Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

Richeldi, L., du Bois, R. M., Raghu, G., Azuma, A., Brown, K. K., Costabel, U., Cottin, V., Flaherty, K. R., Hansell, D. M., Inoue, Y., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402584 · Cited by 4,654 · see citing works

A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.

King, T. E., Bradford, W. Z., Castro-Bernardini, S., Fagan, E. A., Glaspole, I., Glassberg, M. K., Gorina, E., Hopkins, P. M., Kardatzke, D., Lancaster, L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402582 · Cited by 3,975 · see citing works

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology · doi:10.1038/35036374 · Cited by 2,797 · see citing works

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

Coussens, L. M., Fingleton, B., & Matrisian, L. M. (2002) · Science · doi:10.1126/science.1067100 · Cited by 2,761 · see citing works

A matrix metalloproteinase expressed on the surface of invasive tumour cells

Sato, H., Takino, T., Okada, Y., Cao, J. P., Shinagawa, A., Yamamoto, E., & Seiki, M. (1994) · Nature · doi:10.1038/370061a0 · Cited by 2,534 · see citing works

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

Strongin, A. Y., Collier, I. E., Bannikov, G. A., Marmer, B. L., Grant, G. A., & Goldberg, G. I. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5331 · Cited by 1,589 · see citing works

Regulation of matrix metalloproteinase expression in tumor invasion

Westermarck, J. K., & Kähäri, V. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.8.781 · Cited by 1,494 · see citing works

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

Van Wart, H. E., & Birkedal-Hansen, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5578 · Cited by 1,475 · see citing works

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S. A., Mankani, M., Gehron Robey, P., Poole, A. R., Pidoux, I., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80064-1 · Cited by 1,298 · see citing works

Regulation of matrix metalloproteinases: An overview

Chakraborti, S., Mandal, M., Das, S. K., Mandal, A., & Chakraborti, T. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1026028303196 · Cited by 1,123 · see citing works

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,076 · see citing works

Human and mouse proteases: a comparative genomic approach

Puente, X. S., Sánchez, L. M., Overall, C. M., & López-Otı́n, C. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1111 · Cited by 940 · see citing works

Regulation of matrix metalloproteinase gene expression

Yan, C.-H., & Boyd, D. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.20948 · Cited by 811 · see citing works

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

Liu, F., Mih, J. D., Shea, B. S., Kho, A. T., Sharif, A. S., Tager, A. M., & Tschumperlin, D. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004082 · Cited by 799 · see citing works

Murine models of pulmonary fibrosis

Moore, B. B., & Hogaboam, C. M. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00313.2007 · Cited by 797 · see citing works

Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

Knäuper, V., Will, H., López-Otı́n, C., Smith, B., Atkinson, S. J., Stanton, H., Hembry, R. M., & Murphy, G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17124 · Cited by 747 · see citing works

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

Mu, D., Cambier, S., Fjellbirkeland, L., Baron, J. L., Munger, J. S., Kawakatsu, H., Sheppard, D., Broaddus, V. C., & Nishimura, S. L. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200109100 · Cited by 729 · see citing works

Bone marrow–derived progenitor cells in pulmonary fibrosis

Hashimoto, N., Jin, H., Liu, T., Chensue, S. W., & Phan, S. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18847 · Cited by 715 · see citing works

Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis

Chilosi, M., Poletti, V., Zamò, A., Lestani, M., Montagna, L., Piccoli, P., Pedron, S., Bertaso, M., Scarpa, A., Murer, B., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64282-4 · Cited by 708 · see citing works

Collagenase unwinds triple‐helical collagen prior to peptide bond hydrolysis

Chung, L., Dinakarpandian, D., Yoshida, N., Lauer‐Fields, J. L., Fields, G. B., Visse, R., & Nagase, H. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600318 · Cited by 677 · see citing works

β-Catenin Regulates the Expression of the Matrix Metalloproteinase-7 in Human Colorectal Cancer

Brabletz, T., Jung, A., DAĞ, S., Hlubek, F., & Kirchner, T. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65204-2 · Cited by 671 · see citing works

Bone marrow–derived progenitor cells in pulmonary fibrosis

Hashimoto, N., Jin, H., Liu, T., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418847 · Cited by 621 · see citing works

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

Zuo, F., Kaminski, N., Eugui, E. M., Allard, J. D., Zohar Yakhini, B., Ben‐Dor, A., Lollini, L. O., Morris, D. G., Kim, Y., DeLustro, B., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092134099 · Cited by 620 · see citing works

Shedding of the Matrix Metalloproteinases MMP-2, MMP-9, and MT1-MMP as Membrane Vesicle-Associated Components by Endothelial Cells

Taraboletti, G., D’Ascenzo, S., Borsotti, P., Giavazzi, R., Pavan, A., & Dolo, V. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64887-0 · Cited by 588 · see citing works

MMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis

Rosas, I. O., Richards, T. J., Konishi, K., Zhang, Y., Gibson, K., Lokshin, A. E., Lindell, K. O., Cisneros, J., MacDonald, S. D., Pardo, A., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050093 · Cited by 582 · see citing works

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice

Balbı́n, M., Fueyo, A., Tester, A. M., Pendás, A. M., Pitiot, A. S., Astudillo, A., Overall, C. M., Shapiro, S. D., & López-Otı́n, C. (2003) · Nature Genetics · doi:10.1038/ng1249 · Cited by 536 · see citing works

Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.

Goldberg, G. I., Strongin, A. Y., Collier, I. E., Genrich, L., & Marmer, B. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42873-6 · Cited by 513 · see citing works

Up-Regulation and Profibrotic Role of Osteopontin in Human Idiopathic Pulmonary Fibrosis

Pardo, A., Gibson, K. F., Cisneros, J., Richards, T. J., Yang, Y., Becerril, C., Yousem, S., Herrera, I., Ruiz, V., Selman, M., et al. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020251 · Cited by 492 · see citing works

Matrix Metalloproteinase-8 Is Expressed in Rheumatoid Synovial Fibroblasts and Endothelial Cells

Hanemaaijer, R., Sorsa, T. A., Konttinen, Y. T., Ding, Y., Sutinen, M. M., Visser, H., van Hinsbergh, V. W. M., Helaakoski, T., Kainulainen, T., Rönkä, H., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31504 · Cited by 489 · see citing works

Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition

Purcell, B. P., Lobb, D. C., Charati, M. B., Dorsey, S. M., Wade, R. J., Zellars, K. N., Doviak, H., Pettaway, S., Logdon, C. B., Shuman, J. A., et al. (2014) · Nature Materials · doi:10.1038/nmat3922 · Cited by 480 · see citing works

Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis

Fallowfield, J. A., Mizuno, M., Kendall, T. J., Constandinou, C. M., Benyon, R. C., Duffield, J. S., & Iredale, J. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5288 · Cited by 479 · see citing works

Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted

Greenlee, K. J., Werb, Z., & Kheradmand, F. (2007) · Physiological Reviews · doi:10.1152/physrev.00022.2006 · Cited by 474 · see citing works

CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodelingPreprint

Yu, W., Woessner, J. F., McNeish, J. D., & Stamenkovic, I. (2002) · Genes & Development · doi:10.1101/gad.925702 · Cited by 472 · see citing works

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis

Gibbons, M. A., MacKinnon, A. C., Ramachandran, P., Dhaliwal, K., Duffin, R., Phythian-Adams, A. T., van Rooijen, N., Haslett, C., Howie, S. E., Simpson, A. J., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1719oc · Cited by 466 · see citing works

Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts

Song, E., Ouyang, N., Hörbelt, M., Antus, B., Wang, M., & Exton, M. S. (2000) · Cellular Immunology · doi:10.1006/cimm.2000.1687 · Cited by 447 · see citing works

The cell biology of leukocyte-mediated proteolysis

Owen, C. A., & Campbell, E. J. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.2.137 · Cited by 439 · see citing works

Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)

Suzuki, K., Enghild, J. J., MORODOMI, T., Salvesen, G. S., & Nagase, H. (1990) · Biochemistry · doi:10.1021/bi00496a016 · Cited by 432 · see citing works

TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?

Selman, M., Ruiz, V., Cabrera, S., Segura, L., Ramı́rez, R., Barrios, R. J., & Pardo, A. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.3.l562 · Cited by 426 · see citing works

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

Wilborn, J., Crofford, L. J., Burdick, M. D., Kunkel, S. L., Strieter, R. M., & Peters-Golden, M. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117866 · Cited by 390 · see citing works

The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis

Keane, M. P., Arenberg, D. A., Lynch, J. P., Whyte, R. I., Iannettoni, M. D., Burdick, M. D., Wilke, C. A., Morris, S. B., Glass, M., DiGiovine, B., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.3.1437 · Cited by 382 · see citing works

Wnt Signaling Induces Matrix Metalloproteinase Expression and Regulates T Cell Transmigration

Wu, B., Crampton, S. P., & Hughes, C. C. W. (2007) · Immunity · doi:10.1016/j.immuni.2006.12.007 · Cited by 368 · see citing works

TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P

Murray, L. A., Chen, Q., Kramer, M. S., Hesson, D. P., Argentieri, R. L., Peng, X., Gulati, M., Homer, R. J., Russell, T., van Rooijen, N., et al. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.10.013 · Cited by 362 · see citing works

Unaltered Secretion of β-Amyloid Precursor Protein in Gelatinase A (Matrix Metalloproteinase 2)-deficient Mice

Itoh, T., Ikeda, T., Gomi, H., Nakao, S., Suzuki, T., & Itohara, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22389 · Cited by 356 · see citing works

Human Umbilical Cord Mesenchymal Stem Cells Reduce Fibrosis of Bleomycin-Induced Lung Injury

Moodley, Y., Atienza, D., Manuelpillai, U., Samuel, C. S., Tchongue, J., Ilancheran, S., Boyd, R., & Trounson, A. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080629 · Cited by 356 · see citing works

The Role of the C-terminal Domain of Human Collagenase-3 (MMP-13) in the Activation of Procollagenase-3, Substrate Specificity, and Tissue Inhibitor of Metalloproteinase Interaction

Knäuper, V., Cowell, S., Smith, B., López-Otı́n, C., O'Shea, M., Morris, H., Zardi, L., & Murphy, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7608 · Cited by 350 · see citing works

Expression of Neutrophil Collagenase (Matrix Metalloproteinase-8) in Human Atheroma

Herman, M. P., Sukhova, G. K., Libby, P., Gerdes, N., Tang, N. T., Horton, D. B., Kilbride, M., Breitbart, R. E., Chun, M., & Schönbeck, U. (2001) · Circulation · doi:10.1161/hc4101.097419 · Cited by 348 · see citing works

Stimulation of Matrix Metalloproteinase Production by Recombinant Extracellular Matrix Metalloproteinase Inducer from Transfected Chinese Hamster Ovary Cells

Guo, H., Zucker, S., Gordon, M. K., Toole, B. P., & Biswas, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.24 · Cited by 342 · see citing works

Determinants of Survival in Idiopathic Pulmonary Fibrosis

Schwartz, D. A., Helmers, R. A., Galvin, J. R., Fossen, D. S. V., Frees, K. L., Dayton, C. S., Burmeister, L. F., & Hunninghake, G. W. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.2.8306044 · Cited by 338 · see citing works

Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells.

