Prevalence, Correlates, and Prognosis of Healthy Vascular Aging in a Western Community-Dwelling Cohort: The Framingham Heart Study
Open accessAbstract
Hypertension and increased vascular stiffness are viewed as inevitable parts of aging. To elucidate whether the age-related decrease in vascular function is avoidable, we assessed the prevalence, correlates, and prognosis of healthy vascular aging (HVA) in 3196 Framingham Study participants aged ≥50 years. We defined HVA as absence of hypertension and pulse wave velocity <7.6 m/s (mean+2 SD of a reference sample aged <30 years). Overall, 566 (17.7%) individuals had HVA, with prevalence decreasing from 30.3% in people aged 50 to 59 to 1% in those aged ≥70 years. In regression models adjusted for physical activity, caloric intake, and traditional cardiovascular disease (CVD) risk factors, we observed that lower age, female sex, lower body mass index, use of lipid-lowering drugs, and absence of diabetes mellitus were cross-sectionally associated with HVA ( P <0.001 for all). A unit increase in a cardiovascular health score (Life’s Simple 7) was associated with 1.55-fold (95% confidence interval, 1.38–1.74) age- and sex-adjusted odds of HVA. During a follow-up of 9.6 years, 391 CVD events occurred. In Cox regression models adjusted for traditional CVD risk factors, including blood pressure, HVA was associated with a hazard ratio of 0.45 (95% confidence interval, 0.26–0.77) for CVD relative to absence of HVA. Although HVA is achievable in individuals acculturated to a Western lifestyle, maintaining normal vascular function beyond 70 years of age is challenging. Although our data are observational, our findings support prevention strategies targeting modifiable factors and behaviors and obesity, in particular, to prevent or delay vascular aging and the associated risk of CVD.
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This observational study supports prevention strategies focused on modifiable health factors and behaviors to prevent or delay vascular aging and cardiovascular disease risk and possibly other aging consequences such as cognitive impairment.
“This observational study provides support for prevention strategies focused on modifiable health factors and behaviors to prevent or delay vascular aging and risk of cardiovascular disease and possibly other health consequences associated with aging such as cognitive impairment.179”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [179]
Development of vascular arterial stiffness, a measure of vascular aging, may not be inevitable.
“Furthermore, the development of vascular arterial stiffness, a measure of vascular aging, may not be inevitable.179”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [179]
In the Framingham study, lower age, female sex, lower BMI, use of lipid-lowering drugs, and absence of diabetes mellitus were associated with healthy vascular aging in a cross-sectional study.
“In the Framingham study, lower age, female sex, lower BMI, use of lipid-lowering drugs, and absence of diabetes mellitus in a cross-sectional study were associated with healthy vascular aging.”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [179]
For every 1-unit higher AHA Life's Simple 7 score, there was a 1.55-fold age- and sex-adjusted odds of healthy vascular aging.
“In addition, for every 1-unit higher AHA’s Life’s Simple 7 score (ie, 1 more factor or behavior at ideal levels), there was a 1.55-fold age- and sex-adjusted odds of healthy vascular aging.”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [179]
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BackgroundCerebrovascular Reactivity and Central Arterial Stiffness in Habitually Exercising Healthy Adults
Miller, K. B., Howery, A. J., Harvey, R. E., Eldridge, M. W., & Barnes, J. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01096 · Cited by 42 · see citing works
“In the present study, we report higher central arterial stiffness in older adults, as expected (Kelly et al., 1989); however, PWV values in our sample of older adults were relatively low (<7.6 m/s) (Niiranen et al., 2017).”
BackgroundInfluentialEstimating disease prevalence from drug utilization data using the Random Forest algorithm
Slobbe, L., Füssenich, K., Wong, A., Boshuizen, H. C., Nielen, M. M. J., Polder, J. J., Feenstra, T., & OERS, H. A. M. V. (2018) · European Journal of Public Health · doi:10.1093/eurpub/cky270 · Cited by 32 · see citing works
Currie, G. E., & Delles, C. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09122 · Cited by 28 · see citing works
“There are further limitations of the present article by Niiranen et al.(9) First, although there are good reasons for including blood pressure in their definition of vascular age, it mixes up a risk factor (blood pressure) with its consequences (altered vascular phenotype).”
