Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia.

Mann, C J; Yen, F T; Grant, A M; Bihain, B E

doi:10.1172/jci115535

Cited by 339Lipid metabolism and disordersCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia.

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Mann, C J, Yen, F T, Grant, A M, Bihain, B E·1991·Journal of Clinical Investigation

DOI 10.1172/jci115535

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Abstract

Plasma net cholesteryl ester (CE) transfer and optimum cho- lesteryl ester transfer protein (CETP) activity were determined in primary hypertriglyceridemic (a = 11) and normolipidemic (a = 15) individuals.The hypertriglyceridemic group demon- strated threefold greater net CE transfer leading to enhanced accumulation of CE in VLDL.This increased net transfer was not accompanied by a change in CETP activity.In normolipide- mia, but not in hypertriglyceridemia, net CE transfer correlated with VLDL triglyceride (r = 0.92, P < 0.001).In contrast, net CE transfer in hypertriglyceridemia, but not in normolipide- mia, correlated with CETP activity (r = 0.73, P < 0.01).Correc- tion of hypertriglyceridemia with bezafibrate reduced net CE transfer towards normal and restored the correlation with VLDL triglyceride (r = 0.90, P < 0.005) while suppressing the correlation with CETP activity.That net CE transfer depends on VLDL concentration was confirmed by an increase ofnet CE transfer in normolipidemic plasma supplemented with purified VLDL.Supplementation of purified CETP to normolipidemic plasma did not stimulate net CE transfer.In contrast, net CE transfer was enhanced by addition of CETP to both plasma supplemented with VLDL and hypertriglyceridemic plasma.Thus, in normal subjects, VLDL concentration determines the rate of net CE transfer.CETP becomes rate limiting as VLDL concentration increases, i.e, in hypertriglyceridemia. (J.Clin.Invest.1991.88:2059-2066.)Key words: cholesteryl ester transfer protein * very low density lipoprotein -high density lipoprotein -cardiovascular disease * reverse cholesterol trans- port MO.Bezafibrate (2-[4-[2-[(4-chlorobenzoyl)amino]-ethyl]phenoxy]-2methylpropanoic acid) was obtained from Boehringer Mannheim (for- merly MCP Pharmaceuticals), Livingstone, Scotland. Cholesteryl Ester Transfer in Hypertriglyceridemia 2059

