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Cited by 230Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Midlife and Late-Life Blood Pressure and Dementia in Japanese Elderly: The Hisayama Study

Ninomiya, Toshiharu, Ohara, Tomoyuki, Hirakawa, Yoichiro, Yoshida, Daigo, Doi, Yasufumi, Hata, Jun, Kanba, Shigenobu, Iwaki, Toru, Kiyohara, Yutaka·2011·Hypertension
DOI 10.1161/hypertensionaha.110.163055
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Abstract

The associations between blood pressure and dementia have been inconclusive. We followed up a total of 668 community-dwelling Japanese individuals without dementia, aged 65 to 79 years, for 17 years and examined the associations of late-life and midlife hypertension with the risk of vascular dementia and Alzheimer disease using the Cox proportional hazards model. During the follow-up, 76 subjects experienced vascular dementia and 123 developed Alzheimer disease. The age- and sex-adjusted incidence of vascular dementia significantly increased with elevated late-life blood pressure levels (normal: 2.3, prehypertension: 8.4, stage 1 hypertension: 12.6, and stage 2 hypertension: 18.9 per 1000 person-years; P(trend)<0.001), whereas no such association was observed for Alzheimer disease (P(trend)=0.88). After adjusting for potential confounding factors, subjects with prehypertension and stage 1 or stage 2 hypertension had 3.0-fold, 4.5-fold, and 5.6-fold greater risk of vascular dementia, respectively, compared with subjects with normal blood pressure. Likewise, there was a positive association of midlife blood pressure levels with the risk of vascular dementia but not with the risk of Alzheimer disease. Compared with those without hypertension in both midlife and late life, subjects with midlife hypertension had an ≈5-fold greater risk of vascular dementia, regardless of late-life blood pressure levels. Our findings suggest that midlife hypertension and late-life hypertension are significant risk factors for the late-life onset of vascular dementia but not for that of Alzheimer disease in a general Japanese population. Midlife hypertension is especially strongly associated with a greater risk of vascular dementia, regardless of late-life blood pressure levels.

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Crossref · 10.1161/hypertensionaha.110.163055

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  1. Fratiglioni L, Launer LJ, Andersen K, Breteler MM, Copeland JR, Dartigues JF, Lobo A, Martinez-Lage J, Soininen H, Hofman A. Incidence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts–Neurologic Diseases in the Elderly Research Group. Neurology. 2000;54 (11 suppl 5):S10–S15

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Metadata

Authors
Ninomiya, T., Ohara, T., Hirakawa, Y., Yoshida, D., Doi, Y., Hata, J., Kanba, S., Iwaki, T., & Kiyohara, Y.
Affiliations
Kyushu University (JP)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-07
Volume
58
Issue
1
Pages
22-28
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.110.163055
OpenAlex
W2129684069
Cited by
230
References
43
Citations by year
2026: 8 · 2025: 5 · 2024: 10 · 2023: 14 · 2022: 16 · 2021: 20 · 2020: 16 · 2019: 21 · 2018: 19 · 2017: 22 · 2016: 17 · 2015: 13 · 2014: 18 · 2013: 12 · 2012: 14
FWCI
10.72
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Society for the Promotion of Science (23590798, 22300116, 22240073)
  • National Institute on Aging
  • National Institute of Neurological Disorders and Stroke
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
blood pressure, midlife hypertension, vascular dementia, Alzheimer's disease, dementia risk factors, prehypertension, Japanese older adults, community-dwelling older adults
MeSH terms
Aged, Aging, Blood Pressure, Female, Humans, Hypertension, Japan, Male, Prospective Studies, Risk Factors, Urban Population, Dementia, Vascular, Incidence

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