Angiotensin II

Cai, H. “., Li, Z., Dikalov, S., Holland, S. M., Hwang, J., Jo, H., Dudley, S. C., & Harrison, D. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208884200 · Cited by 182 · see citing works

Mechanisms of H2O2-induced oxidative stress in endothelial cells

Coyle, C. H., Martínez, L. J., Coleman, M. C., Spitz, D. R., Weintraub, N. L., & Kader, K. N. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.02.017 · Cited by 160 · see citing works

Dual Effect of Ceramide on Human Endothelial Cells

Li, H., Junk, ‬. C., Huwiler, A., Burkhardt, C., Wallerath, T., Pfeilschifter, J. M., & Förstermann, U. (2002) · Circulation · doi:10.1161/01.cir.0000035650.05921.50 · Cited by 156 · see citing works

Endothelial Nitric Oxide Synthase

Tai, S. C., Robb, G. B., & Marsden, P. A. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000109171.50229.33 · Cited by 153 · see citing works

Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide

Wedgwood, S., & Black, S. M. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00283.2004 · Cited by 150 · see citing works

High Glucose-Induced Tyrosine Nitration in Endothelial Cells: Role of eNOS Uncoupling and Aldose Reductase Activation

El‐Remessy, A. B., Abou-Mohamed, G., Caldwell, R. W., & Caldwell, R. B. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1022 · Cited by 140 · see citing works

Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction

Rigor, R. R., Shen, Q., Pivetti, C. D., Wu, M. H., & Yuan, S. Y. (2012) · Medicinal Research Reviews · doi:10.1002/med.21270 · Cited by 130 · see citing works

Which NADPH Oxidase Isoform Is Relevant for Ischemic Stroke? The Case for Nox 2

Kahles, T., & Brandes, R. P. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4721 · Cited by 125 · see citing works

Exercise in the Metabolic Syndrome

Golbidi, S., Mesdaghinia, A., & Laher, I. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/349710 · Cited by 131 · see citing works

Atorvastatin Restores Endothelial Function in Normocholesterolemic Smokers Independent of Changes in Low-Density Lipoprotein

Beckman, J. A., Liao, J. K., Hurley, S., Garrett, L. A., Chui, D.-S., Mitra, D. L., & Creager, M. A. (2004) · Circulation Research · doi:10.1161/01.res.0000134628.96682.9b · Cited by 119 · see citing works

Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training

Davis, M. E., Cai, H. “., McCann, L. A., Fukai, T., & Harrison, D. G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00918.2002 · Cited by 119 · see citing works

Regulation of Xanthine Oxidoreductase Protein Expression by Hydrogen Peroxide and Calcium

McNally, J. S., Saxena, A., Cai, H. “., Dikalov, S., & Harrison, D. G. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000170827.16296.6e · Cited by 115 · see citing works

Oral administration of bisphenol A induces high blood pressure through angiotensin II/CaMKII‐dependent uncoupling of eNOS

Saura, M., Marquez, S. B., Reventún, P., Olea‐Herrero, N., Arenas, M. I., Moreno‐Gómez‐Toledano, R., Gómez‐Parrizas, M., Muñóz‐Moreno, C., Martínez, M. G.-S., Zaragoza, C., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-252460 · Cited by 113 · see citing works

Histamine Upregulates Gene Expression of Endothelial Nitric Oxide Synthase in Human Vascular Endothelial Cells

Li, H., Burkhardt, C., Heinrich, U., Brausch, I., Xia, N., & Förstermann, U. (2003) · Circulation · doi:10.1161/01.cir.0000066697.19571.af · Cited by 109 · see citing works

Flavonoids from Artichoke (Cynara scolymus L.) Up-Regulate Endothelial-Type Nitric-Oxide Synthase Gene Expression in Human Endothelial Cells

Li, H., Xia, N., Brausch, I., Yao, Y., & Förstermann, U. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.066639 · Cited by 110 · see citing works

NADPH oxidase in the vasculature: Expression, regulation and signalling pathways; role in normal cardiovascular physiology and its dysregulation in hypertension

Knock, G. A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.09.029 · Cited by 108 · see citing works