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Hepatic lipase and cholesterol ester transfer protein contribute to remodeling of LDL and HDL particles, and which has the predominant effect depends on the triglyceride content of VLDL.
“Hepatic lipase and cholesterol ester transfer protein contribute to the remodeling processes; whether hepatic lipase or cholesterol ester transfer protein has the predominant effect on the size and density of LDL and HDL particles depends on the triglyceride content of very low-density lipoproteins (VLDL) (27,28).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [27]
The Discussion reports that CETP-mediated cholesteryl ester transfer changes with VLDL concentration and may help explain differences in HDL cholesteryl ester concentration. It does not compare CETP with hepatic lipase or establish that VLDL triglyceride content determines which has the predominant effect on LDL and HDL particle size and density. (LLM, conf=0.87)
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study
Castelli, W. P. (1986) · JAMA · doi:10.1001/jama.256.20.2835 · Cited by 2,305 · see citing works
HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study
Castelli, W. P., Doyle, J. T., Gordon, T., Hames, C. G., Hjortland, M. C., Hulley, S. B., Kagan, A., & Zukel, W. J. (1977) · Circulation · doi:10.1161/01.cir.55.5.767 · Cited by 1,492 · see citing works
Increased High-Density Lipoprotein Levels Caused by a Common Cholesteryl-Ester Transfer Protein Gene Mutation
Inazu, A., Brown, M. L., Hesler, C. B., Agellon, L. B., Koizumi, J., Takata, K., Maruhama, Y., Mabuchi, H., & Tall, A. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011013231803 · Cited by 862 · see citing works
Separation and quantitation of subclasses of human plasma high density lipoproteins by a simple precipitation procedure
Gidez, L. I., Miller, G. J., Burstein, M., Slagle, S., & Eder, H. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38059-7 · Cited by 757 · see citing works
PLASMA LIPID TRANSFER PROTEINS
Tall, A. R. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.001315 · Cited by 639 · see citing works
Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins
Brown, M. L., Inazu, A., Hesler, C. B., Agellon, L. B., Mann, C., Whitlock, M. E., Marcel, Y. L., Milne, R. W., Koizumi, J., Mabuchi, H., et al. (1989) · Nature · doi:10.1038/342448a0 · Cited by 467 · see citing works
Self-citation
Plasma lipid transfer proteins.
Tall, A. R. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38819-2 · Cited by 377 · see citing works
Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice
Agellon, L. B., Walsh, A., Hayek, T., Moulin, P., Jiang, X., Shelanski, S. A., Breslow, J. L., & Tall, A. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99088-5 · Cited by 295 · see citing works
High-density lipoprotein cholesterol and coronary heart disease in hypercholesterolemic men: the Lipid Research Clinics Coronary Primary Prevention Trial.
Gordon, D. J., Knoke, J. D., Probstfield, J. L., Superko, H. R., & Tyroler, H. A. (1986) · Circulation · doi:10.1161/01.cir.74.6.1217 · Cited by 289 · see citing works
Isolation and characterization of human plasma lipid transfer proteins.
Albers, J., Tollefson, J. H., Chen, C. H., & Steinmetz, A. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.1.49 · Cited by 285 · see citing works
Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment.
Eisenberg, S., Gavish, D., Oschry, Y., FAINARU, M., & Deckelbaum, R. J. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111444 · Cited by 284 · see citing works
Inter-relationship of lipids transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma.
Morton, R. E., & Zilversmit, D. B. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44293-1 · Cited by 246 · see citing works
Plasma concentrations of cholesteryl ester transfer protein in hyperlipoproteinemia. Relation to cholesteryl ester transfer protein activity and other lipoprotein variables.
McPherson, R., Mann, C. J., Tall, A. R., Hogue, M., Martin, L., Milne, R. W., & Marcel, Y. L. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.4.797 · Cited by 214 · see citing works
Self-citation
Mechanisms of enhanced cholesteryl ester transfer from high density lipoproteins to apolipoprotein B-containing lipoproteins during alimentary lipemia.
Tall, A. R., Sammett, D., & Granot, E. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112417 · Cited by 195 · see citing works
Transfers and exchanges of esterified cholesterol between plasma lipoproteins
Barter, P. J., Hopkins, G. J., & Calvert, G. D. (1982) · Biochemical Journal · doi:10.1042/bj2080001 · Cited by 191 · see citing works
Accelerated transfer of cholesteryl esters in dyslipidemic plasma. Role of cholesteryl ester transfer protein.
Tall, A. R., Granot, E., Brocia, R. W., Tabas, I. A., Hesler, C. B., Williams, K. R., & Denke, M. A. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112940 · Cited by 191 · see citing works
Reversible modification of human plasma low density lipoproteins toward triglyceride-rich precursors. A mechanism for losing excess cholesterol esters.
Deckelbaum, R. J., Eisenberg, S., Oschry, Y., Butbul, E., Sharon, I., & Olivecrona, T. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)65171-7 · Cited by 161 · see citing works
Cholesterol net transport, esterification, and transfer in human hyperlipidemic plasma.
Fielding, P. E., Fielding, C. J., Havel, R. J., Kane, J. P., & Tun, P. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110789 · Cited by 147 · see citing works
Effects of postprandial lipemia on plasma cholesterol metabolism.
Castro, G., & Fielding, C. J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111786 · Cited by 123 · see citing works
Levels and interrelationships of serum and lipoprotein cholesterol and triglycerides. Association with adiposity and the consumption of ethanol, tobacco, and beverages containing caffeine.
PHILLIPS, N. R., Havel, R. J., & Kane, J. P. (1981) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.1.1.13 · Cited by 121 · see citing works
Discoidal complexes of A and C apolipoproteins with lipids and their reactions with lecithin: cholesterol acyltransferase.
Jonas, A. M., Sweeny, S. A., & Herbert, P. N. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82151-6 · Cited by 119 · see citing works
Plasma high-density lipoprotein concentration and subfraction distribution in relation to triglyceride metabolism
Nikkilä, E. A., Taskinen, M., & Sane, T. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90629-6 · Cited by 100 · see citing works
Lipoprotein lipase enhances the cholesteryl ester transfer protein-mediated transfer of cholesteryl esters from high density lipoproteins to very low density lipoproteins.
Tall, A. R., Sammett, D., Vita, G., Deckelbaum, R. J., & Olivecrona, T. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42741-4 · Cited by 94 · see citing works
Free cholesterol is a potent regulator of lipid transfer protein function.
Morton, R. E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37745-7 · Cited by 89 · see citing works
Inhibition of cholesteryl ester transfer protein activity by monoclonal antibody. Effects on cholesteryl ester formation and neutral lipid mass transfer in human plasma.
Yen, F. T., Deckelbaum, R. J., Mann, C. J., Marcel, Y. L., Milne, R. W., & Tall, A. R. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114112 · Cited by 84 · see citing works
Self-citation
Cholesterol content of red blood cells and low-density lipoproteins in hypertriglyceridemia
Vakakis, N., Redgrave, T. G., SMALL, D. M., & Castelli, W. P. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90285-0 · Cited by 36 · see citing works
Relationship between cholesteryl ester transfer activity and high density lipoprotein composition in hyperlipidemic patients
Sparks, D. L., Frohlich, J., Lacko, A. G., & Pritchard, P. H. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90080-4 · Cited by 29 · see citing works
Factors affecting the rate of catalyzed transfer of cholesteryl esters in plasma
Fielding, C. J. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90627-2 · Cited by 26 · see citing works

Flagged first, then by citations

1 of the 30 references couldn’t be matched to a known paper.

