Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: a systematic review

Yaşlı Kadınlarda Üreme Sağlığı

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A review of saliva: normal composition, flow, and function.

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Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: Current state of research

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T he D iagnostic A pplications of S aliva — A R eview

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Saliva specimen: A new laboratory tool for diagnostic and basic investigation

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Stress-induced changes in human salivary alpha-amylase activity—associations with adrenergic activity

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Review: The physiology of saliva and transfer of drugs into saliva.

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Salivary Proteomics for Oral Cancer Biomarker Discovery

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The salivary microbiota as a diagnostic indicator of oral cancer: A descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma subjects

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Saliva as a Diagnostic Fluid

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Salivary Proteins: Protective and Diagnostic Value in Cariology?

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The Proteomes of Human Parotid and Submandibular/Sublingual Gland Salivas Collected as the Ductal Secretions

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Use of salivary biomarkers in biobehavioral research: cotton-based sample collection methods can interfere with salivary immunoassay results

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The “trouble” with salivary testosterone

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Saliva as a tool for monitoring steroid, peptide and immune markers in sport and exercise science

Papacosta, E., & Nassis, G. P. (2011) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2011.03.004 · Cited by 379

Current Status of Salivary Hormone Analysis

Gröschl, M. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.108910 · Cited by 370

Saliva as a diagnostic fluid.

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Saliva Composition and Exercise

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α-Amylase as a reliable and convenient measure of sympathetic activity: don’t start salivating just yet!

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Saliva: A potential media for disease diagnostics and monitoring

Liu, J., & Duan, Y. (2012) · Oral Oncology · doi:10.1016/j.oraloncology.2012.01.021 · Cited by 308

The rôle of saliva in maintaining oral health and as an aid to diagnosis.

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Proteomic Identification of Salivary Biomarkers of Type-2 Diabetes

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Salivary α-Amylase: Role in Dental Plaque and Caries Formation

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Characterization of the differentiated antioxidant profile of human saliva

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Application of microchip assay system for the measurement of C-reactive protein in human saliva

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Sources of biological and methodological variation in salivary cortisol and their impact on measurement among healthy adults: A review

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Measurement of salivary cortisol in 2012 – laboratory techniques and clinical indications

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Comparative proteomic analysis of human whole saliva

Huang, C. (2004) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2004.06.003 · Cited by 193

Therapeutic Drug Monitoring of Antiepileptic Drugs by Use of Saliva

Patsalos, P. N., & Berry, D. J. (2013) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e31827c11e7 · Cited by 190

Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics

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Detection of measles, mumps, and rubella antibodies in saliva using antibody capture radioimmunoassay

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Development of transcriptomic biomarker signature in human saliva to detect lung cancer

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Salivary Diagnostics: A Brief Review

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Evaluation of saliva collection devices for the analysis of steroids, peptides and therapeutic drugs

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Distribution and roles of aquaporins in salivary glands

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Salivaomics

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Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma: Current State and Recent Advances

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Salivary uric acid as a noninvasive biomarker of metabolic syndrome

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Potential applications of human saliva as diagnostic fluid.

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Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection method

Gallagher, P., Leitch, M., Massey, A., McAllister-Williams, R., & Young, A. H. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106060585 · Cited by 137

Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases

Fábián, T., Fejérdy, P., & Csermely, P. (2008) · Current Genomics · doi:10.2174/138920208783884900 · Cited by 129

Evaluation of a radioimmunoassay and establishment of a reference interval for salivary cortisol in healthy subjects in Denmark

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Metabolic Disease Risk in Children by Salivary Biomarker Analysis

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Longitudinal Study of the Association Between Smoking as a Periodontitis Risk and Salivary Biomarkers Related to Periodontitis

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Diagnosis of hepatitis a and b by testing saliva

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Salivary Soluble CD44: A Potential Molecular Marker for Head and Neck Cancer

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Genetic Diagnosis and Testing in Clinical Practice

McPherson, E. W. (2006) · Clinical Medicine & Research · doi:10.3121/cmr.4.2.123 · Cited by 106

Streptococcus pneumoniae in Saliva of Dutch Primary School Children

Wyllie, A. L., Chu, M. L. J. N., Schellens, M. H. B., Gastelaars, J. V. E., Jansen, M., ENDE, A. V. D., Bogaert, D., Sanders, E. A. M., & Trzciński, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102045 · Cited by 105