Up-Regulation of Endothelial Nitric Oxide Synthase via Phosphatidylinositol 3-Kinase Pathway Contributes to Ischemic Tolerance in the CA1 Subfield of Gerbil Hippocampus

Hashiguchi, A., Yano, S., Morioka, M., Hamada, J., Ushio, Y., Takeuchi, Y., & Fukunaga, K. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000110539.96047.fc · Cited by 105 · see citing works

Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: A bell-shaped signaling response

Thomas, S., Kotamraju, S., Zielonka, J., Harder, D. R., & Kalyanaraman, B. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.005 · Cited by 100 · see citing works

Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38 MAPK, HSP27 and actin reorganization in endothelial cells

Nguyen, A., Chen, P., & Cai, H. “. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.061 · Cited by 98 · see citing works

The opposing roles of NO and oxidative stress in cardiovascular disease

Ritchie, R. H., Drummond, G. R., Sobey, C. G., Silva, T. M. D., & Kemp‐Harper, B. K. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.12.017 · Cited by 98 · see citing works

CaM Kinase II-dependent pathophysiological signalling in endothelial cells

Cai, H. “., Liu, D., & Garcia, J. G. N. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm010 · Cited by 97 · see citing works

Calcium/Calmodulin-Dependent Kinase II Mediates the Phosphorylation and Activation of NADPH Oxidase 5

Pandey, D., Gratton, J.-P., Rafikov, R., Black, S. M., & Fulton, D. J. R. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.070193 · Cited by 95 · see citing works

Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase

Lauer, N., Suvorava, T., Rüther, U., JACOB, R., MEYER, W., Harrison, D. G., & Kojda, G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.09.010 · Cited by 95 · see citing works

Oxidative Stress and Endothelial Nitric Oxide Bioactivity

Thomas, S. R., Chen, K., & Keaney, J. F. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603764816541 · Cited by 91 · see citing works

Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice

Laude, K. M., Cai, H. “., Fink, B., Hoch, N. E., Weber, D. S., McCann, L. A., Kojda, G., Fukai, T., Schmidt, H. H. H. W., Dikalov, S., et al. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00637.2004 · Cited by 93 · see citing works

Vascular endothelial ageing, heartbeat after heartbeat

Thorin, É., & Thorin‐Trescases, N. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp236 · Cited by 91 · see citing works

β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase

Su, K., Shyue, S., Kou, Y. R., Ching, L., Chiang, A.-N., Yu, Y., Chen, C., Pan, C.-C., & Lee, T. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22678 · Cited by 90 · see citing works

Exercise and NO production: relevance and implications in the cardiopulmonary system

Носарев, А. В., Smagliy, L. V., Anfinogenova, Y., Popov, S. V., & Капилевич, Л. В. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00073 · Cited by 81 · see citing works

Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK

Shafique, E., Choy, W. C., Liu, Y., Feng, J., Cordeiro, B., Lyra, A., Arafah, M., Yassin-Kassab, A., Zanetti, A. V. D., Clements, R., et al. (2013) · Aging · doi:10.18632/aging.100569 · Cited by 76 · see citing works

Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease

Maiocchi, S. L., Ku, J., Thai, T., Chan, E., Rees, M. D., & Thomas, S. R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107711 · Cited by 75 · see citing works

Endothelial control of vasomotion and nitric oxide production.

Harrison, D., & Cai, H. (1996) · Cardiology Clinics · doi:10.1016/s0733-8651(03)00073-0 · Cited by 77 · see citing works

Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newborn

Afolayan, A. J., Eis, A., Teng, R., Bakhutashvili, I., Kaul, S., Davis, J. M., & Konduri, G. G. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00098.2012 · Cited by 74 · see citing works

Exercise and the Cardiovascular System

Golbidi, S., & Laher, I. (2012) · Cardiology Research and Practice · doi:10.1155/2012/210852 · Cited by 72 · see citing works

Physical inactivity causes endothelial dysfunction in healthy young mice

Suvorava, T., Lauer, N., & Kojda, G. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.06.030 · Cited by 66 · see citing works

Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII*1

Cai, H. “. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.04.012 · Cited by 66 · see citing works

Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle

Hellsten, Y., Nielsen, J., Lykkesfeldt, J., Bruhn, M., Silveira, L. R., Pilegaard, H., & Bangsbo, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.02.029 · Cited by 65 · see citing works

Peri/Epicellular Protein Disulfide Isomerase Sustains Vascular Lumen Caliber Through an Anticonstrictive Remodeling Effect

Tanaka, L. Y., Araújo, H. A., Hironaka, G. K., Araujo, T. L. S., Takimura, C. K., Rodriguez, A. I., Casagrande, A., Gutierrez, P. S., Lemos, P. A., & Laurindo, F. R. M. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06177 · Cited by 63 · see citing works

Exercise-induced activation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS

Akita, Y., Otani, H., Matsuhisa, S., Kyoi, S., Enoki, C., Hattori, R., Imamura, H., Kamihata, H., Kimura, Y., & Iwasaka, T. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01102.2006 · Cited by 61 · see citing works

Exogenous superoxide mediates pro-oxidative, proinflammatory, and procoagulatory changes in primary endothelial cell cultures

Jacobi, J. M., Kristal, B., Chezar, J., Shaul, S. M., & Sela, S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.010 · Cited by 61 · see citing works

Sexual dimorphism in reduced-size liver ischemia and reperfusion injury in mice: Role of endothelial cell nitric oxide synthase

Harada, H., Pavlick, K. P., Hines, I. N., Lefer, D. J., Hoffman, J. M., Bharwani, S., Wolf, R. E., & Grisham, M. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0235680100 · Cited by 58 · see citing works

Redox Balance in the Aging Microcirculation: New Friends, New Foes, and New Clinical Directions

Muller‐Delp, J. M., Gurovich, A. N., Christou, D. D., & Leeuwenburgh, C. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00139.x · Cited by 57 · see citing works

Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods

Nethi, S. K., Veeriah, V., Barui, A. K., Rajendran, S., Mattapally, S., Misra, S., Chatterjee, S., & Patra, C. R. (2015) · Nanoscale · doi:10.1039/c5nr01327e · Cited by 56 · see citing works

The Effect of Tetramethylpyrazine on Hydrogen Peroxide‐Induced Oxidative Damage in Human Umbilical Vein Endothelial Cells

Li, W., Liu, H., Li, X., Wu, J., Xu, G., Teng, Y., Ding, S., & Yu, C. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00470.x · Cited by 51 · see citing works

HIV gp120 induces endothelial dysfunction in tumour necrosis factor-α-activated porcine and human endothelial cells

Jiang, J., Fu, W., Wang, X., Lin, P. H., Yao, Q. C., & Chen, C. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq013 · Cited by 51 · see citing works

Exercise improves endothelial function: A local analysis of production of nitric oxide and reactive oxygen species

Tanaka, L. Y., Bechara, L. R. G., dos Santos, A. M., Jordão, C. P., de Sousa, L. G. O., Bartholomeu, T., Ventura, L. I., Laurindo, F. R. M., & Ramires, P. R. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.01.003 · Cited by 50 · see citing works

Vascular remodeling: A redox-modulated mechanism of vessel caliber regulation

Tanaka, L. Y., & Laurindo, F. R. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.025 · Cited by 50 · see citing works

Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats

Hung, M., Yeung, H. M., Lau, C., Poon, A. M. S., Tipoe, G. L., & Fung, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061125 · Cited by 49 · see citing works

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

Douglas, G., Hale, A., Patel, J., Chuaiphichai, S., Zen, A. A. H., Rashbrook, V. S., Trelfa, L., Crabtree, M. J., McNeill, E., & Channon, K. M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy078 · Cited by 49 · see citing works

Exercise and the Aging Endothelium

Golbidi, S., & Laher, I. (2013) · Journal of Diabetes Research · doi:10.1155/2013/789607 · Cited by 48 · see citing works

Reactive oxygen species as cardiovascular mediators: Lessons from endothelial-specific protein overexpression mouse models

Suvorava, T., & Kojda, G. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.04.005 · Cited by 47 · see citing works

Activation of the Calcium/Calmodulin-Dependent Protein Kinases as a Consequence of Oxidative Stress

