The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Tolerance to the humoral and hemodynamic effects of caffeine in man.
Open accessAbstract
Acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, and urinary catecholamines. Using a double-blind design, the effects of chronic caffeine administration on these same variables were assessed. Near complete tolerance, in terms of both humoral and hemodynamic variables, developed over the first 1-4 d of caffeine. No long-term effects of caffeine on blood pressure, heart rate, plasma renin activity, plasma catecholamines, or urinary catecholamines could be demonstrated. Discontinuation of caffeine ingestion after 7 d of administration did not result in a detectable withdrawal phenomenon relating to any of the variables assessed.
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“These opinions and advisories are based upon a relatively small collection of caffeine studies that have been publicised in both scientific and lay literature and in the media over the past few decades [10], [17], [25].”
From No Evidence of Dehydration with Moderate Daily Coffee Intake: A Counterbalanced Cross-Over Study in a Free-Living Population (2014) · cites this paper as [25]
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“In short-term studies, it has been shown to increase blood pressure and peripheral vascular resistance, but tolerance rapidly develops. 4”
From Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform (2001) · cites this paper as [4]
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“In short-term studies, it has been shown to increase blood pressure and peripheral vascular resistance, but tolerance rapidly develops. 4”
From Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform (2001) · cites this paper as [4]
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“In short-term studies, it has been shown to increase blood pressure and peripheral vascular resistance, but tolerance rapidly develops. 4”
From Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform (2001) · cites this paper as [4]
In the citing paper
“Earlier studies which claimed to show tolerance to the pressor effects of caffeine [11,[16][17][18] have not mirrored 'normal' staggered caffeine consumption but are characterized by a prior period of prolonged abstinence followed by a high dose of caffeine administered once or twice daily.”
From Central and peripheral effects of sustained caffeine use: tolerance is incomplete (2002) · cites this paper as [11]
In the citing paper
“the effects of CAF on epinephrine are blunted within 1-4 d (36) of ingestion”
From The Glucose Intolerance Induced by Caffeinated Coffee Ingestion Is Less Pronounced than That Due to Alkaloid Caffeine in Men (2006) · cites this paper as [36]
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Citations
Cites
Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure
Robertson, D., Frölich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., & Oates, J. A. (1978) · New England Journal of Medicine · doi:10.1056/nejm197801262980403 · Cited by 757
Self-citationA simplified radiometric assay for plasma norepinephrine and epinephrine
Passon, P. G., & Peuler, J. D. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90517-4 · Cited by 637
Clutter, W. E., Bier, D. M., Shah, S. D., & Cryer, P. E. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109840 · Cited by 576
Beavo, J. A., ROGERS, N. L., Crofford, O. B., Hardman, J. G., Ew, S., & NEWMAN, E. V. (1970) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)15265-6 · Cited by 471
Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man.
Robertson, D., Johnson, G., Robertson, R. M., Nies, A. S., Shand, D. G., & Oates, J. A. (1979) · Circulation · doi:10.1161/01.cir.59.4.637 · Cited by 467
Self-citationElectromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle
DROOGMANS, G., & Casteels, R. (1984) · Developments in cardiovascular medicine · doi:10.1007/978-1-4757-1171-4_35 · Cited by 431
Are Methylxanthine Effects Due to Antagonism of Endogenous Adenosine?
Fredholm, B. B. (1979) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(79)90046-4 · Cited by 409
ELECTROMECHANICAL AND PHARMACOMECHANICAL COUPLING IN VASCULAR SMOOTH MUSCLE
Somlyo, A. V., & Somlyo, A. P. (1968) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27848-x · Cited by 304
Boston Collaborative Drug Surveillance Program
Jick, H. (1978) · BMJ · doi:10.1136/bmj.1.6109.365-a · Cited by 248
Release of norepinephrine in the central nervous system by theophylline and caffeine
Berkowitz, B. A., Tarver, J., & Spector, S. (1970) · European Journal of Pharmacology · doi:10.1016/0014-2999(70)90158-5 · Cited by 212
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Heishman, S. J., Heishman, J., & Henningfield, J. E. (1999) · CRC Press eBooks · doi:10.1201/9781439822470.ch7 · Cited by 6
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Riksen, N. P., Hausenloy, D. J., & Yellon, D. M. (2008) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-008-6108-9 · Cited by 6
“These findings do not necessarily hold true for chronic coffee consumption, particularly because tolerance to the cardiovascular effects of caffeine has been described [13].”
