The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.
Open accessAbstract
The predominant lipoxygenase products of arachidonic acid were extracted and purified from synovial fluid and sonicates of synovial tissue of patients with rheumatoid arthritis (RA), spondyloarthritis (SA), or a noninflammatory arthropathy (NIA). The concentration of 5(S),12(R)-dihydroxy-6,8,10-(trans/trans/cis)-14-cis-eicosatetraenoic acid (leukotriene B4) in synovial fluid was elevated significantly in patients with RA and a positive latex test for rheumatoid factor (P < 0.05, n = 14) and in patients with SA (P < 0.05, n = 10), compared with that of subjects with NIA (n = 9). The content of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE), but not of leukotriene B4, was elevated significantly in synovial tissue of seven patients with RA in comparison with that of four subjects with NIA (P < 0.05). A single intra-articular injection of corticosteroid significantly lowered the synovial fluid level of leukotriene B4 in six patients with RA. These data suggest an involvement of the potent chemotactic factors 5-HETE and leukotriene B4 in human inflammatory disease.
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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Self-citationBorgeat, P., & Samuelsson, B. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.7.3213 · Cited by 470
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Cited by
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875
Control of vascular permeability by polymorphonuclear leukocytes in inflammation
Wedmore, C. V., & Williams, T. J. (1981) · Nature · doi:10.1038/289646a0 · Cited by 849
Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease
Sharon, P., & Stenson, W. F. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80015-3 · Cited by 738
Lewis, R. A., & Austen, K. F. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111312 · Cited by 656
Lewis, R. A., & Austen, K. F. (1981) · Nature · doi:10.1038/293103a0 · Cited by 473
Metadata
- Authors
- Klickstein, L. B., Shapleigh, C., & Goetzl, E. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1980-11-01
- Volume
- 66
- Issue
- 5
- Pages
- 1166-1170
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2033426097
- Cited by
- 345
- References
- 12
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis. https://app.cochat.ai/papers/10.1172/jci109947
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- Klickstein, L. B., Shapleigh, C., & Goetzl, E. J. (1980). Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis. Journal of Clinical Investigation. https://doi.org/10.1172/jci109947
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