Franklin, R. A., Rodriguez–Mora, O., LaHair, M. M., & McCubrey, J. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1807 · Cited by 47 · see citing works

Alterations in endothelial nitric oxide synthase activity and their relevance to blood pressure

Suvorava, T., Metry, S., Pick, S., & Kojda, G. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115256 · Cited by 48 · see citing works

Hydrogen Peroxide Potentiates Volume-sensitive Excitatory Amino Acid Release via a Mechanism Involving Ca2+/Calmodulin-dependent Protein Kinase II

Haskew-Layton, R. E., Mongin, A. A., & Kimelberg, H. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409803200 · Cited by 46 · see citing works

Cyclin D1 degradation enhances endothelial cell survival upon oxidative stress

Fasanaro, P., Magenta, A., Zaccagnini, G., Cicchillitti, L., Fucile, S., Eusebi, F., Biglioli, P., Capogrossi, M. C., & Martelli, F. (2006) · The FASEB Journal · doi:10.1096/fj.05-4695fje · Cited by 45 · see citing works

CaMKII knockdown attenuates H2O2-induced phosphorylation of ERK1/2, PKB/Akt, and IGF-1R in vascular smooth muscle cells

Bouallegue, A., Pandey, N. R., & Srivastava, A. K. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.06.022 · Cited by 44 · see citing works

Oxidative stress disrupts nitric oxide synthase activation in liver endothelial cells

Karaa, A., Kamoun, W. S., & Clemens, M. G. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.014 · Cited by 43 · see citing works

Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress

Siu, K. L., Gao, L., & Cai, H. “. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.713149 · Cited by 42 · see citing works

Evolution of Oxidative Stress and Inflammation During Hemodialysis and Their Contribution to Cardiovascular Disease

Wratten, M. L., Galaris, D., Tetta, C., & Sevanian, A. (2002) · Antioxidants and Redox Signaling · doi:10.1089/152308602762197470 · Cited by 41 · see citing works

Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity

Kumar, S., Sun, X., Wedgwood, S., & Black, S. M. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90205.2008 · Cited by 39 · see citing works

Aging-Induced Impairment of Vascular Function: Mitochondrial Redox Contributions and Physiological/Clinical Implications

Tracy, E. P., Hughes, W. E., Beare, J. E., Rowe, G., Beyer, A., & LeBlanc, A. J. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0031 · Cited by 38 · see citing works

CaMKII regulates intracellular Ca2+ dynamics in native endothelial cells

Toussaint, F., Charbel, C., Blanchette, A., & Ledoux, J. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.06.005 · Cited by 36 · see citing works

A novel role for caveolin-1 in regulating endothelial nitric oxide synthase activation in response to H2O2 and shear stress

Tian, J., Hou, Y., Lü, Q., Wiseman, D. A., Fonseca, F. V., Elms, S. C., Fulton, D. J., & Black, S. M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.023 · Cited by 35 · see citing works

20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt

Bodiga, S., Gruenloh, S. K., Gao, Y., Manthati, V. L., Dubasi, N., Falck, J. R., Medhora, M. M., & Jacobs, E. R. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00298.2009 · Cited by 35 · see citing works

Angiotensin II stimulates nitric oxide production in pulmonary artery endothelium via the type 2 receptor

Olson, S. C., Oeckler, R. A., Li, X., Du, L., Traganos, F., Zhao, X., & Burke-Wolin, T. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00312.2003 · Cited by 35 · see citing works

Redox-Sensitive Up-Regulation of eNOS by Purple Grape Juice in Endothelial Cells: Role of PI3-Kinase/Akt, p38 MAPK, JNK, FoxO1 and FoxO3a

Alhosin, M., Anselm, E., Rashid, S. K., Kim, J. H., Gaban, S. V. F., Bronner, C., & Schini‐Kerth, V. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057883 · Cited by 34 · see citing works

Ginsenoside Rb1 Reverses H2O2-induced Senescence in Human Umbilical Endothelial Cells

