Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep: II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing’s syndrome of endogenous depression and anorexia nervosa
Open accessAbstract
Studies were performed to determine the effects of intracerebroventricular norepinephrine (NE) or neuropeptide Y (NPY) on the ovine hypothalamic-pituitary-adrenal (HPA) axis. NE (50 micrograms) increased mean hypophysial-portal corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) levels (1 h, 1.3- and 2.9-fold; 4 h, 2.2- and 5.7-fold) and caused acute and sustained increases in mean plasma ACTH and cortisol. NPY (50 microgram) also increased mean CRF and AVP levels (1 h, 1.4- and 4.2-fold; 4 h, 1.1- and 1.9-fold), increased pituitary-adrenal activity at 1 h, and caused ACTH hypersecretion at 4 h. When added to cultured ovine anterior pituitary cells, NPY neither increased basal ACTH release nor augmented CRF- or AVP-induced ACTH release. We conclude that: (a) activation of either the central noradrenergic or NPY pathways causes an acute and sustained stimulation of the ovine HPA axis; (b) such activation increases the AVP/CRF ratio, suggesting a dominant role for AVP in the ovine stress response; and (c) the central noradrenergic or NPY systems may cause sustained HPA activation by attenuating or disrupting the glucocorticoid negative feedback on those brain areas concerned with regulation of the HPA axis. The possible roles of the central noradrenergic and NPY systems in the etiology of the hypercortisolemia of endogenous depression and anorexia nervosa are discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
The regulation and function of c-fos and other immediate early genes in the nervous system
Sheng, M., & Greenberg, M. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90106-p · Cited by 2,432 · see citing works
Tatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254 · see citing works
Carroll, B. J. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780260017001 · Cited by 2,243 · see citing works
Swanson, L. W., Sawchenko, P. E., Rivier, J., & Vale, W. W. (2008) · Neuroendocrinology · doi:10.1159/000123454 · Cited by 1,953 · see citing works
Corticosteroid inhibition of acth secretion
KELLER-WOOD, M. E., & DALLMAN, M. F. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-1 · Cited by 1,219 · see citing works
Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
Schüle, R., Rangarajan, P. N., Kliewer, S. A., Ransone, L. J., Bolado, J., Yang, N., Verma, I. M., & Evans, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90397-w · Cited by 1,204 · see citing works
Sawchenko, P. E., & Swanson, L. W. (1982) · Brain Research Reviews · doi:10.1016/0165-0173(82)90010-8 · Cited by 1,141 · see citing works
Neuropeptide Y Distribution in the Rat Brain
Allen, Y. S., Adrian, T. E., Allen, J. M., Tatemoto, K., Crow, T. J., Bloom, S. R., & Polak, J. M. (1983) · Science · doi:10.1126/science.6136091 · Cited by 1,097 · see citing works
The anatomy of neuropeptide-y-containing neurons in rat brain
Chronwall, B. M., DiMaggio, D. A., Massari, V. J., Pickel, V. M., Ruggiero, D. A., & O’Donohue, T. L. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90260-x · Cited by 1,088 · see citing works
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965 · see citing works
Clarke, I. J., & Cummins, J. T. (1982) · Endocrinology · doi:10.1210/endo-111-5-1737 · Cited by 921 · see citing works
Self-citationAntoni, F. A. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-4-351 · Cited by 888 · see citing works
Everitt, B. J., Hökfelt, T. G. M., Terenius, L. Y., Tatemoto, K., Mutt, V., & Goldstein, M. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90036-8 · Cited by 871 · see citing works
Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions
Esler, M., Jennings, G., Lambert, G., Meredith, I., Horne, M., & Eisenhofer, G. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.4.963 · Cited by 794 · see citing works
Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W. T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142101 · Cited by 766 · see citing works
Neuropeptide Y distribution in human brain
Adrian, T. E., Allen, J. M., Bloom, S. R., Ghatei, M. A., Rossor, M. N., Roberts, G. W., Crow, T. J., Tatemoto, K., & Polak, J. M. (1983) · Nature · doi:10.1038/306584a0 · Cited by 701 · see citing works
Neuroreptide Y: Stimulation of feeding and drinking by injection into the paraventricular nucleus
Stanley, B. G., & LEIBOWITZ, S. F. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90032-8 · Cited by 665 · see citing works
Kalra, S. P., Dubé, M., Sahu, A., Phelps, C. P., & Kalra, P. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10931 · Cited by 665 · see citing works
Sawchenko, P. E., Swanson, L. W., Grzanna, R., Howe, P. R. C., Bloom, S. R., & Polak, J. M. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902410203 · Cited by 663 · see citing works
Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus
Valentino, R. J., Foote, S. L., & Aston‐Jones, G. (1983) · Brain Research · doi:10.1016/0006-8993(83)90615-7 · Cited by 603 · see citing works
VALE, W., VAUGHAN, J., SMITH, M., & YAMAMOTO, G. (1983) · Endocrinology · doi:10.1210/endo-113-3-1121 · Cited by 563 · cited 1× · see citing works
“The effect of CRFon ACTHrelease is potentiated by arginine vasopressin (AVP), oxytocin, angiotensin II, and the catecholamines norepinephrine and epinephrine (5, 6).”