BackgroundKhan, A., Ali, T. M., Imran, M., Ali, S., & Khan, M. (2017) · Current Research in Nutrition and Food Science Journal · doi:10.12944/crnfsj.5.3.09 · Cited by 5
Bors, L. A., Bajza, Á., Kocsis, D., & Erdő, F. (2018) · Orvosi Hetilap · doi:10.1556/650.2018.30993 · Cited by 5
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Wang, K., & Song, M. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.02.004 · Cited by 5
Caffeine, Creatine, and Food–Drug Synergy: Ergogenics and Applications to Human Health
Graham, T. E., & Moisey, L. L. (2005) · CRC Press eBooks · doi:10.1201/9781420038255-17 · Cited by 5
Dietary factors and hypertension
Huttunen, J. K., Pietinen, P., Nissinen, A. M., & Puska, P. (1985) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1985.tb08892.x · Cited by 5
Hursel, R., & Westerterp‐Plantenga, M. S. (2009) · Wiley eBooks · doi:10.1002/9780813819679.ch10 · Cited by 5
Physiological and clinical effects of tea
Marks, V. (1992) · Tea · doi:10.1007/978-94-011-2326-6_21 · Cited by 5
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Neims, A. H. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1986.tb07701.x · Cited by 5
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Rodricks, J. V., Turnbull, D., Chowdhury, F., & Wu, F. (2020) · Wiley eBooks · doi:10.1002/9781119438922.ch6 · Cited by 5
Soldato, D., Havas, J., Crane, T. E., Presti, D., Lapidari, P., Rassy, N., Pistilli, B., Martin, É., Mastro, L. D., Martin, A., et al. (2022) · Cancer · doi:10.1002/cncr.34401 · Cited by 4
“Caffeine, however, can also contribute to insomnia and induce anxiety,(54) although these effects may be partially related to patterns of consumption, individual metabolism,(55) genetic,(56) clinical predisposition, and tolerance.(57) To our knowledge, this is the first study to provide a comprehensive, longitudinal e…”
BackgroundBarbagallo, M., Springer, A., Vanetta, C., Allemann, M., Lee, P., Saravi, S. S. S., Aeschbacher, S., Luciani, M., Bonati, L. H., Moschovitis, G., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.124.034365 · Cited by 4
Using caffeine for physical exercise: advantages and risks
Ramírez-Montes, C. A., & Osório, J. H. (2013) · Revista de la Facultad de Medicina · Cited by 4
Caffeine Psychopharmacology and Effects on Cognitive Performance and Mood
James, J. E. (2012) · doi:10.1007/978-1-137-00689-9_14 · Cited by 4
Integrated TK–TD modeling for drug-induced concurrent tachycardia and QT changes in beagle dogs
Wu, F., Heimbach, T., Hatsis, P., Tang, H.-M., Dugyala, R. R., Yue, Q., Wang, T., & He, H. (2017) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-017-9532-2 · Cited by 4
James, J. E. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0338-9_26 · Cited by 4
May, D. B., Young, L. Y., & Wiser, T. H. (1992) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-13175-4_7 · Cited by 4
Dietary Caffeine and Its Toxicity
Bergman, J., & DEWS, P. B. (1987) · Elsevier eBooks · doi:10.1016/b978-0-12-332602-7.50014-6 · Cited by 4
Cheung, M., Quach, J. L., Chan, A., Nguyen, N. N., & Shah, S. A. (2016) · Journal of Caffeine Research · doi:10.1089/jcr.2016.0013 · Cited by 3
“34 Hence, the risks associated with an initially elevated blood pressure could be decreased with exposure.”
Anwar, S., Verma, P., & Dutt, R. (2022) · Current Traditional Medicine · doi:10.2174/2215083808666220321145436 · Cited by 4
Energy drinks - product ingredients and their potential toxicity
Sekuła, M. J., Kaleta, N., Pawłucki, P., Maciak, A., Domagalski, Ł., Andrasz, E., & Cuper, P. (2023) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.44.01.012 · Cited by 3
“[28] Nie ma natomiast badań, które opisywałyby szkodliwy wpływ na organizm napojów energetycznych stosowanych przez kilka lub kilkanaście lat w dużych dawkach.”
