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A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
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Studied on the oxidation of oleic and octanoic acids to ketone bodies were carried out in homogenates and in mitochondrial fractions of livers taken from fed and fasted rats. Malonyl-CoA inhibited ketogenesis from the former but not from the latter substrate. The site of inhibition appeared to be the carnitine acyltransferase I reaction. The effect was specific and easily reversible. Inhibitory concentrations were in the range of values obtained in livers from fed rats by others. It is proposed that malonyl-CoA functions as both precursor for fatty acid synthesis and suppressor of fatty acid oxidation. As such, it might be an important element in the carbohydrate-induced sparing of fatty acid oxidation.
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“Some important players to consider in this regard include acetyl-CoA carboxylase (ACC2) (21), the mitochondrial lipid transporter CPT1A (13, 22), and metabolites such as acetyl-CoA and malonyl-CoA (23).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [23]
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Cites
Role of carnitine in hepatic ketogenesis.
McGarry, J., Robles-Valdés, C., & Foster, D. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.11.4385 · Cited by 260
Self-citationMcGarry, J. D., Meier, J. M., & Foster, D. W. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44471-2 · Cited by 246
Self-citationMcGarry, J., Wright, P. H., & Foster, D. W. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108038 · Cited by 227
Self-citationPalmityl-coa:carnitine palmityltransferase
Norum, K. R. (1964) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(64)90103-8 · Cited by 202
Lossow, W. J., & Chaikoff, I. L. (1955) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(55)90173-9 · Cited by 193
The Regulation of Ketogenesis from Octanoic Acid
McGarry, J., & Foster, D. W. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62443-3 · Cited by 183
Self-citationThe Concentration of Malonyl-Coenzyme A and the Control of Fatty Acid Synthesis in Vivo
Guynn, R. W., Veloso, D., & Veech, R. L. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44633-4 · Cited by 182
Hormonal Control of Ketogenesis
McGarry, J. (1977) · Archives of Internal Medicine · doi:10.1001/archinte.137.4.495 · Cited by 166
Self-citationKetone Body Metabolism in the Ketosis of Starvation and Alloxan Diabetes
McGarry, J., Guest, M. J., & Foster, D. W. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)63806-8 · Cited by 161
Self-citationThe Regulation of Ketogenesis from Oleic Acid and the Influence of Antiketogenic Agents
McGarry, J. D., & Foster, D. W. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61782-x · Cited by 150
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Cook, G. A., M. R. Lakshmanan, and R. L. Veech. 1977. The effect of glucagon on hepatic malonyl-CoA concen- tration and on lipid synthesis. Fed. Proc. 36: 672.
Cited by
Sorted by citations
Items 101–200 of 729
McGarry, J., Stark, M. J., & Foster, D. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34394-6 · Cited by 188
Self-citationJoyal, J., Gantner, M. L., & Smith, L. E. H. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.11.002 · Cited by 193
Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye‐Agyeman, F., Gonsalves, W. I., Lou, Z., Karnitz, L. M., Goetz, M. P., & Hitosugi, T. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.030 · Cited by 189
PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue
Lee, Y., Yu, X., Gonzales, F., Mangelsdorf, D. J., Wang, M.-Y., Richardson, C., Witters, L. A., & Unger, R. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182420899 · Cited by 181
Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets
Tan, S. K., Hougen, H. Y., Merchan, J. R., Gonzalgo, M. L., & Welford, S. M. (2022) · Nature Reviews Urology · doi:10.1038/s41585-022-00654-6 · Cited by 181
Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation
Soeters, M. R., Soeters, P. B., Schooneman, M. G., Houten, S. M., & Romijn, J. A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00397.2012 · Cited by 177
Thyfault, J. P., Rector, R. S., Uptergrove, G. M., Borengasser, S. J., Morris, E. M., Wei, Y., Laye, M. J., Burant, C., Qi, N., Ridenhour, S. E., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169060 · Cited by 175