Huhtala, P., Tuuttila, A., Chow, L. T., Lohi, J. J., Keski‐Oja, J., & Tryggvason, K. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55326-6 · Cited by 333 · see citing works

Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis

Herazo-Maya, J. D., Noth, I., Duncan, S. R., Kim, S., Ma, S.-F., Tseng, G. C., Feingold, E., Juan-Guardela, B. M., Richards, T. J., Lussier, Y., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005964 · Cited by 325 · see citing works

Matrilysin (Matrix Metalloproteinase-7) Mediates E-Cadherin Ectodomain Shedding in Injured Lung Epithelium

McGuire, J. K., Li, Q., & Parks, W. C. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64318-0 · Cited by 323 · see citing works

Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage

Wang, X., Manner, P. A., Horner, A. A., Shum, L., Tuan, R. S., & Nuckolls, G. H. (2004) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2004.08.008 · Cited by 311 · see citing works

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling

Lanone, S., Zheng, T., Zhu, Z., Liu, W., Lee, C. G., Ma, B., Chen, Q., Homer, R., Wang, J., Rabach, L. A., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14136 · Cited by 306 · see citing works

Regulation of pulmonary fibrosis by chemokine receptor CXCR3

Jiang, D., Liang, J., Hodge, J. A., Lu, B., Zhu, Z., Yu, S., Fan, J., Gao, Y., Yin, Z., Homer, R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci16861 · Cited by 300 · see citing works

Human endothelial gelatinases and angiogenesis

Nguyen, M. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00007-3 · Cited by 300 · see citing works

Distinct Populations of Stromal Cells Express Collagenase-3 (MMP-13) and Collagenase-1 (MMP-1) in Chronic Ulcers but Not in Normally Healing Wounds

Vaalamo, M., Mattila, L., Johansson, N., Kariniemi, A., Karjalainen‐Lindsberg, M., Kähäri, V., & Saarialho‐Kere, U. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12276722 · Cited by 287 · see citing works

Integrin α2β1 Is a Positive Regulator of Collagenase (MMP-1) and Collagen α1(I) Gene Expression

Riikonen, T., Westermarck, J. K., Koivisto, L., Broberg, A., Kähäri, V., & Heino, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13548 · Cited by 279 · see citing works

Induction of Collagenase-3 (MMP-13) Expression in Human Skin Fibroblasts by Three-dimensional Collagen Is Mediated by p38 Mitogen-activated Protein Kinase

Ravanti, L., Heino, J., López-Otı́n, C., & Kähäri, V. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2446 · Cited by 278 · see citing works

Epilysin, a Novel Human Matrix Metalloproteinase (MMP-28) Expressed in Testis and Keratinocytes and in Response to Injury

Lohi, J., Wilson, C. L., Roby, J. D., & Parks, W. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m001599200 · Cited by 270 · see citing works

Epigenetic Regulation of miR-17∼92 Contributes to the Pathogenesis of Pulmonary Fibrosis

Dakhlallah, D. A., Batte, K., Wang, Y., Cantemir-Stone, C. Z., Yan, P. S., Nuovo, G. J., Mikhail, A. A., Hitchcock, C. L., Wright, V. P., Nana-Sinkam, S. P., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201205-0888oc · Cited by 267 · see citing works

Membrane-Bound Matrix Metalloproteinase-8 on Activated Polymorphonuclear Cells Is a Potent, Tissue Inhibitor of Metalloproteinase-Resistant Collagenase and Serpinase

Owen, C. A., Hu, Z., López-Otı́n, C., & Shapiro, S. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7791 · Cited by 257 · see citing works

Yeast Nuclear Extract Contains Two Major Forms of RNA Polymerase II Mediator Complexes

Liu, Y., Ranish, J. A., Aebersold, R. H., & Hahn, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009586200 · Cited by 255 · see citing works

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling

Lanone, S., Zheng, T., Zhu, Z., Liu, W., Lee, C. G., Ma, B., Chen, Q., Homer, R., Wang, J., Rabach, L. A., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214136 · Cited by 247 · see citing works

Matrix Metalloproteinase 3 Is a Mediator of Pulmonary Fibrosis

Yamashita, C. M., Dolgonos, L., Zemans, R. L., Young, S. K., Robertson, J. V., Briones, N. J., Suzuki, T., Campbell, M., Gauldie, J., Radisky, D. C., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.06.041 · Cited by 246 · see citing works

Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases.

Fukuda, Y., Ishizaki, M., Kudoh, S., Kitaichi, M., & Yamanaka, N. (1998) · PubMed · Cited by 243 · see citing works

Altered DNA Methylation Profile in Idiopathic Pulmonary Fibrosis

Sanders, Y. Y., Ambalavanan, N., Halloran, B., Zhang, X., Liu, H., Crossman, D. K., Bray, M., Zhang, K., Thannickal, V. J., & Hagood, J. S. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201201-0077oc · Cited by 242 · see citing works

Identification and Enzymatic Characterization of Two Diverging Murine Counterparts of Human Interstitial Collagenase (MMP-1) Expressed at Sites of Embryo Implantation

Balbı́n, M., Fueyo, A., Knäuper, V., López, J. M., Álvarez, J., Sánchez, L. M., Quesada, V., Bordallo, J., Murphy, G., & López-Otı́n, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007674200 · Cited by 239 · see citing works

Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.

Hayashi, T., Stetler‐Stevenson, W. G., Fleming, M. V., Fishback, N. F., Koss, M., Liotta, L. A., Ferrans, V. J., & Travis, W. D. (1996) · Europe PMC (PubMed Central) · Cited by 233 · see citing works

Insulin-Like Growth Factor Binding Proteins 3 and 5 Are Overexpressed in Idiopathic Pulmonary Fibrosis and Contribute to Extracellular Matrix Deposition

Pilewski, J. M., Liu, L., Henry, A. C., Knauer, A. V., & Feghali‐Bostwick, C. A. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62263-8 · Cited by 230 · see citing works

Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury

Cheng, S., Pollock, A. S., Mahimkar, R., Olson, J. L., Lovett, D. H., Cheng, S., Pollock, A. S., Mahimkar, R., Olson, J. L., & Lovert, D. H. (2006) · The FASEB Journal · doi:10.1096/fj.06-5898fje · Cited by 223 · see citing works

Characteristic Elevation of Matrix Metalloproteinase Activity in Idiopathic Interstitial Pneumonias

Suga, M., Iyonaga, K., Okamoto, T., Gushima, Y., Miyakawa, H., Akaike, T., & Ando, M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.5.9906096 · Cited by 221 · see citing works

Activation of p38α MAPK Enhances Collagenase-1 (Matrix Metalloproteinase (MMP)-1) and Stromelysin-1 (MMP-3) Expression by mRNA Stabilization

Reunanen, N., Li, S.-P., Ahonen, M., Foschi, M., Han, J., & Kähäri, V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204296200 · Cited by 221 · see citing works

Preclinical and Clinical Studies of MMP Inhibitors in Cancer

Drummond, A. H., BECKETT, P., Brown, P. D. N., Bone, E. A., Davidson, A. H., GALLOWAY, W. A., Gearing, A. J. H., Huxley, P., LABER, D., McCourt, M., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07688.x · Cited by 220 · see citing works

Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases

Heljäsvaara, R., Nyberg, P., Luostarinen, J., Parikka, M., Heikkilä, P., Rehn, M., Sorsa, T. A., Salo, T. A., & Pihlajaniemi, T. A. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.03.021 · Cited by 218 · see citing works

p38 Mitogen-Activated Protein Kinase–Driven MAPKAPK2 Regulates Invasion of Bladder Cancer by Modulation of MMP-2 and MMP-9 Activity

Kumar, B., Koul, S., Petersen, J., Khandrika, L., Hwa, J. S., Meacham, R. B., Wilson, S., & Koul, H. K. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2918 · Cited by 217 · see citing works

Abnormal Re-epithelialization and Lung Remodeling in Idiopathic Pulmonary Fibrosis: The Role of ΔN-p63

Chilosi, M., Poletti, V. E., Murer, B., Lestani, M., Cancellieri, A., Montagna, L., Piccoli, P., Cangi, M. G., Semenzato, G., & Doglioni, C. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000032380.82232.67 · Cited by 212 · see citing works

Pro-collagenase-1 (Matrix Metalloproteinase-1) Binds the α2β1 Integrin upon Release from Keratinocytes Migrating on Type I Collagen

Dumin, J. A., Dickeson, S. K., Stricker, T. P., Bhattacharyya‐Pakrasi, M., Roby, J. D., Santoro, S. A., & Parks, W. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104179200 · Cited by 211 · see citing works

Fragments of human fibroblast collagenase. Purification and characterization

Clark, I. M., & Cawston, T. E. (1989) · Biochemical Journal · doi:10.1042/bj2630201 · Cited by 210 · see citing works

OxLDL up‐regulates microRNA‐29b, leading to epigenetic modifications of MMP‐2/MMP‐9 genes: a novel mechanism for cardiovascular diseases

Chen, K., Wang, Y., Hu, C.-Y., Chang, W., Liao, Y., Dai, C., & Juo, S. H. (2011) · The FASEB Journal · doi:10.1096/fj.10-174904 · Cited by 208 · see citing works

Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin.

