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Tolerance to the humoral and hemodynamic effects of caffeine in man.
Open accessAbstract
Acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, and urinary catecholamines. Using a double-blind design, the effects of chronic caffeine administration on these same variables were assessed. Near complete tolerance, in terms of both humoral and hemodynamic variables, developed over the first 1-4 d of caffeine. No long-term effects of caffeine on blood pressure, heart rate, plasma renin activity, plasma catecholamines, or urinary catecholamines could be demonstrated. Discontinuation of caffeine ingestion after 7 d of administration did not result in a detectable withdrawal phenomenon relating to any of the variables assessed.
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“These opinions and advisories are based upon a relatively small collection of caffeine studies that have been publicised in both scientific and lay literature and in the media over the past few decades [10], [17], [25].”
From No Evidence of Dehydration with Moderate Daily Coffee Intake: A Counterbalanced Cross-Over Study in a Free-Living Population (2014) · cites this paper as [25]
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“In short-term studies, it has been shown to increase blood pressure and peripheral vascular resistance, but tolerance rapidly develops. 4”
From Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform (2001) · cites this paper as [4]
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“In short-term studies, it has been shown to increase blood pressure and peripheral vascular resistance, but tolerance rapidly develops. 4”
From Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform (2001) · cites this paper as [4]
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“In short-term studies, it has been shown to increase blood pressure and peripheral vascular resistance, but tolerance rapidly develops. 4”
From Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform (2001) · cites this paper as [4]
In the citing paper
“Earlier studies which claimed to show tolerance to the pressor effects of caffeine [11,[16][17][18] have not mirrored 'normal' staggered caffeine consumption but are characterized by a prior period of prolonged abstinence followed by a high dose of caffeine administered once or twice daily.”
From Central and peripheral effects of sustained caffeine use: tolerance is incomplete (2002) · cites this paper as [11]
In the citing paper
“the effects of CAF on epinephrine are blunted within 1-4 d (36) of ingestion”
From The Glucose Intolerance Induced by Caffeinated Coffee Ingestion Is Less Pronounced than That Due to Alkaloid Caffeine in Men (2006) · cites this paper as [36]
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Citations
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Kafein, etki mekanizmaları ve fiziksel performansa etkileri
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Coffee consumption, clinic, 24-hour and home blood pressure. Findings from the PAMELA study
Quarti‐Trevano, F., Dell’Oro, R., Vanoli, J., Bombelli, M., Facchetti, R., Mancia, G., & Grassi, G. M. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.05.017 · Cited by 6
Miller, L. S., & Miller, S. E. (1996) · Perceptual and Motor Skills · doi:10.2466/pms.1996.82.3.891 · Cited by 6
Kassis, O., Katz, N., Ravid, S., & Pillar, G. (2013) · PubMed · Cited by 6
Roberts, A. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00030-9 · Cited by 6
Caffeine improves sprint-distance performance among Division II collegiate swimmers.
Vanata, D. F., Mazzino, N., Bergosh, R. G., & Graham, P. (2014) · The Sport Journal · Cited by 6
Sözlü, S., Yılmaz, B., & Tek, N. A. (2017) · Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi · doi:10.22312/sdusbed.273937 · Cited by 6
Cardiovascular Effects of Caffeine in Rabbits Involve Beta-1 Adrenergic Receptor Activation
Nabofa, W., & Alada, A. R. A. (2020) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2019.0019 · Cited by 8
“Theobservedincreaseinthecirculatingcatecholaminein response to caffeine in this study agrees with a few earlier reported acute studies in humans 4 and rats.”
Treml, B., Schöpf, E., Geiger, R., Niederwanger, C., Löckinger, A., Kleinsasser, A. T., & Bachler, M. (2020) · Nutrients · doi:10.3390/nu12061738 · Cited by 6
“As early as 1981, frequent caffeine consumers have been shown to respond less to acute administration than caffeine-naive individuals [25].”
BackgroundCaffeine’s Effects on the Human Stress Axis
Nehlig, A. (2004) · CRC Press eBooks · doi:10.1201/9780203618851-15 · Cited by 6
Kliszczewicz, B. M., Bechke, E. E., Williamson, C. M., Green, Z., Bailey, P., McLester, J. R., & McLester, C. N. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0271-1 · Cited by 6
Haigh, R. A., Harper, G. D., Fotherby, M. D., Hurd, J., Macdonald, I. A., & Potter, J. F. (1993) · European Journal of Clinical Pharmacology · doi:10.1007/bf02440857 · Cited by 6
“Tolerance to caffeine may develop with regular intake in these young subjects however, resulting in little or no blood pressure response when caffeine is consumed without a preceeding period of abstinence [Robertson et al. 1981].”
BackgroundSatoh, H., & Tanaka, T. (1997) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050281 · Cited by 6
Influence of slow calcium-channel blockade on the cardiovascular effects of coffee
Smits, P., Thien, T. A., & Laar, A. V. (1986) · European Journal of Clinical Pharmacology · doi:10.1007/bf00614297 · Cited by 6
“Perhaps an increase in PRA after coffee may occur only after a longer period of abstinence from caffeine, as tolerance to the humoral effects of caffeine has been described (Robertson et al. 1981).”
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“most widely used drug in western society (1).”
Background
Metadata
- Authors
- Robertson, D., Wade, D., Workman, R., Woosley, R. L., & Oates, J. A.
- Affiliations
- Vanderbilt University (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1981-04-01
- Volume
- 67
- Issue
- 4
- Pages
- 1111-1117
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC370671
- OpenAlex
- W1970693682
- Cited by
- 501
- References
- 35
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 15 · 2017: 9 · 2016: 13 · 2015: 5 · 2014: 16 · 2013: 16 · 2012: 9
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- caffeine, tolerance (pharmacology and immunology), blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, urinary catecholamines, methylxanthines, caffeine withdrawal, hemodynamic effects
- MeSH terms
- Adult, Blood Pressure, Caffeine, Catecholamines, Double-Blind Method, Drug Tolerance, Female, Hemodynamics, Humans, Male, Middle Aged, Renin
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