The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Immunosenescent CD8 + T Cells and C-X-C Chemokine Receptor Type 3 Chemokines Are Increased in Human Hypertension
Open accessAbstract
The pathogenic role of T cells in hypertension has been documented well in recent animal studies. However, the existence of T-cell–driven inflammation in human hypertension has not been confirmed. Therefore, we undertook immunologic characterization of T cells from patients with hypertension and measured circulating levels of C-X-C chemokine receptor type 3 chemokines, which are well-known tissue-homing chemokines for T cells. We analyzed immunologic markers on T cells from patients with hypertension by multicolor flow cytometry. We then measured circulating levels of the C-X-C chemokine receptor type 3 chemokines, monokine induced by γ interferon (IFN), IFN γ–induced protein 10, and IFN-inducible T-cell α chemoattractant, in patients with hypertension and in age- and sex-matched control subjects by the cytometric bead array method. In addition, we examined histological features of IFN-inducible T-cell α chemoattractant expression from renal biopsy specimens of patients with hypertensive nephrosclerosis and control subjects. The total T-cell population from patients with hypertension showed an increased fraction of immunosenescent, proinflammatory, cytotoxic CD8 + T cells. Circulating levels of C-X-C chemokine receptor type 3 chemokines were significantly higher in patients with hypertension than in control subjects. Furthermore, immunohistochemical staining revealed increased expression of the T-cell chemokine, IFN-inducible T-cell α chemoattractant, in the proximal and distal tubules of patients with hypertensive nephrosclerosis. Immunosenescent CD8 + T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension, suggesting a role for T-cell–driven inflammation in hypertension. A more detailed characterization of CD8 + T cells may offer new opportunities for the prevention and treatment of human hypertension.
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Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
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Inflammation, Immunity, and Hypertension
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CD28− T cells: their role in the age-associated decline of immune function
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Cited by
Inflammation, Immunity, and Hypertensive End-Organ Damage
McMaster, W. G., Kirabo, A., Madhur, M. S., & Harrison, D. G. (2015) · Circulation Research · doi:10.1161/circresaha.116.303697 · Cited by 708
Endothelial Dysfunction and Hypertension
Konukoglu, D., & Uzun, H. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2016_90 · Cited by 594
Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension
Barbaro, N. R., Foss, J. D., Kryshtal, D. O., Tsyba, N., Kumaresan, S., Xiao, L., Mernaugh, R. L., Itani, H. A., Loperena, R., Chen, W., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.002 · Cited by 282
Czesnikiewicz‐Guzik, M., Nosalski, R., Mikolajczyk, T. P., Vidler, F., Dohnal, T., Dembowska, E., Graham, D., Harrison, D. G., & Guzik, T. J. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14536 · Cited by 61
Gingival fluid inflammatory biomarkers and hypertension in African Americans
Khocht, A., Rogers, T., Janal, M. N., & Brown, M. (2017) · JDR Clinical & Translational Research · doi:10.1177/2380084417694335 · Cited by 21
Metadata
- Authors
- Youn, J.-C., Yu, H. T., Lim, B. J., Koh, M. J., Lee, J., Chang, D.-Y., Choi, Y. S., Lee, S.-H., Kang, S.-M., Jang, Y., Yoo, O. J., Shin, E.-C., & Park, S.
- Venue
- Hypertension
- Published
- 2013-07
- Volume
- 62
- Issue
- 1
- Pages
- 126-133
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2168671157
- Cited by
- 284
- References
- 23
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Youn, J.-C., Yu, H. T., Lim, B. J., Koh, M. J., Lee, J., Chang, D.-Y., Choi, Y. S., Lee, S.-H., Kang, S.-M., Jang, Y., Yoo, O. J., Shin, E.-C., & Park, S. (2013). Immunosenescent CD8 + T Cells and C-X-C Chemokine Receptor Type 3 Chemokines Are Increased in Human Hypertension. Hypertension. https://doi.org/10.1161/hypertensionaha.113.00689
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