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Coronary Artery Calcium, Brain Function and Structure: The AGES-Reykjavik Study
Open accessAbstract
Background and Purpose— Several cardiovascular risk factors are associated with cognitive disorders in older persons. Little is known about the association of the burden of coronary atherosclerosis with brain structure and function. Methods— This is a cross-sectional analysis of data from the Age, Gene, Environment Susceptibility (AGES)-Reykjavik Study cohort of men and women born 1907 to 1935. Coronary artery calcification (CAC), a marker of atherosclerotic burden, was measured with CT. Memory, speed of processing, and executive function composites were calculated from a cognitive test battery. Dementia was assessed in a multistep procedure and diagnosed according to international guidelines. Quantitative data on total intracranial and tissue volumes (total, gray matter volume, white matter volume, and white matter lesion volume), cerebral infarcts, and cerebral microbleeds were obtained with brain MRI. The association of CAC with dementia (n=165 cases) and cognitive function in nondemented subjects (n=4085), and separately with MRI outcomes, was examined in multivariate models adjusting for demographic and vascular risk factors. Analyses tested whether brain structure mediated the associations of CAC to cognitive function. Results— Subjects with higher CAC were more likely to have dementia and lower cognitive scores, more likely to have lower white matter volume, gray matter volume, and total brain tissue, and to have more cerebral infarcts, cerebral microbleeds, and white matter lesions. The relations of cognitive performance and dementia to CAC were significantly attenuated when the models were adjusted for brain lesions and volumes. Conclusions— In a population-based sample, increasing atherosclerotic load assessed by CAC is associated with poorer cognitive performance and dementia, and these relations are mediated by evidence of brain pathology.
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“However, at 1- or 6-year follow-up, the cognitive decline in these patients was no different from that observed in controls with an equivalent burden of coronary artery disease who opted for medical treatment or percutaneous coronary intervention.364,365”
From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [365]
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Citations
Cites
Studies of interference in serial verbal reactions
Stroop, J. R. (1935) · Journal of Experimental Psychology · doi:10.1037/h0054651 · Cited by 18,622
Development and validation of a geriatric depression screening scale: a preliminary report
Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, V. O. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90033-4 · Cited by 15,025
Quantification of coronary artery calcium using ultrafast computed tomography
Agatston, A. S., Janowitz, W. R., Hildner, F. J., Zusmer, N. R., Viamonte, M., & Detrano, R. (1990) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(90)90282-t · Cited by 7,786
Cognitive Stimulation in Patients with Dementia: Randomized Controlled Trial
Mapelli, D., Rosa, E. D., Nocita, R., & Sava, D. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353457 · Cited by 3,477
Wechsler Adult Intelligence Scale--Fourth Edition
Wechsler, D. (2012) · PsycTESTS Dataset · doi:10.1037/t15169-000 · Cited by 2,232
Risk of dementia in diabetes mellitus: a systematic review
Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., & Scheltens, P. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70284-2 · Cited by 2,187
Decomposing adult age differences in working memory
Salthouse, T. A., & Babcock, R. L. (1991) · Developmental Psychology · doi:10.1037/0012-1649.27.5.763 · Cited by 1,373
The diagnosis of ischaemic heart pain and intermittent claudication in field surveys.
