The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Pressure Amplification Explains Why Pulse Pressure Is Unrelated to Risk in Young Subjects
Abstract
Pulse pressure rather than diastolic pressure is the best predictor of coronary heart disease risk in older subjects, but the converse is true in younger subjects. We hypothesized that this disparity results from an age-related difference in pressure amplification from the aorta to brachial artery. Data from 212 subjects age <50 years and 230 subjects age ≥50 years were abstracted from a community database. All subjects were free from cardiovascular disease, diabetes, and medication. Peripheral blood pressure was assessed by sphygmomanometry. Radial artery waveforms recorded noninvasively by applanation tonometry were used to derive central blood pressure. Pressure amplification (peripheral/central pulse pressure ratio) was linearly related to age ( r =0.7; P <0.001). There was an inverse, linear relationship between amplification and diastolic pressure in the younger group ( r =0.3; P <0.001) but not in older subjects ( r =0.1; P =0.2). There was no relationship in either group when the amplification ratio was calculated with nonaugmented central pressure. Amplification is reduced in older subjects because of enhanced wave reflection. In younger, but not older, subjects, amplification declines as diastolic pressure rises. Therefore, peripheral pulse pressure underestimates the effect that diastolic pressure has on central pulse pressure in younger subjects. This may explain why diastolic pressure is a better predictor of risk in this age group and suggests that assessment of central pressure may improve risk stratification further.
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Hemodynamic Patterns of Age-Related Changes in Blood Pressure: The Framingham Heart Study
Franklin, S. S., Gustin, W., Wong, N. D., Larson, M. G., Weber, M. A., Kannel, W. B., & Levy, D. (1997) · Circulation · doi:10.1161/01.cir.96.1.308 · Cited by 2,321
Self-citationImpact of Aortic Stiffness on Survival in End-Stage Renal Disease
Blacher, J., Guerin, A. P., Pannier, B., Marchais, S. J., Safar, M. E., & London, G. M. (1999) · Circulation · doi:10.1161/01.cir.99.18.2434 · Cited by 2,138
Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients
Blacher, J., Asmar, R., Djane, S., London, G. M., & Safar, M. E. (1999) · Hypertension · doi:10.1161/01.hyp.33.5.1111 · Cited by 1,493
Chen, C.-H., Nevo, E., Fetics, B., Pak, P. H., Yin, F. C. P., Maughan, W. L., & Kass, D. A. (1997) · Circulation · doi:10.1161/01.cir.95.7.1827 · Cited by 1,307
Systolic versus diastolic blood pressure and risk of coronary heart disease
Kannel, W. B., Gordon, T., & Schwartz, M. J. (1971) · The American Journal of Cardiology · doi:10.1016/0002-9149(71)90428-0 · Cited by 925
KARAMANOGLU, M., O'ROURKE, M. F., AVOLIO, A. P., & KELLY, R. P. (1993) · European Heart Journal · doi:10.1093/eurheartj/14.2.160 · Cited by 873
Wave reflection in the systemic circulation and its implications in ventricular function
O??Rourke, M. F., & Kelly, R. P. (1993) · Journal of Hypertension · doi:10.1097/00004872-199304000-00001 · Cited by 278
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Expert consensus document on arterial stiffness: methodological issues and clinical applications
Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I., Struijker-Boudier, H., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl254 · Cited by 6,077
Self-citationMechanical Factors in Arterial Aging
O’Rourke, M. F., & Hashimoto, J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.12.050 · Cited by 1,250
Goldstein, S. A., Evangelista, A., Abbara, S., Arai, A., Asch, F. M., Badano, L. P., Bolen, M. A., Connolly, H. M., Cuéllar-Calàbria, H., Czerny, M., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.11.015 · Cited by 641
Arterial Aging: Is It an Immutable Cardiovascular Risk Factor?
Najjar, S. S., Scuteri, A., & Lakatta, E. G. (2005) · Hypertension · doi:10.1161/01.hyp.0000177474.06749.98 · Cited by 640
Avolio, A. P., Van Bortel, L. M., Boutouyrie, P., Cockcroft, J. R., McEniery, C. M., Protogerou, A. D., Roman, M. J., Safar, M. E., Segers, P., & Smulyan, H. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.134379 · Cited by 521
Self-citation
Metadata
- Authors
- Wilkinson, I. B., Franklin, S. S., Hall, I. R., Tyrrell, S., & Cockcroft, J. R.
- Venue
- Hypertension
- Published
- 2001-12
- Volume
- 38
- Issue
- 6
- Pages
- 1461-1466
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2169725605
- Cited by
- 273
- References
- 9
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- closed
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