The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue.
Open accessAbstract
The regulation of ob gene expression in abdominal subcutaneous adipose tissue was investigated using a reverse transcription-competitive PCR method to quantify the mRNA level of leptin. Leptin mRNA level was highly correlated with the body mass index of 26 subjects (12 lean, 7 non-insulin-dependent diabetic, and 7 obese patients). The effect of fasting on ob gene expression was investigated in 10 subjects maintained on a hypocaloric diet (1045 KJ/d) for 5 d. While their metabolic parameters significantly changed (decrease in insulinemia, glycemia, and resting metabolic rate and increase in plasma ketone bodies), the caloric restriction did not modify the leptin mRNA level in the adipose tissue. To verify whether insulin regulates ob gene expression, six lean subjects underwent a 3-h euglycemic hyperinsulinemic (846 +/- 138 pmol/liter) clamp. Leptin and Glut 4 mRNA levels were quantified in adipose tissue biopsies taken before and at the end of the clamp. Insulin infusion produced a significant threefold increase in Glut 4 mRNA while leptin mRNA was not affected. It is concluded that ob gene expression is not acutely regulated by insulin or by metabolic factors related to fasting in human abdominal subcutaneous adipose tissue.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498
Increased obese mRNA expression in omental fat cells from massively obese humans
Hamilton, B. S., Paglia, D., Kwan, A. Y. M., & Deitel, M. (1995) · Nature Medicine · doi:10.1038/nm0995-953 · Cited by 526
Cited by
The biology of leptin: a review.
Houseknecht, K. L., Baile, C. A., Matteri, R. L., & Spurlock, M. E. (1998) · Journal of Animal Science · doi:10.2527/1998.7651405x · Cited by 744
Evidence That Glucose Metabolism Regulates Leptin Secretion from Cultured Rat Adipocytes
Mueller, W. M., Gregoire, F. M., Stanhope, K. L., Mobbs, C. V., Mizuno, T. M., Warden, C. H., Stern, J. S., & Havel, P. J. (1998) · Endocrinology · doi:10.1210/en.139.2.551 · Cited by 434
Auwerx, J., & Staels, B. (1998) · The Lancet · doi:10.1016/s0140-6736(97)06348-4 · Cited by 391
Self-citationRegulation of Body Weight in Humans
Jéquier, E., & Tappy, L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.451 · Cited by 373
Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.
Millet, L., Vidal, H., Andreelli, F., Larrouy, D., Riou, J. P., Ricquier, D., Laville, M., & Langin, D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119811 · Cited by 351
Self-citation
Metadata
- Authors
- Vidal, H., Auboeuf, D., De Vos, P., Staels, B., Riou, J. P., Auwerx, J., & Laville, M.
- Venue
- Journal of Clinical Investigation
- Published
- 1996-07-15
- Volume
- 98
- Issue
- 2
- Pages
- 251-255
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2156471241
- Cited by
- 181
- References
- 4
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. https://app.cochat.ai/papers/10.1172/jci118786
- The paper
- Vidal, H., Auboeuf, D., De Vos, P., Staels, B., Riou, J. P., Auwerx, J., & Laville, M. (1996). The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. Journal of Clinical Investigation. https://doi.org/10.1172/jci118786
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