Betsuyaku, T., Fukuda, Y., Parks, W. C., Shipley, J., & Senior, R. M. (2000) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64563-4 · Cited by 203 · see citing works

MMP expression and abnormal lung permeability are important determinants of outcome in IPF

McKeown, S., Richter, A. G., O’Kane, C. M., McAuley, D. F., & THICKETT, D. R. (2008) · European Respiratory Journal · doi:10.1183/09031936.00060708 · Cited by 202 · see citing works

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

Marshall, D. C. L., Lyman, S. K., McCauley, S., Kovalenko, M. A., Spangler, R., Liu, C., Lee, M., O’Sullivan, C., Barry-Hamilton, V., Ghermazien, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127063 · Cited by 201 · see citing works

Inhibition of Pulmonary Fibrosis by the Chemokine IP-10/CXCL10

Tager, A. M., Kradin, R. L., LaCamera, P. P., Bercury, S. D., Campanella, G. S. V., Leary, C. P., Polosukhin, V. V., Zhao, L.-H., Sakamoto, H., Blackwell, T. S., et al. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0175oc · Cited by 199 · see citing works

Structure of alveolar epithelial cells in patients with fibrotic lung disorders.

Kawanami, O., Ferrans, V. J., & Crystal, R. G. (1982) · PubMed · Cited by 198 · see citing works

Global Methylation Patterns in Idiopathic Pulmonary Fibrosis

Rabinovich, E. I., Kapetanaki, M. G., Steinfeld, I., Gibson, K. F., Pandit, K. V., Yu, G., Zohar Yakhini, B., & Kaminski, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033770 · Cited by 197 · see citing works

Fibronectin Upregulates Gelatinase B (MMP-9) and Induces Coordinated Expression of Gelatinase A (MMP-2) and Its Activator MT1-MMP (MMP-14) by Human T Lymphocyte Cell Lines. A Process Repressed Through RAS/MAP Kinase Signaling Pathways

Esparza, J., Vilardell, C., Calvo, J., Juan, M., Vives, J., Urbano-Márquez, A., Yagüe, J., & Cid, M. C. (1999) · Blood · doi:10.1182/blood.v94.8.2754.420k09_2754_2766 · Cited by 195 · see citing works

Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis

Uchinami, H., Seki, E., Brenner, D. A., & D'Armiento, J. M. (2006) · Hepatology · doi:10.1002/hep.21268 · Cited by 194 · see citing works

Classical Macrophage Activation Up-Regulates Several Matrix Metalloproteinases through Mitogen Activated Protein Kinases and Nuclear Factor-κB

Huang, W., Sala‐Newby, G. B., Susana, A., Johnson, J. L., & Newby, A. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042507 · Cited by 191 · see citing works

AP-1 and Cbfa/Runt Physically Interact and Regulate Parathyroid Hormone-dependent MMP13 Expression in Osteoblasts through a New Osteoblast-specific Element 2/AP-1 Composite Element

Heß, J., Porte, D., Münz, C., & Angel, P. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010601200 · Cited by 188 · see citing works

Egr-1 Mediates Extracellular Matrix-driven Transcription of Membrane Type 1 Matrix Metalloproteinase in Endothelium

Haas, T. L., Stitelman, D. H., Davis, S. J., Apte, S., & Madri, J. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22679 · Cited by 188 · see citing works

Transforming Growth Factor (TGF)-β1 Stimulates Pulmonary Fibrosis and Inflammation via a Bax-dependent, Bid-activated Pathway That Involves Matrix Metalloproteinase-12

Kang, H., Cho, S. J., Lee, C. G., Homer, R., & Elias, J. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610764200 · Cited by 186 · see citing works

Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis

Yang, I. V., Pedersen, B. S., Rabinovich, E., Hennessy, C. E., Davidson, E., Murphy, E., Guardela, B. J., Tedrow, J. R., Zhang, Y., Singh, M. K., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201408-1452oc · Cited by 186 · see citing works

MMP Mediated Degradation of Type IV Collagen Alpha 1 and Alpha 3 Chains Reflects Basement Membrane Remodeling in Experimental and Clinical Fibrosis – Validation of Two Novel Biomarker Assays

Sand, J. M. B., Larsen, L., Hogaboam, C. M., Martínez, F. J., Han, M. K., Larsen, M. R., Nawrocki, A., Zheng, Q., Karsdal, M. A., & Leeming, D. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084934 · Cited by 185 · see citing works

The PEA3 Subfamily of Ets Transcription Factors Synergizes with β-Catenin–LEF-1 To Activate Matrilysin Transcription in Intestinal Tumors

Crawford, H. C., Fingleton, B., Gustavson, M. D., Kurpios, N. A., Wagenaar-Miller, R. A., Hassell, J. A., & Matrisian, L. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1370-1383.2001 · Cited by 175 · see citing works

Anti-Vascular Endothelial Growth Factor Gene Therapy Attenuates Lung Injury and Fibrosis in Mice

Hamada, N., Kuwano, K., Yamada, M., Hagimoto, N., Hiasa, K., Egashira, K., Nakashima, N., Maeyama, T., Yoshimi, M., & Nakanishi, Y. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.2.1224 · Cited by 170 · see citing works

Epilysin (MMP-28) induces TGF-β mediated epithelial to mesenchymal transition in lung carcinoma cells

Illman, S. A., Lehti, K., Keski‐Oja, J., & Lohi, J. (2006) · Journal of Cell Science · doi:10.1242/jcs.03157 · Cited by 168 · see citing works

Syndecan-2 Mediates Adhesion and Proliferation of Colon Carcinoma Cells

Park, H., Kim, Y., Lim, Y., Han, I., & Oh, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202435200 · Cited by 165 · see citing works

Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF

Henry, M. T., McMahon, K., Mackarel, A. J., Prikk, K., Sorsa, T. A., Maisi, P., Sepper, R., FitzGerald, M. X., & O'CONNOR, C. M. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00022302 · Cited by 163 · see citing works

Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases and Attenuates IL-13–Dependent Fibrosis

Madala, S. K., Pesce, J. T., Ramalingam, T. R., Wilson, M. S., Minnicozzi, S. C., Cheever, A. W., Thompson, R. W., Mentink‐Kane, M. M., & Wynn, T. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903008 · Cited by 162 · see citing works

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

Hirata, M., Kugimiya, F., Fukai, A., Saito, T., Yano, F., Ikeda, T., Mabuchi, A., Sapkota, B. R., Akune, T., Nishida, N., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr540 · Cited by 159 · see citing works

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

Sela-Passwell, N., Kikkeri, R. V., Dym, O., Rozenberg, H., Margalit, R., Arad‐Yellin, R., Eisenstein, M., Brenner, O. J., Shoham, T., Danon, T., et al. (2011) · Nature Medicine · doi:10.1038/nm.2582 · Cited by 158 · see citing works

Human Macrophage Metalloelastase. GENOMIC ORGANIZATION, CHROMOSOMAL LOCATION, GENE LINKAGE, AND TISSUE-SPECIFIC EXPRESSION

Belaaouaj, A., Shipley, J. M., Kobayashi, D. K., Zimonjic, D. B., Popescu, N. C., Silverman, G. A., & Shapiro, S. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14568 · Cited by 157 · see citing works

Metalloproteinases in idiopathic pulmonary fibrosis

Dancer, R. C. A., Wood, A. M., & THICKETT, D. R. (2011) · European Respiratory Journal · doi:10.1183/09031936.00024711 · Cited by 157 · see citing works

Chondrocyte matrix metalloproteinase-8: up-regulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints.

Chubinskaya, S., Huch, K. M., Mikecz, K., Cs‐Szabó, G., Hasty, K. A., Kuettner, K. E., & Cole, A. A. (1996) · PubMed · Cited by 150 · see citing works

Prostaglandin E ₂ induces fibroblast apoptosis by modulating multiple survival pathways

Huang, S. K., White, E. S., Wettlaufer, S. H., Grifka, H., Hogaboam, C. M., Thannickal, V. J., Horowitz, J. C., & Peters-Golden, M. (2009) · The FASEB Journal · doi:10.1096/fj.08-128801 · Cited by 147 · see citing works

Biochemical Characterization of the Catalytic Domain of Human Matrix Metalloproteinase 19

Stracke, J. O., Hutton, M., Stewart, M., Pendás, A. M., Smith, B., López-Otı́n, C., Murphy, G., & Knäuper, V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.14809 · Cited by 146 · see citing works

Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat

Corbel, M., Caulet-Maugendre, S., Germain, N., Molet, S., Lagente, V., & Boichot, E. (2001) · The Journal of Pathology · doi:10.1002/path.826 · Cited by 145 · see citing works

Essential Role of MMP-12 in Fas-Induced Lung Fibrosis

Matute‐Bello, G., Wurfel, M. M., Lee, J. S., Park, D. R., Frevert, C. W., Madtes, D. K., Shapiro, S. D., & Martin, T. R. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0471oc · Cited by 144 · see citing works

Induction of pulmonary fibrosis by cerium oxide nanoparticles

Ma, J. Y., Mercer, R. R., Barger, M., Schwegler-Berry, D., Scabilloni, J., Ma, J. K., & Castranova, V. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.05.005 · Cited by 142 · see citing works

Collagen Binding Properties of the Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Hemopexin C Domain

Tam, E. M., Wu, Y., Butler, G. S., Stack, M. S., & Overall, C. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206874200 · Cited by 141 · see citing works

Human decidua and invasive trophoblasts are rich sources of nearly all human matrix metalloproteinases

Anacker, J., Segerer, S. E., Hagemann, C., Feix, S., Kapp, M., Bausch, R., & Kämmerer, U. (2011) · Molecular Human Reproduction · doi:10.1093/molehr/gar033 · Cited by 139 · see citing works

Control of extracellular matrix assembly by syndecan-2 proteoglycan

Klass, C. M., Couchman, J., & Woods, A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.3.493 · Cited by 137 · see citing works

