The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Gender differences in regional fatty acid metabolism before and after meal ingestion.
Open accessAbstract
UNLABELLED: These studies were conducted to determine whether men and women differ with regards to their overnight postabsorptive (basal) and postprandial fatty acid kinetics. Systemic oleate turnover ([9,10(3)H]oleate) was measured before and after the consumption of a mixed meal. Leg and splanchnic free fatty acid (FFA) uptake and release were measured, allowing the calculation of upper-body subcutaneous FFA release. RESULTS: basal oleate flux was virtually identical in men and women (3.0 +/- 3 versus 2.9 +/- 0.4 mumol.kg FFM-1.min-1), however, oleate Ra suppressed more in women than in men following meal ingestion (0.5 +/- 0.1 versus 0.8 +/- 0.1 mumol.kg FFM-1.min-1, P < 0.05). The fractional contribution of basal, regional FFA release to total FFA flux was not significantly different between men and women. In contrast, oleate release by upper-body subcutaneous adipose tissue was significantly greater (30 +/- 5 vs 8 +/- 3 mumol/min, respectively, P < 0.01) in men than in women during the meal nadir of FFA flux, whereas splanchnic oleate release was a greater percentage (39 +/- 7% vs 20 +/- 3%, respectively, P < 0.05) of nadir oleate Ra in women than in men. Thus, normal weight men and women differ significantly in the postprandial regulation of adipose tissue lipolysis in that men's upper-body subcutaneous adipose tissue is more resistant to the antilipolytic effects of meal ingestion. Differential regulation of regional adipose tissue lipolysis could contribute to the gender based differences in body fat distribution.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“The relative contribution of leg adipose tissue lipolysis to systemic FFA is significantly greater in women than men (67, 70)”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [67]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Upon consumption of a mixed meal, the nadir of plasma FFA concentrations is very similar in young (~27 y), normal weight males and females, although the absolute release rate of FFA is slightly greater in males (67).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [67]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In males, FFA release from the upper body subcutaneous adipose tissue accounts for a greater proportion of total FFA released than in females, and leg adipose tissue account for a greater proportion of total FFA release than in males (Figure 6) (67).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [67]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“We pooled data from femoral artery, femoral vein and hepatic vein catheterization studies that included measures of blood flow, body composition and isotopic tracer techniques to assess the variability and sex-differences regional FFA release (33, 65–70).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [67]
The cited source says what the claim attributes to it.
In the citing paper
“For both women (33) and men (67), FFA release rates per kg are greater from upper body than from lower body subcutaneous adipose tissue (Figure 4).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [67]
The cited source says what the claim attributes to it.
In the citing paper
“When given a test meal comprising 1/3 of daily energy needs, changes in plasma insulin and glucose concentrations across a 6-hour period are similar in normal weight males and females (67, 69, 87).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [67]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kvist, H., Chowdhury, B., Grangård, U., Tylén, U., & Sjöström, L. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.6.1351 · Cited by 794
Influence of body fat distribution on free fatty acid metabolism in obesity.
Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113997 · Cited by 683
Self-citationSex differences in the relation of visceral adipose tissue accumulation to total body fatness
Lemieux, S., Prud’homme, D., Bouchard, C., Tremblay, A., & Després, J. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.4.463 · Cited by 570
Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.
Boden, G., Jadali, F., White, J. V., Liang, Y. T., Mozzoli, M. A., Chen, X., Coleman, E., & Smith, C. R. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115399 · Cited by 494
Interaction between glucose and free fatty acid metabolism in human skeletal muscle.