BackgroundBai, F.-L., Yamano, M., Shiotani, Y., Emson, P. C., Smith, A. D., Powell, J. F., & Tohyama, M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90730-9 · Cited by 524 · see citing works
Butler, P., Weiss, J., Stout, J., & Nemeroff, C. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-01-00176.1990 · Cited by 402 · see citing works
Glucose Inhibition of the Glucose-sensitive Neurone in the Rat Lateral Hypothalamus
Oomura, Y., Ooyama, H., Sugimori, M., Nakamura, T., & YAMADA, Y. (1974) · Nature · doi:10.1038/247284a0 · Cited by 358 · see citing works
Effect of neuropeptide Y on ingestive behaviors in the rat
Morley, J. E., Levine, A. S., Gosnell, B. A., Kneip, J. M., & Grace, M. K. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.252.3.r599 · Cited by 292 · see citing works
Wahlestedt, C., Skagerberg, G., Ekman, R., Heilig, M. A., Sundler, F., & Håkanson, R. (1987) · Brain Research · doi:10.1016/0006-8993(87)90176-4 · Cited by 285 · see citing works
Vandesande, F., Dierickx, K., & Mey, J. D. (1977) · Cell and Tissue Research · doi:10.1007/bf00220167 · Cited by 270 · see citing works
Pathways to the Secretion of Adrenocorticotropin: A View from the Portal*
Plotsky, P. M. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00231.x · Cited by 258 · see citing works
Glucose responding neurons in the nucleus tractus solitarius of the rat: In vitro study
Mizuno, Y., & Oomura, Y. (1984) · Brain Research · doi:10.1016/0006-8993(84)90466-9 · Cited by 245 · see citing works
Hotta, M., Shibasaki, T., Masuda, A., Imaki, T., Demura, H., LING, N. C., & SHIZUME, K. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-2-319 · Cited by 239 · see citing works
Engler, D., Pham, T., Fullerton, M. J., Ooi, G., Funder, J. W., & Clarke, I. J. (2008) · Neuroendocrinology · doi:10.1159/000125141 · Cited by 235 · see citing works
Self-citationNorepinephrine and Its Metabolites in Cerebrospinal Fluid, Plasma, and Urine
Roy, A. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800330081010 · Cited by 208 · see citing works
Plotsky, P. M., BRUHN, T. O., & Vale, W. (1985) · Endocrinology · doi:10.1210/endo-117-1-323 · Cited by 196 · see citing works
Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vitro.