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Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism
Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E., & Fruchart, J.-C. (1998) · Circulation · doi:10.1161/01.cir.98.19.2088 · Cited by 1,786 · see citing works
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448 · see citing works
Plasma cholesteryl ester transfer protein
Tall, A. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36957-1 · Cited by 953 · see citing works
Metabolic origins and clinical significance of LDL heterogeneity
Berneis, K. K., & Krauss, R. M. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200004-jlr200 · Cited by 896 · see citing works
Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline
Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3213 · Cited by 887 · see citing works
Cholesteryl Ester Transfer Protein
Barter, P. J., Brewer, H. B., Chapman, M. J., Hennekens, C. H., Rader, D. J., & Tall, A. R. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000054658.91146.64 · Cited by 868 · see citing works
Postprandial lipoprotein metabolism and atherosclerosis.
Karpe, F. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00548.x · Cited by 360 · see citing works
Dyslipidaemia
Durrington, P. N. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14234-1 · Cited by 311 · see citing works
Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis
Attie, A., Kastelein, J. J. P., & Hayden, M. R. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31498-x · Cited by 284 · see citing works
Alterations in high‐density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins
Borggreve, S. E., Vries, R. D., & Dullaart, R. P. F. (2003) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2003.01263.x · Cited by 277 · see citing works
Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity
Rashid, S., Watanabe, T., Sakaue, T., & Lewis, G. F. (2003) · Clinical Biochemistry · doi:10.1016/s0009-9120(03)00078-x · Cited by 277 · see citing works
The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects
Noone, E., Roche, H. M., Nugent, A. P., & Gibney, M. J. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002615 · Cited by 240 · see citing works
Effects of graded amounts (0–50 g) of dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults
Dubois, C., Beaumier-Gallon, G., Juhel, C., Armand, M., Portugal, H., Pauli, A.-M., Borel, P., Latge, C., & Lairon, D. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.1.31 · Cited by 218 · see citing works
Heterogeneity at theCETPGene Locus
Kuivenhoven, J. A., de Knijff, P., Boer, J. M. A., Smalheer, H. A., Botma, G.-J., Seidell, J. C., Kastelein, J. J. P., & Pritchard, P. H. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.3.560 · Cited by 210 · see citing works
Apolipoproteins: metabolic role and clinical biochemistry applications
Dominiczak, M. H., & Caslake, M. J. (2011) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1258/acb.2011.011111 · Cited by 238 · see citing works
Triglycerides Are Major Determinants of Cholesterol Esterification/Transfer and HDL Remodeling in Human Plasma
Murakami, T., Michelagnoli, S., Longhi, R., Gianfranceschi, G., Pazzucconi, F., Calabresi, L., Sirtori, C. R., & Franceschini, G. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.1819 · Cited by 201 · see citing works
Effect of adiposity on plasma lipid transfer protein activities: a possible link between insulin resistance and high density lipoprotein metabolism
Dullaart, R. P. F., Sluiter, W. J., Dikkeschei, L. D., Hoogenberg, K., & van Tol, A. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb00987.x · Cited by 195 · see citing works
Fenofibrate Reduces Plasma Cholesteryl Ester Transfer From HDL to VLDL and Normalizes the Atherogenic, Dense LDL Profile in Combined Hyperlipidemia
Guérin, M., Bruckert, É., Dolphin, P. J., Turpin, G., & Chapman, M. J. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.6.763 · Cited by 194 · see citing works
Regulation of cholesteryl ester transfer protein (CETP) activity: review of in vitro and in vivo studies
Lagrost, L. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)90047-7 · Cited by 192 · see citing works
Reduction in the concentration and activity of plasma cholesteryl ester transfer protein by alcohol.
Hannuksela, M. L., Marcel, Y. L., Kesäniemi, Y. A., & Savolainen, M. J. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41437-3 · Cited by 192 · see citing works
The nicotinic acid receptor–a new mechanism for an old drug
Karpe, F., & Frayn, K. N. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16359-9 · Cited by 186 · see citing works
The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target
Offermanns, S. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.05.008 · Cited by 179 · see citing works
Correlation of serum triglyceride and its reduction by ω-3 fatty acids with lipid transfer activity and the neutral lipid compositions of high-density and low-density lipoproteins
Pownall, H. J., Brauchi, D., Kilinç, C., Osmundsen, K., Pao, Q., Payton-Ross, C., Gotto, A. M., & Ballantyne, C. M. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00301-3 · Cited by 179 · see citing works
Niacin Increases HDL by Reducing Hepatic Expression and Plasma Levels of Cholesteryl Ester Transfer Protein in APOE*3Leiden.CETP Mice
