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A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
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Studied on the oxidation of oleic and octanoic acids to ketone bodies were carried out in homogenates and in mitochondrial fractions of livers taken from fed and fasted rats. Malonyl-CoA inhibited ketogenesis from the former but not from the latter substrate. The site of inhibition appeared to be the carnitine acyltransferase I reaction. The effect was specific and easily reversible. Inhibitory concentrations were in the range of values obtained in livers from fed rats by others. It is proposed that malonyl-CoA functions as both precursor for fatty acid synthesis and suppressor of fatty acid oxidation. As such, it might be an important element in the carbohydrate-induced sparing of fatty acid oxidation.
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“Some important players to consider in this regard include acetyl-CoA carboxylase (ACC2) (21), the mitochondrial lipid transporter CPT1A (13, 22), and metabolites such as acetyl-CoA and malonyl-CoA (23).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [23]
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Role of carnitine in hepatic ketogenesis.
McGarry, J., Robles-Valdés, C., & Foster, D. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.11.4385 · Cited by 260
Self-citationMcGarry, J. D., Meier, J. M., & Foster, D. W. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44471-2 · Cited by 246
Self-citationMcGarry, J., Wright, P. H., & Foster, D. W. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108038 · Cited by 227
Self-citationPalmityl-coa:carnitine palmityltransferase
Norum, K. R. (1964) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(64)90103-8 · Cited by 202
Lossow, W. J., & Chaikoff, I. L. (1955) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(55)90173-9 · Cited by 193
The Regulation of Ketogenesis from Octanoic Acid
McGarry, J., & Foster, D. W. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62443-3 · Cited by 183
Self-citationThe Concentration of Malonyl-Coenzyme A and the Control of Fatty Acid Synthesis in Vivo
Guynn, R. W., Veloso, D., & Veech, R. L. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44633-4 · Cited by 182
Hormonal Control of Ketogenesis
McGarry, J. (1977) · Archives of Internal Medicine · doi:10.1001/archinte.137.4.495 · Cited by 166
Self-citationKetone Body Metabolism in the Ketosis of Starvation and Alloxan Diabetes
McGarry, J., Guest, M. J., & Foster, D. W. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)63806-8 · Cited by 161
Self-citationThe Regulation of Ketogenesis from Oleic Acid and the Influence of Antiketogenic Agents
McGarry, J. D., & Foster, D. W. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61782-x · Cited by 150
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- Cook, G. A., M. R. Lakshmanan, and R. L. Veech. 1977. The effect of glucagon on hepatic malonyl-CoA concen- tration and on lipid synthesis. Fed. Proc. 36: 672.
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Yue, J. T. Y., & Lam, T. K. T. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.013 · Cited by 83
Williams, K. J., & Wu, X. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.004 · Cited by 83
Brindle, N. P. J., Zammit, V. A., & Pogson, C. I. (1985) · Biochemical Journal · doi:10.1042/bj2320177 · Cited by 84
3 Enzymes of Triacylglycerol Formation in Mammals
Bell, R. M., & Coleman, R. (1983) · The Enzymes · doi:10.1016/s1874-6047(08)60301-7 · Cited by 80
Hepatic fatty acid oxidation and ketogenesis after clofibrate treatment
Mannaerts, G. P., Thomas, J. R., Debeer, L. J., McGarry, J., & Foster, D. W. (1978) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(78)90063-2 · Cited by 80
Self-citationKetogenesis and malonyl coenzyme A content of isolated rat hepatocytes.
Cook, G. A., King, M. T., & Veech, R. L. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40853-2 · Cited by 79
Katz, N. R. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5041-5_10 · Cited by 78
Ontko, J. A., & Johns, M. L. (1980) · Biochemical Journal · doi:10.1042/bj1920959 · Cited by 78
Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research
Uusitupa, H., Rasinkangas, P., Lehtinen, M. J., Mäkelä, S. M., Airaksinen, K., Anglenius, H., Ouwehand, A. C., & Maukonen, J. (2020) · Nutrients · doi:10.3390/nu12040892 · Cited by 78
Metabolic Flexibility and Its Impact on Health Outcomes
Palmer, B. F., & Clegg, D. J. (2022) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2022.01.012 · Cited by 84
Casals, N., Roca, N., Guerrero, M., Gil‐Gómez, G., Ayté, J., Ciudad, C. J., & Hegardt, F. G. (1992) · Biochemical Journal · doi:10.1042/bj2830261 · Cited by 77
l -carnitine acyltransferase in intact peroxisomes is inhibited by malonyl-CoA
Derrick, J. P., & Ramsay, R. R. (1989) · Biochemical Journal · doi:10.1042/bj2620801 · Cited by 77
Goedeke, L., Perry, R. J., & Shulman, G. I. (2019) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104727 · Cited by 76
Regulation of fatty acid oxidation in untrained vs. trained men during exercise
Sidossis, L. S., Wolfe, R. R., & Coggan, A. R. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.3.e510 · Cited by 79
Lysosomal triacylglycerol lipase and lipolysis in isolated rat hepatocytes.