Calogero, A. E., Gallucci, W. T., Chrousos, G. P., & Gold, P. W. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113687 · Cited by 188 · see citing works
Burger, H., Vw, L., & Gc, R. (1972) · PubMed · Cited by 185 · see citing works
Liposits, Z., Sievers, L., & Paull, W. K. (1988) · Histochemistry · doi:10.1007/bf00570278 · Cited by 182 · see citing works
Kaye, W. H. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810180048008 · Cited by 174 · see citing works
Akana, S. F., Dallman, M. F., BRADBURY, M. J., Scribner, K. A., Strack, A. M., & Walker, C. D. (1992) · Endocrinology · doi:10.1210/endo.131.1.1319329 · Cited by 168 · see citing works
Hypercortisolism and its possible neural bases
Sapolsky, R. M., & Plotsky, P. M. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90032-w · Cited by 161 · see citing works
PRESENCE OP CORTICOTROPIN RELEASING FACTOR-LIKE IMMUNOREACTIVITY IN HYPOPHYSIAL PORTAL BLOOD
Gibbs, D. M., & Vale, W. (1982) · Endocrinology · doi:10.1210/endo-111-4-1418 · Cited by 159 · see citing works
Relationships between brain noradrenergic activity and blood glucose
Smythe, G. A., Grunstein, H. S., Bradshaw, J. E., Nicholson, M. V., & Compton, P. (1984) · Nature · doi:10.1038/308065a0 · Cited by 155 · see citing works
Liposits, Z., Phelix, C. F., & Paull, W. K. (1986) · Histochemistry and Cell Biology · doi:10.1007/bf00495783 · Cited by 149 · see citing works
Reincke, M., Allolio, B., Würth, G., & Winkelmann, W. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.1.8392081 · Cited by 147 · see citing works
BRUHN, T. O., Sutton, R. E., RIVIER, C. L., & Vale, W. (2008) · Neuroendocrinology · doi:10.1159/000123974 · Cited by 141 · see citing works
Caraty, A., Grino, M., Locatelli, A., Guillaume, V, Boudouresque, F., Conte-Devolx, B., & Oliver, C. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114626 · Cited by 128 · see citing works
Agnati, L. F., Fuxé, K., Yu, Z.-Y., Härfstrand, A., Okret, S., Wikström, A. C., Goldstein, M., Zoli, M., Vale, W., & Gustafsson, J.-Α. (1985) · Neuroscience Letters · doi:10.1016/s0304-3940(85)80070-7 · Cited by 121 · see citing works
Familari, M., Smith, I., Smith, R., & Funder, J. W. (2008) · Neuroendocrinology · doi:10.1159/000125214 · Cited by 116 · cited 2× · see citing works
“Stimulation of the Ovine Hypothalamic-Pituitary-Adrenal Axis 1441 (9) rid 8”
BackgroundSelf-citationGehlert, D. R., Chronwall, B. M., Schafer, M. P., & O’Donohue, T. L. (1987) · Synapse · doi:10.1002/syn.890010106 · Cited by 114 · see citing works
Tsagarakis, S., Holly, J. M. P., REES, L. H., BESSER, G. M., & Grossman, A. B. (1988) · Endocrinology · doi:10.1210/endo-123-4-1962 · Cited by 107 · see citing works
Mortola, J. F., LIU, J. H., GILLIN, J. C., Rasmussen, D. D., & Yen, S. S. C. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-5-962 · Cited by 105 · see citing works
Self-citationLiu, J., Robinson, P. J., Funder, J. W., & Engler, D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77278-5 · Cited by 91 · see citing works
Self-citationThe Production Rate of Cortisol Declines during Recovery from Anorexia Nervosa*
Walsh, B. T., Katz, J. L., Levin, J., Kream, J., Fukushima, D. K., Weiner, H., & Zumoff, B. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-1-203 · Cited by 89 · see citing works
Glucoresponsive neurons in rat ventromedial hypothalamic tissue slices in vitro
Ono, T., Nishino, H., Fukuda, M., Sasaki, K., Muramoto, K., & Oomura, Y. (1982) · Brain Research · doi:10.1016/0006-8993(82)90295-5 · Cited by 85 · see citing works
Suda, T., TOZAWA, F., YAMADA, M., USHIYAMA, T., Tomori, N., Sumitomo, T., NAKAGAMI, Y., Demura, H., & SHIZUME, K. (1988) · Endocrinology · doi:10.1210/endo-123-3-1371 · Cited by 82 · see citing works
Autelitano, D. J., Blum, M., Lopingco, M. C., Allen, R. G., & Roberts, J. L. (2008) · Neuroendocrinology · doi:10.1159/000125327 · Cited by 76 · see citing works
Widmaier, E. P., LIM, A. T. W., & Vale, W. (1989) · Endocrinology · doi:10.1210/endo-124-2-583 · Cited by 73 · see citing works