BackgroundFrequencies of CYP1A2 Single Nucleotide Polymorphism in Indonesian and Its Effect on Blood Pressure
Sugiono, E., Wijaya, A., Santoso, A., Sandra, F., Patellongi, I. J., & Yusuf, I. (2018) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v10i3.374 · Cited by 3
Methylxanthines as Adenosine Receptor Antagonists
Parsons, W. J., & Stiles, G. L. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-4-643_1 · Cited by 3
Cardiac arrest: a case-based review
Li, Y., Huang, Y. H., & Li, S. (2014) · World Journal of Emergency Medicine · doi:10.5847/wjem.j.issn.1920-8642.2014.03.002 · Cited by 3
Ulutaş, D. S. S., Acar, N. E., & Yıldırım, İ. (2019) · Türkiye Spor Bilimleri Dergisi · doi:10.32706/tusbid.542906 · Cited by 3
Substance Use and Addictive Disorders: Caffeine
Meredith, S. E., & Griffiths, R. R. (2015) · Wiley eBooks · doi:10.1002/9781118753378.ch73 · Cited by 3
Magkos, F., & Kavouras, S. A. (2004) · CRC Press eBooks · doi:10.1201/9780203507704.ch17 · Cited by 4
Caffeine and Cardiovascular Outcomes: Current Evidence and Clinical Perspectives
Neshat, N., Frishman, W. H., & Aronow, W. S. (2026) · Cardiology in Review · doi:10.1097/crd.0000000000001252 · Cited by 2
Associations of urinary caffeine and caffeine metabolites with metabolic syndrome in US adults
Zhou, J., & Qin, L. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1280215 · Cited by 2
Habtemariam, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102922-0.00021-3 · Cited by 2
Influence of Smoking, Alcohol, Caffeine and Recreational Drugs on Cardiac Autonomic Tests
Ghuran, A., & Malík, M. (1998) · Springer eBooks · doi:10.1007/978-94-017-1057-2_13 · Cited by 2
Acute Effects of Caffeine on Arterial Stiffness in Young Healthy Subjects
Nam, C., Kim, K. S., Lee, Y. S., Nam, C., Lee, S. H., Han, S. W., Hur, S., Kim, Y. N., & Kim, K. B. (2005) · Korean Circulation Journal · doi:10.4070/kcj.2005.35.11.841 · Cited by 2
Dietary Conjugated Linoleic Acid: An Old Fatty Acid with Potential New Applications
Belury, M. A., & Koster, C. (2004) · Cited by 2
Testing Low Doses of Caffeine on Respiratory Resistance Using the Airflow Perturbation Device
Montgomery, M. K., Luk, A., Johnson, A. T., & Vossoughi, J. (2017) · Open Journal of Respiratory Diseases · doi:10.4236/ojrd.2017.72006 · Cited by 2
Childs, E., & de Wit, H. (2012) · Wiley eBooks · doi:10.1002/9781119949893.ch17 · Cited by 2
Dattilo, G. L. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.152.4.797 · Cited by 2
Consumo de café y diabetes mellitus
Rojo‐Martínez, G., Morcillo, S., Almaraz, M. C., & Soriguer, F. (2005) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(05)71064-0 · Cited by 2
The Effects of Caffeine on Psychological Functioning
Edelmann, R. J., & Moxon, S. (1985) · Nutrition and Health · doi:10.1177/026010618500400105 · Cited by 2
Maternal Caffeine Consumption and its Relationship to Adverse Pregnancy Outcomes
Potdar, N. (2010) · Figshare · Cited by 2
Barceloux, D. G. (2012) · Wiley eBooks · doi:10.1002/9781118105955.ch55 · Cited by 2
Sikiru, L., & Musa, D. I. (2008) · African Research Review · doi:10.4314/afrrev.v2i1.41036 · Cited by 1
Energydrinks in der Notfallmedizin – verleihen nicht nur Flügel
Knapp, J., Zylla, M. M., Schaper, A., Michalski, D., Härtwig, S., & Bernhard, M. K. (2017) · Notfall + Rettungsmedizin · doi:10.1007/s10049-017-0386-3 · Cited by 1
Caffeine’s Effects on the Human Stress Axis
Lovallo, W. R., & Al’Absi, M. (2004) · Nutrition, brain, and behavior./Nutrition, brain and behavior · doi:10.1201/9780203618851.ch8 · Cited by 1
Miyauchi, T., Haraguchi, T., Emoto, T., Takawaki, K., Matsudaira, M., & Inobe, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-25041-0 · Cited by 1
“Additionally, it has been suggested that caffeine in coffee may result in the development of tolerance through continuous oral intake over four consecutive days 27 .”