Debeer, L. J., Thomas, J., Schepper, P. J. D., & Mannaerts, G. P. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86776-5 · Cited by 76
Self-citationWanders, R. J. A., Visser, G., Ferdinandusse, S., Vaz, F. M., & Houtkooper, R. H. (2020) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2020.9.3.313 · Cited by 76
Wallenius, K., Kroon, T., Hagstedt, T., Löfgren, L., Sörhede‐Winzell, M., Boucher, J., Lindén, D., & Oakes, N. D. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100176 · Cited by 77
Hepatic fatty acid partitioning
Hodson, L., & Frayn, K. N. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283462e16 · Cited by 76
Physiological and chemical responses in water-deprived Awassi ewes treated with vitamin C
Ghanem, A. M., Jaber, L., Said, M. A., Barbour, E. K., & Hamadeh, S. K. (2007) · Journal of Arid Environments · doi:10.1016/j.jaridenv.2007.06.005 · Cited by 75
Role of the Liver in Regulation of Ketone Body Production during Sepsis
Wannemacher, R. W., Pace, J. G., Beall, F. A., Dinterman, R. E., Petrella, V. J., & Neufeld, H. A. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109617 · Cited by 74
Inhibition of FASN reduces the synthesis of medium-chain fatty acids in goat mammary gland
Zhu, J., Luo, J., Wang, W., Yu, K., Wang, H. B., Shi, H., Sun, Y., Lin, X., & Li, J. (2014) · animal · doi:10.1017/s1751731114001323 · Cited by 72
Klotho-induced insulin resistance: a blessing in disguise?
Unger, R. H. (2006) · Nature Medicine · doi:10.1038/nm0106-56 · Cited by 71
History of L-carnitine: Implications for renal disease
Matera, M., Bellinghieri, G., Costantino, G., Santoro, D., Calvani, M., & Savica, V. (2003) · Journal of Renal Nutrition · doi:10.1053/jren.2003.50010 · Cited by 71
Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα
Ratman, D., Mylka, V., Bougarne, N., Pawlak, M., Caron, S., Hennuyer, N., Paumelle, R., Cauwer, L. D., Thommis, J., Rider, M. H., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw742 · Cited by 73
Nutrient sensors and their crosstalk
Sung, Y., Yu, Y. C., & Han, J. M. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01006-z · Cited by 73
Jansen, M. S., Cook, G. A., Song, S., & Park, E. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001752200 · Cited by 70
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Bansal, N., Gupta, A. K., Mitash, N., Shakya, P. S., Mandhani, A., Mahdi, A. A., Sankhwar, S. N., & Mandal, S. K. (2013) · Journal of Proteome Research · doi:10.1021/pr400859w · Cited by 69
The role of glucagon in the regulation of plasma lipids
Schade, D. S., Woodside, W. F., & Eaton, R. P. (1979) · Metabolism · doi:10.1016/0026-0495(79)90215-4 · Cited by 71
Collins, S., Sinclair, G. B., McIntosh, S., Bamforth, F. J., Thompson, R. G., Sobol, I., Osborne, G., Corriveau, A., dos Santos, M. C., Hanley, B., et al. (2010) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2010.07.013 · Cited by 68
Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis
Perry, R. J., Peng, L., Abulizi, A., Kennedy, L., Cline, G. W., & Shulman, G. I. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88477 · Cited by 68
Incomplete palmitate oxidation in cell-free systems of rat and human muscles
Veerkamp, J. H., van Moerkerk, H. T. B., Glatz, J. F. C., & van Hinsbergh, V. W. M. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90064-4 · Cited by 67
Akkaoui, M., Cohen, I., Esnous, C., Lenoir, V., Sournac, M., Girard, J. R., & Prip‐Buus, C. (2009) · Biochemical Journal · doi:10.1042/bj20081932 · Cited by 66
Long- and medium-chain fatty acid oxidation is increased in exercise-trained human skeletal muscle
Jong-Yeon, K., Hickner, R. C., Dohm, G. L., & Houmard, J. A. (2002) · Metabolism · doi:10.1053/meta.2002.31326 · Cited by 68
Glucagon and diabetes: A reappraisal
Lefèbvre, P. J., & LUYCKX, A. S. (1979) · Diabetologia · doi:10.1007/bf01223153 · Cited by 65
