Abnormalities in carbohydrate tolerance associated with elevated plasma nonesterified fatty acids.

Schalch, D S; Kipnis, D M

doi:10.1172/jci105308

Cited by 210Diet, Metabolism, and DiseaseDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

Abnormalities in carbohydrate tolerance associated with elevated plasma nonesterified fatty acids.

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Schalch, D S, Kipnis, D M·1965·Journal of Clinical Investigation

DOI 10.1172/jci105308PMC PMC289704

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Increased plasma free fatty acid concentrations are associated with insulin resistance in humans.
“It has long been recognized that increased plasma free fatty acids are associated with insulin resistance in humans (1).”
From Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis (2010) · cites this paper as [1]

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Authors: Schalch, D. S., & Kipnis, D. M.
Affiliations: Washington University in St. Louis (US)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1965-12-01
Volume: 44
Issue: 12
Pages: 2010-2020
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci105308
PMC: PMC289704
OpenAlex: W2096217291
Cited by: 210
References: 38
Citations by year: 2025: 1 · 2023: 1 · 2019: 1 · 2017: 1 · 2016: 3 · 2012: 5
FWCI: 20.43
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: carbohydrate tolerance, free fatty acids, plasma free fatty acids, hypertriglyceridemia, insulin resistance, glucose metabolism
MeSH terms: Adult, Diabetes Mellitus, Dietary Fats, Fatty Acids, Female, Glucose, Glucose Tolerance Test, Heparin, Humans, Hyperlipidemias, Insulin, Male, Middle Aged

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