The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.
Open accessAbstract
A decade of intense investigation has established a central role for lipoprotein receptors in regulating plasma cholesterol traffic. These receptors bind cholesterol-carrying lipoproteins and transport them into cells by receptor-mediated endocytosis. The receptor for low density lipoprotein (LDL) was the first discovered; it has been purified and its structure characterized. The LDL receptor was described in cultured human fibroblasts; identical receptors are now known to function in liver as well as in extrahepatic tissues. Operationally, the LDL/LDL receptor system can be considered the primary transport mechanism for endogenous cholesterol. Dietary cholesterol, on the other hand, is transported from the intestine in chylomicron remnants, which enter hepatocytes via distinct chylomicron remnant receptors. The chylomicron remnant/remnant receptor system is to exogenous cholesterol transport as the LDL/LDL receptor system is to endogenous cholesterol transport. In this article, we review recent developments in this rapidly advancing field.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“While LDL biology is mostly relevant for peripheral diseases32,54,55”
From Decreased lipidated ApoE‐receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes (2025) · cites this paper as [54]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Prescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?
Juma, S., Imrhan, V., Vijayagopal, P., & Prasad, C. (2014) · Lifestyle Genomics · doi:10.1159/000370213 · Cited by 1,908
Lipoprotein receptors and cholesterol homeostasis
Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 756
Human apolipoprotein E. The complete amino acid sequence
Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34702-1 · Cited by 741
Regulation of Plasma Cholesterol by Lipoprotein Receptors
Brown, M. S., Kovanen, P. T., & Goldstein, J. L. (1981) · Science · doi:10.1126/science.6261329 · Cited by 702
Self-citationPolymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man
UTERMANN, G., HEES, M., & STEINMETZ, A. (1977) · Nature · doi:10.1038/269604a0 · Cited by 666
Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563
Windler, E. E. T., Kovanen, P. T., Chao, Y. S., Brown, M. S., Havel, R. J., & Goldstein, J. L. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70487-6 · Cited by 456
Self-citationSherrill, B. C., Innerarity, T. L., & Mahley, R. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85951-3 · Cited by 426
Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
Kovanen, P. T., Bilheimer, D. W., Goldstein, J. L., Jaramillo, J. J., & Brown, M. S. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.2.1194 · Cited by 421
Self-citationLipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.
Hui, D. Y., Innerarity, T. L., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69254-9 · Cited by 383
Research works printed but not linked: 13
- [4]4. Kita, T., J. L. Goldstein, M. S. Brown, Y. Watanabe, C. A. Hornick, and R. J. Havel. 1982. Proc. Natl. Acad. Sci. USA. 79:3623-3627.
- [11]11. Kovanen, P. T., M. S. Brown, S. K. Basu, D. W. Bilheimer, and J. L. Goldstein. 1981. Proc. Natl. Acad. Sci. USA. 78:1396-1400.
- [3]3. percholesterolemia. Chapter 33. In The Metabolic Basis of Inherited Disease. J. B. Stanbury, J. B. Wyngaarden, D. S. Fredrickson, J. L. Goldstein, and M. S. Brown, editors. Fifth ed. McGraw-Hill Book Co., New York. 672-712.
- [12]12. Angelin, B., C. A. Raviola, T. L. Innerarity, and R. W. 34. Bilheimer, D. W., Y. Watanabe, and T. Kita. 1982. Proc. Mahley. 1983. J. Clin. Invest. 71:816-831. Natl. Acad. Sci. USA. 79:3305-3309.
- [14]14. Bilheimer, D. W., S. M. Grundy, M. S. Brown, and J. L. Goldstein. 1983. Proc. Natl. Acad. Sci. USA. In press.
- [16]16. Kovanen, P. T., D. W. Bilheimer, J. L. Goldstein, J. J. Jaramillo, and M. S. Brown. 1981. Proc. Natl. Acad. Sci. USA. 78:1194-1198.
- [18]18. Thompson, G. R., A. K. Soutar, F. A. Spengel, A. Jadhav, S. J. P. Gavigan, and N. B. Myant. 1981. Proc. Natl. Acad. Sci. USA. 78:2591-2695.
- [22]22. Goldstein, J. L., T. Kita, and M. S. Brown. 1983. N. Engl. J. Med. In press.
- [36]36. Mahley, R. W., K. H. Weisgraber, G. W. Melchior, T. L. Innerarity, and K. S. Holcombe. 1980. Proc. Natl. Acad. Sci. USÁ. 77:225-229.
- [40]40. Mahley, R. W., and B. Angelin. 1983. Adv. Intern. Med. In press.
- [43]43. Rall, S. C., Jr., K. H. Weisgraber, T. L. Innerarity, and R. W. Mahley. 1982. Proc. Natl. Acad. Sci. USA. 79:4696-4700.
- [46]46. Havel, R. J., Y-S. Chao, E. E. Windler, L. Kotite, and L. S. S. Guo. 1980. Proc. Natl. Acad. Sci. USA. 77:43494353.
- [53]53. Bilheimer, D. W., S. M. Grundy, M. S. Brown, and J. L. Goldstein. 1983. Trans. Assn. Am. Phys. In press.
Cited by
Sorted by citations
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Self-citationApolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
Plasma lipoproteins: apolipoprotein structure and function.
Mahley, R. W., Innerarity, T. L., Rall, S. C., & Weisgraber, K. H. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34443-6 · Cited by 1,155
HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia
Oates, J. A., Wood, A. J. J., & Grundy, S. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807073190105 · Cited by 760
Ishibashi, S., Goldstein, J. L., Brown, M. S., Herz, J., & Burns, D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117179 · Cited by 731
Self-citation
Metadata
- Authors
- Brown, M. S., & Goldstein, J. L.
- ORCID
- Goldstein, J L
- Venue
- Journal of Clinical Investigation
- Published
- 1983-09-01
- Volume
- 72
- Issue
- 3
- Pages
- 743-747
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1129238
- OpenAlex
- W2137716547
- Cited by
- 545
- References
- 48
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 13
- FWCI
- 66.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (HL20948)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- lipoprotein receptors, liver, LDL receptor, receptor-mediated endocytosis, chylomicron remnants, dietary cholesterol, hepatocytes
- MeSH terms
- Animals, Apolipoproteins, Apolipoproteins E, Apoproteins, Binding, Competitive, Cholesterol, Cyclohexanones, Dogs, Guinea Pigs, Cricetinae, Humans, Hyperlipoproteinemia Type II, Liver, Macaca mulatta, Molecular Weight, Rabbits, Receptors, Cell Surface, Receptors, LDL, Receptors, Lipoprotein, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
