Cited by 154Clinical Nutrition and GastroenterologySepsis Diagnosis and TreatmentEnhanced Recovery After Surgery

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Permissive Underfeeding or Standard Enteral Feeding in High– and Low–Nutritional-Risk Critically Ill Adults. Post Hoc Analysis of the PermiT Trial

Arabi, Yaseen M., Aldawood, Abdulaziz S., Al-Dorzi, Hasan M., Tamim, Hani M., Haddad, Samir H., Jones, Gwynne, McIntyre, Lauralyn, Solaiman, Othman, Sakkijha, Maram H., Sadat, Musharaf, Mundekkadan, Shihab, Kumar, Anand, Bagshaw, Sean M., Mehta, Sangeeta·2017·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.201605-1012oc

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Abstract

RATIONALE: The optimal nutritional strategy for critically ill adults at high nutritional risk is unclear. OBJECTIVES: To examine the effect of permissive underfeeding with full protein intake compared with standard feeding on 90-day mortality in patients with different baseline nutritional risk. METHODS: This is a post hoc analysis of the PermiT (Permissive Underfeeding versus Target Enteral Feeding in Adult Critically Ill Patients) trial. MEASUREMENTS AND MAIN RESULTS: Nutritional risk was categorized by the modified Nutrition Risk in Critically Ill score, with high nutritional risk defined as a score of 5-9 and low nutritional risk as a score of 0-4. Additional analyses were performed by categorizing patients by body mass index, prealbumin, transferrin, phosphate, urinary urea nitrogen, and nitrogen balance. Based on the Nutrition Risk in Critically Ill score, 378 of 894 (42.3%) patients were categorized as high nutritional risk and 516 of 894 (57.7%) as low nutritional risk. There was no association between feeding strategy and mortality in the two categories; adjusted odds ratio (aOR) of 0.84 (95% confidence interval [CI], 0.56-1.27) for high nutritional risk and 1.01 (95% CI, 0.64-1.61) for low nutritional risk (interaction P = 0.53). Findings were similar in analyses using other definitions, with the exception of prealbumin. The association of permissive underfeeding versus standard feeding and 90-day mortality differed when patients were categorized by baseline prealbumin level (≤0.10 g/L: aOR, 0.57 [95% CI, 0.31-1.05]; >0.10 and ≤0.15 g/L: aOR, 0.79 [95% CI, 0.42-1.48]; >0.15 g/L: aOR, 1.55 [95% CI, 0.80, 3.01]; interaction P = 0.009). CONCLUSIONS: Among patients with high and low nutritional risk, permissive underfeeding with full protein intake was associated with similar outcomes as standard feeding.

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Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
Taylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476
Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial
The National Heart, L., Rice, T. W., Wheeler, A. P., Thompson, B. T., Steingrub, J., Hite, R. D., Moss, M., Morris, A., Dong, N., & Rock, P. (2012) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.2012.137 · Cited by 935
Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool
Heyland, D. K., Dhaliwal, R., Jiang, X., & Day, A. G. (2011) · Critical Care · doi:10.1186/cc10546 · Cited by 863
Refeeding syndrome: what it is, and how to prevent and treat it
Mehanna, H. M., Moledina, J., & Travis, J. (2008) · BMJ · doi:10.1136/bmj.a301 · Cited by 706
Permissive underfeeding or standard enteral feeding in critically ill adults
Arabi, Y. M., Aldawood, A. S., Haddad, S. H., Al-Dorzi, H. M., Tamim, H. M., Jones, G., Mehta, S., McIntyre, L., Solaiman, O., Sakkijha, M. H., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1502826 · Cited by 614
Self-citation
Hepatic proteins and nutrition assessment.
Fuhrman, M., Charney, P., & Mueller, C. (2004) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.05.213 · Cited by 581
Identifying critically-ill patients who will benefit most from nutritional therapy: Further validation of the “modified NUTRIC” nutritional risk assessment tool
Rahman, A., Hasan, R. M., Agarwala, R., Martin, C. M., Day, A. G., & Heyland, D. K. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.01.015 · Cited by 550
Refeeding Hypophosphatemia in Critically Ill Patients in an Intensive Care Unit
Marik, P. E. (1996) · Archives of Surgery · doi:10.1001/archsurg.1996.01430220037007 · Cited by 324
Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial
Doig, G. S., Simpson, F., Heighes, P. T., Bellomo, R., Chesher, D., Caterson, I. D., Reade, M. C., & Harrigan, P. W. J. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00418-x · Cited by 308
Physical and Cognitive Performance of Patients with Acute Lung Injury 1 Year after Initial Trophic versus Full Enteral Feeding. EDEN Trial Follow-up
Needham, D. M., Dinglas, V. D., Morris, P. E., Jackson, J. C., Hough, C. L., Méndez-Téllez, P. A., Wozniak, A. W., Colantuoni, E., Ely, E. W., Rice, T. W., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201304-0651oc · Cited by 287

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Wang, M.-Y., Wang, C., Chen, W.-S., Chu, C., Wu, H.-P., Liu, M., Lin, Y., Kao, K., Liang, C., Chen, W., et al. (2022) · Disease Markers · doi:10.1155/2022/7389258 · Cited by 12
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Hung, K.-Y., Chen, T.-H., Lee, Y.-F., & Fang, W. (2023) · Nutrients · doi:10.3390/nu15173814 · Cited by 11
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Charles, E. J., Kane, W. J., Willcutts, K. F., O’Donnell, K. B., Petroze, R. T., & Sawyer, R. G. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.11.011 · Cited by 10
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Umbrello, M., Marini, J. J., & Formenti, P. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093216 · Cited by 10
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de Souza, I. A. O., Ribeiro, P. C., Jonckheer, J., Waele, E. D., & Taniguchi, L. U. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270455 · Cited by 3
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Authors: Arabi, Y. M., Aldawood, A. S., Al-Dorzi, H. M., Tamim, H. M., Haddad, S. H., Jones, G., McIntyre, L., Solaiman, O., Sakkijha, M. H., Sadat, M., Mundekkadan, S., Kumar, A., Bagshaw, S. M., & Mehta, S.
Affiliations: King Saud bin Abdulaziz University for Health Sciences (SA)
King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
University of Ottawa (CA)
King Faisal Specialist Hospital & Research Centre (SA)
Health Sciences Centre (CA)
University of Alberta (CA)
Mount Sinai Hospital (CA)
Corresponding author: Arabi, Yaseen M.
ORCID: Arabi, Yaseen M.
Tamim, Hani M.
Haddad, Samir H.
McIntyre, Lauralyn
Sadat, Musharaf
Kumar, Anand
Bagshaw, Sean M.
Mehta, Sangeeta
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2017-03-01
Volume: 195
Issue: 5
Pages: 652-662
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.201605-1012oc
OpenAlex: W2517641494
Cited by: 153
References: 25
Citations by year: 2026: 5 · 2025: 15 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 13 · 2020: 30 · 2019: 19 · 2018: 26 · 2017: 15
FWCI: 20.88
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Canada Research Chairs
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
Keywords: permissive underfeeding, enteral nutrition, critically ill adults, nutritional risk, 90-day mortality, prealbumin, protein intake, nitrogen balance
MeSH terms: Adult, Energy Intake, Canada, Critical Care, Enteral Nutrition, Female, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Nutritional Status, Risk, Saudi Arabia, Odds Ratio, Critical Illness, Hospital Mortality, Caloric Restriction

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Permissive Underfeeding or Standard Enteral Feeding in High– and Low–Nutritional-Risk Critically Ill Adults. Post Hoc Analysis of the PermiT Trial

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