Whitnall, M. H. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902750103 · Cited by 72 · see citing works
Caraty, A., Grino, M., Locatelli, A., & Oliver, C. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80572-2 · Cited by 70 · see citing works
Emanuel, R. L., Girard, D. M., Thull, D. L., & Majzoub, J. A. (1990) · Endocrinology · doi:10.1210/endo-126-6-3016 · Cited by 65 · see citing works
Antoni, F. A., Fink, G., & Sheward, W. J. (1990) · Journal of Endocrinology · doi:10.1677/joe.0.1250175 · Cited by 63 · see citing works
Central catecholaminergic system stimulates secretion of CRH at different sites
SZAFARCZYK, A., Guillaume, V., Conte‐Devolx, B., Alonso, G., Malaval, F., Parés-Herbute, N., Oliver, C., & ASSENMACHER, I. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.4.e463 · Cited by 57 · see citing works
Schwartz, J., & Vale, W. (1988) · Endocrinology · doi:10.1210/endo-122-4-1695 · Cited by 55 · see citing works
Recht, L. D., Hoffman, D. L., Haldar, J., Silverman, A., & Zimmerman, E. A. (2008) · Neuroendocrinology · doi:10.1159/000123208 · Cited by 51 · see citing works
Buma, P., & Nienwenhuys, R. (1988) · Cell and Tissue Research · doi:10.1007/bf00213831 · Cited by 47 · see citing works
Pradier, P., Davicco, M. J., Safwate, A., Tournaire, C., Dalle, M., Barler, J. P., & Delost, P. (1986) · European Journal of Endocrinology · doi:10.1530/acta.0.1110093 · Cited by 45 · see citing works
Regulation of corticotropin-releasing factor secretion in vitro by glucose
Widmaier, E. P., Plotsky, P. M., Sutton, S. W., & Vale, W. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.3.e287 · Cited by 45 · see citing works
Engler, D., Pham, T., Fullerton, M. J., Clarke, I. J., & Funder, J. W. (2008) · Neuroendocrinology · doi:10.1159/000125139 · Cited by 44 · see citing works
Self-citationUr, E., Dinan, T. G., O’Keane, V., Clare, A. W., McLoughlin, L., REES, L. H., Turner, T. H., Grossman, A. B., & Besser, M. (2008) · Neuroendocrinology · doi:10.1159/000126271 · Cited by 39 · see citing works
Liu, J., Clarke, I. J., Funder, J. W., & Engler, D. (1991) · Endocrinology · doi:10.1210/endo-129-1-200 · Cited by 37 · see citing works
Self-citationComparison of Adrenocorticotropin Control in Brattleboro, Long-Evans, and Wistar Rats
Tannahill, L. A., Dow, R. C., Fairhall, K. M., Robinson, I. C. A. F., & Fink, G. (2008) · Neuroendocrinology · doi:10.1159/000125077 · Cited by 30 · see citing works
Tillet, Y. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90641-6 · Cited by 30 · see citing works
Brain neuropeptide Y in the control of adrenocorticotropic hormone secretion in the dog
Inui, A., Inoue, T., Nakajima, M., Okita, M., Sakatani, N., Okimura, Y., Chihara, K., & Baba, S. (1990) · Brain Research · doi:10.1016/0006-8993(90)91369-r · Cited by 27 · see citing works
Redecker, P. (1991) · Histochemistry and Cell Biology · doi:10.1007/bf00315747 · Cited by 8 · see citing works
Anatomy of Vasopressin-Producing Cells
Zimmerman, E. A. (2015) · Frontiers of hormone research · doi:10.1159/000410094 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 77 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- [37]37. Engler, D., J.-P. Liu, J. W. Funder, and 1. J. Clarke. 1992. Evidence that the central neuropeptide Y system activates the hypothalamic-pituitary-adrenal axis in the conscious sheep. Proceedings ofthe 74th Annual Meeting ofthe Endo- crine Society, San Antonio, TX. 148. (Abstr.)
- [58]58. Hu, S.-B., and L. A. Tannahill. 1992. Mechanisms of noradrenaline me- diated-corticotropin-releasing factor-4 1 (CRF) release from cultured foetal hypo- thalamic cells. Proceedings ofthe 74th Annual Meeting ofthe Endocrine Society, San Antonio, TX. 149. (Abstr.)
- [72]72. Suda, T., Y. Sato, T. Sumitomo, Y. Nakano, F. Tozawa, I. Iwai, and H. Demura. 1992. Neuropeptide Y stimulates CRF gene expression in the rat hypo- thalamus. Proceedings ofthe 9th International Congress of Endocrinology, Nice, France. 75. (Abstr.)
