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Cited by 199Stress Responses and CortisolAdrenal Hormones and DisordersPregnancy-related medical research

The corticotrophin releasing hormone test in late pregnancy: lack of adrenocorticotrophin and cortisol response

SCHULTE, HEINRICH M., WEISNER, DIETRICH, ALLOLIO, BRUNO·1990·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1990.tb00470.x
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Abstract

SUMMARY: Biologically active corticotrophin‐releasing‐hormone (CRH) is produced by the placenta in large amounts and can be measured in the maternal circulation during third trimester of pregnancy. Its physiological significance is unknown. To further investigate the action of CRH in pregnancy, we performed a standard CRH‐test (1 μg/kg synthetic human CRH) in seven pregnant women 1 week prior to their calculated delivery data and 4‐5 weeks post‐partum. No response of plasma ACTH to CRH administration could be measured in any of the third trimester pregnant women. Post‐partum, basal ACTH levels were significantly lower (1.6 |Mp 0.3 vs 5.3 |Mp 0.2 pmo1/1) and reacted promptly to CRH administration (1.6 |Mp 0.3–4.2 |Mp 0.5 pmol/1; P < 0.05). Concentrations of cortisol in plasma and salivary cortisol paralleled the ACTH response to administration of CRH. However, one pregnant woman experienced physical and emotional stress during the CRH‐test and reacted with a sharp rise in cortisol secretion. The lack of the ACTH and cortisol response in this study to exogenously administered CRH in third trimester pregnancy may be due to high circulating glucocorticoid concentrations, desensitization of the pituitary corticotroph and/or in part due to circulating specific CRH‐carrier protein.

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Crossref · 10.1111/j.1365-2265.1990.tb00470.x

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  • The timing effect may be due to pregnancy anxiety being highest at 19 weeks and decreasing over gestation, consistent with previous observations of reduced stress reactivity as pregnancy advances.

    “This effect of timing may be due to the fact that pregnancy anxiety is highest at 19 weeks gestation and decreases over the course of gestation, which is in line with previous observations of reduced physiological and psychological stress reactivity as pregnancy advances (Schulte et al., 1990; Glynn et al., 2001; Glynn et al., 2004; de Weerth & Buitelaar, 2005; Glynn et al., 2008)”

    From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Schulte et al., 1990

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Authors
SCHULTE, H. M., WEISNER, D., & ALLOLIO, B.
Affiliations
  • Christian-Albrechts-Universität zu Kiel (DE)
  • University of Cologne (DE)
Corresponding author
SCHULTE, HEINRICH M.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1990-07
Volume
33
Issue
1
Pages
99-106
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.1990.tb00470.x
OpenAlex
W1994345705
Cited by
199
References
34
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 2 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 3 · 2015: 9 · 2014: 7 · 2013: 10 · 2012: 10
FWCI
1.32
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6572 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
Keywords
pregnancy, third trimester, ACTH, cortisol, postpartum period, salivary cortisol, glucocorticoid feedback, pituitary corticotrophs
MeSH terms
Adolescent, Adrenocorticotropic Hormone, Adult, Corticotropin-Releasing Hormone, Female, Humans, Hydrocortisone, Pregnancy, Saliva

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