Cited by 81Stress Responses and CortisolNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep: II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing’s syndrome of endogenous depression and anorexia nervosa

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Liu, J P, Clarke, I J, Funder, J W, Engler, D·1994·Journal of Clinical Investigation

Abstract

Studies were performed to determine the effects of intracerebroventricular norepinephrine (NE) or neuropeptide Y (NPY) on the ovine hypothalamic-pituitary-adrenal (HPA) axis. NE (50 micrograms) increased mean hypophysial-portal corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) levels (1 h, 1.3- and 2.9-fold; 4 h, 2.2- and 5.7-fold) and caused acute and sustained increases in mean plasma ACTH and cortisol. NPY (50 microgram) also increased mean CRF and AVP levels (1 h, 1.4- and 4.2-fold; 4 h, 1.1- and 1.9-fold), increased pituitary-adrenal activity at 1 h, and caused ACTH hypersecretion at 4 h. When added to cultured ovine anterior pituitary cells, NPY neither increased basal ACTH release nor augmented CRF- or AVP-induced ACTH release. We conclude that: (a) activation of either the central noradrenergic or NPY pathways causes an acute and sustained stimulation of the ovine HPA axis; (b) such activation increases the AVP/CRF ratio, suggesting a dominant role for AVP in the ovine stress response; and (c) the central noradrenergic or NPY systems may cause sustained HPA activation by attenuating or disrupting the glucocorticoid negative feedback on those brain areas concerned with regulation of the HPA axis. The possible roles of the central noradrenergic and NPY systems in the etiology of the hypercortisolemia of endogenous depression and anorexia nervosa are discussed.

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  1. [37]37. Engler, D., J.-P. Liu, J. W. Funder, and 1. J. Clarke. 1992. Evidence that the central neuropeptide Y system activates the hypothalamic-pituitary-adrenal axis in the conscious sheep. Proceedings ofthe 74th Annual Meeting ofthe Endo- crine Society, San Antonio, TX. 148. (Abstr.)
  2. [58]58. Hu, S.-B., and L. A. Tannahill. 1992. Mechanisms of noradrenaline me- diated-corticotropin-releasing factor-4 1 (CRF) release from cultured foetal hypo- thalamic cells. Proceedings ofthe 74th Annual Meeting ofthe Endocrine Society, San Antonio, TX. 149. (Abstr.)
  3. [72]72. Suda, T., Y. Sato, T. Sumitomo, Y. Nakano, F. Tozawa, I. Iwai, and H. Demura. 1992. Neuropeptide Y stimulates CRF gene expression in the rat hypo- thalamus. Proceedings ofthe 9th International Congress of Endocrinology, Nice, France. 75. (Abstr.)

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Authors
Liu, J. P., Clarke, I. J., Funder, J. W., & Engler, D.
Affiliations
Baker Heart and Diabetes Institute (AU)
Venue
Journal of Clinical Investigation
Published
1994-04-01
Volume
93
Issue
4
Pages
1439-1450
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2027873041
Cited by
81
References
77
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 1
FWCI
3.04
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Monash University
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
corticotropin-releasing factor, vasopressin, hypothalamic-pituitary-adrenal axis, norepinephrine, neuropeptide Y, intracerebroventricular administration, ACTH secretion, cortisol, glucocorticoid negative feedback, stress response, hypercortisolism, endogenous depression, anorexia nervosa, sheep
MeSH terms
Animals, Anorexia Nervosa, Arginine Vasopressin, Corticotropin-Releasing Hormone, Cushing Syndrome, Depression, Female, Hypothalamo-Hypophyseal System, Neuropeptide Y, Norepinephrine, Pituitary-Adrenal System, Sheep, Sodium Chloride

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