Cited by
Sorted by citations
Salivary cortisol as a biomarker in stress research
Hellhammer, D. H., Wüst, S., & Kudielka, B. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.026 · Cited by 1,925 · see citing works
Endocrinology of the stress response
Charmandari, E., Tsigos, C., & Chrousos, G. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.120816 · Cited by 1,799 · see citing works
Endocrine and Paracrine Regulation of Birth at Term and Preterm*
Challis, J. R. G., Matthews, S. G., Gibb, W., & Lye, S. J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0407 · Cited by 995 · see citing works
Chrousos, G. P., Torpy, D. J., & Gold, P. W. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-3-199808010-00012 · Cited by 707 · see citing works
What’s in a Name? In Search of Leptin’s Physiologic Role1
Flier, J. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.5.4779 · Cited by 518 · see citing works
Pediatric Stress: Hormonal Mediators and Human Development
Charmandari, E., Kino, T., Souvatzoglou, E., & Chrousos, G. P. (2003) · Hormone Research in Paediatrics · doi:10.1159/000069325 · Cited by 364 · see citing works
Toxic Stress in Children and Adolescents
Bucci, M., Marques, S. S., Oh, D., & Harris, N. B. (2016) · Advances in Pediatrics · doi:10.1016/j.yapd.2016.04.002 · Cited by 295 · see citing works
Windle, R. J., Wood, S. A., Shanks, N., Lightman, S. L., & Ingram, C. D. (1998) · Endocrinology · doi:10.1210/en.139.2.443 · Cited by 276 · see citing works
A neurodevelopmental model for anorexia nervosa
Connan, F., Campbell, I. C., Katzman, M. A., Lightman, S. L., & Treasure, J. L. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00101-x · Cited by 255 · see citing works
Henry, B. A., Goding, J. W., Alexander, W. S., Tilbrook, A. J., Canny, B. J., Dunshea, F. R., Rao, A., Mansell, A. S., & Clarke, I. J. (1999) · Endocrinology · doi:10.1210/en.140.3.1175 · Cited by 238 · see citing works
Self-citationWindle, R. J., Wood, S. A., Lightman, S. L., & Ingram, C. D. (1998) · Endocrinology · doi:10.1210/endo.139.10.6238 · Cited by 201 · see citing works
Wolak, M. L., DeJoseph, M. R., Cator, A. D., Mokashi, A. S., Brownfield, M. S., & Urban, J. H. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10823 · Cited by 199 · see citing works
Gestational Hypoxia and Developmental Plasticity
Ducsay, C. A., Goyal, R., Pearce, W. J., Wilson, S. M., Hu, X., & Zhang, L. (2018) · Physiological Reviews · doi:10.1152/physrev.00043.2017 · Cited by 203 · see citing works
Neuroendocrine Responses to Starvation and Weight Loss
Schwartz, M. W., & Seeley, R. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199706193362507 · Cited by 265 · see citing works
A review of endocrine changes in anorexia nervosa
Støving, R. K., Hangaard, J., Hansen‐Nord, M., & Hagen, C. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)00049-1 · Cited by 151 · see citing works
Anorexia nervosa, self–starvation and the reward of stress
Bergh, C. E. K., & Södersten, P. (1996) · Nature Medicine · doi:10.1038/nm0196-21 · Cited by 135 · see citing works
Russell, S. H., Small, C. J., Dakin, C. L., Abbott, C. R., Morgan, D. G. A., Ghatei, M. A., & Bloom, S. R. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00672.x · Cited by 128 · see citing works
Sainsbury, A., Rohner-Jeanrenaud, F., Cusin, I., Zakrzewska, K. E., Halban, P. A., Gaillard, R. C., & Jeanrenaud, B. (1997) · Diabetologia · doi:10.1007/s001250050820 · Cited by 115 · see citing works
Dinan, T. G., & Scott, L. V. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00443.x · Cited by 110 · see citing works
Organization and Integration of the Endocrine System: The Arousal and Sleep Perspective
Chrousos, G. P. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.04.004 · Cited by 103 · see citing works
New model for the regulation of energy balance and adiposity by the central nervous system
Kaiyala, K., Woods, S. C., & Schwartz, M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.5.1123s · Cited by 98 · see citing works