BackgroundVascular aging and preclinical target organ damage in community-dwelling elderly
Ji, H., Teliewubai, J., Lu, Y., Xiong, J., Yu, S., Chi, C., Li, J., Blacher, J., Zhang, Y., & Xu, Y. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001692 · Cited by 27 · see citing works
Zhou, N., Ma, B., Stoll, S., Hays, T. T., & Qiu, H. (2017) · Aging Cell · doi:10.1111/acel.12653 · Cited by 26 · see citing works
“Age is a well-known risk factor for hypertension (Sun, 2015; Niiranen et al., 2017).”
BackgroundNew Insight into the Mechanisms of Ginkgo Biloba Extract in Vascular Aging Prevention
Li, X., Lu, L., Chen, J., Zhang, C., Chen, H., & Huang, H. (2019) · Current Vascular Pharmacology · doi:10.2174/1570161117666190621150725 · Cited by 24 · see citing works
Oyenuga, A., Folsom, A. R., Cheng, S. C., Tanaka, H., & Meyer, M. L. (2019) · American Journal of Hypertension · doi:10.1093/ajh/hpz057 · Cited by 23 · see citing works
Connecting vascular aging and frailty in Alzheimer’s disease
Sabbatinelli, J., Ramini, D., Giuliani, A., Recchioni, R., Spazzafumo, L., & Olivieri, F. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111444 · Cited by 23 · see citing works
Freeberg, K. A., Craighead, D. H., Martens, C. R., You, Z., Chonchol, M., & Seals, D. R. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.881703 · Cited by 23 · see citing works
Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects
Sang, Y., Wu, X., Miao, J., Cao, M., Ruan, L., & Zhang, C. (2020) · Medical Science Monitor · doi:10.12659/msm.923112 · Cited by 22 · see citing works
Increased risk for new‐onset hypertension in midlife male snorers: The 14‐year follow‐up study
Lee, S. K., Choi, K., Chang, Y. H., Kim, J., & Shin, C. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12757 · Cited by 22 · see citing works
“Man Is as Old as His Arteries” Taken Literally
Weber, T., & Mayer, C. C. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.16128 · Cited by 22 · see citing works
Body Silhouette Trajectories Across the Lifespan and Vascular Aging
van Sloten, T. T., Boutouyrie, P., Lisan, Q., Tafflet, M., Thomas, F., Guibout, C., Climie, R. E., Pannier, B., Sharman, J. E., Laurent, S., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11442 · Cited by 21 · see citing works
Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
Ji, H., Xiong, J., Yu, S., Chi, C., Bai, B., Teliewubai, J., Lu, Y., Zhang, Y., & Xu, Y. (2018) · Journal of Visualized Experiments · doi:10.3791/57083 · Cited by 20 · see citing works
Bonafini, S., Giontella, A., Tagetti, A., Montagnana, M., Benati, M., Danese, E., Minuz, P., Maffeis, C., Antoniazzi, F., & Fava, C. (2019) · Hypertension Research · doi:10.1038/s41440-018-0173-7 · Cited by 20 · see citing works
Danninger, K., Hafez, A., Binder, R. K., Aichberger, M., Hametner, B., Wassertheurer, S., & Weber, T. (2019) · Journal of Human Hypertension · doi:10.1038/s41371-019-0222-y · Cited by 21 · see citing works
Cross-sectional analysis of pulsatile hemodynamics across the adult life span
Weber, T., Wassertheurer, S., Hametner, B., Moebus, S., Pundt, N., Mahabadi, A. A., Roggenbuck, U., Lehmann, N., Jöckel, K., & Erbel, R. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000002178 · Cited by 20 · see citing works
Healthy Vascular Aging Is Associated With Higher Cardiorespiratory Fitness
Fleenor, B. S., Carlini, N. A., Kaminsky, L. A., Whaley, M. H., Peterman, J. E., & Harber, M. P. (2021) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000530 · Cited by 20 · see citing works
Carlini, N. A., Harber, M. P., & Fleenor, B. S. (2024) · The Journal of Physiology · doi:10.1113/jp285636 · Cited by 20 · see citing works
Sang, Y., Cao, M., Wu, X., Ruan, L., & Zhang, C. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01846-x · Cited by 19 · see citing works
“Pulse wave velocity is considered a physiological method for quantifying vascular aging [9, 10].”
