Cellulose and collagen derived micro-nano structured scaffolds for bone tissue engineering
Abstract
Scaffold based bone tissue engineering (BTE) has made great progress in regenerating lost bone tissue. Materials of natural and synthetic origin have been used for scaffold fabrication. Scaffolds derived from natural polymers offer greater bioactivity and biocompatibility with mammalian tissues to favor tissue healing, due to their similarity to native extracellular matrix (ECM) components. Often it is a challenge to fabricate natural polymer based scaffolds for BTE applications without compromising their bioactivity, while maintaining adequate mechanical properties. In this work, we report the fabrication and characterization of cellulose and collagen based micro-nano structured scaffolds using human osteoblasts (HOB) for BTE applications. These porous micro-nano structured scaffolds (average pore diameter 190 +/- 10 microm) exhibited mechanical properties in the mid range of human trabecular bone (compressive modulus 266.75 +/- 33.22 MPa and strength 12.15 3 +/- 2.23 MPa). These scaffolds supported the greater adhesion and phenotype maintenance of cultured HOB as reflected by higher levels of osteogenic enzyme alkaline phosphatase and mineral deposition compared to control polyester micro-nano structured scaffolds of identical pore properties. These natural polymer based micro-nano structured scaffolds may serve as alternatives to polyester based scaffolds for BTE applications.
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Synthetic polymers are prone to acidic degradation that liberates products harmful to tissue healing.
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From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [14]
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“…which highlights the significant demand for further in vitro studies of the scaffold before using them in the clinic (Akkouch et al., 2011; Aravamudhan et al., 2013; Bae et al., 2011; Chuenjitkuntaworn et al., 2010; Costa‐Pinto et al., 2012; Cui et al., 2012; Fernandez et al., 2010;…”
BackgroundBone Regenerative Medicine and Bone Grafting
Harsini, S. M. (2018) · Open Access Journal of Veterinary Science & Research · doi:10.23880/oajvsr-16000167 · Cited by 3 · see citing works
Grassie, K., & Khan, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823893-6.00002-4 · Cited by 3 · see citing works
Nanocellulose from the Appalachian Hardwood Forest and Its Potential Applications
Hassanzadeh, M. (2018) · doi:10.33915/etd.5780 · Cited by 4 · see citing works
Non‑isothermal crystallization kinetics of polycaprolactone-based composite membranes
Pang, J., Tan, D., Huang, C., et al. (2022) · Journal of Polymer Research · doi:10.1007/s10965-022-03335-5 · Cited by 2 · see citing works
“and 250 mL H2O were added to the three-neck flask and kept at 80 °C under magnetic stirring for 4 h to prepare the BNCF, the detailed steps using the methodology described by previous studies [22].”
MethodIn Vivo Biocompatibility of Non-derivatized Cellulose Regenerated Using Ionic Liquids
Gould, M. L., Ratnayake, J. T., Ramesh, N., Powlay, T. J., Curnow, O. J., Staiger, M. P., & Dias, G. J. (2022) · Journal of Polymers and the Environment · doi:10.1007/s10924-022-02640-w · Cited by 3 · see citing works
“Nanostructured cellulose-collagen scaffolds seeded with human osteoblasts showed enhanced cell adhesion, maintenance of phenotype, significantly improved alkaline phosphatase activity (a sign of osteogenic differentiation) and better mineral deposition compared to control polyester scaffolds with identical pore proper…”
BackgroundStereological assessment of engineered tissues and their scaffolds
Dockery, P., & Biggs, M. J. P. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-087-3.00008-0 · Cited by 2 · see citing works
Pseudoarthrosis: search for treatment methods of delayed consolidation and non-union
Самодай, В. Г., Starikov, A. O., Калашников, П. И., et al. (2022) · Medical news of the North Caucasus · doi:10.14300/mnnc.2022.17028 · Cited by 1 · see citing works
Bone tissue engineering, scaffold requirements and the utilization of natural polymers
Fadahunsi, A. A., Johnson, M., Rahman, S., & Mason, M. D. (2026) · Cellulose · doi:10.1007/s10570-026-06985-6 · Cited by 2 · see citing works
The Evolution and Application of Regenerative Engineering
James, R., & Laurencin, C. T. (2014) · MRS Proceedings · doi:10.1557/opl.2014.804 · Cited by 1 · see citing works
Self-citationAptamer-Mediated Selective Protein Affinity to Improve Scaffold Biocompatibility
Parisi, L., Galli, C., Elviri, L., Bianchera, A., Lagonegro, P., Lumetti, S., Manfredi, E., & Macaluso, G. M. (2016) · InTech eBooks · doi:10.5772/63265 · Cited by 1 · see citing works
“Together with collagen, chitosan, alginate, and cellulose are promising biomaterial for bone tissue engineering applications [27–30].”
Background
- Authors
- Aravamudhan, A., Ramos, D. M., Nip, J., Harmon, M. D., James, R., Deng, M., Laurencin, C. T., Yu, X., & Kumbar, S. G.
- Affiliations
- UConn Health (US)
- ORCID
- Venue
- Journal of Biomedical Nanotechnology
- Publisher
- American Scientific Publishers
- Published
- 2013-04-01
- Volume
- 9
- Issue
- 4
- Pages
- 719-731
- ISSN
- 1550-7033 (ISSN-L)
- OpenAlex
- W1967212772
- Cited by
- 113
- References
- 0
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 14 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 12 · 2017: 5 · 2016: 13 · 2015: 2 · 2014: 20 · 2013: 5
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- bone tissue engineering, cellulose, collagen, human osteoblasts, osteogenic differentiation, alkaline phosphatase, mineral deposition, porous scaffolds, compressive modulus, extracellular matrix mimicry
- MeSH terms
- Alkaline Phosphatase, Bone and Bones, Cell Survival, Cells, Cultured, Cellulose, Collagen, Humans, Microspheres, Minerals, Osteoblasts, Particle Size, Solvents, Porosity, Compressive Strength, Tissue Engineering, Cell Proliferation, Tissue Scaffolds, Nanofibers
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