Arginine Vasopressin Is Associated with Hypercortisolemia and Suicide Attempts in Depression
Inder, W. J., Donald, R. A., Prickett, T. C. R., FRAMPTON, C. M. A., Sullivan, P. F., Mulder, R., & Joyce, P. R. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00301-6 · Cited by 88 · see citing works
Hypothalamus as an Endocrine Organ
Clarke, I. J. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140019 · Cited by 104 · see citing works
Self-citationHenry, B. A., Tilbrook, A. J., Dunshea, F. R., Rao, A., Blache, D., Martin, G. B., & Clarke, I. J. (2000) · Endocrinology · doi:10.1210/endo.141.4.7434 · Cited by 83 · see citing works
Self-citationPasquali, R., Anconetani, B., Chattat, R., Biscotti, M., Spinucci, G., Casimirri, F., Vicennati, V., Carcello, A., & Labate, A. M. M. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90290-5 · Cited by 109 · see citing works
Prolonged exercise increases peripheral plasma ACTH, CRH, and AVP in male athletes
Inder, W. J., Hellemans, J., Swanney, M. P., Prickett, T. C. R., & Donald, R. A. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.3.835 · Cited by 82 · see citing works
Engler, D., Redei, E., & Kola, I. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0376 · Cited by 79 · see citing works
Self-citationVasopressin as a target for antidepressant development: an assessment of the available evidence
Scott, L. V., & Dinan, T. G. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00026-5 · Cited by 78 · see citing works
Regulation of the hypothalamo-pituitary-adrenocortical axis in fetal sheep
Matthews, S. G., & Challis, J. R. G. (1996) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(96)00126-9 · Cited by 79 · see citing works
Warnes, K. E., Morris, M. J., Symonds, M. E., Phillips, I., Clarke, I. J., Owens, J. A., & McMillen, I. C. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00172.x · Cited by 69 · see citing works
Self-citationCizza, G., Lotsikas, A. J., Licinio, J., Gold, P. W., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4139 · Cited by 64 · see citing works
Update on Endocrine Disturbances in Anorexia Nervosa
Støving, R. K., Hangaard, J., & Hagen, C. (2001) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2001.14.5.459 · Cited by 64 · see citing works
Schwartz, M. W., Strack, A. M., & Dallman, M. F. (1997) · Regulatory Peptides · doi:10.1016/s0167-0115(97)01043-4 · Cited by 57 · see citing works
Figueiredo, D. F., Gertler, A., Cabello, G., Decuypere, E. M. P., Buyse, J. G., & Dridi, S. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0414-6 · Cited by 57 · see citing works
Morimoto, I., Yamamoto, S., Kai, K., Fujihira, T., Morita, E., & Eto, S. (2000) · Neuroendocrinology · doi:10.1159/000054557 · Cited by 53 · see citing works
Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation
Szczepanska‐Sadowska, E. K., Wsół, A., Cudnoch‐Jędrzejewska, A., & Żera, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111465 · Cited by 53 · see citing works
Decreased central and peripheral catecholaminergic activation in obese Zucker rats
Pacák, K., McCarty, R. C., Palkovits, M., Cizza, G., Kopin, I. J., Goldstein, D. S., & Chrousos, G. P. (1995) · Endocrinology · doi:10.1210/endo.136.10.7664655 · Cited by 51 · see citing works
The Neuroendocrinology of Stress
Kaltsas, G., Chrousos, G. P., & Sternberg, E. M. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546396.013 · Cited by 50 · see citing works
Hapiak, V., Summers, P., Ortega, A., Law, W. J., Stein, A., & Komuniecki, R. W. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1324-13.2013 · Cited by 49 · see citing works
Clarke, I. J., Pompolo, S., Scott, C., Rawson, J. A., Caddy, D. J., Jakubowska, A. E., & Pereira, A. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00694.x · Cited by 46 · see citing works
Self-citationConstitutional Thinness and Anorexia Nervosa: A Possible Misdiagnosis?