van der Hoorn, J. W. A., de Haan, W., Berbée, J. F. P., Havekes, L. M., Jukema, J. W., Rensen, P. C. N., & Princen, H. M. G. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.171363 · Cited by 173 · see citing works
New Functional Promoter Polymorphism, CETP/−629, in Cholesteryl Ester Transfer Protein (CETP) Gene Related to CETP Mass and High Density Lipoprotein Cholesterol Levels
Dachet, C., Poirier, O., Cambien, F., Chapman, J., & Rouis, M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.507 · Cited by 168 · see citing works
Postprandial lipemia and cardiovascular disease
Hyson, D. A., Rutledge, J. C., & Berglund, L. (2003) · Current Atherosclerosis Reports · doi:10.1007/s11883-003-0033-y · Cited by 160 · see citing works
Pharmacological modulation of cholesteryl ester transfer protein, a new therapeutic target in atherogenic dyslipidemia
Goff, W. L., Guérin, M., & Chapman, M. J. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.10.001 · Cited by 148 · see citing works
Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia
Bruce, C., Sharp, D. S., & Tall, A. R. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33876-1 · Cited by 147 · see citing works
Effects of two different fibric acid derivatives on lipoproteins, cholesteryl ester transfer, fibrinogen, plasminogen activator inhibitor and paraoxonase activity in type IIb hyperlipoproteinaemia
Durrington, P. N., Mackness, M., Bhatnagar, D., Julier, K., Prais, H., Arrol, S., Morgan, J., & Wood, G. N. I. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00003-3 · Cited by 143 · see citing works
Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities.
Miesenböck, G., Hölzl, B., Föger, B., Brandstätter, E., Paulweber, B., Sandhofer, F., & Patsch, J. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116222 · Cited by 144 · see citing works
Studies of a targeted risk reduction intervention through defined exercise (STRRIDE).
Kraus, W., Torgan, C., Duscha, B., Norris, J., Brown, S. A., Cobb, F., Bales, C., Annex, B., Samsa, G., Houmard, J., et al. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200110000-00025 · Cited by 161 · see citing works
Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism. Studies in transgenic mice.
Hayek, T., Azrolan, N., Verdery, R. B., Walsh, A., Chajek‐Shaul, T., Agellon, L. B., Tall, A. R., & Breslow, J. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116683 · Cited by 134 · see citing works
Elevated plasma cholesteryl ester transfer in NIDDM: relationships with apolipoprotein B-containing lipoproteins and phospholipid transfer protein
Riemens, S. C., van Tol, A., Sluiter, W. J., & Dullaart, R. P. F. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00111-7 · Cited by 131 · see citing works
GENETICS OF LIPOPROTEIN ABNORMALITIES ASSOCIATED WITH CORONARY HEART DISEASE SUSCEPTIBILITY
Breslow, J. L. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.233 · Cited by 128 · see citing works
Association of Postprandial Triglyceride and Retinyl Palmitate Responses With Newly Diagnosed Exercise-Induced Myocardial Ischemia in Middle-Aged Men and Women
Ginsberg, H. N., Jones, J., Blaner, W. S., Thomas, A., Karmally, W., Fields, L., Blood, D. K., & Begg, M. D. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.1829 · Cited by 128 · see citing works
Effect of 6 dietary fatty acids on the postprandial lipid profile, plasma fatty acids, lipoprotein lipase, and cholesterol ester transfer activities in healthy young men
Tholstrup, T., Sandström, B., Bysted, A., & Hølmer, G. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.198 · Cited by 120 · see citing works
Higher plasma lipid transfer protein activities and unfavorable lipoprotein changes in cigarette-smoking men.
Dullaart, R. P. F., Hoogenberg, K., Dikkeschei, B. D., & van Tol, A. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.10.1581 · Cited by 115 · see citing works
Effects of medium-chain fatty acids and oleic acid on blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities
Tholstrup, T., Ehnholm, C., Jauhiainen, M., Petersen, M., Høy, C., Lund, P., & Sandström, B. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.564 · Cited by 111 · see citing works
The Impact of Postprandial Lipemia in Accelerating Atherothrombosis
Roche, H. M., & Gibney, M. J. (2000) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/204748730000700504 · Cited by 110 · see citing works
Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women
Asztalos, B. F., Swarbrick, M. M., Schaefer, E. J., Dallal, G. E., Horvath, K. V., Ai, M., Stanhope, K. L., Austrheim-Smith, I. T., Wolfe, B. M., Ali, M., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.p900015 · Cited by 108 · see citing works
Effects of coconut oil, butter, and safflower oil on lipids and lipoproteins in persons with moderately elevated cholesterol levels.
Cox, C., Mann, J. I., Sutherland, W. H. F., Chisholm, A. W., & Skeaff, M. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41497-x · Cited by 108 · see citing works
Plasma phospholipid transfer protein activity is related to insulin resistance: impaired acute lowering by insulin in obese Type II diabetic patients
Riemens, S. C., van Tol, A., Sluiter, W. J., & Dullaart, R. P. F. (1998) · Diabetologia · doi:10.1007/s001250051009 · Cited by 107 · see citing works
CETP and Atherosclerosis
Barter, P. J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2029 · Cited by 107 · see citing works
