Cited by 139Dementia and Cognitive Impairment ResearchCardiac Imaging and DiagnosticsNeurological Disease Mechanisms and Treatments

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Coronary Artery Calcium, Brain Function and Structure: The AGES-Reykjavik Study

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Vidal, Jean-Sébastien, Sigurdsson, Sigurdur, Jonsdottir, Maria K., Eiriksdottir, Gudny, Thorgeirsson, Gudmundur, Kjartansson, Olafur, Garcia, Melissa E., van Buchem, Mark A., Harris, Tamara B., Gudnason, Vilmundur, Launer, Lenore J.·2010·Stroke

DOI 10.1161/strokeaha.110.579581PMC PMC3298743

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Abstract

Background and Purpose— Several cardiovascular risk factors are associated with cognitive disorders in older persons. Little is known about the association of the burden of coronary atherosclerosis with brain structure and function. Methods— This is a cross-sectional analysis of data from the Age, Gene, Environment Susceptibility (AGES)-Reykjavik Study cohort of men and women born 1907 to 1935. Coronary artery calcification (CAC), a marker of atherosclerotic burden, was measured with CT. Memory, speed of processing, and executive function composites were calculated from a cognitive test battery. Dementia was assessed in a multistep procedure and diagnosed according to international guidelines. Quantitative data on total intracranial and tissue volumes (total, gray matter volume, white matter volume, and white matter lesion volume), cerebral infarcts, and cerebral microbleeds were obtained with brain MRI. The association of CAC with dementia (n=165 cases) and cognitive function in nondemented subjects (n=4085), and separately with MRI outcomes, was examined in multivariate models adjusting for demographic and vascular risk factors. Analyses tested whether brain structure mediated the associations of CAC to cognitive function. Results— Subjects with higher CAC were more likely to have dementia and lower cognitive scores, more likely to have lower white matter volume, gray matter volume, and total brain tissue, and to have more cerebral infarcts, cerebral microbleeds, and white matter lesions. The relations of cognitive performance and dementia to CAC were significantly attenuated when the models were adjusted for brain lesions and volumes. Conclusions— In a population-based sample, increasing atherosclerotic load assessed by CAC is associated with poorer cognitive performance and dementia, and these relations are mediated by evidence of brain pathology.

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Authors: Vidal, J.-S., Sigurdsson, S., Jonsdottir, M. K., Eiriksdottir, G., Thorgeirsson, G., Kjartansson, O., Garcia, M. E., van Buchem, M. A., Harris, T. B., Gudnason, V., & Launer, L. J.
Affiliations: From LEDB (J.-S.V., M.E.G., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, Md; The Icelandic Heart Association (S.S., M.K.J., G.E., O.K., V.G.), Kopavogur, Iceland; Faculty of Psychology (M.K.J.), University of Iceland, Reykjavik, Iceland; Faculty of Medicine (G.T., V.G.), University of Iceland, Reykjavik, Iceland; Department of Medicine (G.T.), Landspitali University Hospital, Reykjavik, Iceland; Departments of Neurology and Radiology (O.K.), Landspitali...
University of Iceland (IS)
ORCID: Sigurdsson, Sigurdur
Harris, Tamara B.
Gudnason, Vilmundur
Launer, Lenore J.
Venue: Stroke
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2010-05
Volume: 41
Issue: 5
Pages: 891-897
ISSN: 0039-2499 (ISSN-L)
1524-4628
DOI: 10.1161/strokeaha.110.579581
PMC: PMC3298743
OpenAlex: W2147366626
Cited by: 139
References: 37
Citations by year: 2026: 6 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 6 · 2016: 9 · 2015: 18 · 2014: 10 · 2013: 13 · 2012: 4
FWCI: 6.10
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Stroke (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Hirsla (Landspítali University Hospital) (submittedVersion)
Funders: Hjartavernd (N01-AG-1-2100)
National Institutes of Health (n01ag12100-57-0-2, N01-AG-1-2100)
National Institute on Aging (N01-AG12100, N01-AG012100)
National Heart, Lung, and Blood Institute (Z01HL004607)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: coronary artery calcification, atherosclerosis, dementia, cognitive function, white matter lesions, cerebral infarction, cerebral microbleeds, gray matter volume, brain tissue volume, cardiovascular risk factors, older adults
MeSH terms: Aged, Aged, 80 and over, Aging, Brain, Calcinosis, Cognition Disorders, Coronary Artery Disease, Coronary Vessels, Cross-Sectional Studies, Environment, Female, Humans, Iceland, Magnetic Resonance Imaging, Male, Cohort Studies, Genetic Predisposition to Disease

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Coronary Artery Calcium, Brain Function and Structure: The AGES-Reykjavik Study

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