The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Role of Inducible Nitric Oxide Synthase in Endotoxin-induced Acute Lung Injury
Abstract
The role of nitric oxide (NO) in lung injury remains unclear. Both beneficial and detrimental roles have been proposed. In this study, we used mutant mice lacking the inducible nitric oxide synthase (iNOS) to assess the role of this isoform in sepsis-associated lung injury. Wild-type and iNOS knockout mice were injected with either saline or Escherichia coli endotoxin (LPS) 25 mg/kg and killed 6, 12, and 24 h later. Lung injury was evaluated by measuring lactate dehydrogenase activity in the bronchoalveolar lavage, pulmonary wet/dry ratio, and immunostaining for nitrotyrosine formation. In the wild-type mice, LPS injection elicited more than a 3-fold rise in lactate dehydrogenase activity, a significant rise in lung wet/dry ratio and extensive nitrotyrosine staining in large airway and alveolar epithelium, macrophages, and pulmonary vascular cells. This was accompanied by induction of iNOS protein and increased lung nitric oxide synthase activity. By comparison, LPS injection in iNOS knockout mice elicited no iNOS induction and no significant changes in lung NOS activity, lactate dehydrogenase activity, lung wet/dry ratio, or pulmonary nitrotyrosine staining. These results indicate that mice deficient in iNOS gene are more resistant to LPS-induced acute lung injury than are wild-type mice.
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Cites
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“Moreover, most of the available selective iNOS inhibitors also influence ecNOS and nNOS, both of which are expressed in numerous pulmonary cell types and play important roles in the regulation of pulmonary blood flow, airway tone, and epithelial cell function (4).”
BackgroundNitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization
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Cited by
Contribution of Neutrophils to Acute Lung Injury
Grommes, J., & Soehnlein, O. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00138 · Cited by 1,313
The innate immune response of the respiratory epithelium: Innate immunity in the airway
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Inhaled Nitric Oxide Therapy in Adults
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Transepithelial Migration of Neutrophils
Zemans, R. L., Colgan, S. P., & Downey, G. P. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0348tr · Cited by 339
Oxidant-Antioxidant Balance in Acute Lung Injury*
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Metadata
- Authors
- KRISTOF, A. S., GOLDBERG, P., LAUBACH, V., & HUSSAIN, S. N. A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-12-01
- Volume
- 158
- Issue
- 6
- Pages
- 1883-1889
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2045873616
- Cited by
- 277
- References
- 34
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- KRISTOF, A. S., GOLDBERG, P., LAUBACH, V., & HUSSAIN, S. N. A. (1998). Role of Inducible Nitric Oxide Synthase in Endotoxin-induced Acute Lung Injury. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.158.6.9802100
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