The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
An Official American Thoracic Society Workshop Report: Obesity and Asthma
Abstract
Rationale: The developed world is currently facing an epidemic of obesity. With the increased prevalence of obesity has come the recognition that obesity is a risk factor for asthma. Objectives: The purpose of this workshop was to bring together experts in the field of asthma, with experts in the field of obesity to review the current state-of-the-art knowledge regarding obesity and asthma, with the goal of furthering our understanding of the link between these two disease entities to help define important future directions for research. Methods: Speakers were invited to give presentations highlighting recent developments in their area of expertise that were related to obesity and lung disease. These presentations were followed by interactive discussion. A writing committee from among the participants produced a document summarizing the proceedings. Measurements and Main Results: The participants found that obesity was a risk factor for asthma in all demographic groups studied. Asthma in the obese may represent a unique phenotype of asthma, with more severe disease that does not respond as well to conventional therapy. Factors that could contribute to the pathogenesis of asthma in the obese include both mechanical factors and altered inflammation and immune responses related to the obese state. Conclusions: There is an urgent need for research to better understand the mechanisms of asthma in the obese, and to develop new therapies specifically targeted to this unique patient population.
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Citations
Cites
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“The mechanical effect of obesity on lung function is more strongly associated with central body fat distribution (34), and a subset of obese individuals demonstrate a phenotype of enhanced systemic inflammation and insulin resistance (35) that may be more relevant in an inflammatory model of obesity– asthma pathogenes…”
Background
Cited by
Diet, metabolites, and “western-lifestyle” inflammatory diseases
Thorburn, A. N., Macia, L., & Mackay, C. R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.014 · Cited by 879
Obesity Is Not Protective against Fracture in Postmenopausal Women: GLOW
Compston, J. E., Watts, N. B., Chapurlat, R., Cooper, C., Boonen, S., Greenspan, S., Pfeilschifter, J., Silverman, S., Díez-Pérez, A., Lindsay, R., et al. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.06.013 · Cited by 552
Obesity and Airway Dysanapsis in Children with and without Asthma
Forno, E., Weiner, D. J., Mullen, J., Sawicki, G., Kurland, G., Han, Y. Y., Cloutier, M. M., Canino, G., Weiss, S. T., Litonjua, A. A., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201605-1039oc · Cited by 287
Self-citationOverweight, Obesity, and Lung Function in Children and Adults—A Meta-analysis
Forno, E., Han, Y.-Y., Mullen, J., & Celedón, J. C. (2018) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2017.07.010 · Cited by 286
Self-citationEffects of Weight Loss on Airway Responsiveness in Obese Adults With Asthma
Pakhale, S., Baron, J., Dent, R., Vandemheen, K., & Aaron, S. D. (2015) · Chest · doi:10.1378/chest.14-3105 · Cited by 84
Metadata
- Authors
- Dixon, A. E., Holguin, F., Sood, A., Salome, C. M., Pratley, R. E., Beuther, D. A., Celedón, J. C., & Shore, S. A.
- Venue
- Proceedings of the American Thoracic Society
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09
- Volume
- 7
- Issue
- 5
- Pages
- 325-335
- ISSN
- 1546-3222 (ISSN-L)
- 1943-5665
- OpenAlex
- W2158263320
- Cited by
- 348
- References
- 14
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dixon, A. E., Holguin, F., Sood, A., Salome, C. M., Pratley, R. E., Beuther, D. A., Celedón, J. C., & Shore, S. A. (2010). An Official American Thoracic Society Workshop Report: Obesity and Asthma. Proceedings of the American Thoracic Society. https://doi.org/10.1513/pats.200903-013st
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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