Lipoprotein disorders in diabetes mellitus
Brown, W. V. (1994) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30180-8 · Cited by 106 · see citing works
Accelerated cholesteryl ester transfer in noninsulin-dependent diabetes mellitus
Bagdade, J. D., Lane, J. D., Subbaiah, P. V., OTTO, M., & Ritter, M. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90177-v · Cited by 106 · see citing works
Effects of dietary cholesterol and fat saturation on plasma lipoproteins in an ethnically diverse population of healthy young men.
Fielding, C. J., Havel, R., Todd, K., Yeo, K. E., Schloetter, M., Weinberg, V., & Frost, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117705 · Cited by 114 · see citing works
Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women
Asztalos, B. F., Swarbrick, M. M., Schaefer, E. J., Dallal, G. E., Horvath, K. V., Ai, M., Stanhope, K. L., Austrheim-Smith, I. T., Wolfe, B. M., Ali, M. R., et al. (2009) · Journal of Lipid Research · doi:10.1194/jlr.p900015-jlr200 · Cited by 102 · see citing works
Contribution of Hepatic Lipase, Lipoprotein Lipase, and Cholesteryl Ester Transfer Protein to LDL and HDL Heterogeneity in Healthy Women
Carr, M. C., Ayyobi, A. F., Murdoch, S. J., Deeb, S. S., & Brunzell, J. D. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000013284.47317.95 · Cited by 100 · see citing works
Effect of Alcohol on Lipids and Lipoproteins in Relation to Atherosclerosis
Hannuksela, M. L., Liisanantti, M. K., & Savolainen, M. J. (2002) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360290795529 · Cited by 97 · see citing works
Relation Between Cholesterol Ester Transfer Protein Activities and Lipoprotein Cholesterol in Patients With Hypercholesterolemia and Combined Hyperlipidemia
Tatò, F., Vega, G. L., Tall, A. R., & Grundy, S. M. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.1.112 · Cited by 97 · see citing works
Increased concentration of plasma cholesteryl ester transfer protein in nephrotic syndrome: role in dyslipidemia.
Moulin, P., Gb, A., Ginsberg, H., & Tall, A. R. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41339-2 · Cited by 97 · see citing works
Effects of moderate amounts of emulsified dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults
Dubois, C., Armand, M., Azaı̈s-Braesco, V., Portugal, H., Pauli, A.-M., Bernard, P., Latge, C., Lafont, H., Borel, P., & Lairon, D. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.3.374 · Cited by 95 · see citing works
Comparison of the effects of fibrates versus statins on plasma lipoprotein(a) concentrations: a systematic review and meta-analysis of head-to-head randomized controlled trials
Sahebkar, A., Simental‐Mendía, L. E., Watts, G. F., Șerban, M.-C., & Banach, M. (2017) · BMC Medicine · doi:10.1186/s12916-017-0787-7 · Cited by 93 · see citing works
Molecular Cloning and Expression of Lipid Transfer Inhibitor Protein Reveals Its Identity with Apolipoprotein F
Wang, X., Driscoll, D. M., & Morton, R. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.3.1814 · Cited by 90 · see citing works
Postprandial triglyceride‐rich lipoprotein metabolism and insulin sensitivity in nonalcoholic steatohepatitis patients
Cassader, M., Gambino, R., Musso, G., Depetris, N., Mecca, F., Cavallo‐Perin, P., Pacini, G., Rizzetto, M., & Pagano, G. (2001) · Lipids · doi:10.1007/s11745-001-0822-5 · Cited by 88 · see citing works
Androgen deficiency and atherosclerosis: The lipid link
Traish, A. M., Abdou, R. Y., & Kypreos, K. E. (2009) · Vascular Pharmacology · doi:10.1016/j.vph.2009.09.003 · Cited by 84 · see citing works
Alterations in the main steps of reverse cholesterol transport in male patients with primary hypertriglyceridemia and low HDL-cholesterol levels
Brites, F. D., Bonavita, C. D., Geitere, C. D., Cloës, M., Delfly, B., Yael, M. J., Fruchart, J., Wikinski, R. L. W., & Castro, G. R. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00452-9 · Cited by 83 · see citing works
(n-3) Fatty Acid Supplementation in Moderately Hypertriglyceridemic Adults Changes Postprandial Lipid and Apolipoprotein B Responses to a Standardized Test Meal
Tinker, L. F., Parks, E. J., Behr, S. R., Schneeman, B. O., & Davis, P. A. (1999) · Journal of Nutrition · doi:10.1093/jn/129.6.1126 · Cited by 83 · see citing works
Relationship of Plasma Cholesteryl Ester Transfer Protein to HDL Cholesterol
Föger, B., Ritsch, A., Doblinger, A., Wessels, H., & Patsch, J. R. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.12.1430 · Cited by 81 · see citing works
Decreased cholesteryl ester transfer protein (CETP) mRNA and protein and increased high density lipoprotein following lipopolysaccharide administration in human CETP transgenic mice.
Masucci-Magoulas, L., Moulin, P., Jiang, X., Richardson, H., Walsh, A., Breslow, J. L., & Tall, A. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117832 · Cited by 79 · see citing works
Increasing High-Density Lipoprotein Cholesterol in Dyslipidemia by Cholesteryl Ester Transfer Protein Inhibition
Forrester, J. S., Makkar, R., & Shah, P. K. (2005) · Circulation · doi:10.1161/01.cir.0000160860.36911.bd · Cited by 79 · see citing works
Plasma Cholesteryl Ester Transfer Is a Determinant of Intima-Media Thickness in Type 2 Diabetic and Nondiabetic Subjects
