Saliva specimen: A new laboratory tool for diagnostic and basic investigation
Abstract
The assay of saliva is an increasing area of research with implications for basic and clinical purposes. Although this biological fluid is easy to manipulate and collect, careful attention must be directed to limit variation in specimen integrity. Recently, the use of saliva has provided a substantial addition to the diagnostic armamentarium as an investigative tool for disease processes and disorders. In addition to its oral indications, the analysis of saliva provides important information about the functioning of various organs within the body. In this respect, endocrine research certainly occupies a central role. The present review considers the laboratory aspects of salivary assays with respect to the different analytes including ions, drugs and various non-protein/protein compounds such as hormones and immunoglobulins. This review also examines the consequences of preanalytical variation with respect to collection strategy and subsequent storage conditions. It is likely that the use of saliva in assays will continue to expand thus providing a new instrument of investigation for physiologic as well as pathophysiologic states.
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Saliva is a complex oral fluid, produced mainly by the parotid gland and composed of numerous constituents, such as metabolites, enzymes, hormones, proteins, microorganisms and ions.
“Saliva is a complex oral fluid, which is produced mainly by the parotid gland and is composed of numerous constituents, such as metabolites, enzymes, hormones, proteins, microorganisms and ions125,135-140.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [137]
Saliva is considered an attractive and emerging option compared to direct blood analysis for quantifying biomarkers related to human performance due to its noninvasive nature and continuous supply.
“Saliva is considered an attractive and emerging option compared to direct blood analysis for quantifying biomarkers related to human performance due to its noninvasive nature and continuous supply11 (Table 3).”
From Wearable sensors for monitoring the physiological and biochemical profile of the athlete (2019) · cites this paper as [11]
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- Authors
- Chiappin, S., Antonelli, G., Gatti, R., & De Palo, E. F.
- Affiliations
- University of Padua (IT)
- ORCID
- Antonelli, Giorgia
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 383
- Issue
- 1-2
- Pages
- 30-40
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2005686804
- Cited by
- 828
- References
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- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Keywords
- saliva, pre-analytical variability, sample collection, specimen storage, salivary hormones, salivary immunoglobulins, endocrine research, diagnostic biomarkers
- MeSH terms
- Humans, Saliva, Clinical Laboratory Techniques, Diagnostic Techniques and Procedures, Clinical Chemistry Tests
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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