MethodPotential Role of Antihypertensive Medications in Preventing Excessive Arterial Stiffening
Jia, G., Aroor, A. R., Martinez‐Lemus, L. A., & Sowers, J. R. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0876-9 · Cited by 18 · see citing works
Association of Vascular Aging With Cardiovascular Disease in Middle-Aged Chinese People
Zuo, Y., Chen, S., Tian, X., Wang, P., Wu, S., & Wang, A. (2023) · JACC Asia · doi:10.1016/j.jacasi.2023.07.014 · Cited by 17 · see citing works
Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7
Aguayo, L., Cotoc, C., Guo, J. W., Labarthe, D. R., Allen, N. B., Marino, B. S., Davis, M. M., Uttal, S. E., Lloyd‐Jones, D. M., & Perak, A. M. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.038566 · Cited by 17 · see citing works
Gómez‐Sánchez, L., Tamayo‐Morales, O., Suárez-Moreno, N., Bermejo-Martín, J. F., Domínguez-Martín, A., Martín-Oterino, J.-Á., Martín‐González, J. I., Calle, D. G., García-García, Á., Lugones‐Sánchez, C., et al. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1236430 · Cited by 18 · see citing works
Lipoproteins and Cardiovascular Redox Signaling: Role in Atherosclerosis and Coronary Disease
Haghikia, A., & Landmesser, U. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7052 · Cited by 15 · see citing works
Wadström, B. N., Engström, G., & Nilsson, P. M. (2020) · Journal of Human Hypertension · doi:10.1038/s41371-020-0353-1 · Cited by 14 · see citing works
“Age-independent definitions of HVA, have been suggested [6] based on findings of attenuated vascular ageing in small studies on populations leading hunter-gatherer lifestyles.”
BackgroundInfluentialYang, Y., Wang, A., Yuan, X., Zhao, Q., Liu, X., Chen, S., Wang, X., Wang, Y., Wu, S., & Wang, Y. (2019) · Aging · doi:10.18632/aging.102170 · Cited by 14 · see citing works
Vaura, F. C., Salomaa, V. V., Kantola, I. M., Kaaja, R., Lahti, L., & Niiranen, T. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.13984 · Cited by 13 · see citing works
Self-citationExercise and Carotid Properties in the Young–The KiGGS-2 Study
Königstein, K., Büschges, J. C., Sarganas, G., Krug, S., Neuhauser, H. K., & Schmidt‐Trucksäss, A. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.767025 · Cited by 13 · see citing works
Sang, Y., Mao, K., Cao, M., Wu, X., Ruan, L., & Zhang, C. (2021) · Journal of International Medical Research · doi:10.1177/0300060521998889 · Cited by 12 · see citing works
Liu, L., Yang, X., Liao, Y., Wang, C., & Wang, Y. (2022) · Toxicology Research · doi:10.1093/toxres/tfac051 · Cited by 11 · see citing works
Tomiyama, H., Imai, T., Shiina, K., Higashi, Y., Nakano, H., Takahashi, T., Fujii, M., Matsumoto, C., Yamashina, A., & Chikamori, T. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21481 · Cited by 11 · see citing works
“Low arterial stiffness has been reported to be associated with a low risk of development of CVD, 4–6 and the importance of lifestyle modifications and other interventions aimed at reducing the risk levels of CVRFs to maintain a low arterial stiffness in the general population, including healthy…”
BackgroundNilsson, P. M., Laurent, S., Cunha, P. M. G. M., Olsen, M. H., Rietzschel, E., Franco, O. H., Ryliškytė, L., Strazhesko, I., Vlachopoulos, C., Chen, C.-H., et al. (2018) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 11 · see citing works
Stepanyan, A., Brojakowska, A., Zakharyan, R., Hakobyan, S., Davitavyan, S., Sirunyan, T., Khachatryan, G., Khlgatian, M. K., Bisserier, M., Zhang, S., et al. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02565-9 · Cited by 10 · see citing works
Freitas, E. G. B., de Souza, D. F., & Filho, S. R. F. (2018) · Kidney & Blood Pressure Research · doi:10.1159/000495634 · Cited by 10 · see citing works
Styczyński, G., Cienszkowska, K., Ludwiczak, M., & Szmigielski, C. A. (2021) · Journal of Human Hypertension · doi:10.1038/s41371-020-00466-4 · Cited by 10 · see citing works
Ying, K. E., Feng, W., Ying, W., Li, X., Xing, D., Sun, Y., Chen, Y., & Sanders, P. W. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102296 · Cited by 9 · see citing works
Vascular Aging, Cardiovascular-Kidney-Metabolic Syndrome, and Cardiovascular Risk
Shi, J., Ye, X., Yu, S., Zhao, Y., Xiong, J., Ji, H., & Zhang, Y. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.102242 · Cited by 9 · see citing works
Tavoian, D., Ramos-Barrera, L. E., Craighead, D. H., Seals, D. R., Bedrick, E. J., Alpert, J. S., Mashaqi, S., & Bailey, E. F. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.760203 · Cited by 8 · see citing works
Influencing factors of supernormal vascular aging in Chinese population
Tao, B., Li, Y., Wang, C., Luo, X., Chen, S., Wang, G., Yang, P., Hou, L., Cui, L., & Wu, S. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000003023 · Cited by 8 · see citing works
“49% individuals who had cardiovascular health scores of 0–1 [15].”