Salivary transcriptomic biomarkers for detection of ovarian cancer: for serous papillary adenocarcinoma

Lee, Y.-H., Kim, J., Zhou, H., Kim, B. W., & Wong, D. T. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0829-0 · Cited by 103

Thiocyanate Levels in Human Saliva: Quantitation by Fourier Transform Infrared Spectroscopy

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Investigation and identification of potential biomarkers in human saliva for the early diagnosis of oral squamous cell carcinoma

Wang, Q., Gao, P., Wang, X., & Duan, Y. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.10.004 · Cited by 102

Salivary Creatinine Estimation as an Alternative to Serum Creatinine in Chronic Kidney Disease Patients

Ramesh, V., Govindarajan, V., Oza, N., Parameswaran, S., Dhanasekaran, B. P., & Prashad, K. V. (2014) · International Journal of Nephrology · doi:10.1155/2014/742724 · Cited by 96

Biochemical Composition and Electrolyte Balance of "Unstimulated" Whole Human Saliva

Rehak, N. N., Cecco, S. A., & Csákó, G. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.049 · Cited by 90

Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle

Blicharz, T. M., Rissin, D. M., Bowden, M., Hayman, R. B., DiCesare, C. A., Bhatia, J. S., Grand-Pierre, N., Siqueira, W. L., Helmerhorst, E. J., Loscalzo, J., et al. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.105320 · Cited by 87

Catecholamines in human saliva

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Relationship between lactate dehydrogenase activity in saliva and oral health status

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Determination of levetiracetam in human plasma/serum/saliva by liquid chromatography-electrospray tandem mass spectrometry

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Salivary Cortisol and Immunoglobulin A Responses to Simulated and Official Jiu-Jitsu Matches

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Parameters of oxidative stress in saliva from diabetic and parenteral drug addict patients

Arana, C., Cutando, A., Ferrera, M. J., Moreno, G. G., Worf, C. V., Bolaños, M. J., Escames, G., & Acuña-Castroviejo, D. (2006) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2006.00469.x · Cited by 73

Saliva as a potential tool for cystic fibrosis diagnosis

Gonçalves, A. C., Marson, F. A. L., de Mendonça, R. M. H., Ribeiro, J. D., Ribeiro, A. F., Paschoal, I. A., & Levy, C. E. (2013) · Diagnostic Pathology · doi:10.1186/1746-1596-8-46 · Cited by 71

Reference intervals for saliva analytes collected by a standardized method in a physically active population

Nunes, L. A. S., Brenzikofer, R., & de Macedo, D. V. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.09.012 · Cited by 71

Evaluation of salivary sialic acid, total protein, and total sugar in oral cancer: A preliminary report

Hallikeri, K., Sanjay, P. R., & Shivashankara, A. R. (2008) · Indian Journal of Dental Research · doi:10.4103/0970-9290.44529 · Cited by 68

The Oral Fluid MEMS/NEMS Chip (OFMNC): Diagnostic & Translational Applications

Li, Y., Denny, P., Ho, C., Montemagno, C. D., Shi, W., Qi, F., Wu, B. M., Wolinsky, L. E., & Wong, D. T. (2005) · Advances in Dental Research · doi:10.1177/154407370501800102 · Cited by 64

Assessment of salivary urea as a less invasive alternative to serum determinations

Cardoso, E. M. L., Arregger, A. L., Tumilasci, O. R., Elbert, A. E., & Contreras, L. N. (2008) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510802588076 · Cited by 60

Introducing rapid oral–fluid HIV testing among high risk populations in Shandong, China: feasibility and challenges

Marley, G., Kang, D., Wilson, E. C., Huang, T., Qian, Y., Li, X., Tao, X., Wang, G., Xun, H., & Ma, W. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-422 · Cited by 60

Proteomics of saliva: personal experience.

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Measurement of salivary metabolite biomarkers for early monitoring of oral cancer with ultra performance liquid chromatography–mass spectrometry

Wang, Q., Gao, P., Cheng, F., Wang, X., & Duan, Y. (2013) · Talanta · doi:10.1016/j.talanta.2013.11.008 · Cited by 56

The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries

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Effects of storage time on stability of salivary immunoglobulin A and lysozyme

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Salivary urate in gout, exercise, and diurnal variation

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Determination of uric acid and p-aminohippuric acid in human saliva and urine using capillary electrophoresis with electrochemical detectionPotential application in fast diagnosis of renal disease

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Detection of Recent Cannabis Use by Saliva 9-THC Radioimmunoassay

Gross, S. J., Worthy, T. E., Nerder, L. J., Zimmermann, E., Soares, J. R., & Lomax, P. (1985) · Journal of Analytical Toxicology · doi:10.1093/jat/9.1.1 · Cited by 42

Intraindividual Variability of Carbamazepine, Phenobarbital, and Phenytoin Concentrations in Saliva

Miles, M. V., Tennison, M. B., & Greenwood, R. (1991) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199103000-00013 · Cited by 40

Saliva as a source of genomic DNA for genetic studies: review of current methods and applications.