ENA-78 Is an Important Angiogenic Factor in Idiopathic Pulmonary Fibrosis

Keane, M. P., Belperio, J. A., Burdick, M. D., Lynch, J. P., Fishbein, M. C., & Strieter, R. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.12.2104106 · Cited by 136 · see citing works

Upregulation of MMPs by soluble E‐cadherin in human lung tumor cells

Nawrocki‐Raby, B., Gilles, C., Polette, M., Bruyneel, E. A., Laronze, J., Bonnet, N., Foidart, J., Mareel, M. M. K., & Birembaut, P. L. (2003) · International Journal of Cancer · doi:10.1002/ijc.11168 · Cited by 134 · see citing works

Overexpression of Alveolar Macrophage Gelatinase B (MMP-9) in Patients with Idiopathic Pulmonary Fibrosis: Effects of Steroid and Immunosuppressive Treatment

Lemjabbar, H., Gosset, P., Lechapt, E., Franco‐Montoya, M., Wallaert, B., HARF, A., & Lafuma, C. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.5.3260 · Cited by 133 · see citing works

Predisposition for Disrepair in the Aged Lung

Sueblinvong, V., Neujahr, D. C., Mills, S. T., Roser‐Page, S., Guidot, D. M., Rojas, M. M., Ritzenthaler, J. D., & Roman, J. (2011) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318234c132 · Cited by 131 · see citing works

The First Stage of Transforming Growth Factor β1 Activation is Release of the Large Latent Complex from the Extracellular Matrix of Growth Plate Chondrocytes by Matrix Vesicle Stromelysin-1 (MMP-3)

Maeda, S., Dean, D. D., Gómez, R., Schwartz, Z., & Boyan, B. D. (2002) · Calcified Tissue International · doi:10.1007/s002230010032 · Cited by 131 · see citing works

Prostaglandin E2 Inhibits Fibroblast Migration by E-Prostanoid 2 Receptor–Mediated Increase in PTEN Activity

White, E. S., Atrasz, R. G., Dickie, E. G., Aronoff, D. M., Stambolic, V., Mak, T. W., Moore, B. B., & Peters-Golden, M. L. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0126oc · Cited by 131 · see citing works

Expression of Matrix Metalloproteases by Fibrocytes: Possible Role in Migration and Homing

de Alba, C. G., Becerril, C., Ruiz, V., González, Y., Reyes, S., García, J. A., Selman, M., & Pardo, A. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0028oc · Cited by 129 · see citing works

MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis

Gharib, S. A., Johnston, L. K., Huizar, I., Birkland, T. P., Hanson, J. F., Wang, Y., Parks, W. C., & Manicone, A. M. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1112587 · Cited by 129 · see citing works

Overexpression of MMP9 in macrophages attenuates pulmonary fibrosis induced by bleomycin

Cabrera, S., Gaxiola, M., Arreola, J. L., Ramı́rez, R., Jara, P., D'Armiento, J. M., Richards, T. J., Selman, M., & Pardo, A. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.06.022 · Cited by 128 · see citing works

Syndecan-2 Regulates Transforming Growth Factor-β Signaling

Chen, L., Klass, C. M., & Woods, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300430200 · Cited by 122 · see citing works

Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage

Manetti, M., Guiducci, S., Romano, E., Bellando-Randone, S., Conforti, M. L., Ibba‐Manneschi, L., & Matucci‐Cerinic, M. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200837 · Cited by 122 · see citing works

Blockade of the Wnt/.BETA.-Catenin Pathway Attenuates Bleomycin-Induced Pulmonary Fibrosis

Kim, T., Kim, S., Seo, J.-Y., Chung, H., Kwak, H. J., Lee, S., Yoon, H. J., Shin, D. H., Park, S. S., & Sohn, J. W. (2011) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.223.45 · Cited by 122 · see citing works

Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis

Akhavani, M., Madden, L., Buysschaert, I., Sivakumar, B., Kang, N., & Paleolog, E. M. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2689 · Cited by 122 · see citing works

Mechanical Strain Induces Collagenase-3 (MMP-13) Expression in MC3T3-E1 Osteoblastic Cells

Yang, C., Chien, C., Yao, C. J., Hsiao, L., Huang, Y., & Wu, C. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401343200 · Cited by 121 · see citing works

31 control of extracellular matrix assembly by syndecan-2 proteoglycan

Couchman, Klass, & Woods, A. (1999) · PubMed · Cited by 119 · see citing works

Notch Induces Myofibroblast Differentiation of Alveolar Epithelial Cells via Transforming Growth Factor- -Smad3 Pathway

Aoyagi, K., Maeno, T., Matsui, H., Ueno, M., Hara, K., Aoki, Y., Aoki, F., Shimizu, T., Doi, H., Kawai‐Kowase, K., et al. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0140oc · Cited by 118 · see citing works

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase‐2 in idiopathic pulmonary fibrosis

Coward, W. R., Feghali‐Bostwick, C. A., Jenkins, G. R., Knox, A. J., & Pang, L. (2014) · The FASEB Journal · doi:10.1096/fj.13-241760 · Cited by 118 · see citing works

Unbalanced collagenases/TIMP-1 expression and epithelial apoptosis in experimental lung fibrosis

Ruiz, V., Ordóñez‐Razo, R. M., Berumen-Campos, J., Ramı́rez, R., Uhal, B. D., Becerril, C., Pardo, A., & Selman, M. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00183.2003 · Cited by 118 · see citing works

Matrix Metalloproteinases Promote Inflammation and Fibrosis in Asbestos-Induced Lung Injury in Mice

Tan, R. J., Fattman, C. L., Niehouse, L. M., Tobolewski, J. M., Hanford, L. E., Li, Q., Monzon, F. A., Parks, W. C., & Oury, T. D. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0471oc · Cited by 117 · see citing works

Peripheral blood biomarkers in idiopathic pulmonary fibrosis

Vij, R., & Noth, I. (2012) · Translational research · doi:10.1016/j.trsl.2012.01.012 · Cited by 117 · see citing works

Fragmentation of human polymorphonuclear-leucocyte collagenase

Knäuper, V., Osthues, A., DeClerck, Y. A., Langley, K. E., Bläser, J., & Tschesche, H. (1993) · Biochemical Journal · doi:10.1042/bj2910847 · Cited by 117 · see citing works

Tissue Inhibitor of Metalloproteinase-1 Deficiency Amplifies Acute Lung Injury in Bleomycin-Exposed Mice

Kim, K. H., Burkhart, K. M., Chen, P., Frevert, C. W., Randolph‐Habecker, J., Hackman, R. C., Soloway, P. D., & Madtes, D. K. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0111oc · Cited by 115 · see citing works

Matrix Metalloproteinase-19 Is a Key Regulator of Lung Fibrosis in Mice and Humans

Yu, G., Kovkarova-Naumovski, E., Jara, P., Parwani, A. V., Kass, D. J., Ruiz, V., López-Otı́n, C., Rosas, I. O., Gibson, K. F., Cabrera, S., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201202-0302oc · Cited by 115 · see citing works

Inducible Expression of Tissue Inhibitor of Metalloproteinases–Resistant Matrix Metalloproteinase-9 on the Cell Surface of Neutrophils

Owen, C. A., Hu, Z., Barrick, B., & Shapiro, S. D. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0034oc · Cited by 114 · see citing works

Wnt Coreceptor Lrp5 is a Driver of Idiopathic Pulmonary Fibrosis

Lam, A. P., Herazo‐Maya, J. D., Sennello, J. A., Flozak, A. S., Russell, S., Mutlu, G. M., Budinger, G. R. S., DasGupta, R., Varga, J., Kaminski, N., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201401-0079oc · Cited by 112 · see citing works

Pivotal Role of Matrix Metalloproteinase 13 in Extracellular Matrix Turnover in Idiopathic Pulmonary Fibrosis

Nkyimbeng, T., Ruppert, C., Shiomi, T., Dahal, B. K., Láng, G., Seeger, W., Okada, Y., D'Armiento, J. M., & Günther, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073279 · Cited by 111 · see citing works

Matrix Metalloproteinase (MMP)-1 Induces Lung Alveolar Epithelial Cell Migration and Proliferation, Protects from Apoptosis, and Represses Mitochondrial Oxygen Consumption

Herrera, I., Cisneros, J., Maldonado, M., Ramı́rez, R., Ortíz-Quintero, B., Ansó, E., Chandel, N. S., Selman, M., & Pardo, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.459784 · Cited by 109 · see citing works

Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10

García-Prieto, E., González-López, A., Cabrera, S., Astudillo, A., Gutiérrez‐Fernández, A., Fanjul‐Fernández, M., Batalla-Solís, E., Puente, X. S., Fueyo, A., López-Otı́n, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013242 · Cited by 108 · see citing works

Repression of IP-10 by Interactions between Histone Deacetylation and Hypermethylation in Idiopathic Pulmonary Fibrosis

Coward, W. R., Watts, K., Feghali‐Bostwick, C. A., Jenkins, G. R., & Pang, L. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01527-09 · Cited by 103 · see citing works

MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages

Rohani, M. G., McMahan, R. S., Razumova, M. V., Hertz, A. L., Cieslewicz, M., Pun, S. H., Regnier, M., Wang, Y., Birkland, T. P., & Parks, W. C. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.167 · Cited by 101 · see citing works

Approaching the degradome in idiopathic pulmonary fibrosis

Pardo, A., Selman, M., & Kaminski, N. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.11.020 · Cited by 100 · see citing works

Rac1-mediated Mitochondrial H2O2 Generation Regulates MMP-9 Gene Expression in Macrophages via Inhibition of SP-1 and AP-1

Murthy, S., Ryan, A. J., He, C., Mallampalli, R. K., & Carter, A. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.099655 · Cited by 99 · see citing works

Macrophage Migration and Invasion Is Regulated by MMP10 Expression

Murray, M. Y., Birkland, T. P., Howe, J. D., Rowan, A. D., Fidock, M. D., Parks, W. C., & Gavrilović, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063555 · Cited by 98 · see citing works

Epigenetic Repression of Matrix Metalloproteinases in Myofibroblastic Hepatic Stellate Cells through Histone Deacetylases 4