Maternal Caffeine Consumption and Pregnancy Outcomes
James, J. E. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12741-9_10 · Cited by 1
Rawal, S. R. (2013) · Cited by 1
Summerell, E., Wong, I., & Denson, T. F. (2023) · Springer eBooks · doi:10.1007/978-3-031-31547-3_91 · Cited by 2
How to Induce Arrhythmias with Caffeine?
Lazea, C. (2019) · Springer eBooks · doi:10.1007/978-3-319-92729-9_13 · Cited by 1
CNS Stimulants and Athletic Performance
Wenger, G. R. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5499-4_14 · Cited by 1
Jacobson, M. A. (2011) · UVic’s Research and Learning Repository (University of Victoria) · Cited by 1
Gauvin, M. (2016) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/thesis-gauvin-mark-2016 · Cited by 1
Coffee intake, glucose metabolism and gene polymorphisms: response to Kawada
Robertson, T. M., Clifford, M. N., Penson, S., Williams, P., & Robertson, M. D. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518002817 · Cited by 1
“Indeed, just 7 d caffeine intake was sufficient to reverse its acute adrenalin-raising effect((7)).”
BackgroundShapiro, M. S., Hickman, A., & Jonah, S. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4794711
Behavioral Pharmacology of Caffeine
Evans, S. M. (1998) · Springer eBooks · doi:10.1007/978-1-4757-2913-9_6 · Cited by 2
Coffee Intake and Risk of Hypertension: The Johns Hopkins Precursors Study
Klag, M. J., Wang, N.-Y., Meoni, L. A., Brancati, F. L., Cooper, L. A., Liang, K.-Y., Young, J. H., & Ford, D. E. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.6.657 · Cited by 4
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Diepvens, K. (2007) · Research Publications (Maastricht University) · doi:10.26481/dis.20071102kd
Triggers for energy expenditure: Thermogenic ingredients & circadian aspects
Hursel, R. (2011) · Research Publications (Maastricht University) · doi:10.26481/dis.20110415rh
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Haile, L., Gallagher, M. S., & Robertson, R. J. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1917-8_15
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Wai, N., Khaled, M., & Sikarwar, A. (2015) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2015/15037
“days of caffeine [30].”
Association of Caffeine C onsumption and Sleep Patt erns in Emerging Adults
Hawkshead, C. T. (2008)
Effect of theophylline on blood level of catecholamines
Saprygina, T. V., Tsoi, A. N., & Be, K. (1988) · Pharmaceutical Chemistry Journal · doi:10.1007/bf00773607
The Effects of Caffeine and Caffeine Withdrawal/Deprivation on Hostage Negotiator Performance
Mullins, W. C. (2003) · Journal of Police Crisis Negotiations · doi:10.1300/j173v03n02_06
Hypoglycemia unawareness. Pathophysiological and pharmacological aspects
de Galan, B. E. (2003) · Radboud Repository (Radboud University)
The effect of caffeine on tinnitus : Friend or foe?
Buick, D. L. (1992) · UC Research Repository (University of Canterbury) · doi:10.26021/6415
Probiotic Supplementation, The Gut Microbiota, and Cardiovascular Health
Boutagy, N. E. (2014) · VTechWorks (Virginia Tech)
Mioto, B. M. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2016.tde-24022016-150125
Goto, A., & Liu, S. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849734752-00369
Habitual coffee consumption and blood pressure: A study of self-defense
Wakabayashi, K., Kono, S., Shinchi, K., Honjol, S., Todorokil, I., Sakurai, Y., Umeda, T., Imanishi, K., & Yoshizawa, N. (1998)
[The effect of caffeine on hypertension].
Stisen, A. B., Lambrechtsen, J., & Puggaard, L. (2005) · PubMed
Genetic Determinants of the Acute Effects and Withdrawal Symptoms of Caffeine
Tasevski, E. L. D. (2010) · TSpace (University of Toronto)
Blood Pressure Effects of Dietary Caffeine Are a Risk for Cardiovascular Disease
James, J. E. (2006) · CRC Press eBooks · doi:10.1201/9781420006568.ch6
de Cardiologia, P., & Paulo, S. (2015)
The effects of caffeine on delay discounting in humans
Markham, A. D. (2010) · JMU Scholoraly Commons (James Madison University)
Genetic Variability in Caffeine Acute Effects and Withdrawal Symptoms
Brathwaite, J. M. (2011) · TSpace (University of Toronto)
Virtanen, H. (2017) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/24696
Peerapen, P., & Thongboonkerd, V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815864-7.00007-6
Caffeine in Beverages: Cardiovascular Effects
Mattioli, A. V., Puviani, M. B., & Farinetti, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815864-7.00008-8
A Study of Caffeine and Its Metabolites in Human Body Fluids.