de Vries, R., Perton, F. G., Dallinga‐Thie, G. M., van Roon, A. M., Wolffenbuttel, B. H. R., van Tol, A., & Dullaart, R. P. F. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3554 · Cited by 79 · see citing works
A high-density lipoprotein-mediated drug delivery system
Mo, Z., Ren, K., Liu, X., Tang, Z., & Yi, G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.030 · Cited by 75 · see citing works
LDL and HDL enriched in triglyceride promote abnormal cholesterol transport
Skeggs, J. W., & Morton, R. E. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m100431-jlr200 · Cited by 73 · see citing works
“In most individuals, plasma TG levels, not CETP concentrations, are rate limiting to this remodeling process ( 9 ).”
Background
HDL-subpopulation patterns in response to reductions in dietary total and saturated fat intakes in healthy subjects.
Berglund, L., Oliver, E. H., Fontanez, N., Holleran, S., Matthews, K., Roheim, P., Ginsberg, H., Ramakrishnan, R., & Lefevre, M. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.6.992 · Cited by 78 · see citing works
Postprandial lipoprotein metabolism, genes and risk of cardiovascular disease
López‐Miranda, J., Pérez‐Martínez, P., Marı́n, C., Moreno, J. A., Gómez, P., & Pérez‐Jiménez, F. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000217894.85370.c2 · Cited by 72 · see citing works
Differences in apolipoprotein and lipid composition between human chylomicron remnants and very low density lipoproteins isolated from fasting and postprandial plasma
Björkegren, J., Karpe, F., Milne, R. W., & Hamsten, A. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32522-0 · Cited by 72 · see citing works
Determinants of Plasma HDL-Cholesterol in Hypertriglyceridemic Patients
Tatò, F., Vega, G. L., & Grundy, S. M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.1.56 · Cited by 72 · see citing works
The Effect of Cholesteryl Ester Transfer Protein −629C→A Promoter Polymorphism on High-Density Lipoprotein Cholesterol Is Dependent on Serum Triglycerides
Borggreve, S. E., Hillege, H. L., Wolffenbuttel, B. H. R., de Jong, P. E., Bakker, S. J. L., van der Steege, G., van Tol, A., & Dullaart, R. P. F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0182 · Cited by 71 · see citing works
Flushing out the role of GPR109A (HM74A) in the clinical efficacy of nicotinic acid
Pike, N. B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27160 · Cited by 71 · see citing works
Cholesteryl ester transfer protein and its plasma regulator
Morton, R. E. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199908000-00006 · Cited by 70 · see citing works
Pravastatin Modulates Cholesteryl Ester Transfer From HDL to ApoB-Containing Lipoproteins and Lipoprotein Subspecies Profile in Familial Hypercholesterolemia
Guérin, M., Dolphin, P. J., Talussot, C., Gardette, J., Berthézène, F., & Chapman, M. J. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.9.1359 · Cited by 70 · see citing works
Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: High-throughput assay by Invader® assay
Nagano, M., Yamashita, S., Hirano, K., Ito, M., Maruyama, T., Ishihara, M., Sagehashi, Y., Oka, T., Kujiraoka, T., Hattori, H., et al. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200024-jlr200 · Cited by 69 · see citing works
Intraperitoneal insulin therapy corrects abnormalities in cholesteryl ester transfer and lipoprotein lipase activities in insulin-dependent diabetes mellitus.
Bagdade, J. D., Dunn, F. L., Eckel, R. H., & Ritter, M. C. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.12.1933 · Cited by 68 · see citing works
Current concepts in triglyceride metabolism, pathophysiology, and treatment
Abourjaili, G., Shtaynberg, N., Wetz, R. V., Costantino, T. G., & Abela, G. S. (2010) · Metabolism · doi:10.1016/j.metabol.2009.11.014 · Cited by 66 · see citing works
Effects of low-fat diet, calorie restriction, and running on lipoprotein subfraction concentrations in moderately overweight men
Williams, P. T., Krauss, R. M., Stefanick, M. L., VRANIZAN, K. M., & Wood, P. D. (1994) · Metabolism · doi:10.1016/0026-0495(94)90210-0 · Cited by 66 · see citing works
Increased transfer of cholesteryl esters from high density lipoproteins to low density and very low density lipoproteins in patients with angiographic evidence of coronary artery disease
Bhatnagar, D., Durrington, P. N., Channon, K. M., Prais, H., & Mackness, M. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90220-o · Cited by 66 · see citing works
Lipid Transfer Protein Activities in Type 1 Diabetic Patients Without Renal Failure and Nondiabetic Control Subjects and Their Association With Coronary Artery Calcification
Colhoun, H. M., Scheek, L. M., Rubens, M. B., van Gent, T., Underwood, S. R., Fuller, J., & van Tol, A. (2001) · Diabetes · doi:10.2337/diabetes.50.3.652 · Cited by 65 · see citing works
Cholesteryl ester transfer protein gene polymorphisms are associated with carotid atherosclerosis in men
Kakko, Tamminen, Päivänsalo, Kauma, Rantala, Lilja, Reunanen, Kesäniemi, & Savolainen (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00595.x · Cited by 65 · see citing works
Circadian variation of postprandial lipemia
Romon, M., Fur, C. L., Lebel, P., Edmé, J.-L., Fruchart, J., & Dallongeville, J. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.4.934 · Cited by 63 · see citing works
LDL particle size in familial combined hyperlipidemia: effects of serum lipids, lipoprotein-modifying enzymes, and lipid transfer proteins
