The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Sleep, Memory & Brain Rhythms
Open accessAbstract
Sleep occupies roughly one-third of our lives, yet the scientific community is still not entirely clear on its purpose or function. Existing data point most strongly to its role in memory and homeostasis: that sleep helps maintain basic brain functioning via a homeostatic mechanism that loosens connections between overworked synapses, and that sleep helps consolidate and re-form important memories. In this review, we will summarize these theories, but also focus on substantial new information regarding the relation of electrical brain rhythms to sleep. In particular, while REM sleep may contribute to the homeostatic weakening of overactive synapses, a prominent and transient oscillatory rhythm called “sharp-wave ripple” seems to allow for consolidation of behaviorally relevant memories across many structures of the brain. We propose that a theory of sleep involving the division of labor between two states of sleep–REM and non-REM, the latter of which has an abundance of ripple electrical activity–might allow for a fusion of the two main sleep theories. This theory then postulates that sleep performs a combination of consolidation and homeostasis that promotes optimal knowledge retention as well as optimal waking brain function.
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Prior studies did not specifically test overnight sleep-mediated memory consolidation that may have been a more sensitive test for sleep-mediated synaptic potentiation.
“Although these studies did not reveal a change in cognitive performance, improvement or worsening, they were too short in duration to observe possible SWS-mediated effects on course of neurodegeneration, and did not specifically test overnight sleep-mediated memory consolidation that may have been a more sensitive test for sleep-mediated synaptic potentiation [14].”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [14]
The section labeled Abstract (page unavailable) links sleep-mediated memory consolidation to the possibility that synapses active during learning are selectively maintained or enhanced. It does not say that an overnight consolidation test would be more sensitive to synaptic potentiation, or assess whether the prior studies used such a test. (LLM, conf=0.82)
Experimental — accuracy not yet measuredPrior studies of trazodone were too short in duration to observe possible SWS-mediated effects on course of neurodegeneration.
“Although these studies did not reveal a change in cognitive performance, improvement or worsening, they were too short in duration to observe possible SWS-mediated effects on course of neurodegeneration, and did not specifically test overnight sleep-mediated memory consolidation that may have been a more sensitive test for sleep-mediated synaptic potentiation [14].”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [14]
The paper’s discussion of slow-wave sleep and memory consolidation (section labeled Abstract; page unavailable) does not assess trazodone studies or their duration. Searches for trazodone and neurodegeneration found no passage addressing whether those studies were too short to observe effects on neurodegeneration. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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Citations
Cites
Neuronal Oscillations in Cortical Networks
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Sleep Drives Metabolite Clearance from the Adult Brain
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Self-citationSelective suppression of hippocampal ripples impairs spatial memory
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Self-citationSleep and waking modulate spine turnover in the adolescent mouse cortex
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Research works printed but not linked: 3
- 10.1016/j.neuron.2008.09.014 · DOI · Paper page
- 10.1016/j.neuron.2010.09.023 · DOI · Paper page
- Words, 1995, Cognition, 21, 803
Cited by
Sorted by citations
Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers
La, A. L., Walsh, C. M., Neylan, T. C., Vossel, K. A., Yaffe, K., Krystal, A. D., Miller, B. L., & Karageorgiou, E. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-181145 · Cited by 83
Cognitive and Physiologic Impacts of the Infraslow Oscillation
Watson, B. O. (2018) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00044 · Cited by 74
Self-citationTemporal associations between sleep slow oscillations, spindles and ripples
Oyanedel, C. N., Durán, E., Niethard, N., Inostroza, M., & Born, J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14906 · Cited by 71
Sleep stage dynamics in neocortex and hippocampus
Durán, E., Oyanedel, C. N., Niethard, N., Inostroza, M., & Born, J. (2018) · Sleep · doi:10.1093/sleep/zsy060 · Cited by 52
Metadata
- Authors
- Watson, B. O., & Buzsáki, G.
- Affiliations
- Cornell University (US)
- New York University (US)
- Venue
- Daedalus
- Publisher
- MIT Press - Journals
- Published
- 2015-01
- Volume
- 144
- Issue
- 1
- Pages
- 67-82
- ISSN
- 0011-5266 (ISSN-L)
- 1548-6192
- PMC
- PMC4474162
- OpenAlex
- W2157749883
- Cited by
- 99
- References
- 17
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 15 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 13 · 2017: 12 · 2016: 6 · 2015: 1
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Daedalus (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH054671, R01MH107396, K08MH107662)
- National Institute of Neurological Disorders and Stroke (R01NS034994)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sleep function, memory consolidation, sleep homeostasis, synaptic homeostasis, REM sleep, NREM sleep, sharp-wave ripples, neural oscillations, sleep theory, knowledge retention
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