Stearoyl‐CoA desaturase as a new drug target for obesity treatment
Dobrzyń, A., & Ntambi, J. M. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00177.x · Cited by 173
The role of stearoyl-CoA desaturase in the control of metabolism
Dobrzyń, A., & Ntambi, J. M. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.011 · Cited by 169
Mitochondrial Carnitine Palmitoyltransferase I Isoform Switching in the Developing Rat Heart
Brown, N. F., Weis, B. C., Husti, J. E., Foster, D. W., & McGarry, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.15.8952 · Cited by 167
Self-citationTaylor, R., & Agius, L. (1988) · Biochemical Journal · doi:10.1042/bj2500625 · Cited by 166
New Aspects of Ketone Bodies in Energy Metabolism of Dairy Cows: A Review
Holtenius, P., & Holtenius, K. (1996) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.1996.tb00491.x · Cited by 172
Leptin and the Control of Metabolism: Role for Stearoyl-CoA Desaturase-1 (SCD-1)
Cohen, P., & Friedman, J. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.9.2455s · Cited by 165
Hepatic Fatty Acid Trafficking: Multiple Forks in the Road
Mashek, D. G. (2013) · Advances in Nutrition · doi:10.3945/an.113.004648 · Cited by 167
Advances in myocardial energy metabolism: metabolic remodelling in heart failure and beyond
Sun, Q., Karwi, Q. G., Wong, N. K. P., & Lopaschuk, G. D. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae231 · Cited by 164
Metabolic regulation of citrate and iron by aconitases: role of iron–sulfur cluster biogenesis
Tong, W.-H., & Rouault, T. A. (2007) · BioMetals · doi:10.1007/s10534-006-9047-6 · Cited by 165
Houten, S. M., Wanders, R. J. A., & Ranea‐Robles, P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165720 · Cited by 160
Lipid Metabolism in Metabolic-Associated Steatotic Liver Disease (MASLD)
Syed‐Abdul, M. M. (2023) · Metabolites · doi:10.3390/metabo14010012 · Cited by 166
Plasma Lipoproteins and Regulation of Hepatic Metabolism of Fatty Acids in Altered Thyroid States*
Heimberg, M., Olubadewo, J. O., & Wilcox, H. G. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-4-590 · Cited by 153
β-catenin-activated hepatocellular carcinomas are addicted to fatty acids
Senni, N., Savall, M., Granados, D. C., Alves‐Guerra, M., Sartor, C., Lagoutte, I., Gougèlet, A., Terris, B., Gilgenkrantz, H., Perret, C., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315448 · Cited by 160
Portincasa, P., Khalil, M., Mahdi, L., Perniola, V., Idone, V., Graziani, A., Baffy, G., & Ciaula, A. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115640 · Cited by 167
Regulation of plasma fatty acid oxidation during low- and high-intensity exercise
Sidossis, L. S., Gastaldelli, A., Klein, S., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.6.e1065 · Cited by 151
Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging
Gong, Z., Tas, E., Yakar, S., & Muzumdar, R. H. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.022 · Cited by 153
The role of ATP citrate-lyase in the metabolic regulation of plasma lipids
PEARCE, N. J., Yates, J. W., Berkhout, T. A., Jackson, B., Tew, D. G., Boyd, H., Camilleri, P., Sweeney, P. J., Gribble, A. D., Shaw, A. N., et al. (1998) · Biochemical Journal · doi:10.1042/bj3340113 · Cited by 144
Britton, C. H., Schultz, R. A., Zhang, B., Esser, V., Foster, D. W., & McGarry, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.1984 · Cited by 144
Self-citationGenetic determinants of hepatic steatosis in man
Hooper, A. J., Adams, L. A., & Burnett, J. R. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r008896 · Cited by 149
Pramfalk, C., Pavlides, M., Banerjee, R., McNeil, C. A., Neubauer, S., Karpe, F., & Hodson, L. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2649 · Cited by 138
Perspective: Hexosamines and Nutrient Sensing
Rossetti, L. (2000) · Endocrinology · doi:10.1210/endo.141.6.7566 · Cited by 138
Kim, C.-W., Moon, Y.-A., Park, S. W., Cheng, D., Kwon, H. J., & Horton, J. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001292107 · Cited by 136
Zammit, V. A. (1999) · Progress in Lipid Research · doi:10.1016/s0163-7827(99)00002-8 · Cited by 136
Mechanisms of Kaempferol in the treatment of diabetes: A comprehensive and latest review
Yang, Y., Chen, Z., Zhao, X., Xie, H., Du, L., Gao, H. L., & Xie, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.990299 · Cited by 140
Mechanism responsible for 5-(tetradecyloxy)-2-furoic acid inhibition of hepatic lipogenesis.