Vakkilainen, J., Jauhiainen, M., Ylitalo, K., Nuotio, I. O., Viikari, J. S. A., Ehnholm, C., & Taskinen, M. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31489-9 · Cited by 63 · see citing works
Unusual high-density lipoprotein subclass distribution during late pregnancy
Silliman, K., Tall, A. R., Kretchmer, N., & Forte, T. M. (1993) · Metabolism · doi:10.1016/0026-0495(93)90156-i · Cited by 61 · see citing works
Evidence for Nonesterified Fatty Acids as Modulators of Neutral Lipid Transfers in Normolipidemic Human Plasma
Lagrost, L., Florentin, E., Guyard‐Dangremont, V., Athias, A., Gandjini, H., Lallemant, C., & Gambert, P. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.9.1388 · Cited by 61 · see citing works
Genetic variations in the cholesteryl ester transfer protein gene and high density lipoprotein cholesterol levels in Taiwanese Chinese
Hsu, L., Ko, Y., Hsu, K., Ko, Y.-H., & Lee, Y. (2001) · Human Genetics · doi:10.1007/s00439-001-0640-z · Cited by 60 · see citing works
Different effects of palmitic and stearic acid-enriched diets on serum lipids and lipoproteins and plasma cholesteryl ester transfer protein activity in healthy young women
Schwab, U., Maliranta, H. M., Sarkkinen, E. S., Savolainen, M. J., Kesäniemi, Y. A., & Uusitupa, M. I. J. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90044-x · Cited by 59 · see citing works
Inefficiency of insulin therapy to correct apolipoprotein A-I metabolic abnormalities in non-insulin-dependent diabetes mellitus
Duvillard, L., Pont, F., Florentin, E., Gambert, P., & Vergès, B. L. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00473-6 · Cited by 59 · see citing works
Combined effects of lipid transfers and lipolysis on gradient gel patterns of human plasma LDL.
Lagrost, L., Gambert, P., & Lallemant, C. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.8.1327 · Cited by 59 · see citing works
Cholesteryl ester transfer protein and atherosclerosis
Inazu, A., Koizumi, J., & Mabuchi, H. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200008000-00008 · Cited by 58 · see citing works
Chronic oat bran intake alters postprandial lipemia and lipoproteins in healthy adults
Dubois, C., Armand, M., Senft, M., Portugal, H., Pauli, A.-M., Bernard, P., Lafont, H., & Lairon, D. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.2.325 · Cited by 58 · see citing works
Differential response to low-fat diet between low and normal HDL-cholesterol subjects
Asztalos, B. F., LeFevre, M. L., Wong, L., Foster, T. A., Tulley, R. T., WINDHAUSER, M. M., Zhang, W., & Roheim, P. S. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34470-9 · Cited by 57 · see citing works
Effects of increasing amounts of dietary cholesterol on postprandial lipemia and lipoproteins in human subjects.
Dubois, C., Armand, M., Mekki, N., Portugal, H., Pauli, A.-M., Bernard, P. M., Lafont, H., & Lairon, D. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39946-6 · Cited by 57 · see citing works
Plasma lipoprotein composition, apolipoprotein(a) concentration and isoforms in β-thalassemia
Maioli, M. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)06095-4 · Cited by 56 · see citing works
HDLs, Diabetes, and Metabolic Syndrome
Vollenweider, P., von Eckardstein, A., & Widmann, C. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_12 · Cited by 55 · see citing works
Treatment of Dyslipidemias to Prevent Cardiovascular Disease in Patients with Type 2 Diabetes
Khavandi, M., Duarte, F., Ginsberg, H. N., & Reyes‐Soffer, G. (2017) · Current Cardiology Reports · doi:10.1007/s11886-017-0818-1 · Cited by 56 · see citing works
Functional interaction between −629C/A, −971G/A and −1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study
Frisdal, É., Klerkx, A. H. E. M., Goff, W. L., Tanck, M. W. T., Lagarde, J., Jukema, J. W., Kastelein, J. J. P., Chapman, M. J., & Guérin, M. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi291 · Cited by 54 · see citing works
Postprandial Lipemia and Remnant Lipoproteins
Cohn, J. S. (2006) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2006.07.003 · Cited by 54 · see citing works
Taq1B CETP polymorphism, plasma CETP, lipoproteins, apolipoproteins and sex differences in a Jewish population sample characterized by low HDL-cholesterol
Kark, J. D., Sinnreich, R., Leitersdorf, E., Friedlander, Y., Shpitzen, S., & Luc, G. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00408-6 · Cited by 54 · see citing works
Simvastatin-induced decrease in the transfer of cholesterol esters from high density lipoproteins to very low and low density lipoproteins in normolipidemic subjects
Ahnadi, C.-E., Berthézène, F., & Ponsin, G. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90024-o · Cited by 54 · see citing works
CETP inhibition in cardiovascular risk management: a critical appraisal
Dullaart, R. P. F., Dallinga‐Thie, G. M., Wolffenbuttel, B. H. R., & van Tol, A. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01756.x · Cited by 54 · see citing works
Association between plasma HDL-cholesterol concentration and Taq1B CETP gene polymorphism in non-insulin-dependent diabetes mellitus
Bernard, S., Moulin, P., Lagrost, L., Picard, S., Elchebly, M., Ponsin, G., Chapuis, F. R., & Berthézène, F. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34203-6 · Cited by 54 · see citing works