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Liu, Y., & Birsoy, K. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.02.016 · Cited by 65
Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity
Wolfgang, M. J., & Lane, M. D. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07978.x · Cited by 66
Mitochondrial Metabolism in Major Neurological Diseases
Zhou, Z., Austin, G. L., Young, L. E. A., Johnson, L. A., & Sun, R. C. (2018) · Cells · doi:10.3390/cells7120229 · Cited by 67
The effects of clofibrate feeding on the metabolism of palmitate and erucate in isolated hepatocytes
Christiansen, R. Z., Osmundsen, H., Borrebæk, B., & Bremer, J. (1978) · Lipids · doi:10.1007/bf02533618 · Cited by 64
The potential role of olive oil‐derived MUFA in insulin sensitivity
Tierney, A. C., & Roche, H. M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700143 · Cited by 64
Insulin Resistance and NAFLD: A Dangerous Liaison beyond the Genetics
Manco, M. (2017) · Children · doi:10.3390/children4080074 · Cited by 45
Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation
Castaño, D., Larequi, E., Belza, I., Astudillo, A. M., Martínez‐Ansó, E., Balsinde, J., Argemí, J., Aragón, T., Moreno-Aliaga, M. J., Muntané, J., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.012 · Cited by 62
Diet, obesity and diabetes: a current update
Walker, C. G., Zariwala, M. G., Holness, M. J., & Sugden, M. C. (2006) · Clinical Science · doi:10.1042/cs20060150 · Cited by 62
Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD
Inci, M. K., Park, S., Helsley, R. N., Attia, S. L., & Softic, S. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109224 · Cited by 65
The role of hepatic lipid composition in obesity‐related metabolic disease
Willis, S. A., Bawden, S., Malaikah, S., Sargeant, J. A., Stensel, D. J., Aithal, G. P., & King, J. A. (2021) · Liver International · doi:10.1111/liv.15059 · Cited by 63
Sex Differences in Hepatic De Novo Lipogenesis with Acute Fructose Feeding
Low, W. S., Cornfield, T., Charlton, C. A., Tomlinson, J., & Hodson, L. (2018) · Nutrients · doi:10.3390/nu10091263 · Cited by 62
McGarry, J., Mannaerts, G. P., & Foster, D. W. (1978) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(78)90150-9 · Cited by 60
Self-citationA Balance of Lipid-Sensing Mechanisms in the Brain and Liver
Caspi, L., Wang, P. Y. T., & Lam, T. K. T. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.07.005 · Cited by 58
Malonyl CoA inhibition of carnitine palmityltransferase in rat heart mitochondria
Paulson, D. J., Ward, K. M., & Shug, A. L. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)81201-6 · Cited by 59
Zammit, V. A. (1981) · Biochemical Journal · doi:10.1042/bj1980075 · Cited by 58
Janssen, J. A. M. J. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105488 · Cited by 70
Zordoky, B. N. M., Nagendran, J., Pulinilkunnil, T., Kienesberger, P. C., Masson, G., Waller, T. J., Kemp, B. E., Steinberg, G. R., & Dyck, J. R. B. (2014) · Circulation Research · doi:10.1161/circresaha.115.304538 · Cited by 60
McKay, T. B., Hjortdal, J., Priyadarsini, S., & Karamichos, D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176017 · Cited by 59
McGarry, J., & Foster, D. W. (1981) · Biochemical Journal · doi:10.1042/bj2000217 · Cited by 57
Self-citationHelsley, R. N., Park, S., Vekaria, H. J., Sullivan, P. G., Conroy, L. R., Sun, R. C., Romero, M. D. M., Herrero, L., Bons, J., King, C. D., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.010 · Cited by 57
Casteels, M., Schepers, L., Eldere, J. V., Eyssen, H., & Mannaerts, G. P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68832-5 · Cited by 56
Self-citationKobayashi, Y., Kumita, S., Fukushima, Y., Ishihara, K., Suda, M., & Sakurai, M. (2013) · Journal of Cardiology · doi:10.1016/j.jjcc.2013.05.004 · Cited by 55
Abela, L., Spiegel, R., Crowther, L. M., Klein, A., Steindl, K., Papuc, S. M., Joset, P., Zehavi, Y., Rauch, A., Plecko, B., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176363 · Cited by 54