Estour, B., Galusca, B., & Germain, N. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00175 · Cited by 41 · see citing works
Ducsay, C. A., Hyatt, K., Młynarczyk, M., Kaushal, K. M., & Myers, D. A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00077.2006 · Cited by 38 · see citing works
Yuen, B. S. J., Owens, P. C., Symonds, M. E., Keisler, D. H., McFarlane, J. R., Kauter, K., & McMillen, I. C. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.025254 · Cited by 37 · see citing works
Hastings, J. A., McClure-Sharp, J. M., & Morris, M. J. (2001) · Brain Research · doi:10.1016/s0006-8993(00)02874-2 · Cited by 33 · see citing works
Raff, H., Jacobson, L., & Cullinan, W. E. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00259.2003 · Cited by 29 · see citing works
Barker‐Gibb, & Clarke, I. J. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00514.x · Cited by 29 · see citing works
Self-citationHypothalamus as an Endocrine Organ
Clarke, I. J. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00605.x · Cited by 28 · see citing works
Self-citationAlexander, S. L., & IRVINE, C. H. G. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00542.x · Cited by 28 · see citing works
Altered levels of neuropeptides characterize the brain of lupus prone mice
Bracci‐Laudiero, L., Aloe, L., Lundeberg, T., Theodorsson, E., & Stenfors, C. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00737-5 · Cited by 27 · see citing works
Regulation and adaptation of endocrine axes at high altitude
Keenan, D. M., Hefti, J. P., Veldhuis, J. D., & von Wolff, M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00243.2019 · Cited by 22 · see citing works
Krukoff, MacTavish, & Jhamandas, V. (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00391.x · Cited by 22 · see citing works
Corticosteroid receptors and the central nervous system
Funder, J. W. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90283-6 · Cited by 21 · see citing works
Self-citationRegulation of corticosteroid receptors in patients with anorexia nervosa and Cushing's syndrome.
Armanini, D., Spinella, P., Simoncini, M., Basso, A., Zovato, S., Pozzan, G., Palo, C. D., Bucciante, G., & Karbowiak, I. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1580435 · Cited by 19 · see citing works
Schinke, C., Hesse, S., Rullmann, M., Becker, G., Luthardt, J., Zientek, F., Patt, M., Stoppe, M., Schmidt, E., Meyer, K., et al. (2018) · Stress · doi:10.1080/10253890.2018.1511698 · Cited by 17 · see citing works
Albero, R., Sanz, A., & Playán, J. (2004) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(04)74599-4 · Cited by 14 · see citing works
Yoon, C., Kang, M., Bae, K.-J., & Yoon, J. (2015) · Journal of Women s Health · doi:10.1089/jwh.2014.5161 · Cited by 16 · see citing works
Hewagalamulage, S. D., Clarke, I. J., Young, I. R., Rao, A., & Henry, B. A. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12233 · Cited by 15 · see citing works
Self-citationBergendahl, M., Vance, M. L., Iranmanesh, A., Thorner, M. O., & Veldhuis, J. D. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636290 · Cited by 126 · see citing works
Hewagalamulage, S. D., Clarke, I. J., Rao, A., & Henry, B. A. (2016) · Endocrinology · doi:10.1210/en.2016-1287 · Cited by 14 · see citing works
Self-citationTurner, A. I., Rivalland, E. T. A., Clarke, I. J., Lambert, G. W., Morris, M. J., & Tilbrook, A. J. (2002) · Neuroendocrinology · doi:10.1159/000067584 · Cited by 14 · see citing works
Self-citation[Family support and quality of life of pregnant women during pregnancy and after birth].