Rose, G. A. (1962) · Europe PMC (PubMed Central) · Cited by 1,328
Pathogenesis of Leukoaraiosis: A Review
Pantoni, L., & Garcia, J. H. (1997) · Stroke · doi:10.1161/01.str.28.3.652 · Cited by 1,225
The age-dependent relation of blood pressure to cognitive function and dementia
Qiu, C., Winblad, B., & Fratiglioni, L. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70141-1 · Cited by 1,138
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Morisson, L., & Chousterman, B. G. (2022) · Lessons from the ICU · doi:10.1007/978-3-030-94133-8_32 · Cited by 1
Yahagi‐Estevam, M., Farias‐Itao, D. S., Leite, R. E. P., Rodriguez, R. D., Pasqualucci, C. A., Nitríni, R., Filho, W. J., Power, M. C., & Suemoto, C. K. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220820 · Cited by 1
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Chousterman, B. G., Payen, D. M., & Pirracchio, R. (2012) · Références en réanimation · doi:10.1007/978-2-8178-0287-9_25
Nilsson, P. M., Román, G. C., Sellke, F. W., Seshadri, S. S., Arnett, K., Bennett, D. A., Chui, H. C., Higashida, R. T., Lindquist, R. D., Nyenhuis, D. L., et al. (2011)
Self-citationChui, H. C., Higashida, R. T., Lindquist, R. D., Nilsson, P. M., Petersen, C., Schneider, J. A., Tzourio, C., Arnett, D. K., Launer, L. J., Laurent, S., et al. (2013)
Self-citationSantiago, C. (2014) · TSpace (University of Toronto)
Wang, J., Ji, H., Jia, H., & Guan, D. (2018) · Biomedical Research - India · doi:10.4066/biomedicalresearch.29-17-2931
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Şahin, H., & Gökçe, M. (2021) · Turkish Journal of Cerebrovascular Diseases · doi:10.5505/tbdhd.2021.37108
van Sloten, T. T. (2015) · Research Publications (Maastricht University) · doi:10.26481/dis.20150520ts
Kawasaki, R., & Wong, T. Y. (2011) · Ophthalmology · doi:10.1016/j.ophtha.2011.08.009
Sun, Z., Chu, T., liu, W., bi, Z., guo, Y., sun, M., Mao, N., Liu, J., Xie, H., & Ma, H. (2022) · Research Square · doi:10.21203/rs.3.rs-2324818/v1
Changes of Resting-State Brain Network in Patients with Coronary Heart Disease
刘, 万. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1351056
Li, C., He, D., Yang, C., Zhang, L., & Pop‐Busui, R. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112909
Brutto, V. J. D., Gutiérrez, J. M., & Brutto, Ó. H. D. (2026) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2026.108598
藤吉, 朗., 椎野, 顯., 久松, 隆., 鳥居, さ., 鈴木, 仙., 国村彩子, 瀬川, 裕., 門田, 文., 大久保, 孝., 野﨑, 和., et al. (2020) · Institutional Repositories DataBase (IRDB)
Coronary artery disease and neurocognitive performance among older adults in UgandaPreprint
Migisha, R., Lombardi, J., Byakika‐Kibwika, P., Nakasujja, N., Maling, S., Kangwagye, P., Muhwezi, A., Longenecker, C. T., Okello, S., Acan, M., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10737115/v1
Advanced brain age and longitudinal cognitive decline in healthy older adults
Kristinsson, S., Newman-Norlund, R., Bonilha, L., Bakos, L., Rorden, C., Sigurdsson, S., Guðnason, V., & Fridriksson, J. (2026) · GeroScience · doi:10.1007/s11357-026-02598-w
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Metadata
- Authors
- Vidal, J.-S., Sigurdsson, S., Jonsdottir, M. K., Eiriksdottir, G., Thorgeirsson, G., Kjartansson, O., Garcia, M. E., van Buchem, M. A., Harris, T. B., Gudnason, V., & Launer, L. J.
- Affiliations
- From LEDB (J.-S.V., M.E.G., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, Md; The Icelandic Heart Association (S.S., M.K.J., G.E., O.K., V.G.), Kopavogur, Iceland; Faculty of Psychology (M.K.J.), University of Iceland, Reykjavik, Iceland; Faculty of Medicine (G.T., V.G.), University of Iceland, Reykjavik, Iceland; Department of Medicine (G.T.), Landspitali University Hospital, Reykjavik, Iceland; Departments of Neurology and Radiology (O.K.), Landspitali...
- University of Iceland (IS)
- Venue
- Stroke
- Published
- 2010-05
- Volume
- 41
- Issue
- 5
- Pages
- 891-897
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- PMC
- PMC3298743
- OpenAlex
- W2147366626
- Cited by
- 139
- References
- 37
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 6 · 2016: 9 · 2015: 18 · 2014: 10 · 2013: 13 · 2012: 4
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- Hjartavernd (N01-AG-1-2100)
- National Institutes of Health (n01ag12100-57-0-2, N01-AG-1-2100)
- National Institute on Aging (N01-AG12100, N01-AG012100)
- National Heart, Lung, and Blood Institute (Z01HL004607)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- coronary artery calcification, atherosclerosis, dementia, cognitive function, white matter lesions, cerebral infarction, cerebral microbleeds, gray matter volume, brain tissue volume, cardiovascular risk factors, older adults
- MeSH terms
- Aged, Aged, 80 and over, Aging, Brain, Calcinosis, Cognition Disorders, Coronary Artery Disease, Coronary Vessels, Cross-Sectional Studies, Environment, Female, Humans, Iceland, Magnetic Resonance Imaging, Male, Cohort Studies, Genetic Predisposition to Disease
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