Chen, X., Shang, L., Deng, S., Li, P., Chen, K., Gao, T., Zhang, X., Chen, Z., & Zeng, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013583 · Cited by 55
The role of RNA m6A methylation in lipid metabolism
Wang, Y., Wang, Y., Gu, J., Su, T., Gu, X., & Feng, Y. Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.866116 · Cited by 54
Development and regulation of ketogenesis in hepatocytes isolated from newborn rats
Ferré, P., Satabin, P., Decaux, J., Escrivá, F., & Girard, J. R. (1983) · Biochemical Journal · doi:10.1042/bj2140937 · Cited by 54
Role of the Heart in Lactate Shuttling
Brooks, G. A. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.663560 · Cited by 56
Pereira, R. O., Wende, A. R., Olsen, C. D., Soto, J. E., Rawlings, T. A., Zhu, Y., Riehle, C., & Abel, E. D. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.02.011 · Cited by 53
Glatzel, D., Koeberle, A., Pein, H., Loeser, K., Stark, A., Keksel, N., Werz, O., Müller, R., Bischoff, I., & Fürst, R. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m080101 · Cited by 54
van Weeghel, M., Abdurrachim, D., Nederlof, R., Argmann, C., Houtkooper, R. H., Hagen, J., Nabben, M., Denis, S. W., Čiapaitė, J., Kolwicz, S. C., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy089 · Cited by 53
Katz, N. R., FISCHER, W., & Giffhorn, S. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07623.x · Cited by 53
Cohen, I., Kohl, C., McGarry, J., Girard, J. R., & Prip‐Buus, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29896 · Cited by 53
Self-citationChristensen, E., Hagve, T., & Christophersen, B. O. (1986) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(86)90220-1 · Cited by 53
The development of ketogenesis at birth in the rat
Ferré, P., Pégorier, J. P., Williamson, D., & Girard, J. R. (1978) · Biochemical Journal · doi:10.1042/bj1760759 · Cited by 53
Steffen, J., Ngo, J., Wang, S.-P., Williams, K., Kramer, H. F., Ho, G., Rodríguez, C. J., Yekkala, K., Amuzie, C. J., Bialecki, R., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101566 · Cited by 55
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
Li, M., Wang, Y., Wei, X., Cai, W.-F., Wu, J., Zhu, M., Wang, Y., Liu, Y., Xiong, J., Qu, Q., et al. (2024) · Cell Research · doi:10.1038/s41422-024-00985-6 · Cited by 52
Gobin, S., Bonnefont, J., Prip‐Buus, C., Mugnier, C., Ferrec, M., Demaugre, F., Saudubray, J., Rostane, H., Djouadi, F., Wilcox, W. R., et al. (2002) · Human Genetics · doi:10.1007/s00439-002-0752-0 · Cited by 52
Pramfalk, C., Pavlides, M., Banerjee, R., McNeil, C. A., Neubauer, S., Karpe, F., & Hodson, L. (2016) · Diabetes · doi:10.2337/db16-0236 · Cited by 51
Regulation of mitochondrial carnitine palmitoyl transferases from liver and extrahepatic tissues
Saggerson, D., Ghadiminejad, I., & Awan, M. (1992) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(92)90023-s · Cited by 51
De novo lipogenesis is essential for platelet production in humans
Kelly, K. L., Reagan, W. J., Sonnenberg, G. E., Clasquin, M. F., Hales, K. J., Asano, S. M., Amor, P. A., Carvajal‐Gonzalez, S., Shirai, N., Matthews, M. D., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00272-9 · Cited by 49
The return of malonyl-CoA to the brain: Cognition and other stories
Fadó, R., Rodríguez‐Rodríguez, R., & Casals, N. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101071 · Cited by 51
Reszko, A. E., Kasumov, T., Comte, B., Pierce, B. A., David, F., Bederman, I. R., Deutsch, J., Rosiers, C. D., & Brunengraber, H. (2001) · Analytical Biochemistry · doi:10.1006/abio.2001.5349 · Cited by 49
Jørgensen, W., Rud, K. A., Mortensen, O. H., Frandsen, L., Grunnet, N., & Quistorff, B. (2017) · Physiological Reports · doi:10.14814/phy2.13207 · Cited by 48
Henriksen, B. S., Curtis, M. E., Fillmore, N., Cardon, B. R., Thomson, D. M., & Hancock, C. R. (2013) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-5-29 · Cited by 49