野原, 真., & 宮城, 重. (2009) · PubMed · Cited by 14 · see citing works
Giussani, D. A., Winter, J. A., Jenkins, S. L., Tame, J. D., Abrams, L. M., Ding, X. Y., & Nathanielsz, P. W. (1998) · Endocrinology · doi:10.1210/endo.139.6.6044 · Cited by 15 · see citing works
Nemoto, T., Sugihara, H., Mano, A., Kano, T., & Shibasaki, T. (2011) · Peptides · doi:10.1016/j.peptides.2011.04.007 · Cited by 12 · see citing works
Yanovski, J. A., Nieman, L. K., Doppman, J. L., Chrousos, G. P., Wilder, R. L., Gold, P. W., & Kalogeras, K. T. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.5.1485 · Cited by 12 · see citing works
Nishiyama, M., Makino, S., Iwasaki, Y., Tanaka, Y., Pournajafi‐Nazarloo, H., Kaneda, T., Asaba, K., & Hashimoto, K. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.065 · Cited by 11 · see citing works
Hasiec, M., Herman, A. P., & Misztal, T. (2015) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2015.04.004 · Cited by 10 · see citing works
Neurochemical Systems Regulating the Hypothalamo-Pituitary-Adrenocortical Axis
Herman, J. P., Figueiredo, H. F., Mueller, N. K., Ostrander, M. M., Zhang, R., Tauchi, M., Choi, D. C., Furay, A. R., Evanson, N. K., Nelson, E., et al. (2006) · Springer eBooks · doi:10.1007/978-0-387-30405-2_13 · Cited by 9 · see citing works
Corticotropin-release inhibitory factor
Engler, D., Liu, J., Clarke, I. J., & Funder, J. W. (1994) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(94)p3202-i · Cited by 9 · see citing works
Self-citationInfluence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis
Stojiljković, A. S., Čupić, Ž., Maćešić, S., Ivanović-Šašić, A., & Kolar-Anić, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.976323 · Cited by 9 · see citing works
Small, C. J., Todd, J. F., Ghatei, M., Smith, D. M., & Bloom, S. R. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00082-2 · Cited by 8 · see citing works
Regulation of Pulsatile and Entropic ACTH Secretion Under Fixed Exogenous Secretagogue Clamps
Roelfsema, F., Aoun, P., Takahashi, P. Y., Erickson, D., Yang, R., & Veldhuis, J. D. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00115 · Cited by 7 · see citing works
Mol, J. A., & Rijnberk, A. (1997) · Elsevier eBooks · doi:10.1016/b978-012396305-5/50020-8 · Cited by 7 · see citing works
Neuroendocrine Actions Of Neuropeptide Y
Crowley, W. R. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18764-3_7 · Cited by 5 · see citing works
Chronic exposure to multiple stressors alters the salivary proteome of piglets
Prims, S., Ostade, X. V., Ayuso, M., Dom, M., Raemdonck, G. V., Cruchten, S. J. M. V., Casteleyn, C. R., & Ginneken, C. J. V. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286455 · Cited by 4 · see citing works
A obesidade estaria relacionada ao aumento do volume das adrenais?
Matos, A. F. D. G., Vieira, A. R., Coutinho, W. F., Madeira, D. M., Carraro, L., Rodrigues, R., Bastos, G., Cabral, M. D., Pantaleão, A., Oliveira, J., et al. (2000) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302000000100005 · Cited by 4 · see citing works
Posttraumatic stress disorder as psychiatric injury in civil litigation
Mendelson, G. (1995) · Psychiatry Psychology and Law · doi:10.1080/13218719509524850 · Cited by 3 · see citing works
Yuan, Q., Wang, L., Zhuang, Y., Lin, D., Xu, Z., Wen, C., Su, W., Huang, Z., & Qiu, Y. (2026) · BMC Psychiatry · doi:10.1186/s12888-025-07753-9 · Cited by 1 · see citing works
NeUROpepTIDe Y-1 ReCepTORs meDIa Te The sUppRessION Of Lh seCReTION bY NpY IN CasTRa TeD maLe sheep
Hileman, S. M., Nestor, C. C., Bogusz, A. L., Billings, H. J., Alent, V., & Goodman, R. L. (2009) · Slovak Journal of Animal Science
Cline, M. A. (2005) · VTechWorks (Virginia Tech)
Communication in the Depressed Brain
Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_7
- Authors
- Liu, J. P., Clarke, I. J., Funder, J. W., & Engler, D.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Venue
- Journal of Clinical Investigation
- Published
- 1994-04-01
- Volume
- 93
- Issue
- 4
- Pages
- 1439-1450
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC294157
- OpenAlex
- W2027873041
- Semantic Scholar
- 14e118e812972f7cc982174536fd01ef286754b2
- Cited by
- 81
- References
- 77
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 1
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Monash University
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- corticotropin-releasing factor, vasopressin, hypothalamic-pituitary-adrenal axis, norepinephrine, neuropeptide Y, intracerebroventricular administration, ACTH secretion, cortisol, glucocorticoid negative feedback, stress response, hypercortisolism, endogenous depression, anorexia nervosa, sheep
- MeSH terms
- Animals, Anorexia Nervosa, Arginine Vasopressin, Corticotropin-Releasing Hormone, Cushing Syndrome, Depression, Female, Hypothalamo-Hypophyseal System, Neuropeptide Y, Norepinephrine, Pituitary-Adrenal System, Sheep, Sodium Chloride
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review