McCune, S. A., & Harris, R. A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86677-2 · Cited by 133
Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane
Fraser, F. W., Corstorphine, C. G., & Zammit, V. A. (1997) · Biochemical Journal · doi:10.1042/bj3230711 · Cited by 133
Tsuboyama-Kasaoka, N., Tsunoda, N., Maruyama, K., Takahashi, M. M., Kim, H., Ikemoto, S., & Ezaki, O. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8818 · Cited by 131
Ormsbee, M., Bach, C., & Baur, D. (2014) · Nutrients · doi:10.3390/nu6051782 · Cited by 130
Actions of insulin on the mammalian heart: metabolism, pathology and biochemical mechanisms
Brownsey, R. W. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00051-5 · Cited by 132
Muoio, D. M., & Koves, T. R. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-083 · Cited by 129
Friedman, J. M. (2002) · Nature · doi:10.1038/415268a · Cited by 127
Neuronal regulation of homeostasis by nutrient sensing
Lam, T. K. T. (2010) · Nature Medicine · doi:10.1038/nm0410-392 · Cited by 125
MILLS, S. E., Foster, D. W., & McGarry, J. (1983) · Biochemical Journal · doi:10.1042/bj2140083 · Cited by 125
Self-citationWeis, B. C., Esser, V., Foster, D. W., & McGarry, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32222-6 · Cited by 124
Self-citationPharmacologic inhibition of lipogenesis for the treatment of NAFLD
Esler, W. P., & Cohen, D. E. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.10.042 · Cited by 122
Sugden, M. C., & Holness, M. J. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.1.8299890 · Cited by 122
Saturated with fat: new perspectives on lipotoxicity
Garbarino, J., & Sturley, S. L. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32832182ee · Cited by 121
Cheng, S., Wang, G., Wang, Y., Cai, L., Qian, K., Ju, L., Liu, X., Xiao, Y., & Wang, X. (2019) · Clinical Science · doi:10.1042/cs20190587 · Cited by 120
Dietary glycemic index and liver steatosis
Valtueña, S., Pellegrini, N., Ardigò, D., Rio, D. D., Numeroso, F., Scazzina, F., Monti, L. D., Zavaroni, I., & Brighenti, F. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.136 · Cited by 123
Pathophysiology of Diabetes Mellitus
Sherwin, R., & Felig, P. (1978) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31766-7 · Cited by 121
The Role of Stearoyl-CoA Desaturase in Body Weight Regulation
Dobrzyń, A. (2004) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2003.12.005 · Cited by 119
The Role of CNS Fuel Sensing in Energy and Glucose Regulation
Cota, D., Proulx, K., & Seeley, R. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.049 · Cited by 122
Bruss, M. L. (1997) · Elsevier eBooks · doi:10.1016/b978-012396305-5/50005-1 · Cited by 117
García‐Ruiz, C., Baulies, A., Marí, M., García-Rovés, P. M., & Fernández-Checa, J. C. (2013) · Free Radical Research · doi:10.3109/10715762.2013.830717 · Cited by 119
Regulation of fatty acid oxidation in mammalian liver
Guzmán, M., & Geelen, M. J. H. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90224-w · Cited by 116
Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats
Cook, G. A., Otto, D. A., & Cornell, N. W. (1980) · Biochemical Journal · doi:10.1042/bj1920955 · Cited by 116
Cook, G. A. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)71315-3 · Cited by 115
The Role of Hypothalamic Malonyl-CoA in Energy Homeostasis
Wolfgang, M. J., & Lane, M. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600016200 · Cited by 115
Wu, Q., Wang, Q., Fu, J., & Ren, R. (2019) · Food & Function · doi:10.1039/c8fo02375a · Cited by 112
Common Metabolic Diseases of Cattle: Ketosis, Milk Fever, Grass Tetany, and Downer Cow Complex
Littledike, E. T., Young, J. W., & Beitz, D. C. (1981) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(81)82715-4 · Cited by 112
Perry, R. J., Rabin-Court, A., Song, J. D., CARDONE, R. L., Wang, Y., Kibbey, R. G., & Shulman, G. I. (2019) · Nature Communications · doi:10.1038/s41467-019-08466-w · Cited by 113
Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma
Liang, L., Kuang, X., He, Y., Zhu, L., Lau, P., Li, X., Luo, D., Gong, L., Zhou, W., Zhang, F., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02077-6 · Cited by 120
Atkinson, L. L., Kozak, R., Kelly, S. E., Onay-Beşi̇kçi̇, A., Russell, J. C., & Lopaschuk, G. D. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00360.2002 · Cited by 110
Chow, J. D. Y., Lawrence, R., Healy, M. E., Dominy, J. E., Liao, J. A., Breen, D. S., Byrne, F. L., Kenwood, B. M., Lackner, C., Okutsu, S., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.02.004 · Cited by 111
Schepers, L., Casteels, M., Vamecq, J., Parmentier, G. G., Veldhoven, P. P. V., & Mannaerts, G. P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69128-8 · Cited by 109
Self-citationLiu, X., Sadhukhan, S., Sun, S., Wagner, G. R., Hirschey, M. D., Qi, L., Lin, H., & Locasale, J. W. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.044859 · Cited by 114
Mok, K. T., Alberto Maiz, G., Yamazaki, K., Sobrado, J., Babayan, V. K., Moldawer, L. L., Bistrian, B. R., & Blackburn, G. L. (1984) · Metabolism · doi:10.1016/0026-0495(84)90244-0 · Cited by 108
DRYNAN, L., QUANT, P. A., & ZAMMIT, V. A. (1996) · Biochemical Journal · doi:10.1042/bj3170791 · Cited by 107
Lipid metabolism in diabetes mellitus
Saudek, C. D., & Eder, H. A. (1979) · The American Journal of Medicine · doi:10.1016/0002-9343(79)91126-4 · Cited by 103
Genomics of the Human Carnitine Acyltransferase Genes
van der Leij, F. R., Huijkman, N., Boomsma, C. M., Kuipers, J. R. G., & Bartelds, B. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3055 · Cited by 101
Fatty acid oxidation and photoreceptor metabolic needs
Fu, Z., Kern, T. S., Hellström, A., & Smith, L. E. H. (2020) · Journal of Lipid Research · doi:10.1194/jlr.tr120000618 · Cited by 98
Luukkonen, P. K., Porthan, K., Ahlholm, N., Rosqvist, F., Dufour, S., Zhang, X., Lehtimäki, T. E., Seppänen, W., Orho‐Melander, M., Hodson, L., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.10.008 · Cited by 97
Bergouignan, A., Momken, I., Schoeller, D. A., Simon, C., & Blanc, S. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.02.004 · Cited by 99
An, Z., Wang, H., Song, P., Zhang, M., Geng, X., & Zou, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703701200 · Cited by 98
RetractedFukuda, N., Azain, M. J., & Ontko, J. A. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45344-1 · Cited by 97
Carnitine palmitoyltransferase 1: Central to cell function
Zammit, V. A. (2008) · IUBMB Life · doi:10.1002/iub.78 · Cited by 100
Insulin resistance protects the heart from fuel overload in dysregulated metabolic states
Taegtmeyer, H., Beauloye, C., Harmancey, R., & Hue, L. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00854.2012 · Cited by 97
Hu, X., Li, Y., Li, C., Fu, Y., Cai, F., Chen, Q., & Li, D. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.01.011 · Cited by 96
Fukuda, N., & Ontko, J. A. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37747-6 · Cited by 95
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
Ross, T. T., Crowley, C., Kelly, K. L., Rinaldi, A., Beebe, D. A., Lech, M. P., Martinez, R. V., Carvajal-Gonzalez, S., Boucher, M., Hirenallur-Shanthappa, D., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.06.001 · Cited by 94
Molecular Basis of Health and Disease
Das, U. N. (2011) · Springer eBooks · doi:10.1007/978-94-007-0495-4 · Cited by 95
Kinetics of plasma triglycerides in abdominal obesity
Björnson, E., Adiels, M., Taskinen, M., & Borén, J. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000375 · Cited by 97
Hepatic ERα accounts for sex differences in the ability to cope with an excess of dietary lipids
Meda, C., Barone, M., Mitro, N., Lolli, F., Pedretti, S., Caruso, D., Maggi, A. C., & Torre, S. D. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.12.009 · Cited by 93
