Cited by 333Salivary Gland Disorders and FunctionsClinical Laboratory Practices and Quality ControlHIV/AIDS oral health manifestations

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Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: a systematic review

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Soares Nunes, Lazaro Alessandro, Mussavira, Sayeeda, Sukumaran Bindhu, Omana·2015·Biochemia Medica

DOI 10.11613/bm.2015.018PMC PMC4470107

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Abstract

This systematic review presents the latest trends in salivary research and its applications in health and disease. Among the large number of analytes present in saliva, many are affected by diverse physiological and pathological conditions. Further, the non-invasive, easy and cost-effective collection methods prompt an interest in evaluating its diagnostic or prognostic utility. Accumulating data over the past two decades indicates towards the possible utility of saliva to monitor overall health, diagnose and treat various oral or systemic disorders and drug monitoring. Advances in saliva based systems biology has also contributed towards identification of several biomarkers, development of diverse salivary diagnostic kits and other sensitive analytical techniques. However, its utilization should be carefully evaluated in relation to standardization of pre-analytical and analytical variables, such as collection and storage methods, analyte circadian variation, sample recovery, prevention of sample contamination and analytical procedures. In spite of all these challenges, there is an escalating evolution of knowledge with the use of this biological matrix.

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Authors: Soares Nunes, L. A., Mussavira, S., & Sukumaran Bindhu, O.
Affiliations: Jain University (IN)
ORCID: Mussavira, Sayeeda
Venue: Biochemia Medica
Publisher: Croatian Society for Medical Biochemistry and Laboratory Medicine
Published: 2015
Volume: 25
Issue: 2
Pages: 177-192
ISSN: 1330-0962 (ISSN-L)
1846-7482
DOI: 10.11613/bm.2015.018
PMC: PMC4470107
OpenAlex: W630391585
Cited by: 333
References: 98
Citations by year: 2026: 18 · 2025: 35 · 2024: 32 · 2023: 21 · 2022: 33 · 2021: 43 · 2020: 39 · 2019: 30 · 2018: 29 · 2017: 33 · 2016: 18 · 2015: 2
FWCI: 3.35
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
Locations: Biochemia Medica (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Hrčak Portal of scientific journals of Croatia (University Computing Centre) (submittedVersion, other-oa)
Funders: Jain University
Topics: Health Sciences › Medicine › Physiology (medical) › Salivary Gland Disorders and Functions
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Health Sciences › Dentistry › General Dentistry › HIV/AIDS oral health manifestations
Keywords: saliva, salivary biomarkers, non-invasive diagnosis, salivary diagnostics, drug monitoring, circadian variation, sample contamination
MeSH terms: Animals, Humans, Reagent Kits, Diagnostic, Saliva, Sensitivity and Specificity, Specimen Handling, Biomarkers, Clinical Laboratory Techniques, Systems Biology

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