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Cited by 41Air Quality and Health ImpactsChronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseases

Ozone exposure, cardiopulmonary health, and obesity: a substantive review

Open access
Koman, Patricia D., Mancuso, Peter·2017·Chemical Research in Toxicology
DOI 10.1021/acs.chemrestox.7b00077PMC PMC5556919
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Abstract

From 1999-2014, obesity prevalence increased among adults and youth. Obese individuals may be uniquely susceptible to the proinflammatory effects of ozone because obese humans and animals have been shown to experience a greater decline in lung function than normal-weight subjects. Obesity is independently associated with limitations in lung mechanics with increased ozone dose. However, few epidemiologic studies have examined the interaction between excess weight and ozone exposure among adults. Using PubMed keyword searches and reference lists, we reviewed epidemiologic evidence to identify potential response-modifying factors and determine if obese or overweight adults are at increased risk of ozone-related health effects. We initially identified 170 studies, of which seven studies met the criteria of examining the interaction of excess weight and ozone exposure on cardiopulmonary outcomes in adults, including four short-term ozone exposure studies in controlled laboratory settings and three community epidemiologic studies. In the studies identified, obesity was associated with decreased lung function and increased inflammatory mediators. Results were inconclusive about the effect modification when data were stratified by sex. Obese and overweight populations should be considered as candidate at-risk groups for epidemiologic studies of cardiopulmonary health related to air pollution exposures. Air pollution is a modifiable risk factor that may decrease lung function among obese individuals with implications for environmental and occupational health policy.

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  • These respiratory effects can aggravate lung diseases such as asthma, emphysema, and chronic bronchitis (COPD).

    “These effects can aggravate lung diseases such as asthma, emphysema, and chronic bronchitis [chronic obstructive pulmonary disease (COPD)].”

    From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [26]

  • Long-term exposure to ozone is likely to be one of many causes of asthma development.

    “Long-term exposure to ozone is likely to be one of many causes of asthma development.”

    From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [26]

  • Children are at increased risk from ozone exposure, as children have a relatively higher dose per body mass and children's lung is still developing.

    “Children are at increased risk from ozone exposure, as children have a relatively higher dose per body mass and children's lung is still developing.”

    From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [26]

  • Ozone can cause adverse respiratory effects such as difficulty of breathing and inflammation of the airways in the general population.

    “Ozone can cause adverse respiratory effects such as difficulty of breathing (e.g., shortness of breath and pain when taking a deep breath) and inflammation of the airways in the general population.”

    From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [26]

  • Ozone exposure is likely to cause premature deaths, and the evidence is stronger for mortality due to respiratory illnesses than for that due to other diseases.

    “Ozone exposure is likely to cause premature deaths, and the evidence is stronger for mortality due to respiratory illnesses than for that due to other diseases.”

    From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [26]

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Research works printed but not linked: 7

  1. [43]Gordon CJ Phillips PM Ledbetter A Snow SJ Schladweiler MC Johnstone AFM Kodavanti UP 2017 Active vs. sedentary lifestyle from weaning to adulthood and susceptibility to ozone in rats Am J Physiol - Lung Cell Mol Physiol 312 L100 27836902
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Authors
Koman, P. D., & Mancuso, P.
Affiliations
University of Michigan (US)
Corresponding author
Koman, Patricia D.
ORCID
Venue
Chemical Research in Toxicology
Publisher
American Chemical Society (ACS)
Published
2017-06-15
Volume
30
Issue
7
Pages
1384-1395
ISSN
  • 0893-228X (ISSN-L)
  • 1520-5010
DOI
10.1021/acs.chemrestox.7b00077
PMC
PMC5556919
OpenAlex
W2621399646
Cited by
41
References
78
Citations by year
2026: 3 · 2025: 1 · 2024: 9 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 2
FWCI
0.31
Type
journal article
Language
en
Open access
Locations
  • Chemical Research in Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Environmental Health Sciences (ES017885, P30ES017885)
  • National Institute for Occupational Safety and Health (T42 OH008455)
  • Flight Attendant Medical Research Institute (CIA-103071)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
ozone exposure, obesity, overweight, cardiopulmonary health, lung function, air pollution, inflammation, effect modification, sex differences, vulnerable populations, environmental health policy
MeSH terms
Air Pollutants, Animals, Cardiovascular Diseases, Environmental Exposure, Humans, Lung, Obesity, Ozone

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