BackgroundGómez‐Sánchez, M., Gómez‐Sánchez, L., Patino-Alonso, M. C., Alonso‐Domínguez, R., Sánchez‐Aguadero, N., Recio-Rodriguez, J. I., González‐Sánchez, J., García‐Ortiz, L., & Gómez-Marcos, M. Á. (2020) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2020.06.040 · Cited by 8 · see citing works
Jae, S. Y., Lee, K. H., Kim, H. J., Kunutsor, S. K., Heffernan, K. S., Climie, R. E., Bunsawat, K., & Kang, M. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19016 · Cited by 7 · see citing works
Gómez‐Sánchez, L., Gómez‐Sánchez, M., Rodríguez‐Sánchez, E., Patino-Alonso, M. C., Alonso‐Domínguez, R., Sánchez‐Aguadero, N., Lugones‐Sánchez, C., Llamas‐Ramos, I., García‐Ortiz, L., Gómez-Marcos, M. Á., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092671 · Cited by 6 · see citing works
“Among the studies that have analysed the association between obesity and HVA, the study of Framingham [20] revealed that a lower BMI was associated with greater prevalence of individuals with HVA.”
ResultTheodoridis, X., Chourdakis, M., Papaemmanouil, A., Chaloulakou, S., Papageorgiou, N., Georgakou, A. V., Chatzis, G. V., & Triantafyllou, Α. (2024) · Life · doi:10.3390/life14091210 · Cited by 6 · see citing works
Zhang, H., Sun, M., Hu, Z., Cao, Y., Hao, M., Li, Y., Li, J., Sun, X., Wang, X., & Jiang, X. (2022) · The journal of nutrition health & aging · doi:10.1007/s12603-022-1802-z · Cited by 6 · see citing works
“Arterial stiffness, which is measured using the pulse wave velocity (PWV), has been proposed as an indicator of vascular ageing (10, 11), and its occurrence has rapidly increased due to the ageing process and unhealthy lifestyles (12-14).”
Gómez‐Sánchez, L., Rodríguez‐Sánchez, E., Ramos, R., Martí‐Lluch, R., Gómez‐Sánchez, M., Lugones‐Sánchez, C., Tamayo‐Morales, O., Sánchez, S. G., Rigo, F., García‐Ortiz, L., et al. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00456-w · Cited by 6 · see citing works
Galvão, R. D. V., Pereira, C. D. S., Freitas, E. G. B., Lima, D. R. A. R. T., Santos, W. D. A. M., de Souza, D. F., Nomelini, Q. S. S., & Filho, S. R. F. (2020) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2020.1783547 · Cited by 6 · see citing works
Gómez‐Sánchez, L., Gómez‐Sánchez, M., Lugones‐Sánchez, C., Tamayo‐Morales, O., González‐Sánchez, S., Rodríguez‐Sánchez, E., García‐Ortiz, L., Gómez-Marcos, M. Á., & on behalf of the EVA Investigators (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245748 · Cited by 6 · see citing works
“The participants characterised by HVA had lower values for the insulin resistance indices than the participants with EVA, which is in line with the results published in the study of Framingham [32].”
