The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Perturbed Equilibrium of Myosin Binding in Airway Smooth Muscle and Its Implications in Bronchospasm
Abstract
In asthma, the mechanisms relating airway obstruction, hyperresponsiveness, and inflammation remain rather mysterious. We show here that regulation of airway smooth muscle length corresponds to a dynamically equilibrated steady state, not the static mechanical equilibrium that had been previously assumed. This dynamic steady state requires as an essential feature a continuous supply of external mechanical energy (derived from tidal lung inflations) that acts to perturb the interactions of myosin with actin, drive the molecular state of the system far away from thermodynamic equilibrium, and bias the muscle toward lengthening. This mechanism leads naturally to the suggestion that excessive airway narrowing in asthma may be associated with the destabilization of that dynamic process and its resulting collapse back to static equilibrium. With this collapse the muscle undergoes a phase transition and virtually freezes at its static equilibrium length. This mechanism may help to elucidate several unexplained phenomena including the multifactorial origins of airway hyperresponsiveness, how allergen sensitization leads to airway hyperresponsiveness, how hyperresponsiveness can persist long after airway inflammation is resolved, and the inability in asthma of deep inspirations to relax airway smooth muscle.
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Citations
Cites
Muscle Structure and Theories of Contraction
Huxley, A. F. (1957) · Progress in Biophysics and Biophysical Chemistry · doi:10.1016/s0096-4174(18)30128-8 · Cited by 2,318
ATPase Activity of Myosin Correlated with Speed of Muscle Shortening
Bárány, M. (1967) · The Journal of General Physiology · doi:10.1085/jgp.50.6.197 · Cited by 1,968
Thermodynamics and Kinetics of a Brownian Motor
Astumian, R. D. (1997) · Science · doi:10.1126/science.276.5314.917 · Cited by 1,411
New insights into the behavior of muscle during active lengthening
Morgan, D. L. (1990) · Biophysical Journal · doi:10.1016/s0006-3495(90)82524-8 · Cited by 724
Myosin Phosphorylation and the Cross-Bridge Cycle in Arterial Smooth Muscle
Dillon, P. F., Aksoy, M. O., Driska, S. P., & Murphy, R. A. (1981) · Science · doi:10.1126/science.6893872 · Cited by 705
The short range stiffness of active mammalian muscle and its effect on mechanical properties
Rack, P. M. H., & Westbury, D. R. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010613 · Cited by 514
Dissociation between Airway Inflammation and Airway Hyperresponsiveness in Allergic Asthma
CRIMI, E., SPANEVELLO, A., NERI, M., IND, P. W., ROSSI, G. A., & BRUSASCO, V. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.1.9703002 · Cited by 508
Mechanics of airway narrowing.
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On the imperfect elasticity of lung tissue
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Self-citationSkloot, G., Permutt, S., & Togias, A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118296 · Cited by 481
Cited by
The effect of obesity on lung function
Dixon, A. E., & Peters, U. (2018) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2018.1506331 · Cited by 889
Physiology of obesity and effects on lung function
Salome, C. M., King, G. G., & Berend, N. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00694.2009 · Cited by 831
Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness
Schachter, L. M. (2001) · Thorax · doi:10.1136/thorax.56.1.4 · Cited by 431
Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness
Krishnan, R., Park, C. Y., Lin, Y.-C., Mead, J., Jaspers, R. T., Trepat, X., Lenormand, G., Tambe, D., Smolensky, A. V., Knoll, A. H., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005486 · Cited by 263
Self-citationDisrupting actin–myosin–actin connectivity in airway smooth muscle as a treatment for asthma?
Lavoie, T. L., Dowell, M. L., Lakser, O. J., Gerthoffer, W. T., Fredberg, J. J., Seow, C. Y., Mitchell, R. W., & Solway, J. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200808-078rm · Cited by 42
Self-citation
Metadata
- Authors
- FREDBERG, J. J., INOUYE, D. S., MIJAILOVICH, S. M., & BUTLER, J. P.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03-01
- Volume
- 159
- Issue
- 3
- Pages
- 959-967
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1997663100
- Cited by
- 310
- References
- 33
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Perturbed Equilibrium of Myosin Binding in Airway Smooth Muscle and Its Implications in Bronchospasm. https://app.cochat.ai/papers/10.1164/ajrccm.159.3.9804060
- The paper
- FREDBERG, J. J., INOUYE, D. S., MIJAILOVICH, S. M., & BUTLER, J. P. (1999). Perturbed Equilibrium of Myosin Binding in Airway Smooth Muscle and Its Implications in Bronchospasm. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.159.3.9804060
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