Lan, Q., & Han, Y. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100011 · Cited by 94 · see citing works

Hypermethylation-mediated silencing of p14ARF in fibroblasts from idiopathic pulmonary fibrosis

Cisneros, J., Hagood, J. S., Checa, M., Ortíz-Quintero, B., Negreros, M., Herrera, I., Ramos, C., Pardo, A., & Selman, M. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00332.2011 · Cited by 93 · see citing works

Degradation of Type IV Collagen by Matrix Metalloproteinases Is an Important Step in the Epithelial-Mesenchymal Transformation of the Endocardial Cushions

Song, W., Jackson, K., & McGuire, P. G. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9919 · Cited by 91 · see citing works

Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation

Folgueras, A. R., Valdés‐Sánchez, T., Llano, E., Menéndez, L., Baamonde, A., Denlinger, B. L., Belmonte, C., Juárez, L. L., Lastra, A., García‐Suárez, O., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908507106 · Cited by 91 · see citing works

Profibrotic Activities for Matrix Metalloproteinase-8 during Bleomycin-Mediated Lung Injury

Craig, V. J., Quintero, P. A., Fyfe, S. E., Patel, A. S., Knolle, M. D., Kobzik, L., & Owen, C. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201043 · Cited by 91 · see citing works

Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers

Kerkelä, E., Ala‐aho, R., Jeskanen, L., Lohi, J. J., Grenman, R. A., Kähäri, V., & Saarialho‐Kere, U. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1634 · Cited by 90 · see citing works

Mice with Tissue Inhibitor of Metalloproteinases 4 (Timp4) Deletion Succumb to Induced Myocardial Infarction but Not to Cardiac Pressure Overload

Koskivirta, I., Kassiri, Z., Rahkonen, O. P., Kiviranta, R., Oudit, G. Y., McKee, T. D., Kytö, V., Saraste, A., Jokinen, E., Liu, P. P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.136820 · Cited by 90 · see citing works

MATRIX METALLOPROTEINASE-2 IS ELEVATED IN THE PLASMA OF WOMEN WITH PREECLAMPSIA

Narumiya, H., Zhang, Y., Fernández-Patrón, C., Guilbert, L. J., & Davidge, S. T. (2001) · Hypertension in Pregnancy · doi:10.1081/prg-100106968 · Cited by 89 · see citing works

Production and Activation of Matrix Metalloproteinase 7 (Matrilysin 1) in the Lungs of Patients With Idiopathic Pulmonary Fibrosis

Fujishima, S., Shiomi, T., Yamashita, S., Yogo, Y., Nakano, Y., Inoue, T., Nakamura, M., Tasaka, S., Hasegawa, N., Aikawa, N., et al. (2010) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2009-0144-oa.1 · Cited by 88 · see citing works

Membrane‐type 1 matrix metalloproteinase is required for normal alveolar development

Atkinson, J. J., Holmbeck, K., Yamada, S. S., Birkedal‐Hansen, H., Parks, W. C., & Senior, R. M. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20267 · Cited by 85 · see citing works

Induction and Regulation of Matrix Metalloproteinase-12 by Cytokines and CD40 Signaling in Monocyte/Macrophages

Wu, L., Fan, J., Matsumoto, S., & Watanabe, T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2368 · Cited by 85 · see citing works

Proteinase-activated Receptor-1 Regulation of Macrophage Elastase (MMP-12) Secretion by Serine Proteinases

Raza, S. L., Nehring, L. C., Shapiro, S. D., & Cornelius, L. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005788200 · Cited by 85 · see citing works

Leukocyte cell surface proteinases: Regulation of expression, functions, and mechanisms of surface localization

Owen, C. A. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.01.020 · Cited by 84 · see citing works

Synergistic cooperation between the AP‐1 and LEF‐1 transcription factors in the activation of the matrilysin promoter by the src oncogene: implications in cellular invasion

Rivat, C., Floch, N. L., Sabbah, M., Teyrol, I., Redeuilh, G., Bruyneel, E. A., Mareel, M., Matrisian, L. M., Crawford, H. C., Gespach, C. P., et al. (2003) · The FASEB Journal · doi:10.1096/fj.03-0132fje · Cited by 81 · see citing works

MMP-1 polymorphisms and the risk of idiopathic pulmonary fibrosis

Checa, M., Ruiz, V., Montaño, M., Velázquez‐Cruz, R., Selman, M., & Pardo, A. (2008) · Human Genetics · doi:10.1007/s00439-008-0571-z · Cited by 80 · see citing works

Matrilysin (Matrix Metalloproteinase-7) Regulates Anti-Inflammatory and Antifibrotic Pulmonary Dendritic Cells That Express CD103 (αEβ7-Integrin)

Manicone, A. M., Huizar, I., & McGuire, J. K. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090101 · Cited by 79 · see citing works

Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis and hypersensitivity pneumonitis

Wim, A., Willems, S., Verleden, S. E., Vanaudenaerde, B. M., Wynants, M., Christophe, D., Jonas, Y., Jana, S., Eric, K., & Verleden, G. M. (2013) · Annals of Thoracic Medicine · doi:10.4103/1817-1737.105718 · Cited by 78 · see citing works

Individual Matrix Metalloproteinases Control Distinct Transcriptional Responses in Airway Epithelial Cells Infected with Pseudomonas aeruginosa

Kassim, S. Y., Gharib, S. A., Mecham, B. H., Birkland, T. P., Parks, W. C., & McGuire, J. K. (2007) · Infection and Immunity · doi:10.1128/iai.00799-07 · Cited by 75 · see citing works

Repression of 92-kDa Type IV Collagenase Expression by MTA1 Is Mediated through Direct Interactions with the Promoter via a Mechanism, Which Is Both Dependent on and Independent of Histone Deacetylation

Yan, C., Wang, H., Toh, Y., & Boyd, D. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210369200 · Cited by 67 · see citing works

Matrix Metalloproteinase-19 Expression in Dermal Wounds and by Fibroblasts in Culture

Hieta, N. K., Impola, U., López-Otı́n, C., Saarialho‐Kere, U., & Kähäri, V. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12533.x · Cited by 66 · see citing works

Structure and Promoter Characterization of the Human Stromelysin-3 Gene

Anglard, P., Melot, T., Guérin, É., Thomas, G. D., & Basset, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20337 · Cited by 66 · see citing works

MMP19 Is Essential for T Cell Development and T Cell-Mediated Cutaneous Immune Responses

Beck, I. M., Rückert, R., Brandt, K., Mueller, M. S., Sadowski, T., Brauer, R., Schirmacher, P., Mentlein, R., & Sedlacek, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002343 · Cited by 63 · see citing works

Synergistic Effect of Thrombin and CD40 Ligand on Endothelial Matrix Metalloproteinase-10 Expression and Microparticle Generation In Vitro and In Vivo

de Lizarrondo, S. M., Roncal, C., Calvayrac, O., Rodrı́guez, C., Varo, N., Purroy, A., Lorente, L., Rodríguez, J. A., Doeuvre, L., Hervás‐Stubbs, S., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.248773 · Cited by 63 · see citing works

Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis

Richter, A. G., McKeown, S., Rathinam, S., Harper, L., Rajesh, P. B., McAuley, D. F., Heljäsvaara, R., & THICKETT, D. R. (2008) · Thorax · doi:10.1136/thx.2008.102814 · Cited by 62 · see citing works

Matrix Metalloproteinase-19 Is Expressed in Myeloid Cells in an Adhesion-Dependent Manner and Associates with the Cell Surface

Mauch, S., Kolb, C., Kolb, B., Sadowski, T., & Sedlacek, R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1244 · Cited by 59 · see citing works

Accelerated Neointima Formation After Vascular Injury in Mice With Stromelysin-3 (MMP-11) Gene Inactivation

LIJNEN, H. R., HOEF, B. V., Vanlinthout, I., Verstreken, M., Rio, M., & Collen, D. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.12.2863 · Cited by 56 · see citing works

Mononuclear Phagocytes and Airway Epithelial Cells: Novel Sources of Matrix Metalloproteinase-8 (MMP-8) in Patients with Idiopathic Pulmonary Fibrosis

Craig, V. J., Polverino, F., Laucho-Contreras, M. E., Shi, Y., Liu, Y., Osorio, J. C., Tesfaigzi, Y., Pinto-Plata, V., Gochuico, B. R., Rosas, I. O., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097485 · Cited by 56 · see citing works

Loss of Matrix Metalloproteinase-13 Attenuates Murine Radiation-Induced Pulmonary Fibrosis

Flechsig, P., Hartenstein, B., Teurich, S., Dadrich, M., Hauser, K., Abdollahi, A., Gröne, H., Angel, P. E., & Huber, P. E. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.12.043 · Cited by 55 · see citing works

Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells

Seomun, Y., Jeong-a, K. I. M., Lee, E. H., & Joo, C. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580041 · Cited by 55 · see citing works

Acidic Fibroblast Growth Factor Induces an Antifibrogenic Phenotype in Human Lung Fibroblasts

Becerril, C., Pardo, A., Montaño, M., Ramos, C., Ramı́rez, R., & Selman, M. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.5.3288 · Cited by 55 · see citing works

Matrix Metalloproteinase Mmp-1a Is Dispensable for Normal Growth and Fertility in Mice and Promotes Lung Cancer Progression by Modulating Inflammatory Responses

Fanjul‐Fernández, M., Folgueras, A. R., Fueyo, A., Balbı́n, M., Suárez, M. F., Fernández-García, M. S., Shapiro, S. D., Freije, J. M. P., & López-Otı́n, C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.439893 · Cited by 52 · see citing works

Macrophage metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice

Manoury, B., Nénan, S., Guénon, I., Boichot, E., Planquois, J., Bertrand, C., & Lagente, V. (2006) · Journal of Inflammation · doi:10.1186/1476-9255-3-2 · Cited by 51 · see citing works

Vanadium Stimulates Human Bronchial Epithelial Cells to Produce Heparin-Binding Epidermal Growth Factor–Like Growth Factor: A Mitogen for Lung Fibroblasts

Zhang, L., Rice, A. B., Adler, K. B., Sannes, P. L., Martin, L. D., Gladwell, W., Koo, J.-S., Gray, T. E., & Bonner, J. C. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.2.4096 · Cited by 51 · see citing works

