The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Body Mass and Glucocorticoid Response in Asthma
Open accessAbstract
RATIONALE: Obesity may alter glucocorticoid response in asthma. OBJECTIVES: To evaluate the relationship between body mass index (BMI, kg/m(2)) and glucocorticoid response in subjects with and without asthma. METHODS: Nonsmoking adult subjects underwent characterization of lung function, BMI, and spirometric response to prednisone. Dexamethasone (DEX, 10(-6) M)-induced mitogen-activated protein kinase phosphatase-1 (MKP-1) and baseline tumor necrosis factor (TNF)-alpha expression were evaluated by polymerase chain reaction in peripheral blood mononuclear cells (PBMCs) and bronchoalveolar lavage cells. The relationship between BMI and expression of MKP-1 and TNF-alpha was analyzed. MEASUREMENTS AND MAIN RESULTS: A total of 45 nonsmoking adults, 33 with asthma (mean [SD] FEV(1)% of 70.7 [9.8]%) and 12 without asthma were enrolled. DEX-induced PBMC MKP-1 expression was reduced in overweight/obese versus lean patients with asthma, with mean (+/- SEM) fold-induction of 3.11 (+/-0.46) versus 5.27 (+/-0.66), respectively (P = 0.01). In patients with asthma, regression analysis revealed a -0.16 (+/-0.08)-fold decrease in DEX-induced MKP-1 per unit BMI increase (P = 0.04). PBMC TNF-alpha expression increased as BMI increased in subjects with asthma, with a 0.27 unit increase in log (TNF-alpha [ng/ml]) per unit BMI increase (P = 0.01). The ratio of PBMC log (TNF-alpha):DEX-induced MKP-1 also increased as BMI increased in patients with asthma (+0.09 +/- 0.02; P = 0.004). In bronchoalveolar lavage cells, DEX-induced MKP-1 expression was also reduced in overweight/obese versus lean patients with asthma (1.36 +/- 0.09-fold vs. 1.76 +/- 0.15-fold induction; P = 0.05). Similar findings were not observed in control subjects without asthma. CONCLUSIONS: Elevated BMI is associated with blunted in vitro response to dexamethasone in overweight and obese patients with asthma.
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International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
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The effect of obesity on lung function
Dixon, A. E., & Peters, U. (2018) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2018.1506331 · Cited by 889
The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma
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Self-citationCo‐morbidities in severe asthma: Clinical impact and management
Porsbjerg, C., & Menzies‐Gow, A. (2017) · Respirology · doi:10.1111/resp.13026 · Cited by 233
Metadata
- Authors
- Sutherland, E. R., Goleva, E., Strand, M., Beuther, D. A., & Leung, D. Y. M.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10-01
- Volume
- 178
- Issue
- 7
- Pages
- 682-687
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2147991740
- Cited by
- 347
- References
- 13
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- green
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