The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Obesity and Airway Dysanapsis in Children with and without Asthma
Open accessAbstract
Abstract Rationale For unclear reasons, obese children with asthma have higher morbidity and reduced response to inhaled corticosteroids. Objectives To assess whether childhood obesity is associated with airway dysanapsis (an incongruence between the growth of the lungs and the airways) and whether dysanapsis is associated with asthma morbidity. Methods We examined the relationship between obesity and dysanapsis in six cohorts of children with and without asthma, as well as the relationship between dysanapsis and clinical outcomes in children with asthma. Adjusted odds ratios (ORs) were calculated for each cohort and in a combined analysis of all cohorts; longitudinal analyses were also performed for cohorts with available data. Hazard ratios (HRs) for clinical outcomes were calculated for children with asthma in the Childhood Asthma Management Program. Measurements and Main Results Being overweight or obese was associated with dysanapsis in both the cross-sectional (OR, 1.95; 95% confidence interval [CI], 1.62–2.35 [for overweight/obese compared with normal weight children]) and the longitudinal (OR, 4.31; 95% CI, 2.99–6.22 [for children who were overweight/obese at all visits compared with normal weight children]) analyses. Dysanapsis was associated with greater lung volumes (FVC, vital capacity, and total lung capacity) and lesser flows (FEV1 and forced expiratory flow, midexpiratory phase), and with indicators of ventilation inhomogeneity and anisotropic lung and airway growth. Among overweight/obese children with asthma, dysanapsis was associated with severe disease exacerbations (HR, 1.95; 95% CI, 1.38–2.75) and use of systemic steroids (HR, 3.22; 95% CI, 2.02–5.14). Conclusions Obesity is associated with airway dysanapsis in children. Dysanapsis is associated with increased morbidity among obese children with asthma and may partly explain their reduced response to inhaled corticosteroids.
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Cited by
Peters, U., Dixon, A. E., & Forno, E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.02.004 · Cited by 934
Self-citationThe effect of obesity on lung function
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Improving lung health in low-income and middle-income countries: from challenges to solutions
Meghji, J., Mortimer, K., Agusti, A., Allwood, B. W., Asher, I., Bateman, E. D., Bissell, K., Bolton, C. E., Bush, A., Celli, B., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00458-x · Cited by 470
Overweight, Obesity, and Lung Function in Children and Adults—A Meta-analysis
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Self-citationClinical significance and applications of oscillometry
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Metadata
- Authors
- Forno, E., Weiner, D. J., Mullen, J., Sawicki, G., Kurland, G., Han, Y. Y., Cloutier, M. M., Canino, G., Weiss, S. T., Litonjua, A. A., & Celedón, J. C.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-02-01
- Volume
- 195
- Issue
- 3
- Pages
- 314-323
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2517190534
- Cited by
- 287
- References
- 41
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Forno, E., Weiner, D. J., Mullen, J., Sawicki, G., Kurland, G., Han, Y. Y., Cloutier, M. M., Canino, G., Weiss, S. T., Litonjua, A. A., & Celedón, J. C. (2017). Obesity and Airway Dysanapsis in Children with and without Asthma. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201605-1039oc
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