Relationship of Plasma Cholesteryl Ester Transfer Protein to HDL Cholesterol
Föger, B., Ritsch, A., Doblinger, A., Wessels, H., & Patsch, J. R. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.12.1430 · Cited by 81 · see citing works
Cholesteryl ester transfer activity in lipoprotein lipase deficiency and other primary hypertriglyceridemias
Iglesias, A., Contreras, J. A., Martínez‐Pardo, M., Bueno, A. E., Herrera, E., & Lasunción, M. A. (1993) · Clinica Chimica Acta · doi:10.1016/0009-8981(93)90023-w · Cited by 15 · see citing works
Triglycerides Are Major Determinants of Cholesterol Esterification/Transfer and HDL Remodeling in Human Plasma
Murakami, T., Michelagnoli, S., Longhi, R., Gianfranceschi, G., Pazzucconi, F., Calabresi, L., Sirtori, C. R., & Franceschini, G. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.1819 · Cited by 201 · see citing works
Cholesteryl Ester Transfer, Lipoproteins, Hypertriglyceridemia, and Atherosclerosis
Eisenberg, S. (1987) · Springer eBooks · doi:10.1007/978-3-642-71753-6_17
Accelerated cholesteryl ester transfer in plasma of patients with hypercholesterolemia.
Bagdade, J. D., Ritter, M. C., & Subbaiah, P. V. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115127 · Cited by 109 · see citing works

Authors: Mann, C. J., Yen, F. T., Grant, A. M., & Bihain, B. E.
Affiliations: Louisiana State University (US)
ORCID: Yen, F T
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1991-12-01
Volume: 88
Issue: 6
Pages: 2059-2066
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci115535
OpenAlex: W2114689977
Cited by: 339
References: 30
Citations by year: 2024: 5 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 10 · 2013: 1 · 2012: 2
FWCI: 17.17
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01hl025596-15)
National Heart, Lung, and Blood Institute (HL255-96)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords: cholesteryl ester transfer, cholesteryl ester transfer protein, hypertriglyceridemia, VLDL, VLDL triglycerides, reverse cholesterol transport, CETP activity, bezafibrate, lipoprotein metabolism, rate-determining step
MeSH terms: Adult, Bezafibrate, Biological Transport, Carrier Proteins, Cholesterol Esters, Glycoproteins, Humans, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Triglycerides, Hypertriglyceridemia, Cholesterol Ester Transfer Proteins

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Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia.

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