Circulating metabolite homeostasis achieved through mass action
Li, X., Hui, S. T., Mirek, E. T., Jonsson, W. O., Anthony, T. G., Lee, W. D., Zeng, X., Jang, C., & Rabinowitz, J. D. (2022) · Nature Metabolism · doi:10.1038/s42255-021-00517-1 · Cited by 49
Localization and effect of ectopic expression of CPT1c in CNS feeding centers
Dai, Y., Wolfgang, M. J., Cha, S. H., & Lane, M. D. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.161 · Cited by 53
Tsoko, M., Beauseigneur, F., Gresti, J., Niot, I., Demarquoy, J., Boichot, J., Bezard, J. A., Rochette, L., & Clouet, P. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00019-v · Cited by 48
Fatty acid oxidation and ketogenesis during development
Girard, J. R., Duée, P., Ferré, P., Pégorier, J. P., Escrivá, F., & Decaux, J. (1985) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19850221 · Cited by 48
Diabetic ketoacidosis : current views on pathogenesis and treatment
Keller, U. B. (1986) · Diabetologia · doi:10.1007/bf00456113 · Cited by 48
Duée, P., Pégorier, J. P., Quant, P. A., Herbin, C., Kohl, C., & Girard, J. R. (1994) · Biochemical Journal · doi:10.1042/bj2980207 · Cited by 47
Moir, A. M. B., & Zammit, V. A. (1993) · Biochemical Journal · doi:10.1042/bj2890049 · Cited by 47
Haan, E., Scholem, R. D., Croll, H. B., & Brown, G. K. (1986) · European Journal of Pediatrics · doi:10.1007/bf00496037 · Cited by 47
Mitochondria homeostasis: Biology and involvement in hepatic steatosis to NASH
Li, Y., Xie, Z., Song, Q., & Li, J.-Y. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00864-z · Cited by 49
Senanayake, V. K., Jin, W., Mochizuki, A., Chitou, B., & Goodenowe, D. B. (2015) · BMC Neurology · doi:10.1186/s12883-015-0411-4 · Cited by 47
Das, U. N. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.01.002 · Cited by 46
Zammit, V. A., Fraser, F. W., & Orstorphine, C. G. (1997) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(96)00015-5 · Cited by 46
Molecular Targets for Obesity Therapy in the Brain
Obici, S. (2009) · Endocrinology · doi:10.1210/en.2009-0409 · Cited by 45
Defective Liver Disposal of Free Fatty Acids in Patients with Impaired Glucose Tolerance
Iozzo, P., Turpeinen, A., Takala, T., Oikonen, V., Bergman, J. R., Grönroos, T. J., Ferrannini, E., Nuutila, P., & Knuuti, J. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031142 · Cited by 45
SIESS, E. A., KIENTSCH-ENGEL, R. I., & WIELAND, O. H. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb05814.x · Cited by 45
Tein, I., Demaugre, F., Bonnefont, J., & Saudubray, J. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90139-1 · Cited by 45
Matched and mismatched metabolic fuels in lymphocyte function
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Metadata
- Authors
- McGarry, J. D., Mannaerts, G. P., & Foster, D. W.
- Affiliations
- University of Texas Health Science Center at Dallas (US)
- ORCID
- McGarry, J D
- Venue
- Journal of Clinical Investigation
- Published
- 1977-07-01
- Volume
- 60
- Issue
- 1
- Pages
- 265-270
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC372365
- OpenAlex
- W2126909426
- Cited by
- 736
- References
- 15
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 22 · 2023: 22 · 2022: 38 · 2021: 18 · 2020: 26 · 2019: 17 · 2018: 29 · 2017: 23 · 2016: 24 · 2015: 14 · 2014: 21 · 2013: 18 · 2012: 19
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fogarty International Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- malonyl-CoA, hepatic fatty acid oxidation, ketogenesis, oleic acid, octanoic acid, ketone bodies, fasting, liver mitochondria, fatty acid synthesis
- MeSH terms
- Animals, Caprylates, Carnitine, Coenzyme A, Fatty Acids, Ketone Bodies, Liver, Male, Malonates, Mitochondria, Liver, Models, Biological, Oleic Acids, Oxidation-Reduction, Rats
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