BackgroundResultGómez‐Sánchez, L., Falcón, D. G., Llamas‐Ramos, R., Rodríguez, M. C., Rodríguez‐Sánchez, E., García‐Ortiz, L., Llamas‐Ramos, I., Gómez‐Sánchez, M., & Gómez-Marcos, M. Á. (2024) · Nutrients · doi:10.3390/nu16152565 · Cited by 5 · see citing works
Associations between circulating metabolites and arterial stiffness
Kauko, A., Palmu, J., Jousilahti, P., Havulinna, A. S., Salomaa, V. V., & Niiranen, T. (2020) · Journal of Human Hypertension · doi:10.1038/s41371-020-00434-y · Cited by 5 · see citing works
Self-citationYan, Y., Cao, Y., Ma, Q., Wang, K., Liao, Y., Sun, Y., Chen, C., Hu, J., Zheng, W., Chu, C., et al. (2022) · Angiology · doi:10.1177/00033197221082712 · Cited by 4 · see citing works
“The addition of the vascular age improved the performance of existing cardiovascular risk prediction models.(32-35) EVA refers to premature alterations in arteries like the aging process.”
BackgroundGómez‐Sánchez, L., Gómez‐Sánchez, M., Rodríguez‐Sánchez, E., Lugones‐Sánchez, C., Tamayo‐Morales, O., González‐Sánchez, S., de Cabo-Laso, Á., García‐Ortiz, L., Gómez-Marcos, M. Á., & on behalf of the EVA Investigators (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2411318 · Cited by 5 · see citing works
Llamas‐Ramos, I., Llamas‐Ramos, R., Alonso‐Domínguez, R., Gómez‐Sánchez, L., Tamayo‐Morales, O., Lugones‐Sánchez, C., Rodríguez‐Sánchez, E., García‐Ortiz, L., & Gómez-Marcos, M. Á. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095450 · Cited by 4 · see citing works
“, based on the studies of Framingham [27] and Gómez Sánchez et al.”
MethodInfluentialAnalysis of the Sex-Specific Risk Factors for Arterial Stiffness
Yuan, J., Wang, C., Zhao, C., Liu, H., Zhang, Y., Liu, M., Fu, T., & Wu, S.-L. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm25478 · Cited by 3 · see citing works
Maritz, M., Fourie, C. M. T., van Rooyen, J. M., & Schutte, A. E. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.05.048 · Cited by 3 · see citing works
Healthy Vascular Ageing and Early Vascular Ageing
Currie, G. E., & Nilsson, P. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-16481-2_29 · Cited by 3 · see citing works
Afsharan, H., Anilkumar, V., Silva, D., Dwivedi, G., Joo, C., & Cense, B. (2023) · Optics and Lasers in Engineering · doi:10.1016/j.optlaseng.2023.107838 · Cited by 3 · see citing works
Serhiyenko, V. A., Долинай, М., Sehin, V. B., Lazur, Y. V., & Serhiyenko, A. A. (2025) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.20.8.2024.1461 · Cited by 3 · see citing works
Javanmardi, E., Okazaki, R. A., Arash, N. M., Minetti, E. T., Weisbrod, R. M., Rizvi, S. H. M., Li, Z., Akubo, C., & Hamburg, N. M. (2025) · American Journal of Hypertension · doi:10.1093/ajh/hpaf107 · Cited by 2 · see citing works
Self-citationLlamas‐Ramos, I., Llamas‐Ramos, R., Rodríguez, M. C., Rodríguez‐Sánchez, E., Gómez-Marcos, M. Á., Gómez‐Sánchez, M., & Gómez‐Sánchez, L. (2025) · Nutrients · doi:10.3390/nu17182963 · Cited by 2 · see citing works
Cardiovascular ageing definition: a scoping review on conceptual and operational frameworks
Vriend, E. M. C., Arita, V. A., Menassa, M., Beigrezaei, S., van Charante, E. P. M., van den Born, B. H., & Franco, O. H. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf741 · Cited by 2 · see citing works
Žagar, A. M., Kolobarić, N., Šušnjara, P., Mihaljević, J., Mihaljević, Z., & Drenjancevic, I. (2026) · Life · doi:10.3390/life16040642 · Cited by 2 · see citing works
“[ 117,118] observed that arterial stiffness is a predictor of hypertension.”