Kelley, D. E., Mokáň, M., Simoneau, J. A., & Mandarino, L. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116603 · Cited by 480
Evans, D. J., Hoffman, R. G., Kalkhoff, R. K., & Kissebah, A. H. (1984) · Metabolism · doi:10.1016/0026-0495(84)90164-1 · Cited by 389
Christie, W. W. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34367-4 · Cited by 387
Havel, R. J., Kane, J. P., BALASSE, E. O., Segel, N., & Basso, L. V. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106422 · Cited by 336
The morphology and metabolism of intraabdominal adipose tissue in men
Mårin, P., Andersson, B., Ottosson, M., Olbe, L. C., Chowdhury, B., Kvist, H., Holm, G., Sjöström, L., & Björntorp, P. A. (1992) · Metabolism · doi:10.1016/0026-0495(92)90016-4 · Cited by 335
Nuutila, P., Knuuti, M. J., Mäki, M., Laine, H., Ruotsalainen, U., Teräs, M., Haaparanta, M., Solin, O., & Yki-Järvinen, H. (1995) · Diabetes · doi:10.2337/diab.44.1.31 · Cited by 253
Effects of body fat distribution on regional lipolysis in obesity.
Martin, M. L., & Jensen, M. D. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115345 · Cited by 252
Self-citationMechanisms underlying regional differences in lipolysis in human adipose tissue.
Wahrenberg, H., Lönnqvist, F., & Arner, P. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114187 · Cited by 251
Adipose tissue distribution measured by magnetic resonance imaging in obese women
Ross, R., Shaw, K., Martel, Y., de Guise, J. A., & Avruch, L. I. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.4.470 · Cited by 214
JENSEN, M. D., Kanaley, J. A., Roust, L. R., O’Brien, P. C., BRAUN, J. S., DUNN, W. L., & Wahner, H. W. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)60695-8 · Cited by 213
Self-citationRegional adipose tissue metabolism in men and postmenopausal women.
Rebuffé-Scrive, M., Lönnroth, P., Mårin, P., Wesslau, C., Björntorp, P. A., & Smith, U. (1987) · PubMed · Cited by 208
Hepatic metabolism of free fatty acids in normal and diabetic dogs
Basso, L. V., & Havel, R. J. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106264 · Cited by 203
Kissebah, A. H., Alfarsi, S., ADAMS, P. W., & Wynn, V. (1976) · Diabetologia · doi:10.1007/bf01220632 · Cited by 199
Postprandial Substrate Deposition in Human Forearm and Adipose Tissues in Vivo
Coppack, S. W., Fisher, R. M., Gibbons, G. F., Humphreys, S. M., McDonough, M. J., Potts, J. L., & Frayn, K. N. (1990) · Clinical Science · doi:10.1042/cs0790339 · Cited by 172
Uptake of individual free fatty acids by skeletal muscle and liver in man
Hagenfeldt, L., Wahren, J., Pernow, B., & Räf, L. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107043 · Cited by 170
Regional differences and effect of weight reduction on human fat cell metabolism
Smith, U., HAMMERSTEN, J., Björntorp, P. A., & Kral, J. G. (1979) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1979.tb00892.x · Cited by 168
Postprandial Free Fatty Acid Kinetics Are Abnormal in Upper Body Obesity
Roust, L. R., & Jensen, M. D. (1993) · Diabetes · doi:10.2337/diab.42.11.1567 · Cited by 164
Self-citationValidation of a new method for determination of free fatty acid turnover
Miles, J. M., Ellman, M., McClean, K. L., & Jensen, M. D. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.252.3.e431 · Cited by 161
Self-citationGroop, L., Bonadonna, R. C., Simonson, D. C., Petrides, A. S., shank, M. L., & DeFronzo, R. A. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.1.e79 · Cited by 128
Saloranta, C., Franssila-Kallunki, A., Ekstrand, A., Taskinen, M., & Groop, L. (1991) · Diabetologia · doi:10.1007/bf00403179 · Cited by 109
Uptake of triglyceride fatty acids in adipose tissue in vivo in man
Mårin, P., Rebuffé-Scrive, M., & Björntorp, P. A. (1990) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1990.tb02263.x · Cited by 101
Micro-Method for Measurement of Sub-Nanomole Amounts of Triacylglycerol
Humphreys, S. M., Fisher, R. M., & Frayn, K. N. (1990) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329002700613 · Cited by 92
Receptor and postreceptor effects of free fatty acids (FFA) on hepatocyte insulin dynamics.
