Renal Sinus Fat and Poor Blood Pressure Control in Middle-Aged and Elderly Individuals at Risk for Cardiovascular Events
Open accessAbstract
Fat in the renal sinus (RS), a region of the kidney in which low pressure venous and lymphatic vessels are present, may indirectly influence blood pressure. The purpose of this study was to assess the association between RS fat and control of blood pressure on receipt of antihypertensive medications. A total of 205 participants aged 55 to 85 years at risk for cardiovascular events underwent MRI assessments of abdominal and RS fat, measurement of blood pressure, and determination of the number of prescribed antihypertensive medications. Multivariable linear regression was used to determine associations among RS fat, blood pressure, and the number of prescribed antihypertensive medications. Abdominal fat averaged 416±160 cm 3 (median and interquartile range of 396 cm 3 and 308 to 518 cm 3 ); intraperitoneal fat averaged 141±73 cm 3 (median and interquartile range of 129 cm 3 and 86 to 194 cm 3 ); and RS fat averaged 4.6±3.2 cm 3 (median and interquartile range of 4.2 cm 3 and 2.2 to 6.6 cm 3 ). After accounting for age, sex, height, body mass index, and intraperitoneal fat, RS fat correlated with the number of prescribed antihypertensive medications ( P =0.010), stage II hypertension ( P =0.02), and renal size ( P ≤0.001). In conclusion, after accounting for other body fat depots and risk factors for hypertension, RS fat volume is associated with the number of prescribed antihypertensive medications and stage II hypertension. These results indicate that further studies are warranted to determine whether fat accumulation in the RS promotes hypertension.
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Excessive adipose deposition around the kidneys, such as renal sinus fat and perirenal fat, may be associated with hypertension even after adjustment for traditional risk factors, including overall adiposity and BMI.
“Evidence suggests that excessive adipose deposition around the kidneys (for example, renal sinus fat (RSF) and perirenal fat (PRF)) may be associated with hypertension even after adjustment for traditional risk factors, including overall adiposity and BMI6,19–21.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [19]
After accounting for other body fat depots and risk factors for hypertension, renal sinus fat volume was highly correlated with the number of blood pressure medications and with stage II hypertension.
“After accounting for other body fat depots and risk factors for hypertension, RSF volume was highly correlated with the number of BP medications and with stage II hypertension19.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [19]
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- Authors
- Chughtai, H. L., Morgan, T. M., Rocco, M., Stacey, B., Brinkley, T. E., Ding, J., Nicklas, B., Hamilton, C., & Hundley, W. G.
- Affiliations
- Wake Forest University Health Sciences (US)
- ORCID
- Venue
- Hypertension
- Published
- 2010-11
- Volume
- 56
- Issue
- 5
- Pages
- 901-906
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3634339
- OpenAlex
- W2112119265
- Cited by
- 172
- References
- 25
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 26 · 2023: 16 · 2022: 10 · 2021: 15 · 2020: 11 · 2019: 14 · 2018: 9 · 2017: 11 · 2016: 6 · 2015: 13 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P30AG021332)
- National Heart, Lung, and Blood Institute (R01HL076438)
- National Cancer Institute (R33 CA1219601, R33CA121296)
- National Center for Research Resources (MO1-RR07122, M01RR007122)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Keywords
- renal sinus fat, blood pressure control, antihypertensive drugs, stage 2 hypertension, abdominal fat, intraperitoneal fat, kidney size, middle-aged and older adults, cardiovascular risk, kidney fat
- MeSH terms
- Adipose Tissue, Antihypertensive Agents, Body Composition, Humans, Hypertension, Kidney, Risk Factors, Linear Models, Abdominal Fat
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