Insulin-induced hypoglycemia stimulates corticotropin-releasing factor and arginine vasopressin secretion into hypophysial portal blood of conscious, unrestrained rams
Open accessAbstract
Insulin-induced hypoglycemia (IIH) is a strong stimulator of pituitary ACTH secretion. The mechanisms by which IIH activates the corticotrophs are still controversial. Indeed, in rats the variations of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) secretion in hypophysial portal blood (HPB) during IIH have been diversely appreciated. This may be due to the stressful conditions required for portal blood collection in rats. We studied the effects of IIH on the secretion of CRF and AVP in HPB and on the release of ACTH and cortisol in peripheral plasma in conscious, unrestrained, castrated rams. After the injection of a low (0.2 IU/kg) or high dose (2 IU/kg) of insulin, ACTH and cortisol levels in peripheral plasma increased in a dose-related manner. After injection of the low dose of insulin, CRF and AVP secretion in HPB were equally stimulated. After injection of the high dose of insulin, CRF secretion was further stimulated, while AVP release was dramatically increased. These results suggest that when the hypoglycemia is moderate, CRF is the main factor triggering ACTH release, and that the increased AVP secretion potentiates the stimulatory effect of CRF. When hypoglycemia is deeper, AVP secretion becomes predominant and may by itself stimulate ACTH release.
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- Authors
- Caraty, A., Grino, M., Locatelli, A., Guillaume, V, Boudouresque, F., Conte-Devolx, B., & Oliver, C.
- Affiliations
- Inserm (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 1990-06-01
- Volume
- 85
- Issue
- 6
- Pages
- 1716-1721
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC296631
- OpenAlex
- W2148568711
- Semantic Scholar
- 2990eb8503cf2e630fdc504619bc11632f9edd27
- Cited by
- 128
- References
- 28
- Citations by year
- 2026: 2 · 2024: 1 · 2021: 4 · 2020: 2 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- insulin-induced hypoglycemia, corticotropin-releasing factor, vasopressin, ACTH secretion, cortisol, hypophysial portal blood, pituitary corticotrophs, rams, hypothalamic-pituitary-adrenal axis
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Blood Glucose, Corticotropin-Releasing Hormone, Hydrocortisone, Hypoglycemia, Insulin, Male, Pituitary Gland, Secretory Rate, Sheep
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