Sleep and waking modulate spine turnover in the adolescent mouse cortex
Open accessAbstract
Cortical development involves synaptic formation and elimination. Although synaptogenesis predominates in the early stages and pruning in the later stages, the two processes are thought to happen concurrently. In adults, synaptic strength is modulated by behavioral state, and we asked whether synaptic remodeling may be affected by sleep and waking states. Using two-photon microscopy in adolescent mice, we found that waking results in a net increase in cortical spines, whereas sleep is associated with net spine loss.
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In juvenile mice in vivo, two-photon microscopy in the sensorimotor cortex revealed a net decrease in spine growth across periods of sleep, although significant spine growth also occurred.
“In juvenile mice in vivo, two-photon microscopy in the sensorimotor cortex revealed a net decrease in spine growth across periods of sleep, although there was also significant spine growth at the same time (772).”
From About Sleep's Role in Memory (2013) · cites this paper as [772]
In adult mice, no similar changes in spine growth across sleep were observed.
“In adult mice, no similar changes were observed.”
From About Sleep's Role in Memory (2013) · cites this paper as [772]
The mechanisms mediating synaptic plasticity during critical periods differ in essential aspects from those during later life, and differences in regulation of synaptic plasticity may still exist between juveniles and adults.
“The mechanisms mediating synaptic plasticity during critical periods in essential aspects differ from those during later life (838) and differences in the regulation of synaptic plasticity may still exist between juveniles and adults (772).”
From About Sleep's Role in Memory (2013) · cites this paper as [772]
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Self-citationLyons, L. C., Vanrobaeys, Y. S., & Abel, T. G. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15787 · Cited by 62 · see citing works
Overnight neuronal plasticity and adaptation to emotional distress
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Brand, S., Lemola, S., Holsboer‐Trachsler, E., Grob, A., & Kalak, N. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s62533 · Cited by 62 · see citing works
Plastic Changes Following Imitation-Based Speech and Language Therapy for Aphasia
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Self-citationSleep, synaptic homeostasis and neuronal firing rates
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Self-citationPugin, F., Metz, A. J., Wolf, M., Achermann, P., Jenni, O. G., & Huber, R. (2015) · SLEEP · doi:10.5665/sleep.4580 · Cited by 59 · see citing works
Neural Consequences of Chronic Short Sleep: Reversible or Lasting?
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Role of Glia in the Regulation of Sleep in Health and Disease
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From Genetics to Structure to Function: Exploring Sleep in Drosophila
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Self-citationAn essential role for MEF2C in the cortical response to loss of sleep in mice
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The Ontogenesis of Mammalian Sleep: Form and Function
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Hayashi, Y. (2013) · Journal of Neurological Disorders · doi:10.4172/2329-6895.1000120 · Cited by 49 · see citing works
Sleep reverts changes in human gray and white matter caused by wake-dependent training
Bernardi, G., Cecchetti, L., Siclari, F., Buchmann, A., Yu, X., Handjaras, G., Bellesi, M., Ricciardi, E., Kecskemeti, S., Riedner, B. A., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.01.020 · Cited by 49 · see citing works
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Sleep pressure modulates single-neuron synapse number in zebrafish
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Loss of Sleep Affects the Ultrastructure of Pyramidal Neurons in the Adolescent Mouse Frontal Cortex
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Self-citationAssociations between brain structure and sleep patterns across adolescent development
Jalbrzikowski, M., Hayes, R. A., Scully, K. E., Franzen, P. L., Hasler, B. P., Siegle, G. J., Buysse, D. J., Dahl, R. E., Forbes, E. E., Ladouceur, C. D., et al. (2021) · SLEEP · doi:10.1093/sleep/zsab120 · Cited by 49 · see citing works
- Authors
- Maret, S., Faraguna, U., Nelson, A. B., Cirelli, C., & Tononi, G.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Cirelli, Chiara
- Tononi, Giulio
- Venue
- Nature Neuroscience
- Published
- 2011-10-09
- Volume
- 14
- Issue
- 11
- Pages
- 1418-1420
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3203346
- OpenAlex
- W2045436209
- Cited by
- 315
- References
- 15
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 19 · 2023: 23 · 2022: 23 · 2021: 14 · 2020: 29 · 2019: 26 · 2018: 16 · 2017: 35 · 2016: 21 · 2015: 15 · 2014: 23 · 2013: 28 · 2012: 16
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Funders
- National Institutes of Health (DP1OD000579)
- National Institute of Mental Health (R01MH091326)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- synaptic plasticity, sleep, wakefulness, synaptic pruning, synaptogenesis, synaptic remodeling, adolescent brain development, cortical development, behavioral state
- MeSH terms
- Animals, Animals, Newborn, Bacterial Proteins, Cerebral Cortex, Electroencephalography, Electromyography, Luminescent Proteins, Mice, Transgenic, Motor Activity, Neurons, Sleep, Ultrasonography, Wakefulness, Microscopy, Confocal, Dendritic Spines, Mice
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