Zuo, J., Qian, K., He, Y., Tan, I., Butlin, M., Avolio, A. P., & Chen, P. (2019) · Artery Research · doi:10.2991/artres.k.191203.001 · Cited by 2 · see citing works
Association of cognitive impairment and arterial hypertension
Isaykina, О. Y., Vekhova, K. A., Drobotov, G. S., Takhirov, R., Isaykina, M. A., & Gorbunov, V. M. (2023) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-20236-4-9 · Cited by 2 · see citing works
Vascular Aging and Cardiovascular Disease
Cunha, P., & Olsen, M. H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15512-3.00015-5 · Cited by 2 · see citing works
Gómez‐Sánchez, M., Gómez‐Sánchez, L., Patino-Alonso, M. C., Alonso‐Domínguez, R., Sánchez‐Aguadero, N., Recio-Rodriguez, J. I., González‐Sánchez, J., García‐Ortiz, L., & Gómez-Marcos, M. Á. (2020) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.06.033 · Cited by 2 · see citing works
Hajdusianek, W., Żórawik, A., Macek, P., Poręba, M., Poręba, R., & Gać, P. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020384 · Cited by 2 · see citing works
“Similar results were obtained by Niiranen TJ et al., who studied the relationship between arterial stiffness measured by pulse wave velocity and cardiovascular health [32].”
ResultA new method for vascular age estimation based on relative risk difference in vascular aging
Tang, Q., Liu, S., Tao, C., Wang, J., Zhao, H., Wang, G., Xu, Z., Ren, Q., Zhang, L., Su, B., et al. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108155 · Cited by 1 · see citing works
Golendyaeva, P. I., Петровна, П. Е., Korennova, O. Y., Shkirinec, A. V., Павловна, П. С., Николаевна, С. С., & Shukil, L. V. (2025) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2025-2516 · Cited by 1 · see citing works
Vascular stiffness and healthy arterial aging in older patients with optimal blood pressure
Jiticovski, A. F. M., de Souza, D. F., Freitas, E. G. B., Ferreira, C. R., Pereira, C. D. S., Galvão, R. D. V., Santos, W. D. A. M., de Oliveira, E. P., & Filho, S. R. F. (2023) · Brazilian Journal of Nephrology · doi:10.1590/2175-8239-jbn-2022-0123en · Cited by 1 · see citing works
Age-related disease: Cardiovascular system
Nilsson, P. M., Fossel, M., Bean, J., & Khera, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00010-4 · Cited by 2 · see citing works
Antihypertensive Effects of Lindera erythrocarpa Makino via NO/cGMP Pathway and Ca2+ and K+ Channels
Shin, S., Park, J., Choi, H.-Y., Bu, Y., & Lee, K. (2024) · Nutrients · doi:10.3390/nu16173003 · Cited by 1 · see citing works
“Maintaining normal blood pressure is crucial; however, hypertension is often deemed an inevitable part of aging, with a prevalence of 60–75% in older adults ( ≥ 60 years) [3,4].”
Background
- Authors
- Niiranen, T. J., Lyass, A., Larson, M. G., Hamburg, N. M., Benjamin, E. J., Mitchell, G. F., & Vasan, R. S.
- Affiliations
- Boston University (US)
- ORCID
- Venue
- Hypertension
- Published
- 2017-08
- Volume
- 70
- Issue
- 2
- Pages
- 267-274
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC5509504
- OpenAlex
- W2763062395
- Cited by
- 126
- References
- 51
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 14 · 2023: 11 · 2022: 16 · 2021: 15 · 2020: 16 · 2019: 13 · 2018: 21 · 2017: 5
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (HHSN268201500001I, HHSN268201500001C, R01HL094898, N01-HC-025195, R01HL107385, R01HL070100, R01HL104184, R01HL126136, R01HL060040)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK082447)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- pulse wave velocity, vascular stiffness, cardiovascular risk, Life's Essential 8, cardiovascular health, body mass index, diabetes mellitus, lipid-lowering drugs, obesity, Framingham Heart Study, community-dwelling older adults, cardiovascular disease prevention
- MeSH terms
- Adult, Age Factors, Aged, Hypolipidemic Agents, Blood Pressure, Cardiovascular Diseases, Female, Humans, Hypertension, Life Style, Male, Middle Aged, Prognosis, Research Design, Risk Factors, Sex Factors, Statistics as Topic, Exercise, Body Mass Index, Prevalence, Risk Assessment, Vascular Stiffness, Pulse Wave Analysis, Protective Factors, Diet, Western
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