Liu, D., Chen, Y., Liu, Y., Hao, B., Zhou, B., Wu, L., Wang, M., Chen, L., Wu, W.-K., & Qian, X. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31823c1d34 · Cited by 34 · see citing works

Influence of Heme and Heme Oxygenase-1 Transfection of Pulmonary Microvascular Endothelium on Oxidant Generation and cGMP

Mingone, C. J., Gupte, S. A., Quan, S., Abraham, N. G., & Wolin, M. S. (2003) · Experimental Biology and Medicine · doi:10.1177/15353702-0322805-22 · Cited by 34 · see citing works

c-Src Inhibition Improves Cardiovascular Function but not Remodeling or Fibrosis in Angiotensin II–Induced Hypertension

Callera, G. E., Antunes, T. T., He, Y., Montezano, A. C. I., Yogi, Á., Savoia, C., & Touyz, R. M. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07699 · Cited by 33 · see citing works

Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation through a calcium and phosphatidylinositol 3-kinase/Akt mechanism

Yang, P., Huang, Y., Zhang, Y., Hsieh, C., & Wung, B. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.09.010 · Cited by 33 · see citing works

Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension

Youn, J. Y., Wang, T., Blair, J., Laude, K. M., Oak, J., McCann, L. A., Harrison, D. G., & Cai, H. “. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00835.2011 · Cited by 32 · see citing works

Attenuation of proinflammatory gene expression and microcirculatory disturbances by endothelinA receptor blockade after orthotopic liver transplantation in pigs

Uhlmann, D., Gaebel, G., Armann, B., Ludwig, S., Hess, J., Pietsch, U., Fiedler, M., Tannapfel, A., Hauss, J., & Witzigmann, H. (2005) · Surgery · doi:10.1016/j.surg.2005.07.006 · Cited by 31 · see citing works

Vascular CaMKII: heart and brain in your arteries

Toussaint, F., Charbel, C., Allen, B. G., & Ledoux, J. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00341.2015 · Cited by 29 · see citing works

Effects of Chronic Swimming Training and Oestrogen Therapy on Coronary Vascular Reactivity and Expression of Antioxidant Enzymes in Ovariectomized Rats

Claudio, E., Endlich, P., Santos, R., Moysés, M., Bissoli, N., Gouvea, S., Silva, J., Lemos, V., & Abreu, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064806 · Cited by 31 · see citing works

Impact of SOD in eNOS uncoupling: a two-edged sword between hydrogen peroxide and peroxynitrite

Kar, S., Bhandar, B., & Kavdia, M. (2012) · Free Radical Research · doi:10.3109/10715762.2012.731052 · Cited by 27 · see citing works

AQP1 differentially orchestrates endothelial cell senescence

Shabanian, K., Shabanian, T., Karsai, G., Pontiggia, L., Paneni, F., Ruschitzka, F. T., Beer, J. H., & Saravi, S. S. S. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103317 · Cited by 25 · see citing works

Hydrogen Peroxide Decreases Endothelial Nitric Oxide Synthase Promoter Activity through the Inhibition of Sp1 Activity

Kumar, S., Sun, X., Wiseman, D. A., Tian, J., Umapathy, N. S., Verin, A. D., & Black, S. M. (2008) · DNA and Cell Biology · doi:10.1089/dna.2008.0775 · Cited by 25 · see citing works

Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII*1

Cai, H. “. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.04.012 · Cited by 66 · see citing works

Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38 MAPK, HSP27 and actin reorganization in endothelial cells

Nguyen, A., Chen, P., & Cai, H. “. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.061 · Cited by 98 · see citing works

Hydrogen Peroxide Activates Endothelial Nitric-oxide Synthase through Coordinated Phosphorylation and Dephosphorylation via a Phosphoinositide 3-Kinase-dependent Signaling Pathway

Thomas, S. R., Chen, K., & Keaney, J. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109107200 · Cited by 381 · see citing works

CaM Kinase II-dependent pathophysiological signalling in endothelial cells

Cai, H. “., Liu, D., & Garcia, J. G. N. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm010 · Cited by 97 · see citing works

Review CaM Kinase II-dependent pathophysiological signalling in endothelial cells

Cai, H., Liu, D., & Garcia, J. G. N. (2014)