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Total and resting energy expenditure in obese women reduced to ideal body weight.
Open accessAbstract
Obesity could be due to excess energy intake or decreased energy expenditure (EE). To evaluate this, we studied 18 obese females (148 +/- 8% of ideal body weight [IBW], mean +/- SD) before and after achieving and stabilizing at IBW for at least 2 mo and a control group of 14 never obese females (< 110% of IBW or < 30% fat). In the obese, reduced obese, and never obese groups, the percent of body fat was 41 +/- 4%, 27 +/- 4%, and 25 +/- 3%; total energy expenditure (TEE) was 2704 +/- 449, 2473 +/- 495, and 2259 +/- 192 kcal/24 h; while resting metabolic rate was 1496 +/- 169, 1317 +/- 159, and 1341 +/- 103 kcal/24 h, respectively. 15 obese subjects who withdrew from the study had a mean initial body composition and EE similar to the subjects who were successful in achieving IBW. In 10 subjects followed for at least one year after stabilizing at IBW there was no significant relationship between the deviation from predicted TEE at IBW and weight regain. These studies indicate that, in a genetically heterogeneous female population, neither the propensity to become obese nor to maintain the obese state are due to an inherent metabolic abnormality characterized by a low EE.
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“First, obese subjects who lose weight by dieting experience a decrease in body mass of multiple tissues and an obligate decrease in energy expenditure (16,17).”
From Long-term Effects of Large-volume Liposuction on Metabolic Risk Factors for Coronary Heart Disease (2008) · cites this paper as [17]
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Ahima, R. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-40116-9_48 · Cited by 2
Redman, L. M., & Ravussin, É. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-400-1_8 · Cited by 2
Kozak, L. P., & Ravussin, É. (2004) · CRC Press eBooks · doi:10.1201/9780203508756.pt1 · Cited by 2
Metadata
- Authors
- Amatruda, J. M., Statt, M. C., & Welle, S. L.
- Affiliations
- University of Rochester Medicine (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1993-09-01
- Volume
- 92
- Issue
- 3
- Pages
- 1236-1242
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC288263
- OpenAlex
- W2002036079
- Cited by
- 117
- References
- 38
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk040816-07)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK40816)
- National Center for Research Resources (RR-00044, M01RR000044)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- obesity, total energy expenditure, resting metabolic rate, weight loss, ideal body weight, weight regain, body composition, body fat percentage, female obesity, energy balance, genetic predisposition to obesity
- MeSH terms
- Adult, Body Composition, Energy Metabolism, Female, Humans, Middle Aged, Obesity, Weight Loss
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