Scott, N. (1986) · Surrey Research Insight Open Access (The University of Surrey)
Gani, A., Lelo, A., Yamin, M., Putra, E. D. L., & Damanik, H. A. (2016) · International Journal of PharmTech Research
O’Connell, M. T. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5356-0_13
(1985) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1985.tb14736.x
Caffeine, Creatine, and Food—Drug Synergy
Moisey, L. L., & Graham, T. E. (2005) · CRC Press eBooks · doi:10.1201/9781420038255.sec6
Caldwell, J. A., & Caldwell, J. A. (2004) · Lung biology in health and disease · doi:10.1201/b14100-21
How (not) to injure the preterm lung
Hütten, M. C. (2016) · doi:10.26481/dis.20161220mh
Musa, D. I. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3794692
Hänsel, R., Keller, K., Rimpler, H., Schneider, G., Aye, R. D., Bauer, I., Baumann, T. W., Beck, M., Beil, A., Blascheck, W., et al. (1992) · Springer eBooks · doi:10.1007/978-3-642-58087-1_3
Summerell, E., Wong, I., & Denson, T. F. (2022) · Springer eBooks · doi:10.1007/978-3-030-98711-4_91-1
Associations of urinary caffeine and caffeine metabolites with metabolic syndrome in U.S. adultsPreprint
Qin, L., & Zhou, J. (2023) · Research Square · doi:10.21203/rs.3.rs-2953101/v1
Ekpenyong, C. E., Nwachuku, C., & Otokpa, D. E. (2020) · Archives of Nephrology · doi:10.22259/2639-3573.0302001
Popa, L. C., Farcaş, S. S., & Andreescu, N. I. (2024) · Research Square · doi:10.21203/rs.3.rs-4963863/v1
Goto, A., & Liu, S. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849733670-00369
Dietary Supplements for Performance Enhancement in Esports
Bayram, H. M., Rogers, E. J., & Arslan, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-99625-2_6
Rayo-Mendez, L. M., Kinzer, C., McMahon, J., Nguyen, M., & Harris, G. K. (2025) · Journal of Nutrition and Metabolism · doi:10.1155/jnme/4174563
“By inhibiting adenosine receptors, cafeine disrupts insulin-mediated glucose uptake, thereby contributing to elevated postprandial blood glucose levels [3, 7, 15, 17].”
Cox, C. P. W., de Lussanet, Q. G., Mulders, T. A., Graven, L. H., Verburg, F. A., & Brabander, T. (2025) · Research Square · doi:10.21203/rs.3.rs-7739411/v1
Kim, S., & Shin, D. (2025) · Nutrition Research and Practice · doi:10.4162/nrp.2025.19.6.943
“Caffeine consumption acutely raises BP, but long-term consumption reduces this effect as the body becomes resistant to caffeine [55].”
Debating coffee and hypertension: coffee may increase the risk for chronic hypertension
Palatini, P. (2026) · American Journal of Hypertension · doi:10.1093/ajh/hpag017
Ist Kaffeegenuss ein kardiovaskulärer Risikofaktor?
Corti, R., Binggeli, C., Sudano, I., Spieker, L. E., Lüscher, T. F., & Noll, G. (1999) · Cardiovascular Medicine · doi:10.3390/cardiovascmed2050053
Caffeine and Semen Quality: Safety and Mechanisms of Actions
Banihani, S. A. (2026) · Andrologia · doi:10.1155/and/3319657
Metadata
- Authors
- Robertson, D., Wade, D., Workman, R., Woosley, R. L., & Oates, J. A.
- Affiliations
- Vanderbilt University (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1981-04-01
- Volume
- 67
- Issue
- 4
- Pages
- 1111-1117
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC370671
- OpenAlex
- W1970693682
- Cited by
- 501
- References
- 35
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 15 · 2017: 9 · 2016: 13 · 2015: 5 · 2014: 16 · 2013: 16 · 2012: 9
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- caffeine, tolerance (pharmacology and immunology), blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, urinary catecholamines, methylxanthines, caffeine withdrawal, hemodynamic effects
- MeSH terms
- Adult, Blood Pressure, Caffeine, Catecholamines, Double-Blind Method, Drug Tolerance, Female, Hemodynamics, Humans, Male, Middle Aged, Renin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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