The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
A Model of Airway Narrowing in Asthma and in Chronic Obstructive Pulmonary Disease
Abstract
We have examined the effect of airway wall thickening, loss of lung recoil, and airway smooth muscle shortening on the increase in airway resistance using a model of the human tracheobronchial tree. The values for airway wall thickening were determined morphometrically on the postmortem or surgically resected lungs of normal subjects, patients with moderate chronic obstructive pulmonary disease, and patients with severe asthma. Loss of recoil was simulated by deflating airways along their pressure-area curves by 1 to 3 cm H2O. Values of smooth muscle shortening between 20 and 40% were used in the model to generate sigmoidal-shaped "dose-response" curves. The analysis shows that moderate amounts of airway wall thickening, which have little effect on baseline resistance, can profoundly affect the airway narrowing caused by smooth muscle shortening--especially if the wall thickening is localized in peripheral airways. The combination of a loss of recoil and airway wall thickening are more than additive in their effect on simulated airway responsiveness. We conclude that airway wall thickening and a loss of lung recoil can partially explain the airway hyperresponsiveness observed in patients with chronic obstructive lung disease and asthma.
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Cites
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Resistance of central and peripheral airways measured by a retrograde catheter
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Self-citationEffects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans
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The shape of the dose-response curve to histamine in asthmatic and normal subjects.
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The prediction of pressure drop and variation of resistance within the human bronchial airways
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A computational model for expiratory flow
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Small Airway Dimensions in Smokers with Obstruction to Airflow
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Self-citationThe Use of the Internal Perimeter to Compare Airway Size and to Calculate Smooth Muscle Shortening
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Self-citationFamilies of lines: random effects in linear regression analysis
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Cited by
GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION
PAUWELS, R. A. (1996) · Arerugī/Arerugi · doi:10.15036/arerugi.45.792 · Cited by 9,994
Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
The Structure of Large and Small Airways in Nonfatal and Fatal Asthma
Carroll, N., Elliot, J., Morton, A., & James, A. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.2.405 · Cited by 720
Self-citationInflammation of small airways in asthma☆☆☆★★★
Hamid, Q., Song, Y., Kotsimbos, T. C., Minshall, E., Bai, T. R., Hegele, R. G., & Hogg, J. C. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70193-3 · Cited by 548
Self-citationDissociation between Airway Inflammation and Airway Hyperresponsiveness in Allergic Asthma
CRIMI, E., SPANEVELLO, A., NERI, M., IND, P. W., ROSSI, G. A., & BRUSASCO, V. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.1.9703002 · Cited by 508
Metadata
- Authors
- Wiggs, B. R., Bosken, C., Paré, P. D., James, A., & Hogg, J. C.
- Venue
- American Review of Respiratory Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-06
- Volume
- 145
- Issue
- 6
- Pages
- 1251-1258
- ISSN
- 0003-0805 (ISSN-L)
- OpenAlex
- W1990990168
- Cited by
- 443
- References
- 15
- FWCI
- 18.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wiggs, B. R., Bosken, C., Paré, P. D., James, A., & Hogg, J. C. (1992). A Model of Airway Narrowing in Asthma and in Chronic Obstructive Pulmonary Disease. American Review of Respiratory Disease. https://doi.org/10.1164/ajrccm/145.6.1251
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