Sun, F., & Reichenberger, E. (2014) · PubMed · Cited by 40

Salivary glucose and antioxidant defense markers in type II diabetes mellitus

Mussavira, S., Dharmalingam, M., & Sukumaran, B. O. (2015) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1306-116 · Cited by 37

Salivary peptidome in type 1 diabetes mellitus

Caseiro, A., Vitorino, R. M. P., Barros, A. S., Ferreira, R. M., Calheiros‐Lobo, M. J., Carvalho, D. M., Duarte, J. A., & Amado, F. M. L. (2011) · Biomedical Chromatography · doi:10.1002/bmc.1677 · Cited by 37

Saliva as a diagnostic fluid in sports medicine: potential and limitations

Nunes, L. A. S., & de Macedo, D. V. (2013) · Jornal Brasileiro de Patologia e Medicina Laboratorial · doi:10.1590/s1676-24442013000400003 · Cited by 37

Data Mining in Genomics

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Determination of salivary cortisol by liquid chromatography-tandem mass spectrometry

Turpeinen, U., Välimäki, M. J., & Hämäläinen, E. K. (2009) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510902890331 · Cited by 35

Production of gender-specific morning salivary cortisol reference intervals using internationally accepted procedures

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A novel assay system for myeloperoxidase activity in whole saliva

Sakamoto, W., Fujii, Y., Kanehira, T., Asano, K., & Izumi, H. (2008) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.12.025 · Cited by 30

Viral Latency in Blood and Saliva of Simian Foamy Virus-Infected Humans

Rua, R., Betsem, E., & Gessain, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077072 · Cited by 30

Alternative markers of glycemic status in diabetes mellitus

Hegde, A., Shenoy, R., Mello, P. D., Smitha, A., Tintu, A. N., & Manjrekar, P. (2010) · Biomedical Research-tokyo · Cited by 27

Salivary vitamins E and C in oral cancer

Rai, B., Kharb, S., Jain, R., & Anand, S. (2007) · Redox Report · doi:10.1179/135100007x200245 · Cited by 25

Biochemical markers in saliva of patients with oral squamous cell carcinoma

Chianeh, Y. R., & Prabhu, K. (2014) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(14)60412-6 · Cited by 21

Reliable detection and quantitation of viral nucleic acids in oral fluid: Liquid phase‐based sample collection in conjunction with automated and standardized molecular assays

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Evaluation of a novel standardized system for collection and quantification of oral fluid

Raggam, R. B., Santner, B. I., Kollroser, M., Gössler, W., Schmied, B., Schmitt, U., Stelzl, E., Lackner, A., Wagner, J., Marth, E., et al. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2008.044 · Cited by 18

Analysis of trace amounts of barbiturates in saliva

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Biochemical Composition and Electrolyte Balance of Unstimulated Whole Human Saliva

Rehak, N. N., Cecco, S. A., & Csákó, G. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.38.10.1081 · Cited by 15

Diagnostic Efficacy of Saliva For Dengue - A Reality in Near Future? A Piloting Initiative

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Assessment of plasma and salivary antioxidant status in patients with recurrent aphthous stomatitis

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Freie Aminosäuren im Gesamtspeichel von Kindern mit Phenylketonurie

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Serum-to-saliva transfer of the immunoreactive insulin (IRI) in children with obesity associated with insulin-resistance.

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Micronuclei and sialic acid as markers of genotoxic damage in tobacco-related oral lesions

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EVALUATION CHEMICAL COMPOSITION OF UNSTIMULATED SALIVA, IN PATIENTS WITH TYPE I DIABETES MELLITUS

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Salivary pH And Salivary Level of Streptococcus Mutans in Beta Thalassemia Major Patients

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Wearable sensors for monitoring the physiological and biochemical profile of the athlete

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Wearable Electrochemical Sensors for the Monitoring and Screening of Drugs

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