The mouse matrix metalloproteinase, epilysin (MMP-28), is alternatively spliced and processed by a furin-like proprotein convertase

Illman, S. A., Keski‐Oja, J., Parks, W. C., & Lohi, J. (2003) · Biochemical Journal · doi:10.1042/bj20030497 · Cited by 49 · see citing works

MT1-MMP–Dependent Remodeling of Cardiac Extracellular Matrix Structure and Function Following Myocardial Infarction

Koenig, G. C., Rowe, R. G., Day, S. M., Sabeh, F., Atkinson, J. J., Cooke, K. R., & Weiss, S. J. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.01.022 · Cited by 49 · see citing works

Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis

Richards, T. J., Park, C., Chen, Y., Gibson, K. F., Di, Y. P., Pardo, A., Watkins, S. C., Choi, A. M. K., Selman, M., Pilewski, J. M., et al. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00319.2011 · Cited by 48 · see citing works

Promoter characterization of the human and mouse epilysin (MMP-28) genes

Illman, S. A., Keski‐Oja, J., & Lohi, J. (2001) · Gene · doi:10.1016/s0378-1119(01)00664-3 · Cited by 48 · see citing works

The Fibronectin-like Domain Is Required for the Type V and XI Collagenolytic Activity of Gelatinase B

O’Farrell, T. J., & Pourmotabbed, T. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0662 · Cited by 48 · see citing works

Matrix Metalloproteinase–7 Coordinates Airway Epithelial Injury Response and Differentiation of Ciliated Cells

Gharib, S. A., Altemeier, W. A., Winkle, L. S. V., Plopper, C. G., Schlesinger, S. Y., Buell, C. A., Brauer, R., Lee, V. S., Parks, W. C., & Chen, P. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0083oc · Cited by 47 · see citing works

A Residue in the S2 Subsite Controls Substrate Selectivity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9

Chen, E. I., Li, W., Godzik, A., Howard, E. W., & Smith, J. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210324200 · Cited by 47 · see citing works

Cell Proliferation during the Process of Bleomycin‐induced Pulmonary Fibrosis in Rats

Kawamoto, M., & Fukuda, Y. (1990) · Acta Pathologica Japonica · doi:10.1111/j.1440-1827.1990.tb01556.x · Cited by 47 · see citing works

WNT7B in fibroblastic foci of idiopathic pulmonary fibrosis

Meuten, T., Hickey, A., Franklin, K., Grossi, B., Tobias, J. R., Newman, D. R., Jennings, S. H., Correa, M. T., & Sannes, P. L. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-62 · Cited by 45 · see citing works

Membrane type-matrix metalloproteinases in idiopathic pulmonary fibrosis.

García-Alvarez, J., Ramı́rez, R., Sampieri, C. L., Nuttall, R. K., Edwards, D. R., Selman, M., & Pardo, A. (2006) · PubMed · Cited by 44 · see citing works

Association of a Functional Polymorphism in the Matrix Metalloproteinase-12 Promoter Region with Systemic Sclerosis in an Italian Population

Manetti, M., Ibba‐Manneschi, L., Fatini, C., Guiducci, S., Cuomo, G., Bonino, C., Bazzichi, L. M., Liakouli, V., Giacomelli, R., Abbate, R., et al. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.100237 · Cited by 44 · see citing works

Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices

Ruiz, P. A., & Járai, G. (2012) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-5-3 · Cited by 44 · see citing works

Transcriptional up‐regulation of MMPs 12 and 13 by asbestos occurs via a PKCδ‐dependent pathway in murine lung

Shukla, A., Barrett, T. F., Nakayama, K., Nakayama, K., Mossman, B. T., Lounsbury, K. M., Shukla, A., Barrett, T. F., Nakayama, K., Nakayama, K., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-4554fje · Cited by 43 · see citing works

Fra-1/AP-1 Transcription Factor Negatively Regulates Pulmonary Fibrosis In Vivo

Rajasekaran, S., Vaz, M. J., & Reddy, S. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041611 · Cited by 41 · see citing works

In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen‐Induced Arthritis

Lim, N. H., Meinjohanns, E., Bou–Gharios, G., Gompels, L. L., Nuti, E., Rossello, A., Devel, L., Dive, V., Meldal, M., & Nagase, H. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38295 · Cited by 40 · see citing works

Deficiency of matrix metalloproteinase-13 increases inflammation after acute lung injury

Sen, A. I., Shiomi, T., Okada, Y., & D'Armiento, J. M. (2010) · Experimental Lung Research · doi:10.3109/01902148.2010.497201 · Cited by 40 · see citing works

Syndecan-2 Is a Novel Target of Insulin-Like Growth Factor Binding Protein-3 and Is Over-Expressed in Fibrosis

Ruiz, X. D., Mlakar, L., Yamaguchi, Y., Su, Y., Larregina, A. T., Pilewski, J. M., & Feghali-Bostwick, C. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043049 · Cited by 39 · see citing works

Rearranging Exosites in Noncatalytic Domains Can Redirect the Substrate Specificity of ADAMTS Proteases

高维强, Zhu, J., Westfield, L. A., Tuley, E. A., Anderson, P. J., & Sadler, J. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.380535 · Cited by 39 · see citing works

Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers

Rowe, R. G., KEENA, D. T., Sabeh, F., Willis, A. L., & Weiss, S. J. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00187.2011 · Cited by 38 · see citing works

Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation

Chapoval, S. P., Lee, C. G., Tang, C., Keegan, A. D., Cohn, L. E., Bottomly, K., & Elias, J. A. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.05.016 · Cited by 36 · see citing works

SP-1 regulation of MMP-9 expression requires Ser586 in the PEST domain

Murthy, S., Ryan, A. J., & Carter, A. B. (2012) · Biochemical Journal · doi:10.1042/bj20120053 · Cited by 36 · see citing works

Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells

Seomun, Y., Kim, J., Lee, E. H., et al. (2001) · Biochemical Journal · doi:10.1042/bj3580041 · Cited by 36 · see citing works

Fibrosis: from mechanisms to medicines

Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works

Senescence and aging: Causes, consequences, and therapeutic avenues

McHugh, D., & Gil, J. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201708092 · Cited by 1,233 · see citing works

Inflammation and immunity in IPF pathogenesis and treatment

Heukels, P., Moor, C. C., von der Thüsen, J. H., Wijsenbeek, M. S., & Kool, M. (2019) · Respiratory Medicine · doi:10.1016/j.rmed.2018.12.015 · Cited by 527 · see citing works

The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396 · see citing works

Macrophage and Fibroblast Interactions in Biomaterial‐Mediated Fibrosis

Witherel, C. E., Abebayehu, D., Barker, T. H., & Spiller, K. L. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801451 · Cited by 374 · see citing works

Immune mechanisms in pulmonary fibrosis

Kolahian, S., Fernandez, I. E., Eickelberg, O., & Hartl, D. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0121tr · Cited by 349 · see citing works

Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics

Raeeszadeh‐Sarmazdeh, M., Do, L. D., & Hritz, B. (2020) · Cells · doi:10.3390/cells9051313 · Cited by 333 · see citing works

Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

Hewlett, J. C., Kropski, J. A., & Blackwell, T. S. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.021 · Cited by 327 · see citing works

Idiopathic Pulmonary Fibrosis and Lung Cancer: Mechanisms and Molecular Targets

Ballester, B., Milara, J., & Cortijo, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030593 · Cited by 308 · see citing works

Oxidative Stress in Pulmonary Fibrosis

Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190017 · Cited by 309 · see citing works

Biophysics of tumor microenvironment and cancer metastasis – a mini review

Emon, B., Bauer, J., Jain, Y., Jung, B., & Saif, T. (2018) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2018.07.003 · Cited by 245 · see citing works

The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis

Murtha, L. A., Schuliga, M. J., Mabotuwana, N. S., Hardy, S. A., Waters, D. W., Burgess, J. K., Knight, D. A., & Boyle, A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00777 · Cited by 227 · see citing works

WNT Signaling in Disease

Li, N., Kaur, P., Bunnag, N., Suresh, J., Sung, I. C. H., Tan, Q. H., Gruber, J., & Tolwinski, N. S. (2019) · Cells · doi:10.3390/cells8080826 · Cited by 219 · see citing works

COVID-19 and pulmonary fibrosis: a potential role for lung epithelial cells and fibroblasts

John, A. E., Joseph, C., Jenkins, G., & Tatler, A. L. (2021) · Immunological Reviews · doi:10.1111/imr.12977 · Cited by 219 · see citing works

Host–Microbial Interactions in Idiopathic Pulmonary Fibrosis

Molyneaux, P. L., Willis‐Owen, S. A. G., Cox, M. J., James, P. L., Cowman, S. A., Loebinger, M. R., Blanchard, A. D., Edwards, L. M., Stock, C. J. W., Daccord, C., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201607-1408oc · Cited by 213 · see citing works

Neutrophils: a cornerstone of liver ischemia and reperfusion injury

de Oliveira, T. H. C., Marques, P. E., Proost, P., & Teixeira, M. M. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.90 · Cited by 211 · see citing works

Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

Walraven, M., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.020 · Cited by 194 · see citing works

Regeneration or Repair? The Role of Alveolar Epithelial Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF)

Confalonieri, P., Volpe, M. C., Jacob, J., Maiocchi, S., Salton, F., Ruaro, B., Confalonieri, M., & Braga, L. (2022) · Cells · doi:10.3390/cells11132095 · Cited by 175 · see citing works

Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition

Scott, L. E., Weinberg, S. H., & Lemmon, C. A. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00135 · Cited by 156 · see citing works

Traditional Chinese medicine for pulmonary fibrosis therapy: Progress and future prospects

Li, L., & Kan, L. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.12.042 · Cited by 148 · see citing works

Matrix Metalloproteinases in Emphysema

Gharib, S., Manicone, A., & Parks, W. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.018 · Cited by 125 · see citing works

Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis

Kokubo, K., Onodera, A., Kiuchi, M., Tsuji, K., Hirahara, K., & Nakayama, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945063 · Cited by 130 · see citing works

Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis

Shi, T., Denney, L., An, H., Ho, L., & Zheng, Y. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru0720-418r · Cited by 134 · see citing works

Biomarkers in idiopathic pulmonary fibrosis

Drakopanagiotakis, F., Wujak, L., Wygrecka, M., & Markart, P. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.023 · Cited by 132 · see citing works

Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis

Mahalanobish, S., Saha, S., Dutta, S., & Sil, P. C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104591 · Cited by 125 · see citing works

Collagen Biosynthesis, Processing, and Maturation in Lung Ageing

Onursal, C., Dick, E., Angelidis, I., Schiller, H. B., & Staab-Weijnitz, C. A. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.593874 · Cited by 122 · see citing works

Immune Mechanisms of Pulmonary Fibrosis with Bleomycin

Ishida, Y., Kuninaka, Y., Mukaida, N., & Kondo, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043149 · Cited by 123 · see citing works

Reviewing the Regulators of COL1A1

Devos, H., Zoidakis, J., Roubelakis, M. G., Latosinska, A., & Vlahou, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210004 · Cited by 119 · see citing works

Matrix Metalloproteinases and Their Inhibitors in Pulmonary Fibrosis: EMMPRIN/CD147 Comes into Play

Chuliá‐Peris, L., Carreres-Rey, C., Gabasa, M., Alcaraz, J., Carretero, J., & Pereda, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136894 · Cited by 121 · see citing works

Macrophages in lung fibrosis

Ogawa, T., Shichino, S., Ueha, S., & Matsushima, K. (2021) · International Immunology · doi:10.1093/intimm/dxab040 · Cited by 108 · see citing works

The Role of Fibrosis in Osteoarthritis Progression

Rim, Y. A., & Ju, J. H. (2020) · Life · doi:10.3390/life11010003 · Cited by 113 · see citing works

Proteomic biomarkers of progressive fibrosing interstitial lung disease: a multicentre cohort analysis

Bowman, W. S., Newton, C. A., Linderholm, A., Neely, M. L., Pugashetti, J. V., Kaul, B., Vo, V., Echt, G., Leon, W., Shah, R., et al. (2022) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00503-8 · Cited by 111 · see citing works

Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics

Ouyang, Z., Dong, L., Feng, Y., Wang, K., Chen, Y., Li, S., Zhou, R., Zhao, Y., & Hu, W. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129841 · Cited by 111 · see citing works

Interplay of Extracellular Matrix and Leukocytes in Lung Inflammation

Wight, T., Frevert, C., Debley, J., Reeves, S. R., Parks, W., & Ziegler, S. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.12.003 · Cited by 106 · see citing works

Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort

on behalf of the IPF-PRO Registry investigators, Todd, J. L., Vinisko, R., Liu, Y., Neely, M. L., Overton, R. A., Flaherty, K. R., Noth, I., Newby, L. K., Lasky, J. A., et al. (2020) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-1103-4 · Cited by 105 · see citing works

Silica particles disorganize the polarization of pulmonary macrophages in mice

Zhao, Y., Hao, C., Bao, L., Wang, D., Li, Y., Qu, Y., Ding, M., Zhao, A., & Yao, W. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110364 · Cited by 102 · see citing works

Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis

Xie, N., Cui, H., Ge, J., Banerjee, S., Guo, S., Dubey, S., Abraham, E. H., Liu, R.-M., & Liu, G. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00235.2017 · Cited by 99 · see citing works

Is the Macrophage Phenotype Determinant for Fibrosis Development?

Lis-López, L., Bauset, C., Seco-Cervera, M., & Cosín‐Roger, J. (2021) · Biomedicines · doi:10.3390/biomedicines9121747 · Cited by 97 · see citing works

Advances in pathogenic mechanisms and management of radiation-induced fibrosis

Wang, B., Wei, J., Meng, L., Wang, H., Qu, C., Chen, X., Xin, Y., & Jiang, X. M. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109560 · Cited by 98 · see citing works

Ferulic Acid: A Review of Pharmacology, Toxicology, and Therapeutic Effects on Pulmonary Diseases

Zhai, Y., Wang, T., Fu, Y., Yu, T., Ding, Y. P., & Nie, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098011 · Cited by 96 · see citing works

Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD)

Laucho-Contreras, M. E., Polverino, F., Tesfaigzi, Y., Pilon, A. L., Celli, B. R., & Owen, C. A. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1139084 · Cited by 90 · see citing works

Matrix metalloproteinases: Expression, regulation and role in the immunopathology of tuberculosis

Sabir, N., Hussain, T. A., Mangi, M. H., Zhao, D., & Zhou, X. (2019) · Cell Proliferation · doi:10.1111/cpr.12649 · Cited by 100 · see citing works

Xuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6/STAT3 signaling pathway

Wang, Y., Sang, X., Shao, R., Qin, H., Chen, X., Xue, Z., Li, L., Wang, Y., Zhu, Y., Chang, Y., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114701 · Cited by 90 · see citing works

Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis

O’Dwyer, D. N., Ashley, S. L., & Moore, B. B. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00221.2016 · Cited by 89 · see citing works

microRNA let-7 Downregulates Ligand Independent Estrogen Receptor Mediated Male Predominant Pulmonary Fibrosis.

Elliot, S., Periera-Simon, S., Xia, X., Catanuto, P., Rubio, G., Shahzeidi, S., Salem, F. E., Shapiro, J., Briegel, K. J., Korach, K., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201903-0508oc · Cited by 74 · see citing works

Fighting the Fiber: Targeting Collagen in Lung Fibrosis

Staab-Weijnitz, C. A. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0342tr · Cited by 83 · see citing works

SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

Wu, M., Liu, F., Sun, J., Li, X., He, X.-Y., Zheng, H., Pei, R., Sun, H., Zhou, Y.-H., Yan, Q., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00849-0 · Cited by 83 · see citing works

Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes?

van Geffen, C., Deißler, A., Quante, M., Renz, H. E., Hartl, D., & Kolahian, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.663203 · Cited by 80 · see citing works

Promising Biomarkers of Radiation-Induced Lung Injury: A Review

Liu, X., Shao, C., & Fu, J. (2021) · Biomedicines · doi:10.3390/biomedicines9091181 · Cited by 74 · see citing works

Is there a role for IL-17 in the pathogenesis of systemic sclerosis?

Chizzolini, C., Dufour, A. M., & Brembilla, N. C. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.09.007 · Cited by 73 · see citing works

Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s)

Garbuzenko, O. B., Ivanova, V., Kholodovych, V., Reimer, D. C., Reuhl, K. R., Yurkow, E. J., Adler, D., & Minko, T. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.04.005 · Cited by 72 · see citing works

The impaired proteases and anti-proteases balance in Idiopathic Pulmonary Fibrosis

Menou, A., Duitman, J., & Crestani, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.001 · Cited by 72 · see citing works

Review: Serum biomarkers in idiopathic pulmonary fibrosis and systemic sclerosis associated interstitial lung disease – frontiers and horizons

Jee, A. S., Sahhar, J., Youssef, P. P., Bleasel, J. F., Adelstein, S., Nguyen, M., & Corte, T. J. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.014 · Cited by 71 · see citing works

Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2

Antar, S. A., Saleh, M. A., & Al-Karmalawy, A. A. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121048 · Cited by 70 · see citing works

Interferon-γ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation

Vu, T. N., Chen, X., Foda, H. D., Smaldone, G. C., & Hasaneen, N. A. (2019) · Respiratory Research · doi:10.1186/s12931-019-1171-2 · Cited by 71 · see citing works

Dynamic human liver proteome atlas reveals functional insights into disease pathways

Niu, L., Geyer, P. E., Gupta, R., Santos, A., Meier, F., Doll, S., Albrechtsen, N. J. W., Klein, S., Ortiz, C., Uschner, F. E., et al. (2022) · Molecular Systems Biology · doi:10.15252/msb.202210947 · Cited by 65 · see citing works

The fibrogenic actions of the coagulant and plasminogen activation systems in pulmonary fibrosis

Schuliga, M. J., Grainge, C., Westall, G. P., & Knight, D. A. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.02.016 · Cited by 69 · see citing works

The emerging roles of interstitial macrophages in pulmonary fibrosis: A perspective from scRNA-seq analyses

Gu, Y., Lawrence, T., Mohamed, R., Liang, Y., & Yahaya, B. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.923235 · Cited by 68 · see citing works

Macrophage-derived MMP12 promotes fibrosis through sustained damage to endothelial cells

Zhou, X., Zhang, C., Yang, S., Yang, L., Luo, W. F., Zhang, W., Zhang, X., & Chao, J. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132733 · Cited by 69 · see citing works

The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review

Zhou, B., Liu, H., Xu, F., & Jia, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01557-2 · Cited by 71 · see citing works

Oxidative Stress in Pulmonary Fibrosis

Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/j.2040-4603.2020.tb00120.x · Cited by 65 · see citing works

Current Concepts of Biliary Atresia and Matrix Metalloproteinase-7: A Review of Literature

Nomden, M., Beljaars, L., Verkade, H. J., Hulscher, J. B. F., & Olinga, P. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.617261 · Cited by 64 · see citing works

Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells

Smith, L. C., Moreno-Caceres, S., Robertson, L. T., Robinson, S., Gant, K. L., Bryant, A. J., & Sabo‐Attwood, T. (2018) · Respiratory Research · doi:10.1186/s12931-018-0861-5 · Cited by 63 · see citing works

Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis

Huang, K. Y., Mishra, K., Park, H., Yi, X., Ouyang, J. F., Petretto, E. G., & Behmoaras, J. V. (2023) · eLife · doi:10.7554/elife.85530 · Cited by 62 · see citing works

Role of ADAM and ADAMTS proteases in pathological tissue remodeling

Wang, Z.-N., Li, W., Chen, S., & Tang, X. X. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01744-z · Cited by 61 · see citing works

Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia

Aguh, C., Dina, Y., Talbot, C. C., & Garza, L. A. (2018) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.05.1257 · Cited by 60 · see citing works

Effects of β-Sitosterol from Corn Silk on TGF-β1-Induced Epithelial–Mesenchymal Transition in Lung Alveolar Epithelial Cells