Hennes, M. M. I., Shrago, E., & Kissebah, A. H. (1990) · PubMed · Cited by 89
Byrne, C. D., Wareham, N. J., Brown, D. C., CLARK, P. M. S., Cox, L., Day, N., Palmer, C. R., Wang, T. W. M., Williams, D. R. R., & Hales, C. N. (1994) · Diabetologia · doi:10.1007/bf00400944 · Cited by 79
Insulin receptor binding and insulin action in human fat cells: Effects of obesity and fasting
Pedersen, O. B., Hjøllund, E., & Sørensen, N. S. (1982) · Metabolism · doi:10.1016/0026-0495(82)90177-9 · Cited by 71
Choice of infusion-sampling mode for tracer studies of free fatty acid metabolism
Jensen, M. D., Rogers, P. J., Ellman, M., & Miles, J. M. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.5.e562 · Cited by 65
Self-citationMeasurement of non-steady-state free fatty acid turnover
Jensen, M. D., Heiling, V. J., & Miles, J. M. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.1.e103 · Cited by 51
Self-citationMcKeigue, P., Laws, A., Chen, Y. I., Marmot, M. G., & Reaven, G. M. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.8.1187 · Cited by 51
Pørksen, N., Munn, S. R., Ferguson, D., O’Brien, T., Veldhuis, J. D., & Butler, P. C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117310 · Cited by 45
Arner, P., Bolinder, J., Engfeldt, P., Hellmér, J., & Östman, J. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111259 · Cited by 43
Postprandial free fatty acid kinetics are abnormal in upper body obesity
Roust, L. R., & Jensen, M. D. (1993) · Diabetes · doi:10.2337/diabetes.42.11.1567 · Cited by 40
Self-citationMarked Increase in Insulin Sensitivity of Human Fat Cells 1 Hour after Glucose Ingestion
Arner, P., Bolinder, J., & Östman, J. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110817 · Cited by 30
Byrne, C. D., Palmer, C., Wang, T. W. M., et al. (1994) · Diabetologia · doi:10.1007/s001250050193 · Cited by 4
Flagged first, then by citations
Cited by
Sorted by citations
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583
Sex differences in human adipose tissues – the biology of pear shape
Karastergiou, K., Smith, S. R., Greenberg, A. S., & Fried, S. K. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-13 · Cited by 1,109
Assessing Adiposity: A Scientific Statement From the American Heart Association
Cornier, M.-A., Després, J.-P., Davis, N., Grossniklaus, D. A., Klein, S., Lamarche, B., Lopez-Jimenez, F., Rao, G., St-Onge, M.-P., Towfighi, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318233bc6a · Cited by 945
Splanchnic lipolysis in human obesity
Nielsen, S., Guo, Z., Johnson, C. M., Hensrud, D. D., & Jensen, M. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21047 · Cited by 933
Self-citationLee, M., Wu, Y., & Fried, S. K. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.10.001 · Cited by 861
Metadata
- Authors
- Jensen, M. D.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Jensen, M D
- ORCID
- Jensen, M D
- Venue
- Journal of Clinical Investigation
- Published
- 1995-11-01
- Volume
- 96
- Issue
- 5
- Pages
- 2297-2303
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC185880
- OpenAlex
- W2127037606
- Cited by
- 191
- References
- 35
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 3 · 2022: 15 · 2021: 3 · 2020: 11 · 2019: 9 · 2018: 3 · 2017: 5 · 2016: 10 · 2015: 6 · 2014: 10 · 2013: 10 · 2012: 11
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Clinic
- Mayo Foundation for Medical Education and Research
- National Institutes of Health (RR-00585)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 45343, R01DK045343)
- National Center for Research Resources (RR-00585, M01RR000585)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- gender differences, fatty acid metabolism, postprandial lipemia, adipose tissue lipolysis, subcutaneous adipose tissue, meal ingestion, body fat distribution
- MeSH terms
- Adipose Tissue, Adult, Fatty Acids, Female, Food, Humans, Male, Organ Specificity, Sex Characteristics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