Altered mitochondrial metabolism in the insulin‐resistant heart
Makrecka‐Kuka, M., Liepinsh, E., Murray, A. J., Lemieux, H., Dambrova, M., Tepp, K., Puurand, M., Käämbre, T., Han, W. H., de Goede, P., et al. (2019) · Acta Physiologica · doi:10.1111/apha.13430 · Cited by 93
Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders
Kleiboeker, B. A., & Lodhi, I. J. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101577 · Cited by 96
Zammit, V. A. (1984) · Progress in Lipid Research · doi:10.1016/0163-7827(84)90005-5 · Cited by 93
Kim, Y. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i29.4689 · Cited by 92
Monsénégo, J., Mansouri, A., Akkaoui, M., Lenoir, V., Esnous, C., Fauveau, V., Tavernier, V., Girard, J., & Prip-Buus, C. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.10.008 · Cited by 91
Yeudall, S., Upchurch, C. M., Seegren, P. V., Pavelec, C. M., Greulich, J., Lemke, M. C., Harris, T. E., Desai, B. N., Hoehn, K. L., & Leitinger, N. (2022) · Science Advances · doi:10.1126/sciadv.abq1984 · Cited by 91
Wolfgang, M. J., Cha, S. H., Millington, D. S., Cline, G. W., Shulman, G. I., Suwa, A., Asaumi, M., Kurama, T., Shimokawa, T., & Lane, M. D. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05255.x · Cited by 90
Absorption and metabolism of the volatile fatty acids in the hind-gut of the rabbit
Marty, J., & Vernay, M. (1984) · British Journal Of Nutrition · doi:10.1079/bjn19840031 · Cited by 89
Effect of Reye's syndrome serum on isolated chinchilla liver mitochondria.
Tonsgard, J. H., & Getz, G. S. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112039 · Cited by 88
The Role of Mitochondrial Fat Oxidation in Cancer Cell Proliferation and Survival
Oliveira, M., & Liesa, M. (2020) · Cells · doi:10.3390/cells9122600 · Cited by 89
Dulloo, A. G., Gubler, M., Montani, J.-P., Seydoux, J., & Solinas, G. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802861 · Cited by 87
Quant, P. A., Tubbs, P. K., & Brand, M. D. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15291.x · Cited by 87
Insights into the Hexose Liver Metabolism—Glucose versus Fructose
Geidl-Flueck, B., & Gerber, P. (2017) · Nutrients · doi:10.3390/nu9091026 · Cited by 85
Green, C., Pramfalk, C., Charlton, C. A., Gunn, P. J., Cornfield, T., Pavlides, M., Karpe, F., & Hodson, L. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000871 · Cited by 85
Bellinghieri, G., Santoro, D., Calvani, M., Mallamace, A., & Savica, V. (2003) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50099 · Cited by 85
Stakkestad, J. A., & Bremer, J. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90025-5 · Cited by 85
Wolfgang, M. J., & Lane, M. D. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092532 · Cited by 85
Fructose drives de novo lipogenesis affecting metabolic health
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Metadata
- Authors
- McGarry, J. D., Mannaerts, G. P., & Foster, D. W.
- Affiliations
- University of Texas Health Science Center at Dallas (US)
- ORCID
- McGarry, J D
- Venue
- Journal of Clinical Investigation
- Published
- 1977-07-01
- Volume
- 60
- Issue
- 1
- Pages
- 265-270
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC372365
- OpenAlex
- W2126909426
- Cited by
- 736
- References
- 15
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 22 · 2023: 22 · 2022: 38 · 2021: 18 · 2020: 26 · 2019: 17 · 2018: 29 · 2017: 23 · 2016: 24 · 2015: 14 · 2014: 21 · 2013: 18 · 2012: 19
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fogarty International Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- malonyl-CoA, hepatic fatty acid oxidation, ketogenesis, oleic acid, octanoic acid, ketone bodies, fasting, liver mitochondria, fatty acid synthesis
- MeSH terms
- Animals, Caprylates, Carnitine, Coenzyme A, Fatty Acids, Ketone Bodies, Liver, Male, Malonates, Mitochondria, Liver, Models, Biological, Oleic Acids, Oxidation-Reduction, Rats
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