Park, Y. J., Bang, I. J., Jeong, M. H., Kim, H. R., Lee, D. E., Kwak, J. H., & Chung, K. H. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02730 · Cited by 59 · see citing works

Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy

Zou, H., Shan, C., Ma, L., Liu, J., Yang, N., & Zhao, J. (2020) · PeerJ · doi:10.7717/peerj.10136 · Cited by 59 · see citing works

Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats

Gao, L., Tang, H., He, H., Liu, J., Mao, J., Ji, H. L., Lin, H., & Wu, T. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00215 · Cited by 59 · see citing works

Inhaled mRNA Nanoformulation with Biogenic Ribosomal Protein Reverses Established Pulmonary Fibrosis in a Bleomycin‐Induced Murine Model

Zhang, R., Jing, W., Chen, C., Zhang, S., Abdalla, M., Sun, P., Wang, G., You, W., Yang, Z., Zhang, J., et al. (2022) · Advanced Materials · doi:10.1002/adma.202107506 · Cited by 58 · see citing works

Cell Cross-Talk in Alveolar Microenvironment: From Lung Injury to Fibrosis

Song, L., Li, K., Chen, H., & Xie, L. (2024) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0426tr · Cited by 58 · see citing works

Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms

Malaviya, R., Kipen, H. M., Businaro, R., Laskin, J. D., & Laskin, D. L. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115272 · Cited by 57 · see citing works

Mechanosensitive Regulation of Fibrosis

Yang, S., & Plotnikov, S. V. (2021) · Cells · doi:10.3390/cells10050994 · Cited by 56 · see citing works

Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection

Rojas, J., Wang, X., Tipper, J. L., Burkett, P. R., Zúñiga, J., Ashtekar, A. R., Polverino, F., Rout, A., Yambayev, I., Hernández, C., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99022 · Cited by 57 · see citing works

Extracellular matrix remodeling in idiopathic pulmonary fibrosis. It is the ‘bed’ that counts and not ‘the sleepers’

Tomos, I. P., Tzouvelekis, A., Aidinis, V., Manali, E. D., Bouros, E., Bouros, D. E., & Papiris, S. A. (2017) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2017.1300533 · Cited by 51 · see citing works

Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome

Zinter, M. S., Delucchi, K., Kong, M. Y. F., Orwoll, B., Spicer, A. C., Lim, M., Alkhouli, M. F., Ratiu, A., McKenzie, A. V., McQuillen, P. S., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201804-0678oc · Cited by 53 · see citing works

Differential Responses to Targeting Matrix Metalloproteinase 9 in Idiopathic Pulmonary Fibrosis

Espíndola, M. S., Habiel, D. M., Coelho, A. L., Stripp, B. R., Parks, W. C., Oldham, J. M., Martínez, F. J., Noth, I., Lopez, D., Mikels, A. J., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201910-1977oc · Cited by 52 · see citing works

Toxicogenomics Data for Chemical Safety Assessment and Development of New Approach Methodologies: An Adverse Outcome Pathway‐Based Approach

Saarimäki, L. A., Morikka, J., Pavel, A., Korpilähde, S., del Giudice, G., Federico, A., Fratello, M., Serra, A., & Greco, D. (2022) · Advanced Science · doi:10.1002/advs.202203984 · Cited by 52 · see citing works

The Role of Immune Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis

Xu, Y., Lan, P., & Wang, T. (2023) · Medicina · doi:10.3390/medicina59111984 · Cited by 57 · see citing works

The current landscape of antifibrotic therapy across different organs: A systematic approach

Fuster‐Martínez, I., & Calatayud, S. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107245 · Cited by 52 · see citing works

Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-β/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo

Pulivendala, G., Bale, S., & Godugu, C. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.114913 · Cited by 52 · see citing works

Physiological Properties, Functions, and Trends in the Matrix Metalloproteinase Inhibitors in Inflammation-Mediated Human Diseases

Kim, I.-S., Yang, W., & Kim, C. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220823112731 · Cited by 53 · see citing works

AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway

Posso, S. V., Quesnot, N., Moraes, J. A., de Brito‐Gitirana, L., Kennedy-Feitosa, E., Barroso, M. V., Pôrto, L. C., Lanzetti, M., & Valença, S. S. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.01.045 · Cited by 51 · see citing works

Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity

Koo, H., Hong, Y., Lim, M.-N., Yim, J., & Kim, W. J. (2016) · International Journal of COPD · doi:10.2147/copd.s103281 · Cited by 50 · see citing works

Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma

Osei, E. T., Mostaço-Guidolin, L. B., Hsieh, A., Warner, S., Fouadi, M., Wang, M. X., Cole, D. J., Maksym, G. N., Hallstrand, T. S., Timens, W., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-65567-z · Cited by 50 · see citing works

Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells

Hao, Y. T., Bates, S., Mou, H., Yun, J. H., Pham, B., Liu, J., Qiu, W., Guo, F., Morrow, J. D., Hersh, C. P., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201910-1958oc · Cited by 49 · see citing works

Dynamic atlas of immune cells reveals multiple functional features of macrophages associated with progression of pulmonary fibrosis

Lv, J., Gao, H., Ma, J., Liu, J., Tian, Y., Yang, C., Li, M., Zhao, Y., Li, Z., Zhang, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1230266 · Cited by 48 · see citing works

LRP1: A chameleon receptor of lung inflammation and repair

Wujak, L. A., Schnieder, J., Schaefer, L., & Wygrecka, M. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.12.007 · Cited by 48 · see citing works

Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

Wang, Y., Chen, S., Bao, S., Li, Y., Wen, Z., Xu, L., Chen, X., Guo, S., Pang, H., Zhou, Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1338922 · Cited by 47 · see citing works

iTRAQ-Based Proteomics Reveals Novel Biomarkers for Idiopathic Pulmonary Fibrosis

Niu, R. L., Liu, Y., Zhang, Y., Zhang, Y., Wang, H., Wang, Y., Wang, W., & Li, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170741 · Cited by 47 · see citing works

Global Gene Expression Analysis in an in vitro Fibroblast Model of Idiopathic Pulmonary Fibrosis Reveals Potential Role for CXCL14/CXCR4

Rodríguez, L. R., Emblom-Callahan, M. C., Chhina, M. K., Bui, S., Aljeburry, B., Tran, L. H., Novak, R., Lemma, M., Nathan, S. D., & Grant, G. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-21889-7 · Cited by 47 · see citing works

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions

Garrett, S. M., Hsu, E., Thomas, J. M., Pilewski, J. M., & Feghali‐Bostwick, C. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225422 · Cited by 47 · see citing works

Identification of Key Candidate Genes Involved in the Progression of Idiopathic Pulmonary Fibrosis

Cui, Y. N., Ji, J., Hou, J., Tan, Y., & Han, X. (2021) · Molecules · doi:10.3390/molecules26041123 · Cited by 45 · see citing works

The Matrix Metalloproteinase‐13 Inhibitor Poricoic Acid ZI Ameliorates Renal Fibrosis by Mitigating Epithelial‐Mesenchymal Transition

Chen, L., Cao, G., Wang, M., Feng, Y., Chen, D., Vaziri, N. D., Zhuang, S., & Zhao, Y. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900132 · Cited by 45 · see citing works

Meprin β contributes to collagen deposition in lung fibrosis

Biasin, V., Wygrecka, M., Marsh, L. M., Becker‐Pauly, C., Brčić, L., Ghanim, B., Klepetko, W., Olschewski, A., & Kwapiszewska, G. (2017) · Scientific Reports · doi:10.1038/srep39969 · Cited by 44 · see citing works

Human apical-out nasal organoids reveal an essential role of matrix metalloproteinases in airway epithelial differentiation

Li, L., Jiao, L., Feng, D., Yuan, Y., Yang, X., Li, J., Jiang, D., Chen, H., Meng, Q., Chen, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44488-1 · Cited by 43 · see citing works

Involvement of Matrix Metalloproteinases in COVID-19: Molecular Targets, Mechanisms, and Insights for Therapeutic Interventions

Salomão, R., Assis, V., Neto, I. V. D. S., Petriz, B. A., Babault, N., Durigan, J. L. Q., & Marqueti, R. D. C. (2023) · Biology · doi:10.3390/biology12060843 · Cited by 42 · see citing works

Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages

Xiang, J., Cheng, S., Feng, T., Wu, Y. L., Xie, W., Zhang, M., Xu, X., & Zhang, C. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.04.016 · Cited by 42 · see citing works

Targeting oxidative stress, proinflammatory cytokines, apoptosis and toll like receptor 4 by empagliflozin to ameliorate bleomycin-induced lung fibrosis

Kabel, A. M., Estfanous, R. S., & Alrobaian, M. (2019) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2019.103316 · Cited by 42 · see citing works

PCSK6 and Survival in Idiopathic Pulmonary Fibrosis

Oldham, J. M., Allen, R. J., Lorenzo-Salazar, J. M., Molyneaux, P. L., Ma, S., Joseph, C., Kim, J. S., Guillén‐Guío, B., Hernández-Beeftink, T., Kropski, J. A., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202205-0845oc · Cited by 42 · see citing works

Role of matrix metalloproteinases in the pathophysiology of idiopathic pulmonary fibrosis

Bhattacharyya, P., Acharya, D., & Roychowdhury, S. (2007) · Lung India · doi:10.4103/0970-2113.44213 · Cited by 4 · see citing works

Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis

Pardo, A., Cabrera, S., Maldonado, M., & Selman, M. (2016) · Respiratory Research · doi:10.1186/s12931-016-0343-6 · Cited by 307 · see citing works

Regulation and pathomechanistic role of matrix metalloproteinases in Idiopathic Pulmonary Fibrosis

Nkyimbeng Takwi, E. H., & Justus Liebig University Giessen (2008) · University writing server of the Justus Liebig University Giessen (Justus-Liebig-Universität Gießen) · doi:10.22029/jlupub-13385

Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis

Mahalanobish, S., Saha, S., Dutta, S., & Sil, P. C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104591 · Cited by 125 · see citing works

Roles of Matrix Metalloproteinases and Their Inhibitors in Idiopathic Pulmonary Fibrosis

Liu, X. (2015) · Journal of Nanchang University